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Research Output 1992 2019

2019

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Saito, H., Hara, K., Tominaga, T., Nakashima, K. & Tanemura, K., Jan 1 2019, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

Permethrin
Neuroglia
Central Nervous System
Learning
Data storage equipment
Neural Stem Cells
Astrocytes
Epigenomics
Central Nervous System
Multipotent Stem Cells

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury

Yoshikawa, Y., Ago, T., Kuroda, J., Wakisaka, Y., Tachibana, M., Komori, M., Shibahara, T., Nakashima, H., Nakashima, K. & Kitazono, T., Feb 1 2019, In : Neuroscience. 398, p. 193-205 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Hippocampus
Cell Proliferation
Wounds and Injuries

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain

Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M. & Nakashima, K., Jun 1 2019, In : Neuroscience Research. 143, p. 31-43 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Tumor Suppressor Genes
Gene Expression
Brain
5 Citations (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., Feb 6 2019, In : Neuron. 101, 3, p. 472-485.e7

Research output: Contribution to journalArticle

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
2 Citations (Scopus)

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

Noguchi, H., Castillo, J. G., Nakashima, K. & Pleasure, S. J., Apr 11 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Adult Stem Cells
Neural Stem Cells
Stem cells
Hedgehogs
Dentate Gyrus
1 Citation (Scopus)

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury

Nakajo, M., Uezono, N., Nakashima, H., Wake, H., Komiya, S., Nishibori, M. & Nakashima, K., Apr 1 2019, In : Neuroscience Research. 141, p. 63-70 8 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Antibodies
Injections
Monoclonal Antibodies
Therapeutics
2018
1 Citation (Scopus)

Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression

Nakashima, H., Tsujimura, K., Irie, K., Ishizu, M., Pan, M., Kameda, T. & Nakashima, K., May 16 2018, In : Journal of Neuroscience. 38, 20, p. 4791-4810 20 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Morphogenesis
Neurons
Cytokines
Induced Pluripotent Stem Cells
4 Citations (Scopus)
Neurogenesis
Valproic Acid
Anticonvulsants
Seizures
Neural Stem Cells

Epigenetic Regulation of Human Neural Stem Cell Differentiation

Honda, M., Nakashima, K. & Katada, S., Jan 1 2018, Results and Problems in Cell Differentiation. Springer Verlag, p. 125-136 12 p. (Results and Problems in Cell Differentiation; vol. 66).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Epigenomics
Cell Differentiation
Histone Code
Induced Pluripotent Stem Cells
5 Citations (Scopus)

Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration

Kameda, T., Imamura, T. & Nakashima, K., Jan 1 2018, In : Cell and Tissue Research. 371, 1, p. 189-199 11 p.

Research output: Contribution to journalReview article

Spinal Cord Regeneration
Neural Stem Cells
Epigenomics
Cell Differentiation
Spinal Cord Injuries
4 Citations (Scopus)

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells

Kimura, A., Matsuda, T., sakai, A., Murao, N. & Nakashima, K., Jan 1 2018, In : Developmental Dynamics. 247, 1, p. 229-238 10 p.

Research output: Contribution to journalArticle

HMGB2 Protein
Adult Stem Cells
Neural Stem Cells
Hippocampus
High Mobility Group Proteins
8 Citations (Scopus)

Neural stem cell therapy aiming at better functional recovery after spinal cord injury

Zhu, Y., Uezono, N., Yasui, T. & Nakashima, K., Jan 1 2018, In : Developmental Dynamics. 247, 1, p. 75-84 10 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Stem Cell Transplantation
Stem Cell Research
14 Citations (Scopus)

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

Kawamura, Y., Takouda, J., Yoshimoto, K. & Nakashima, K., Dec 15 2018, In : Cell Biology and Toxicology. 34, 6, p. 425-440 16 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Glioblastoma
Stem cells
Stem Cells
Epigenomics

Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via olig1 promoter methylation

Semi, K., Sanosaka, T., Namihira, M. & Nakashima, K., Apr 1 2018, In : HAYATI Journal of Biosciences. 25, 2, p. 70-78 9 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Methylation
Oligodendroglia
methylation
Transcription Factors
7 Citations (Scopus)

Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury

Uezono, N., Zhu, Y., Fujimoto, Y., Yasui, T., Matsuda, T., Nakajo, M., Abematsu, M., Setoguchi, T., Mori, S., Takahashi, H. K., Komiya, S., Nishibori, M. & Nakashima, K., May 1 2018, In : STEM CELLS. 36, 5, p. 737-750 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem Cell Transplantation
Spinal Cord Injuries
Induced Pluripotent Stem Cells
Neurons

Rett syndrome and stem cell research

Tsujimura, K. & Nakashima, K., Jun 27 2018, Stem Cell Genetics for Biomedical Research: Past, Present, and Future. Springer International Publishing, p. 27-41 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rett Syndrome
Stem Cell Research
Stem cells
Methyl-CpG-Binding Protein 2
Technology
2017

Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method

Hamazaki, N., Nakashima, K., Hayashi, K. & Imamura, T., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 83-103 21 p. (Methods in Molecular Biology; vol. 1605).

Research output: Chapter in Book/Report/Conference proceedingChapter

Long Noncoding RNA
Untranslated RNA
Interleukin-27
RNA
Transcriptional Activation
8 Citations (Scopus)

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., Sep 19 2017, In : Cell Reports. 20, 12, p. 2992-3003 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Epigenomics
Mental Competency
Neurons
6 Citations (Scopus)

Emerging mechanisms underlying astrogenesis in the developing mammalian brain

Takouda, J., Katada, S. & Nakashima, K., Jan 1 2017, In : Proceedings of the Japan Academy Series B: Physical and Biological Sciences. 93, 6, p. 386-398 13 p.

Research output: Contribution to journalReview article

Neural Stem Cells
stem cells
brain
emerging
Brain
4 Citations (Scopus)
Untranslated RNA
Transcriptional Activation
Mammals
Genes
Gene Expression Profiling
8 Citations (Scopus)

Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells

Yasui, T., Uezono, N., Nakashima, H., Noguchi, H., Matsuda, T., Noda-Andoh, T., Okano, H. & Nakashima, K., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1743-1756 14 p.

Research output: Contribution to journalArticle

Astrocytes
Rett Syndrome
Hypoxia-Inducible Factor 1
Pluripotent Stem Cells
Glial Fibrillary Acidic Protein
1 Citation (Scopus)

Manipulation of promoter-associated noncoding RNAs in mouse early embryos for controlling sequence-specific epigenetic status

Hamazaki, N., Nakashima, K. & Imamura, T., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 271-282 12 p. (Methods in Molecular Biology; vol. 1543).

Research output: Chapter in Book/Report/Conference proceedingChapter

Untranslated RNA
Epigenomics
Transcriptional Activation
Embryonic Structures
Up-Regulation
19 Citations (Scopus)

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

Brulet, R., Matsuda, T., Zhang, L., Miranda, C., Giacca, M., Kaspar, B. K., Nakashima, K. & Hsieh, J., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1506-1515 10 p.

Research output: Contribution to journalArticle

Astrocytes
Neurons
Transcription Factors
Dependovirus
Wounds and Injuries

Novel function of MeCP2 in the pathophysiology of Rett syndrome: Regulation of mTOR signaling mediated by MeCP2-dependent microRNA processing

Tsujimura, K. & Nakashima, K., Jan 1 2017, In : Seikagaku. 89, 1, p. 51-61 11 p.

Research output: Contribution to journalReview article

MicroRNAs
Processing
1 Citation (Scopus)

PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells

Honda, M., Nakashima, K. & Katada, S., Sep 1 2017, In : Journal of Neurochemistry. 142, 6, p. 901-907 7 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Neural Stem Cells
Embryonic Stem Cells
Arginine
Protein-Arginine N-Methyltransferases
2 Citations (Scopus)

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

Kawamura, Y., Katada, S., Noguchi, H., Yamamoto, H., Sanosaka, T., Iihara, K. & Nakashima, K., Nov 1 2017, In : FEBS Letters. 591, 22, p. 3709-3720 12 p.

Research output: Contribution to journalLetter

Meninges
Neural Stem Cells
Brain
Astrocytes
Bone Morphogenetic Protein 4
2016
7 Citations (Scopus)
Untranslated RNA
PC12 Cells
Cell Cycle
Nerve Growth Factor
Acetylation
12 Citations (Scopus)

DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus

Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M. & Nakashima, K., Jun 1 2016, In : Journal of Neuroscience. 36, 22, p. 6050-6068 19 p.

Research output: Contribution to journalArticle

Parahippocampal Gyrus
Dentate Gyrus
Methyltransferases
Neural Stem Cells
DNA
17 Citations (Scopus)

Epigenetic regulation of neural stem cell property from embryo to adult

Murao, N., Noguchi, H. & Nakashima, K., Jan 1 2016, In : Neuroepigenetics. 5, p. 1-10 10 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Stem cells
Epigenomics
Embryonic Structures
Intrinsic Factor
8 Citations (Scopus)

Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation

Ito, K., Sanosaka, T., Igarashi, K., Ideta-Otsuka, M., Aizawa, A., Uosaki, Y., Noguchi, A., Arakawa, H., Nakashima, K. & Takizawa, T., Apr 4 2016, In : Scientific reports. 6, 23903.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Astrocytes
Genes
Cluster Analysis
Cell Nucleus
15 Citations (Scopus)

MicroRNA-214 promotes dendritic development by targeting the schizophrenia-associated gene quaking (Qki)

Irie, K., Tsujimura, K., Nakashima, H. & Nakashima, K., Jun 24 2016, In : Journal of Biological Chemistry. 291, 26, p. 13891-13904 14 p.

Research output: Contribution to journalArticle

Dendrites
MicroRNAs
Morphogenesis
Schizophrenia
Genes
4 Citations (Scopus)

Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood

Noguchi, H., Kimura, A., Murao, N., Namihira, M. & Nakashima, K., Jan 1 2016, In : Neurogenesis. 3, 1, e1232679.

Research output: Contribution to journalComment/debate

Neural Stem Cells
Neurogenesis
Methyltransferases
Anxiety
Epigenomics
137 Citations (Scopus)

Reconstitution in vitro of the entire cycle of the mouse female germ line

Hikabe, O., Hamazaki, N., Nagamatsu, G., Obata, Y., Hirao, Y., Hamada, N., Shimamoto, S., Imamura, T., Nakashima, K., Saitou, M. & Hayashi, K., Nov 10 2016, In : Nature. 539, 7628, p. 299-303 5 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Germ Cells
Oocytes
Fibroblasts
Reproductive Medicine
118 Citations (Scopus)

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions

Morita, S., Noguchi, H., Horii, T., Nakabayashi, K., Kimura, M., Okamura, K., sakai, A., Nakashima, H., Hata, K., Nakashima, K. & Hatada, I., Oct 1 2016, In : Nature Biotechnology. 34, 10, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

Peptides
Amino acids
Catalytic Domain
DNA
Fusion reactions
2015
4 Citations (Scopus)

Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord

Abdulhaleem M, F. A., Song, X., Kawano, R., Uezono, N., Ito, A., Ahmed, G., Hossain, M., Nakashima, K., Tanaka, H. & Ohta, K., May 1 2015, In : Developmental Neurobiology. 75, 5, p. 494-504 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Spinal Cord
Cell Adhesion Molecules
Gene Silencing
Bromodeoxyuridine
Neurogenesis
Nervous System
Immune System
Hippocampus
Communication
39 Citations (Scopus)

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

Andoh-Noda, T., Akamatsu, W., Miyake, K., Matsumoto, T., Yamaguchi, R., Sanosaka, T., Okada, Y., Kobayashi, T., Ohyama, M., Nakashima, K., Kurosawa, H., Kubota, T. & Okano, H., May 27 2015, In : Molecular Brain. 8, 1, 31.

Research output: Contribution to journalArticle

Multipotent Stem Cells
Rett Syndrome
Neural Stem Cells
Induced Pluripotent Stem Cells
Methyl-CpG-Binding Protein 2
14 Citations (Scopus)

Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus

Noguchi, H., Kimura, A., Murao, N., Matsuda, T., Namihira, M. & Nakashima, K., Jun 1 2015, In : Neuroscience Research. 95, p. 1-11 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Methyltransferases
Hippocampus
Neurons
DNA
44 Citations (Scopus)

Gene activation-associated long noncoding RNAs function in mouse preimplantation development

Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K. & Imamura, T., Jan 1 2015, In : Development (Cambridge). 142, 5, p. 910-920 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Transcriptional Activation
Untranslated RNA
Messenger RNA
Genes
11 Citations (Scopus)

Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor

Nakamura, A., Funaya, H., Uezono, N., Nakashima, K., Ishida, Y., Suzuki, T., Wakana, S. & Shibata, T., Nov 1 2015, In : Neuroscience Research. 100, p. 55-62 8 p.

Research output: Contribution to journalArticle

Gait
Costs and Cost Analysis
Nerve Regeneration
Research

Meet our editorial board member

Nakashima, K., Aug 1 2015, In : Current Stem Cell Research and Therapy. 10, 5, 1 p.

Research output: Contribution to journalEditorial

37 Citations (Scopus)

MiR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

Tsujimura, K., Irie, K., Nakashima, H., Egashira, Y., Fukao, Y., Fujiwara, M., Itoh, M., Uesaka, M., Imamura, T., Nakahata, Y., Yamashita, Y., Abe, T., Takamori, S. & Nakashima, K., Sep 22 2015, In : Cell Reports. 12, 11, p. 1887-1901 15 p.

Research output: Contribution to journalArticle

Rett Syndrome
Sirolimus
Phenotype
MicroRNAs
Microcomputers
28 Citations (Scopus)

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

Juliandi, B., Tanemura, K., Igarashi, K., Tominaga, T., Furukawa, Y., Otsuka, M., Moriyama, N., Ikegami, D., Abematsu, M., Sanosaka, T., Tsujimura, K., Narita, M., Kanno, J. & Nakashima, K., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 996-1009 14 p.

Research output: Contribution to journalArticle

Neurogenesis
Valproic Acid
Anticonvulsants
Running
Therapeutics
41 Citations (Scopus)

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Matsuda, T., Murao, N., Katano, Y., Juliandi, B., Kohyama, J., Akira, S., Kawai, T. & Nakashima, K., Mar 9 2015, In : Nature communications. 6, 6514.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
hippocampus
seizures
Neurogenesis
Microglia
2014
56 Citations (Scopus)

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals

Uesaka, M., Nishimura, O., Go, Y., Nakashima, K., Agata, K. & Imamura, T., Jan 17 2014, In : BMC Genomics. 15, 1, 35.

Research output: Contribution to journalArticle

Untranslated RNA
Transcriptional Activation
Mammals
Long Noncoding RNA
Messenger RNA
13 Citations (Scopus)

Epigenetic mechanisms regulating differentiation of neural stem/precursor cells

Adefuin, A. M. D., Kimura, A., Noguchi, H., Nakashima, K. & Namihira, M., Dec 1 2014, In : Epigenomics. 6, 6, p. 637-649 13 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Epigenomics
Untranslated RNA
Oligodendroglia
Brain
19 Citations (Scopus)
Untranslated RNA
Epigenomics
epigenetics
Genes
neurons
29 Citations (Scopus)

Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation

Yi, S. H., He, X. B., Rhee, Y. H., Park, C. H., Takizawa, T., Nakashima, K. & Lee, S. H., Feb 15 2014, In : Development (Cambridge). 141, 4, p. 761-772 12 p.

Research output: Contribution to journalArticle

Epigenomics
Dopamine
Mesencephalon
Phenotype
Neurons

Roles of Epigenetics in the Neural Stem Cell and Neuron

Yamamoto, N., Uesaka, M., Imamura, T. & Nakashima, K., Jun 20 2014, Epigenetics in Psychiatry. Elsevier Inc., p. 51-78 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Epigenomics
Neurons
Oligodendroglia
Neuroglia