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Research Output 1985 2019

  • 1269 Citations
  • 13 h-Index
  • 32 Article
  • 3 Letter
  • 1 Review article
2019

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 1 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome

Phase I safety and pharmacokinetics study of rovalpituzumab tesirine in Japanese patients with advanced, recurrent small cell lung cancer

Udagawa, H., Akamatsu, H., Tanaka, K., Takeda, M., Kanda, S., Kirita, K., Teraoka, S., Nakagawa, K., Fujiwara, Y., Yasuda, I., Okubo, S., Shintani, M., Kosloski, M. P., Scripture, C., Tamura, T. & Okamoto, I., Sep 1 2019, In : Lung Cancer. 135, p. 145-150 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Pharmacokinetics
Safety
Hypoalbuminemia
Retreatment
1 Citation (Scopus)

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., Apr 1 2019, In : Lung Cancer. 130, p. 5-9 5 p.

Research output: Contribution to journalArticle

Antinuclear Antibodies
Non-Small Cell Lung Carcinoma
Safety
Autoimmune Diseases
Disease-Free Survival

The Japanese Lung Cancer Society Guideline for non-small cell lung cancer, stage IV

Akamatsu, H., Ninomiya, K., Kenmotsu, H., Morise, M., Daga, H., Goto, Y., Kozuki, T., Miura, S., Sasaki, T., Tamiya, A., Teraoka, S., Tsubata, Y., Yoshioka, H., Hattori, Y., Imamura, C. K., Katsuya, Y., Matsui, R., Minegishi, Y., Mizugaki, H., Nosaki, K. & 13 others, Okuma, Y., Sakamoto, S., Sone, T., Tanaka, K., Umemura, S., Yamanaka, T., Amano, S., Hasegawa, K., Morita, S., Nakajima, K., Maemondo, M., Seto, T. & Yamamoto, N., Jul 12 2019, In : International Journal of Clinical Oncology. 24, 7, p. 731-770 40 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Guidelines
Japan
Patient Advocacy
2018

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients

Anai, S., Iwama, E., Yoneshima, Y., Otsubo, K., Tanaka, K., Nakanishi, Y. & Okamoto, I., Dec 1 2018, In : Lung Cancer. 126, p. 156-161 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Platinum
Alleles
irinotecan
1 Citation (Scopus)

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
1 Citation (Scopus)

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

Ide, M., Tanaka, K., Sunami, S., Asoh, T., Maeyama, T., Tsuruta, N., Nakanishi, Y. & Okamoto, I., Nov 1 2018, In : Thoracic Cancer. 9, 11, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Non-Small Cell Lung Carcinoma
Pleurisy
Respiratory Function Tests
Neoplasms
1 Citation (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 1 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma

Expression of PD-1 and PD-L1 on cytotoxic T lymphocytes and immune deficiency in a patient with adult T cell leukemia/lymphoma

Yanagihara, T., Ikematsu, Y., Kato, K., Yonekawa, A., Ideishi, S., Tochigi, T., Sugio, T., Miyawaki, K., Tanaka, K., Harada, E., Hamada, N. & Nakanishi, Y., Feb 1 2018, In : Annals of Hematology. 97, 2, p. 359-360 2 p.

Research output: Contribution to journalLetter

Adult T Cell Leukemia Lymphoma
Cytotoxic T-Lymphocytes
5 Citations (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 1 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journalArticle

Oncogenes
Non-Small Cell Lung Carcinoma
Cell Death
Ligands
STAT3 Transcription Factor
12 Citations (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 1 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
13 Citations (Scopus)

Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer

Tanaka, K., Isse, K., Fujihira, T., Takenoyama, M., Saunders, L., Bheddah, S., Nakanishi, Y. & Okamoto, I., Jan 1 2018, In : Lung Cancer. 115, p. 116-120 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
delta protein
Neoplasms
Sex Characteristics
Japan
2 Citations (Scopus)

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Tanaka, K., Martinez, G. J., Yan, X., Long, W., Ichiyama, K., Chi, X., Kim, B. S., Reynolds, J. M., Chung, Y., Tanaka, S., Liao, L., Nakanishi, Y., Yoshimura, A., Zheng, P., Wang, X., Tian, Q., Xu, J., O'Malley, B. W. & Dong, C., May 22 2018, In : Cell Reports. 23, 8, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 3
Th17 Cells
Cell Differentiation
Interleukin-1
Interleukin-6

Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay

Kimura, S., Tanaka, K., Harada, T., Liu, R., Shibahara, D., Kawano, Y., Nakanishi, Y. & Okamoto, I., Nov 1 2018, In : Cancer Science. 109, 11, p. 3657-3661 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
BIBW 2992
7 Citations (Scopus)

Trim33 mediates the proinflammatory function of Th17 cells

Tanaka, S., Jiang, Y., Martinez, G. J., Tanaka, K., Yan, X., Kurosaki, T., Kaartinen, V., Feng, X. H., Tian, Q., Wang, X. & Dong, C., Jul 1 2018, In : Journal of Experimental Medicine. 215, 7, p. 1853-1868 16 p.

Research output: Contribution to journalArticle

Th17 Cells
Interleukin-10
Transforming Growth Factors
Chromatin Assembly and Disassembly
Interleukin-17
2017
4 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., Nov 1 2017, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
23 Citations (Scopus)

Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity

Kim, B. S., Lu, H., Ichiyama, K., Chen, X., Zhang, Y. B., Mistry, N. A., Tanaka, K., Lee, Y. H., Nurieva, R., Zhang, L., Yang, X., Chung, Y., Jin, W., Chang, S. H. & Dong, C., Oct 3 2017, In : Cell Reports. 21, 1, p. 195-207 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmunity
Immunization
Antigens
T-cells
5 Citations (Scopus)

Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1

Ikematsu, Y., Yoneshima, Y., Ijichi, K., Tanaka, K., Harada, T., Oda, Y., Nakanishi, Y. & Okamoto, I., Oct 1 2017, In : Lung Cancer. 112, p. 230-231 2 p.

Research output: Contribution to journalLetter

Carcinoma
Lung
pembrolizumab
16 Citations (Scopus)

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., Jun 1 2017, In : Lung Cancer. 108, p. 75-82 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Alleles
Mutation
Protein-Tyrosine Kinases
1 Citation (Scopus)
2015
32 Citations (Scopus)

Batf is important for IL-4 expression in T follicular helper cells

Sahoo, A., Alekseev, A., Tanaka, K., Obertas, L., Lerman, B., Haymaker, C., Clise-Dwyer, K., McMurray, J. S. & Nurieva, R., Aug 17 2015, In : Nature communications. 6, 7997.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Interleukin-4
cells
Th2 Cells
Basic-Leucine Zipper Transcription Factors
2014
4 Citations (Scopus)

CCAAT/enhancer-binding protein α negatively regulates IFN-γ expression in T cells

Tanaka, S., Tanaka, K., Magnusson, F., Chung, Y., Martinez, G. J., Wang, Y. H., Nurieva, R. I., Kurosaki, T. & Dong, C., Dec 15 2014, In : Journal of Immunology. 193, 12, p. 6152-6160 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Basic-Leucine Zipper Transcription Factors
Immunoglobulin Class Switching
2013
33 Citations (Scopus)

Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by α1 nicotinic acetylcholine receptor-mediated activation in PC9 cells

Wang, S., Takayama, K., Tanaka, K., Takeshita, M., Nakagaki, N., Ijichi, K., Li, H. & Nakanishi, Y., Jan 1 2013, In : Journal of Thoracic Oncology. 8, 6, p. 719-725 7 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
2012
8 Citations (Scopus)

IL-6 induced by double-stranded RNA augments allergic inflammation via suppression of Foxp3+T-cell/IL-10 axis

Matsumoto, K., Asai, Y., Fukuyama, S., Kan-o, K., Matsunaga, Y., Noda, N., Kitajima, H., Tanaka, K., Nakanishi, Y. & Inoue, H., Jun 1 2012, In : American Journal of Respiratory Cell and Molecular Biology. 46, 6, p. 740-747 8 p.

Research output: Contribution to journalArticle

Galactosamine
T-cells
Double-Stranded RNA
Poly C
Interleukin-10
2010
1 Citation (Scopus)

[A case of non-small cell lung cancer with hemodialysis which responded to docetaxel monotherapy].

Abe, Y., Tanaka, K., Matsumoto, K., Takayama, K., Inoue, H., Izumi, M., Inoue, H. & Nakanishi, Y., Jan 1 2010, In : Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 48, 10, p. 769-773 5 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Renal Dialysis
Pleural Effusion
Drug Therapy
2009
521 Citations (Scopus)

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

Lu, L. F., Thai, T. H., Calado, D. P., Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G. B., Lee, H., Yoshimura, A., Rajewsky, K. & Rudensky, A. Y., Jan 16 2009, In : Immunity. 30, 1, p. 80-91 12 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
MicroRNAs
STAT5 Transcription Factor
Cytokines
Autoantigens

Paraneoplastic brainstem encephalitis and subacute sensory neuropathy presenting various neurological symptoms associated with small cell lung cancer

Kudo, K., Izumi, M., Takayama, K., Fukuyama, S., Tanaka, K. & Nakanishi, Y., Oct 1 2009, In : Japanese Journal of Lung Cancer. 49, 6, p. 852-856 5 p.

Research output: Contribution to journalArticle

Paraneoplastic Syndromes
Small Cell Lung Carcinoma
Encephalitis
Brain Stem
Blepharoptosis
25 Citations (Scopus)

Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype

Fukuyama, S., Nakano, T., Matsumoto, T., Oliver, B. G. G., Burgess, J. K., Moriwaki, A., Tanaka, K., Kubo, M., Hoshino, T., Tanaka, H., McKenzie, A. N. J., Matsumoto, K., Aizawa, H., Nakanishi, Y., Yoshimura, A., Black, J. L. & Inoue, H., Jun 1 2009, In : American Journal of Respiratory and Critical Care Medicine. 179, 11, p. 992-998 7 p.

Research output: Contribution to journalArticle

Interleukin-13
Asthma
Cytokines
Phenotype
Lung
2008
124 Citations (Scopus)

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-γ on STAT3 and Smads

Tanaka, K., Ichiyama, K., Hashimoto, M., Yoshida, H., Takimoto, T., Takaesu, G., torisu, T., Hanada, T., Yasukawa, H., Fukuyama, S., Inoue, H., Nakanishi, Y., Kobayashi, T. & Yoshimura, A., Mar 15 2008, In : Journal of Immunology. 180, 6, p. 3746-3756 11 p.

Research output: Contribution to journalArticle

Th1 Cells
Cytokines
T-Lymphocytes
Phenotype
Retinoic Acid Receptors
57 Citations (Scopus)

Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice

Horino, J., Fujimoto, M., Terabe, F., Serada, S., Takahashi, T., Soma, Y., Tanaka, K., Chinen, T., Yoshimura, A., Nomura, S., Kawase, I., Hayashi, N., Kishimoto, T. & Naka, T., Jun 1 2008, In : International Immunology. 20, 6, p. 753-762 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Cytokines
Inflammatory Bowel Diseases
Regulatory T-Lymphocytes
2007

Intracellular negative signals and allergy

Yoshimura, A., Tanaka, K., Okamoto, F. & Kobayashi, T., Jan 1 2007, In : Arerugī = [Allergy]. 56, 6, p. 563-569 7 p.

Research output: Contribution to journalReview article

Suppressor of Cytokine Signaling Proteins
Helper-Inducer T-Lymphocytes
Signal Transduction
Hypersensitivity
Cytokines
89 Citations (Scopus)

Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells

Matsumura, Y., Kobayashi, T., Ichiyama, K., Yoshida, R., Hashimoto, M., Takimoto, T., Tanaka, K., Chinen, T., Shichita, T., Wyss-Coray, T., Sato, K. & Yoshimura, A., Aug 15 2007, In : Journal of Immunology. 179, 4, p. 2170-2179 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Immunosuppression
Dendritic Cells
Cytokines
T-Lymphocytes
2006
29 Citations (Scopus)

The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia

Moriyama, M., Fukuyama, S., Inoue, H., Matsumoto, T., Sato, T., Tanaka, K., Kinjyo, I., Kano, T., Yoshimura, A. & Kojima, M., May 1 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 5

Research output: Contribution to journalArticle

Eosinophilia
Neuropeptides
Eosinophils
Allergens
neuromedin U
2005
77 Citations (Scopus)

Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene

Hanada, T., Tanaka, K., Matsumura, Y., Yamauchi, M., Nishinakamura, H., Aburatani, H., Mashima, R., Kubo, M., Kobayashi, T. & Yoshimura, A., Apr 1 2005, In : Journal of Immunology. 174, 7, p. 4325-4332 8 p.

Research output: Contribution to journalArticle

Th1 Cells
Dendritic Cells
Cytokines
Bone Marrow
Genes
2003
176 Citations (Scopus)

Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity

Hanada, T., Yoshida, H., Kato, S., Tanaka, K., Masutani, K., Tsukada, J., Nomura, Y., Mimata, H., Kubo, M. & Yoshimura, A., Sep 1 2003, In : Immunity. 19, 3, p. 437-450 14 p.

Research output: Contribution to journalArticle

Autoimmunity
Dendritic Cells
Cytokines
B-Lymphocytes
Macrophage Activation
1985
1 Citation (Scopus)

A case of lung carcinoma associated with production of human chorionic gonadotropin

Ninomiya, K., Shigematu, N. & Tanaka, K., Jan 1 1985, In : Japanese Journal of Thoracic Diseases. 23, 5, p. 599-604 6 p.

Research output: Contribution to journalArticle