• 487 Citations
  • 10 h-Index
20122019
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Research Output 2012 2019

  • 487 Citations
  • 10 h-Index
  • 30 Article
2019

Atrial fibrillation observed in a patient with esophageal cancer treated with fluorouracil

Moriyama, S., Yokoyama, T., Irie, K., Ito, M., Tsuchihashi, K., Fukata, M., Kusaba, H., Maruyama, T. & Akashi, K., Nov 2019, In : Journal of Cardiology Cases. 20, 5, p. 183-186 4 p.

Research output: Contribution to journalArticle

Open Access
Esophageal Neoplasms
Fluorouracil
Atrial Fibrillation
Coronary Vessels
Nicorandil

Efficacy and safety of ramucirumab plus modified FOLFIRI for metastatic colorectal cancer

Yoshihiro, T., Kusaba, H., Makiyama, A., Kobayashi, K., Uenomachi, M., Ito, M., Doi, Y., Mitsugi, K., Aikawa, T., Takayoshi, K., Esaki, T., Shimokawa, H., Tsuchihashi, K., ariyama, H., Akashi, K. & Baba, E., May 15 2019, In : International Journal of Clinical Oncology. 24, 5, p. 508-515 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Safety
irinotecan
Confidence Intervals
ramucirumab
2 Citations (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Sulfasalazine
Pulmonary Hypertension
Glutathione
Antioxidants
Chemotherapy
2018
8 Citations (Scopus)

Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody

Yamaguchi, K., Mishima, K., Ohmura, H., Hanamura, F., Ito, M., Nakano, M., Tsuchihashi, K., Ota, S. I., Wada, N., Hiroshi, U., ariyama, H., Kusaba, H., Niiro, H., Akashi, K. & Baba, E., Oct 1 2018, In : Cancer Science. 109, 10, p. 3032-3042 11 p.

Research output: Contribution to journalArticle

Th1 Cells
Melanoma
T-Lymphocytes
Antibodies
Phenotype
4 Citations (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., Mar 4 2018, In : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

Organoids
Thyroglobulin
Iodides
Cell culture
Thyroid Gland
1 Citation (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., Dec 1 2018, In : Cancer Science. 109, 12, p. 3874-3882 9 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Epidermal Growth Factor Receptor
Glioma
Glutamic Acid
Epidermal Growth Factor

Epithelial-mesenchymal transition is activated in CD44-positive malignant ascites tumor cells of gastrointestinal cancer

Nakano, M., Ito, M., Tanaka, R., Ariyama, H., Mitsugi, K., Makiyama, A., Uchino, K., Esaki, T., Tsuruta, N., Hanamura, F., Yamaguchi, K., Okumura, Y., Sagara, K., Takayoshi, K., Nio, K., Tsuchihashi, K., Tamura, S., Shimokawa, H., Arita, S., Miyawaki, K. & 3 others, Kusaba, H., Akashi, K. & Baba, E., Nov 2018, In : Cancer Science. 109, 11, p. 3461-3470 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Epithelial-Mesenchymal Transition
Ascites
Neoplasms
Transforming Growth Factor beta

Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma A case report

Tsuchihashi, K., Arita, S., Fujiwara, M., Iwasaki, K., Hirano, A., Yoshihiro, T., Nio, K., Koga, Y., Esaki, M., ariyama, H., Kusaba, H., Moriyama, T., Ouchida, K., Nagai, E., Nakamura, M., Oda, Y., Akashi, K. & Baba, E., Oct 1 2018, In : Medicine (United States). 97, 41, e12796.

Research output: Contribution to journalArticle

Carcinosarcoma
Neuroendocrine Carcinoma
Sarcoma
Squamous Cell Carcinoma
Etoposide
1 Citation (Scopus)

PD-1+ TIM-3+ T cells in malignant ascites predict prognosis of gastrointestinal cancer

Nakano, M., Ito, M., Tanaka, R., Yamaguchi, K., ariyama, H., Mitsugi, K., Yoshihiro, T., Ohmura, H., Tsuruta, N., Hanamura, F., Sagara, K., Okumura, Y., Nio, K., Tsuchihashi, K., Arita, S., Kusaba, H., Akashi, K. & Baba, E., Sep 1 2018, In : Cancer Science. 109, 9, p. 2986-2992 7 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Gastrointestinal Neoplasms
Ascites
Cell Death
T-Lymphocytes
1 Citation (Scopus)

Role of Predictive Value of the Modified Glasgow Prognostic Score for Later-line Chemotherapy in Patients With Metastatic Colorectal Cancer

Tsuchihashi, K., Ito, M., Moriwaki, T., Fukuoka, S., Taniguchi, H., Takashima, A., Kumekawa, Y., Kajiwara, T., Yamazaki, K., Esaki, T., Makiyama, A., Denda, T., Satake, H., Suto, T., Sugimoto, N., Katsumata, K., Ishikawa, T., Kashiwada, T., Oki, E., Komatsu, Y. & 8 others, Okuyama, H., Sakai, D., Ueno, H., Tamura, T., Yamashita, K., Kishimoto, J., Shimada, Y. & Baba, E., Dec 1 2018, In : Clinical Colorectal Cancer. 17, 4, p. e687-e697

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Therapy
Confidence Intervals
Disease-Free Survival
Survival

Successful chemotherapeutic treatment for metastatic littoral cell angioma: A case report

Takayoshi, K., Doi, G., Tsuruta, N., Yoshihiro, T., Nio, K., Tsuchihashi, K., ariyama, H., Odawara, J., Shimoda, S., Kouhashi, K., Oda, Y., itoh, S., Harimoto, N., Maehara, Y., Kusaba, H., Akashi, K. & Baba, E., Apr 1 2018, In : Medicine (United States). 97, 15, e0378.

Research output: Contribution to journalArticle

Hepatomegaly
Cytotoxins
Deoxyglucose
Liver
Tomography
2 Citations (Scopus)

The risk factors for oxaliplatin-induced peripheral sensory neuropathy and thrombocytopenia in advanced gastric cancer

Yamaguchi, K., Kusaba, H., Makiyama, A., Mitsugi, K., Uchino, K., Tamura, S., Shibata, Y., Esaki, T., Ito, M., Takayoshi, K., Tsuchihashi, K., Arita, S., ariyama, H., Akashi, K. & Baba, E., Oct 1 2018, In : Cancer chemotherapy and pharmacology. 82, 4, p. 625-633 9 p.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nervous System Diseases
Thrombocytopenia
Stomach Neoplasms
Medical problems
2017
4 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., Nov 1 2017, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
28 Citations (Scopus)

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Shitara, K., Doi, T., Nagano, O., Imamura, C. K., Ozeki, T., Ishii, Y., Tsuchihashi, K., Takahashi, S., Nakajima, T. E., Hironaka, S., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Einaga, Y., Kuwata, T., Saya, H. & Ohtsu, A., Mar 1 2017, In : Gastric Cancer. 20, 2, p. 341-349 9 p.

Research output: Contribution to journalArticle

Sulfasalazine
Neoplastic Stem Cells
Stomach Neoplasms
Biopsy
Oxidative Stress
1 Citation (Scopus)

Lingual alveolar soft part sarcoma responsive to pazopanib: A case report

Yoshihiro, T., Tsuchihashi, K., Nio, K., Arita, S., Nakano, T., Yasumatsu, R., Jiroumaru, R., ariyama, H., Kusaba, H., Oda, Y., Akashi, K. & Baba, E., Nov 1 2017, In : Medicine (United States). 96, 44, e8470.

Research output: Contribution to journalArticle

Alveolar Soft Part Sarcoma
Tongue
Articulation Disorders
Lung
Ifosfamide

Metastatic esophageal cancer presenting as shock by injury of vagus nerve mimicking baroreceptor reflex: A case report

Tsuchihashi, K., Yoshihiro, T., Aikawa, T., Nio, K., Takayoshi, K., Yokoyama, T., Fukata, M., Arita, S., ariyama, H., Shimizu, Y., Yoshida, Y., torisu, T., Esaki, M., Odashiro, K., Kusaba, H., Akashi, K. & Baba, E., Dec 1 2017, In : Medicine (United States). 96, 49, e8987.

Research output: Contribution to journalArticle

Vagus Nerve Injuries
Baroreflex
Esophageal Neoplasms
Vagus Nerve
Shock
11 Citations (Scopus)

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)

Shitara, K., Doi, T., Nagano, O., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Kuwata, T., Asai, K., Einaga, Y., Tsuchihashi, K., Suina, K., Maeda, Y., Saya, H. & Ohtsu, A., Nov 1 2017, In : Gastric Cancer. 20, 6, p. 1004-1009 6 p.

Research output: Contribution to journalArticle

Sulfasalazine
Cisplatin
Stomach Neoplasms
Amino Acid Transport System X-AG
Cystine
7 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., Sep 1 2017, In : Cancer Science. 108, 9, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells

Regorafenib-induced retinal and gastrointestinal hemorrhage in a metastatic colorectal cancer patient with liver dysfunction

Tsuchihashi, K., Shimokawa, H., Takayoshi, K., Nio, K., Aikawa, T., Matsushita, Y., Wada, I., Arita, S., ariyama, H., Kusaba, H., Sonoda, K., Akashi, K. & Baba, E., Oct 1 2017, In : Medicine (United States). 96, 42, e8285.

Research output: Contribution to journalArticle

Retinal Hemorrhage
Gastrointestinal Hemorrhage
Liver Diseases
Colorectal Neoplasms
Hemorrhage
8 Citations (Scopus)

Suggestion of added value by bevacizumab to chemotherapy in patients with unresectable or recurrent small bowel cancer

Takayoshi, K., Kusaba, H., Uenomachi, M., Mitsugi, K., Makiyama, C., Makiyama, A., Uchino, K., Shirakawa, T., Shibata, Y., Shinohara, Y., Inadomi, K., Tsuchihashi, K., Arita, S., ariyama, H., Esaki, T., Akashi, K. & Baba, E., Aug 1 2017, In : Cancer Chemotherapy and Pharmacology. 80, 2, p. 333-342 10 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Chemotherapy
Drug Therapy
Adenocarcinoma
oxaliplatin
2016
18 Citations (Scopus)

Current cigarette smoking is a reversible cause of elevated white blood cell count: Cross-sectional and longitudinal studies

Higuchi, T., Omata, F., Tsuchihashi, K., Higashioka, K., Koyamada, R. & Okada, S., Dec 1 2016, In : Preventive Medicine Reports. 4, p. 417-422 6 p.

Research output: Contribution to journalArticle

Leukocyte Count
Longitudinal Studies
Cross-Sectional Studies
Smoking
Smoking Cessation
11 Citations (Scopus)

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells

Okazaki, S., Nakatani, F., Masuko, K., Tsuchihashi, K., Ueda, S., Masuko, T., Saya, H. & Nagano, O., Jan 29 2016, In : Biochemical and Biophysical Research Communications. 470, 1, p. 239-244 6 p.

Research output: Contribution to journalArticle

Neuregulin-1
Chemical activation
Monoclonal Antibodies
Cells
Cell proliferation
6 Citations (Scopus)

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines

Wang, M., Miura, Y., Tsuchihashi, K., Miyano, K., Nagano, O., Yoshikawa, M., Tanabe, A., Makino, J., Mochida, Y., Nishiyama, N., Saya, H., Cabral, H. & Kataoka, K., May 28 2016, In : Journal of Controlled Release. 230, p. 26-33 8 p.

Research output: Contribution to journalArticle

Nanomedicine
Cisplatin
Neck
Head
Neoplastic Stem Cells
24 Citations (Scopus)

The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)

Tsuchihashi, K., Okazaki, S., Ohmura, M., Ishikawa, M., Sampetrean, O., Onishi, N., Wakimoto, H., Yoshikawa, M., Seishima, R., Iwasaki, Y., Morikawa, T., Abe, S., Takao, A., Shimizu, M., Masuko, T., Nagane, M., Furnari, F. B., Akiyama, T., Suematsu, M., Baba, E. & 3 others, Akashi, K., Saya, H. & Nagano, O., May 15 2016, In : Cancer Research. 76, 10, p. 2954-2963 10 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Epidermal Growth Factor Receptor
Glioma
Cystine
Glutamic Acid
2015
13 Citations (Scopus)

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Ohmura, M., Hishiki, T., Yamamoto, T., Nakanishi, T., Kubo, A., Tsuchihashi, K., Tamada, M., Toue, S., Kabe, Y., Saya, H. & Suematsu, M., Apr 30 2015, In : Nitric Oxide - Biology and Chemistry. 46, p. 102-113 12 p.

Research output: Contribution to journalArticle

Mass spectrometry
Tumors
Mass Spectrometry
Cells
Imaging techniques
2 Citations (Scopus)

Successful treatment of adult Langerhans cell histiocytosis with intensified chemotherapy

Minami, M., Shima, T., Kato, K., Yamamoto, H., Tsuchihashi, K., Oku, S., Shimokawa, T., Tochigi, T., Yoshimoto, G., Kamezaki, K., Takenaka, K., Iwasaki, H., Oda, Y., Miyamoto, T. & Akashi, K., Aug 11 2015, In : International journal of hematology. 102, 2, p. 244-248 5 p.

Research output: Contribution to journalArticle

Langerhans Cell Histiocytosis
Drug Therapy
Pediatrics
Therapeutics
Clinical Protocols
2014
4 Citations (Scopus)

Interstitial pneumonia during bevacizumab-based chemotherapy for colorectal cancer

Tamura, S., Kusaba, H., Kubo, N., Ijichi, K., Tsuchihashi, K., Komoda, M., Uchino, K., ariyama, H., Akashi, K. & Baba, E., Jan 1 2014, In : Medical Oncology. 31, 3, 856.

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Colorectal Neoplasms
Drug Therapy
Lung
Pharmaceutical Preparations
2013
48 Citations (Scopus)

Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia

Wada, T., Ishimoto, T., Seishima, R., Tsuchihashi, K., Yoshikawa, M., Oshima, H., Oshima, M., Masuko, T., Wright, N. A., Furuhashi, S., Hirashima, K., Baba, H., Kitagawa, Y., Saya, H. & Nagano, O., Oct 1 2013, In : Cancer Science. 104, 10, p. 1323-1329 7 p.

Research output: Contribution to journalArticle

Metaplasia
Stomach
Cystine
Neoplasms
Carcinogenesis
95 Citations (Scopus)

XCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma

Yoshikawa, M., Tsuchihashi, K., Ishimoto, T., Yae, T., Motohara, T., Sugihara, E., Onishi, N., Masuko, T., Yoshizawa, K., Kawashiri, S., Mukai, M., Asoda, S., Kawana, H., Nakagawa, T., Saya, H. & Nagano, O., Mar 15 2013, In : Cancer Research. 73, 6, p. 1855-1866 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Neoplasms
Cystine
Therapeutics
Neoplastic Stem Cells
2012
178 Citations (Scopus)

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

Yae, T., Tsuchihashi, K., Ishimoto, T., Motohara, T., Yoshikawa, M., Yoshida, G. J., Wada, T., Masuko, T., Mogushi, K., Tanaka, H., Osawa, T., Kanki, Y., Minami, T., Aburatani, H., Ohmura, M., Kubo, A., Suematsu, M., Takahashi, K., Saya, H. & Nagano, O., Jul 6 2012, In : Nature communications. 3, 883.

Research output: Contribution to journalArticle

splicing
Alternative Splicing
metastasis
lungs
cancer