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Research Output 1983 2019

2019

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia
1 Citation (Scopus)

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Open Access
Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia
3 Citations (Scopus)

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

pioglitazone
Nanomedicine
PPAR gamma
Monocytes
Animal Models
2018
1 Citation (Scopus)

BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice

Okadome, J., Matsumoto, T., Yoshiya, K., Matsuda, D., Tamada, K., Onimaru, M., Nakano, K., Egashira, K., Yonemitsu, Y. & Maehara, Y., Aug 1 2018, In : Journal of Vascular Surgery. 68, 2, p. 576-586.e1

Research output: Contribution to journalArticle

Extremities
Ambulatory Surgical Procedures
Muscles
Ischemia
Vascular Endothelial Growth Factor A
3 Citations (Scopus)

Lipid-Lowering Therapy with Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion

Honda, K., Matoba, T., Antoku, Y., Koga, J. I., Ichi, I., Nakano, K., Tsutsui, H. & Egashira, K., Apr 1 2018, In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. 757-771 15 p.

Research output: Contribution to journalArticle

Rabbits
Lipids
Thromboplastin
Serum
Arteries
Monocrotaline
Pulmonary Hypertension
Intravenous Administration
Nanoparticles
Pulmonary Artery
2 Citations (Scopus)
Intravenous Administration
Nanoparticles
Pharmacokinetics
Placebos
Research Personnel
2017

Anti-inflammatory Nanomedicine for Cardiovascular Disease

Katsuki, S., Matoba, T., Koga, J-I., Nakano, K. & Egashira, K., 2017, In : Frontiers in cardiovascular medicine. 4, p. 87

Research output: Contribution to journalReview article

Nanomedicine
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Nanotechnology
Anti-Inflammatory Agents
Cardiovascular Diseases
11 Citations (Scopus)

Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting: the CuVIC trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial

Takase, S., Matoba, T., Nakashiro, S., Mukai, Y., Inoue, S., Oi, K., Higo, T., Katsuki, S., Takemoto, M., Suematsu, N., Eshima, K., Miyata, K., Yamamoto, M., Usui, M., Sadamatsu, K., Satoh, S., Kadokami, T., Hironaga, K., Ichi, I., Todaka, K. & 3 others, Kishimoto, J., Egashira, K. & Sunagawa, K., Feb 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coronary Vessels
Randomized Controlled Trials
Coronary Angiography
5 Citations (Scopus)

Marked augmentation of plga nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Kozuka, C., Shimizu-Okabe, C., Takayama, C., Nakano, K., Morinaga, H., Kinjo, A., Fukuda, K., Kamei, A., Yasuoka, A., Kondo, T., Abe, K., Egashira, K. & Masuzaki, H., Feb 9 2017, In : Drug Delivery. 24, 1, p. 558-568 11 p.

Research output: Contribution to journalArticle

Nanoparticles
Endoplasmic Reticulum Stress
Islets of Langerhans
Hypothalamus
Polyglactin 910
12 Citations (Scopus)

Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model

Nabeshima, A., Pajarinen, J., Lin, T. H., Jiang, X., Gibon, E., Córdova, L. A., Loi, F., Lu, L., Jämsen, E., Egashira, K., Yang, F., Yao, Z. & Goodman, S. B., Feb 1 2017, In : Biomaterials. 117, p. 1-9 9 p.

Research output: Contribution to journalArticle

Polyethylene
Mutant Proteins
Macrophages
Polyethylenes
Bone
17 Citations (Scopus)
Ventricular Remodeling
Nanoparticles
Monocytes
Macrophages
Myocardial Infarction
14 Citations (Scopus)

Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease

Matoba, T., Koga, J. I., Nakano, K., Egashira, K. & Tsutsui, H., Sep 1 2017, In : Journal of Cardiology. 70, 3, p. 206-211 6 p.

Research output: Contribution to journalReview article

Drug Delivery Systems
Nanoparticles
Cardiovascular Diseases
pioglitazone
Monocytes

Nanoparticle-mediated endothelial cell-selective drug delivery system

Nakano, K., Koga, J. I. & Egashira, K., Jul 11 2017, Therapeutic Angiogenesis. Springer Singapore, p. 247-266 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endothelial cells
Nanotechnology
Nanoparticles
Restoration
Skin
2016
14 Citations (Scopus)

Anti-inflammatory nanoparticle for prevention of atherosclerotic vascular diseases

Koga, J. I., Matoba, T. & Egashira, K., Jan 1 2016, In : Journal of atherosclerosis and thrombosis. 23, 7, p. 757-765 9 p.

Research output: Contribution to journalArticle

Vascular Diseases
Nanoparticles
Anti-Inflammatory Agents
Drug Delivery Systems
Tissue
9 Citations (Scopus)
myocardial infarction
nanoparticles
ischemia
myocardium
Reperfusion Injury
5 Citations (Scopus)

BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice

Tanaka, S., Matsumoto, T., Matsubara, Y., Harada, Y., Kyuragi, R., Koga, J. I., Egashira, K., Nakashima, Y., Yonemitsu, Y. & Maehara, Y., Sep 2016, In : Journal of the American Heart Association. 5, 9, e004081.

Research output: Contribution to journalArticle

Apolipoproteins E
Atherosclerosis
Macrophages
Bone Marrow Cells
Bone Marrow
5 Citations (Scopus)

Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation

Osaka, M., Ito, S., Honda, M., Inomata, Y., Egashira, K. & Yoshida, M., Feb 19 2016, In : Scientific reports. 6, 21391.

Research output: Contribution to journalArticle

High Fat Diet
Blood Vessels
Neutrophils
Inflammation
Leukocytes
97 Citations (Scopus)

Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Mar 29 2016, In : Circulation. 133, 13, p. 1249-1263 15 p.

Research output: Contribution to journalArticle

Autophagy
Heart Failure
Pressure
Constriction
Down-Regulation
3 Citations (Scopus)

Ezetimibe reduced hepatic steatosis induced by dietary oxysterols in nonhuman primates

Deushi, M., Osaka, M., Nakano, K., Osada, K., Egashira, K. & Yoshida, M., Oct 1 2016, In : FEBS Open Bio. 6, 10, p. 1008-1015 8 p.

Research output: Contribution to journalArticle

Primates
Cholesterol
Liver
Lipids
High Fat Diet
9 Citations (Scopus)

Intratracheal administration of prostacyclin analogue-incorporated nanoparticles ameliorates the development of monocrotaline and sugen-hypoxia-induced pulmonary arterial hypertension

Akagi, S., Nakamura, K., Matsubara, H., Kondo, M., Miura, D., Matoba, T., Egashira, K. & Ito, H., Apr 1 2016, In : Journal of Cardiovascular Pharmacology. 67, 4, p. 290-298 9 p.

Research output: Contribution to journalArticle

beraprost
Monocrotaline
Epoprostenol
Pulmonary Hypertension
Nanoparticles
18 Citations (Scopus)

Local delivery of mutant CCL2 protein-reduced orthopaedic implant wear particle-induced osteolysis and inflammation in vivo

Jiang, X., Sato, T., Yao, Z., Keeney, M., Pajarinen, J., Lin, T. H., Loi, F., Egashira, K., Goodman, S. & Yang, F., Jan 1 2016, In : Journal of Orthopaedic Research. 34, 1, p. 58-64 7 p.

Research output: Contribution to journalArticle

Osteolysis
Mutant Proteins
Orthopedics
Replacement Arthroplasties
Inflammation
27 Citations (Scopus)

Nanoparticle-mediated delivery of irbesartan induces cardioprotection from myocardial ischemia-reperfusion injury by antagonizing monocyte-mediated inflammation

Nakano, Y., Matoba, T., Tokutome, M., Funamoto, D., Katsuki, S., Ikeda, G., Nagaoka, K., Ishikita, A., Nakano, K., Koga, J. I., Sunagawa, K. & Egashira, K., Jul 11 2016, In : Scientific reports. 6, 29601.

Research output: Contribution to journalArticle

irbesartan
Myocardial Reperfusion Injury
Reperfusion Injury
Nanoparticles
Reperfusion
25 Citations (Scopus)
Reperfusion Injury
Nanoparticles
Myocardium
Mitochondria
Myocardial Infarction
Open Access
Myocardium
Mitochondria
Myocardial Infarction
Membranes
Wounds and Injuries
26 Citations (Scopus)

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

Ikeda, G., Matoba, T., Nakano, Y., Nagaoka, K., Ishikita, A., Nakano, K., Funamoto, D., Sunagawa, K. & Egashira, K., Feb 10 2016, In : Scientific reports. 6, 20467.

Research output: Contribution to journalArticle

Reperfusion Injury
Nanoparticles
Cyclosporine
glycolic acid
Reperfusion
34 Citations (Scopus)

Pioglitazone-incorporated nanoparticles prevent plaque destabilization and rupture by regulating monocyte/macrophage differentiation in ApoE -/-Mice

Nakashiro, S., Matoba, T., Umezu, R., Koga, J. I., Tokutome, M., Katsuki, S., Nakano, K., Sunagawa, K. & Egashira, K., Mar 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 3, p. 491-500 10 p.

Research output: Contribution to journalArticle

pioglitazone
Apolipoproteins E
Nanoparticles
Rupture
Monocytes
1 Citation (Scopus)

Response by Shirakabe et al to letter regarding article, "Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure"

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Aug 9 2016, In : Circulation. 134, 6, p. e75-e76

Research output: Contribution to journalLetter

Autophagy
Mitochondria
Heart Failure
Pressure
15 Citations (Scopus)

The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis

Sato, T., Pajarinen, J., Behn, A., Jiang, X., Lin, T. H., Loi, F., Yao, Z., Egashira, K., Yang, F. & Goodman, S. B., Sep 1 2016, In : Journal of Biomedical Materials Research - Part A. 104, 9, p. 2255-2262 8 p.

Research output: Contribution to journalArticle

Interleukin-4
Structural properties
Bone
Wear of materials
Macrophages
2015
34 Citations (Scopus)

A new therapeutic modality for acute myocardial infarction: Nanoparticle-mediated delivery of pitavastatin induces cardioprotection from ischemia-reperfusion injury via activation of PI3K/Akt pathway and anti-inflammation in a rat model

Nagaoka, K., Matoba, T., Mao, Y., Nakano, Y., Ikeda, G., Egusa, S., Tokutome, M., Nagahama, R., Nakano, K., Sunagawa, K. & Egashira, K., Jul 13 2015, In : PloS one. 10, 7, e0132451.

Research output: Contribution to journalArticle

myocardial infarction
phosphatidylinositol 3-kinase
nanoparticles
ischemia
Reperfusion Injury
13 Citations (Scopus)

Delivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Ulmonary Arterial Hypertension

Akagi, S., Nakamura, K., Miura, D., Saito, Y., Matsubara, H., Ogawa, A., Matoba, T., Egashira, K. & Ito, H., Apr 27 2015, In : International heart journal. 56, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

Monocrotaline
Nanoparticles
Hypertension
Lung
Pulmonary Hypertension
169 Citations (Scopus)

Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress

Ikeda, Y., Shirakabe, A., Maejima, Y., Zhai, P., Sciarretta, S., Toli, J., Nomura, M., Mihara, K., Egashira, K., Ohishi, M., Abdellatif, M. & Sadoshima, J., Jan 16 2015, In : Circulation research. 116, 2, p. 264-278 15 p.

Research output: Contribution to journalArticle

Dynamins
Autophagy
Proteins
Knockout Mice
Down-Regulation

Nanoparticle-mediated drug delivery system for coronary artery disease

Matoba, T., Koga, J. I., Nakano, K. & Egashira, K., Dec 25 2015, In : Drug Delivery System. 30, 4, p. 299-308 10 p.

Research output: Contribution to journalReview article

Drug Delivery Systems
Nanoparticles
Coronary Artery Disease
Myocardial Infarction
Medicine
18 Citations (Scopus)

NF-κB decoy oligodeoxynucleotide enhanced osteogenesis in mesenchymal stem cells exposed to polyethylene particle

Lin, T. H., Sato, T., Barcay, K. R., Waters, H., Loi, F., Zhang, R., Pajarinen, J., Egashira, K., Yao, Z. & Goodman, S. B., Mar 1 2015, In : Tissue Engineering - Part A. 21, 5-6, p. 875-883 9 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Polyethylene
Stem cells
Mesenchymal Stromal Cells
Osteogenesis
9 Citations (Scopus)

NF-κB decoy oligodeoxynucleotide inhibits wear particle-induced inflammation in a murine calvarial model

Sato, T., Pajarinen, J., Lin, T. H., Tamaki, Y., Loi, F., Egashira, K., Yao, Z. & Goodman, S. B., Dec 1 2015, In : Journal of Biomedical Materials Research - Part A. 103, 12, p. 3872-3878 7 p.

Research output: Contribution to journalArticle

NF-kappa B
Oligodeoxyribonucleotides
Wear of materials
Macrophages
RANK Ligand
2014
13 Citations (Scopus)

Mutant monocyte chemoattractant protein 1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopedic implant wear particles

Yao, Z., Keeney, M., Lin, T. H., Pajarinen, J., Barcay, K., Waters, H., Egashira, K., Yang, F. & Goodman, S., Jan 1 2014, In : Journal of Biomedical Materials Research - Part A. 102, 9, p. 3291-3297 7 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Macrophages
Orthopedics
Wear of materials
Cytokines
66 Citations (Scopus)

Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes

Katsuki, S., Matoba, T., Nakashiro, S., Sato, K., Koga, J. I., Nakano, K., Nakano, Y., Egusa, S., Sunagawa, K. & Egashira, K., Feb 25 2014, In : Circulation. 129, 8, p. 896-906 11 p.

Research output: Contribution to journalArticle

Atherosclerotic Plaques
Nanoparticles
Rupture
Monocytes
Chemokine CCL2
31 Citations (Scopus)

Nanoparticle-mediated drug delivery system for cardiovascular disease

Matoba, T. & Egashira, K., Jan 1 2014, In : International heart journal. 55, 4, p. 281-286 6 p.

Research output: Contribution to journalReview article

Drug Delivery Systems
Nanoparticles
Cardiovascular Diseases
Myocardial Reperfusion Injury
Reperfusion Injury
Nanotechnology
Drug Delivery Systems
Cardiovascular Diseases
Therapeutics
64 Citations (Scopus)

Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement

Goodman, S. B., Gibon, E., Pajarinen, J., Lin, T. H., Keeney, M., Ren, P. G., Nich, C., Yao, Z., Egashira, K., Yang, F. & Konttinen, Y. T., Apr 6 2014, In : Journal of the Royal Society Interface. 11, 93, 20130962.

Research output: Contribution to journalReview article

Replacement Arthroplasties
Osteolysis
Orthopedics
Wear of materials
NF-kappa B
28 Citations (Scopus)

Suppression of wear-particle-induced pro-inflammatory cytokine and chemokine production in macrophages via NF-κB decoy oligodeoxynucleotide: A preliminary report

Lin, T. H., Yao, Z., Sato, T., Keeney, M., Li, C., Pajarinen, J., Yang, F., Egashira, K. & Goodman, S. B., Jan 1 2014, In : Acta Biomaterialia. 10, 8, p. 3747-3755 9 p.

Research output: Contribution to journalArticle

Macrophages
Oligodeoxyribonucleotides
Chemokines
Wear of materials
Cytokines
2013
15 Citations (Scopus)

Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice

Kitamoto, S., Egashira, K., Ichiki, T., Han, X., McCurdy, S., Sakuda, S., Sunagawa, K. & Boisvert, W. A., Jul 1 2013, In : American Journal of Pathology. 183, 1, p. 313-325 13 p.

Research output: Contribution to journalArticle

Chitinases
allosamidin
Atherosclerosis
Macrophages
Cholesterol
32 Citations (Scopus)

Mouse models of plaque rupture

Matoba, T., Sato, K. & Egashira, K., Oct 1 2013, In : Current Opinion in Lipidology. 24, 5, p. 419-425 7 p.

Research output: Contribution to journalReview article

Rupture
Apolipoproteins E
Atherosclerotic Plaques
Arteries
High Fat Diet
31 Citations (Scopus)

Mutant MCP-1 protein delivery from layer-by-layer coatings onorthopedic implants to modulate inflammatory response

Keeney, M., Waters, H., Barcay, K., Jiang, X., Yao, Z., Pajarinen, J., Egashira, K., Goodman, S. B. & Yang, F., Dec 1 2013, In : Biomaterials. 34, 38, p. 10287-10295 9 p.

Research output: Contribution to journalArticle

Macrophages
Chemotactic Factors
Proteins
Coatings
Replacement Arthroplasties
34 Citations (Scopus)

Pitavastatin-incorporated nanoparticle-eluting stents attenuate in-stent stenosis without delayed endothelial healing effects in a porcine coronary artery model

Tsukie, N., Nakano, K., Matoba, T., Masuda, S., Iwata, E., Miyagawa, M., Zhao, G., Meng, W., Kishimoto, J., Sunagawa, K. & Egashira, K., Feb 4 2013, In : Journal of Atherosclerosis and Thrombosis. 20, 1, p. 32-45 14 p.

Research output: Contribution to journalArticle

Stents
Nanoparticles
Coronary Vessels
Pathologic Constriction
Swine
2012
68 Citations (Scopus)

Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration

Suzuki, M., Tsujikawa, M., Itabe, H., Du, Z. J., Xie, P., Matsumura, N., Fu, X., Zhang, R., Sonoda, K., Egashira, K., Hazen, S. L. & Kamei, M., Aug 14 2012, In : Journal of Cell Science. 125, 10, p. 2407-2415 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Oxidative Stress
Phospholipids
Chemokine CCL2
Choroidal Neovascularization

Clinical application for intra-coronary nanodds devices

Nakano, K., Egashira, K. & Yufu, T., Jan 1 2012, In : Drug Delivery System. 27, 4, p. 275-282 8 p.

Research output: Contribution to journalArticle

Stents
Equipment and Supplies
Thrombosis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Drug-Eluting Stents
29 Citations (Scopus)
Dietary Cholesterol
Chemokine CCL2
Therapeutic Uses
Nutrition
Infiltration
31 Citations (Scopus)

Nanoparticle-mediated delivery of pioglitazone enhances therapeutic neovascularization in a murine model of hindlimb ischemia

Nagahama, R., Matoba, T., Nakano, K., Kim-Mitsuyama, S., Sunagawa, K. & Egashira, K., Nov 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 10, p. 2427-2434 8 p.

Research output: Contribution to journalArticle

pioglitazone
Hindlimb
Nanoparticles
Peroxisome Proliferator-Activated Receptors
Ischemia
53 Citations (Scopus)

Stress augments insulin resistance and prothrombotic state: Role of visceral adipose-derived monocyte chemoattractant protein-1

Uchida, Y., Takeshita, K., Yamamoto, K., Kikuchi, R., Nakayama, T., Nomura, M., Cheng, X. W., Egashira, K., Matsushita, T., Nakamura, H. & Murohara, T., Jun 1 2012, In : Diabetes. 61, 6, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Insulin Resistance
White Adipose Tissue
Inflammation
Stromal Cells