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Research Output 1992 2019

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2019

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Saito, H., Hara, K., Tominaga, T., Nakashima, K. & Tanemura, K., Jan 1 2019, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

Permethrin
Neuroglia
Central Nervous System
Learning
Data storage equipment
Neural Stem Cells
Astrocytes
Epigenomics
Central Nervous System
Multipotent Stem Cells

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury

Yoshikawa, Y., Ago, T., Kuroda, J., Wakisaka, Y., Tachibana, M., Komori, M., Shibahara, T., Nakashima, H., Nakashima, K. & Kitazono, T., Feb 1 2019, In : Neuroscience. 398, p. 193-205 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Hippocampus
Cell Proliferation
Wounds and Injuries

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain

Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M. & Nakashima, K., Jun 1 2019, In : Neuroscience Research. 143, p. 31-43 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Tumor Suppressor Genes
Gene Expression
Brain
5 Citations (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., Feb 6 2019, In : Neuron. 101, 3, p. 472-485.e7

Research output: Contribution to journalArticle

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
2 Citations (Scopus)

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

Noguchi, H., Castillo, J. G., Nakashima, K. & Pleasure, S. J., Apr 11 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Adult Stem Cells
Neural Stem Cells
Stem cells
Hedgehogs
Dentate Gyrus
1 Citation (Scopus)

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury

Nakajo, M., Uezono, N., Nakashima, H., Wake, H., Komiya, S., Nishibori, M. & Nakashima, K., Apr 1 2019, In : Neuroscience Research. 141, p. 63-70 8 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Antibodies
Injections
Monoclonal Antibodies
Therapeutics
2018
1 Citation (Scopus)

Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression

Nakashima, H., Tsujimura, K., Irie, K., Ishizu, M., Pan, M., Kameda, T. & Nakashima, K., May 16 2018, In : Journal of Neuroscience. 38, 20, p. 4791-4810 20 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Morphogenesis
Neurons
Cytokines
Induced Pluripotent Stem Cells
4 Citations (Scopus)
Neurogenesis
Valproic Acid
Anticonvulsants
Seizures
Neural Stem Cells
4 Citations (Scopus)

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells

Kimura, A., Matsuda, T., sakai, A., Murao, N. & Nakashima, K., Jan 1 2018, In : Developmental Dynamics. 247, 1, p. 229-238 10 p.

Research output: Contribution to journalArticle

HMGB2 Protein
Adult Stem Cells
Neural Stem Cells
Hippocampus
High Mobility Group Proteins

Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via olig1 promoter methylation

Semi, K., Sanosaka, T., Namihira, M. & Nakashima, K., Apr 1 2018, In : HAYATI Journal of Biosciences. 25, 2, p. 70-78 9 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Methylation
Oligodendroglia
methylation
Transcription Factors
7 Citations (Scopus)

Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury

Uezono, N., Zhu, Y., Fujimoto, Y., Yasui, T., Matsuda, T., Nakajo, M., Abematsu, M., Setoguchi, T., Mori, S., Takahashi, H. K., Komiya, S., Nishibori, M. & Nakashima, K., May 1 2018, In : STEM CELLS. 36, 5, p. 737-750 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem Cell Transplantation
Spinal Cord Injuries
Induced Pluripotent Stem Cells
Neurons
2017
8 Citations (Scopus)

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., Sep 19 2017, In : Cell Reports. 20, 12, p. 2992-3003 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Epigenomics
Mental Competency
Neurons
4 Citations (Scopus)
Untranslated RNA
Transcriptional Activation
Mammals
Genes
Gene Expression Profiling
8 Citations (Scopus)

Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells

Yasui, T., Uezono, N., Nakashima, H., Noguchi, H., Matsuda, T., Noda-Andoh, T., Okano, H. & Nakashima, K., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1743-1756 14 p.

Research output: Contribution to journalArticle

Astrocytes
Rett Syndrome
Hypoxia-Inducible Factor 1
Pluripotent Stem Cells
Glial Fibrillary Acidic Protein
19 Citations (Scopus)

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

Brulet, R., Matsuda, T., Zhang, L., Miranda, C., Giacca, M., Kaspar, B. K., Nakashima, K. & Hsieh, J., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1506-1515 10 p.

Research output: Contribution to journalArticle

Astrocytes
Neurons
Transcription Factors
Dependovirus
Wounds and Injuries
1 Citation (Scopus)

PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells

Honda, M., Nakashima, K. & Katada, S., Sep 1 2017, In : Journal of Neurochemistry. 142, 6, p. 901-907 7 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Neural Stem Cells
Embryonic Stem Cells
Arginine
Protein-Arginine N-Methyltransferases
2016
7 Citations (Scopus)
Untranslated RNA
PC12 Cells
Cell Cycle
Nerve Growth Factor
Acetylation
12 Citations (Scopus)

DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus

Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M. & Nakashima, K., Jun 1 2016, In : Journal of Neuroscience. 36, 22, p. 6050-6068 19 p.

Research output: Contribution to journalArticle

Parahippocampal Gyrus
Dentate Gyrus
Methyltransferases
Neural Stem Cells
DNA
8 Citations (Scopus)

Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation

Ito, K., Sanosaka, T., Igarashi, K., Ideta-Otsuka, M., Aizawa, A., Uosaki, Y., Noguchi, A., Arakawa, H., Nakashima, K. & Takizawa, T., Apr 4 2016, In : Scientific reports. 6, 23903.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Astrocytes
Genes
Cluster Analysis
Cell Nucleus
15 Citations (Scopus)

MicroRNA-214 promotes dendritic development by targeting the schizophrenia-associated gene quaking (Qki)

Irie, K., Tsujimura, K., Nakashima, H. & Nakashima, K., Jun 24 2016, In : Journal of Biological Chemistry. 291, 26, p. 13891-13904 14 p.

Research output: Contribution to journalArticle

Dendrites
MicroRNAs
Morphogenesis
Schizophrenia
Genes
137 Citations (Scopus)

Reconstitution in vitro of the entire cycle of the mouse female germ line

Hikabe, O., Hamazaki, N., Nagamatsu, G., Obata, Y., Hirao, Y., Hamada, N., Shimamoto, S., Imamura, T., Nakashima, K., Saitou, M. & Hayashi, K., Nov 10 2016, In : Nature. 539, 7628, p. 299-303 5 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Germ Cells
Oocytes
Fibroblasts
Reproductive Medicine
118 Citations (Scopus)

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions

Morita, S., Noguchi, H., Horii, T., Nakabayashi, K., Kimura, M., Okamura, K., sakai, A., Nakashima, H., Hata, K., Nakashima, K. & Hatada, I., Oct 1 2016, In : Nature Biotechnology. 34, 10, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

Peptides
Amino acids
Catalytic Domain
DNA
Fusion reactions
2015
4 Citations (Scopus)

Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord

Abdulhaleem M, F. A., Song, X., Kawano, R., Uezono, N., Ito, A., Ahmed, G., Hossain, M., Nakashima, K., Tanaka, H. & Ohta, K., May 1 2015, In : Developmental Neurobiology. 75, 5, p. 494-504 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Spinal Cord
Cell Adhesion Molecules
Gene Silencing
Bromodeoxyuridine
39 Citations (Scopus)

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

Andoh-Noda, T., Akamatsu, W., Miyake, K., Matsumoto, T., Yamaguchi, R., Sanosaka, T., Okada, Y., Kobayashi, T., Ohyama, M., Nakashima, K., Kurosawa, H., Kubota, T. & Okano, H., May 27 2015, In : Molecular Brain. 8, 1, 31.

Research output: Contribution to journalArticle

Multipotent Stem Cells
Rett Syndrome
Neural Stem Cells
Induced Pluripotent Stem Cells
Methyl-CpG-Binding Protein 2
14 Citations (Scopus)

Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus

Noguchi, H., Kimura, A., Murao, N., Matsuda, T., Namihira, M. & Nakashima, K., Jun 1 2015, In : Neuroscience Research. 95, p. 1-11 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Methyltransferases
Hippocampus
Neurons
DNA
44 Citations (Scopus)

Gene activation-associated long noncoding RNAs function in mouse preimplantation development

Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K. & Imamura, T., Jan 1 2015, In : Development (Cambridge). 142, 5, p. 910-920 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Transcriptional Activation
Untranslated RNA
Messenger RNA
Genes
11 Citations (Scopus)

Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor

Nakamura, A., Funaya, H., Uezono, N., Nakashima, K., Ishida, Y., Suzuki, T., Wakana, S. & Shibata, T., Nov 1 2015, In : Neuroscience Research. 100, p. 55-62 8 p.

Research output: Contribution to journalArticle

Gait
Costs and Cost Analysis
Nerve Regeneration
Research
37 Citations (Scopus)

MiR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

Tsujimura, K., Irie, K., Nakashima, H., Egashira, Y., Fukao, Y., Fujiwara, M., Itoh, M., Uesaka, M., Imamura, T., Nakahata, Y., Yamashita, Y., Abe, T., Takamori, S. & Nakashima, K., Sep 22 2015, In : Cell Reports. 12, 11, p. 1887-1901 15 p.

Research output: Contribution to journalArticle

Rett Syndrome
Sirolimus
Phenotype
MicroRNAs
Microcomputers
28 Citations (Scopus)

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

Juliandi, B., Tanemura, K., Igarashi, K., Tominaga, T., Furukawa, Y., Otsuka, M., Moriyama, N., Ikegami, D., Abematsu, M., Sanosaka, T., Tsujimura, K., Narita, M., Kanno, J. & Nakashima, K., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 996-1009 14 p.

Research output: Contribution to journalArticle

Neurogenesis
Valproic Acid
Anticonvulsants
Running
Therapeutics
41 Citations (Scopus)

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Matsuda, T., Murao, N., Katano, Y., Juliandi, B., Kohyama, J., Akira, S., Kawai, T. & Nakashima, K., Mar 9 2015, In : Nature communications. 6, 6514.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
hippocampus
seizures
Neurogenesis
Microglia
2014
56 Citations (Scopus)

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals

Uesaka, M., Nishimura, O., Go, Y., Nakashima, K., Agata, K. & Imamura, T., Jan 17 2014, In : BMC Genomics. 15, 1, 35.

Research output: Contribution to journalArticle

Untranslated RNA
Transcriptional Activation
Mammals
Long Noncoding RNA
Messenger RNA
29 Citations (Scopus)

Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation

Yi, S. H., He, X. B., Rhee, Y. H., Park, C. H., Takizawa, T., Nakashima, K. & Lee, S. H., Feb 15 2014, In : Development (Cambridge). 141, 4, p. 761-772 12 p.

Research output: Contribution to journalArticle

Epigenomics
Dopamine
Mesencephalon
Phenotype
Neurons
7 Citations (Scopus)

VPA alleviates neurological deficits and restores gene expression in a mouse model of rett syndrome

Guo, W., Tsujimura, K., Otsuka I, M., Irie, K., Igarashi, K., Nakashima, K. & Zhao, X., Jun 26 2014, In : PloS one. 9, 6, e100215.

Research output: Contribution to journalArticle

valproic acid
Rett Syndrome
Valproic Acid
Gene expression
animal models
2013
25 Citations (Scopus)

Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation

Urayama, S., Semi, K., Sanosaka, T., Hori, Y., Namihira, M., Kohyama, J., Takizawa, T. & Nakashima, K., Apr 26 2013, In : Cell structure and function. 38, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Astrocytes
Chromatin
Genes
Histone Code
38 Citations (Scopus)

Epigenetic regulation of neural stem cell fate during corticogenesis

MuhChyi, C., Juliandi, B., Matsuda, T. & Nakashima, K., Oct 1 2013, In : International Journal of Developmental Neuroscience. 31, 6, p. 424-433 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Epigenomics
Cerebral Cortex
Multipotent Stem Cells
Intrinsic Factor
5 Citations (Scopus)

Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis

Yuniarti, N., Juliandi, B., MuhChyi, C., Noguchi, H., Sanosaka, T. & Nakashima, K., Sep 1 2013, In : Neuroscience Research. 77, 1-2, p. 42-49 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Neurogenesis
Stem Cells
Neurons
Neural Stem Cells
2012
24 Citations (Scopus)

Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid

Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. & Nakashima, K., Jan 1 2012, In : Neuroscience Research. 72, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Valproic Acid
Neurons
Histone Deacetylase Inhibitors
Neurogenesis
Mouse Embryonic Stem Cells
28 Citations (Scopus)

Oxygen levels epigenetically regulate fate switching of neural precursor cells via hypoxia-inducible factor 1α-Notch signal interaction in the developing brain

Mutoh, T., Sanosaka, T., Ito, K. & Nakashima, K., Mar 1 2012, In : STEM CELLS. 30, 3, p. 561-569 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Cell Hypoxia
Astrocytes
Oxygen
Brain
134 Citations (Scopus)

Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells

Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura, K., Sanosaka, T., Juliandi, B., Semi, K., Namihira, M., Komiya, S., Smith, A. & Nakashima, K., Jun 1 2012, In : STEM CELLS. 30, 6, p. 1163-1173 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Spinal Cord Injuries
Stem Cells
Transplantation
Neural Stem Cells
36 Citations (Scopus)

Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation

Saito, A., Kanemoto, S., Kawasaki, N., Asada, R., Iwamoto, H., Oki, M., Miyagi, H., Izumi, S., Sanosaka, T., Nakashima, K. & Imaizumi, K., Aug 15 2012, In : Nature communications. 3, 967.

Research output: Contribution to journalArticle

Unfolded Protein Response
Astrocytes
Transcription Factors
proteins
cells
2011
56 Citations (Scopus)

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

Kuwabara, T., Kagalwala, M. N., Onuma, Y., Ito, Y., Warashina, M., Terashima, K., Sanosaka, T., Nakashima, K., Gage, F. H. & Asashima, M., Dec 1 2011, In : EMBO Molecular Medicine. 3, 12, p. 742-754 13 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Hippocampus
Insulin
Pancreas
Insulin-Like Growth Factor Binding Protein 4
40 Citations (Scopus)

Role of GLI2 in the growth of human osteosarcoma

Nagao, H., Ijiri, K., Hirotsu, M., Ishidou, Y., Yamamoto, T., Nagano, S., Takizawa, T., Nakashima, K., Komiya, S. & Setoguchi, T., Jun 1 2011, In : Journal of Pathology. 224, 2, p. 169-179 11 p.

Research output: Contribution to journalArticle

Osteosarcoma
Growth
Hedgehogs
Cell Cycle
Mesenchymal Stromal Cells
2010
49 Citations (Scopus)

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H. & Nakashima, K., Apr 5 2010, In : Journal of Cell Biology. 189, 1, p. 159-170 12 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Astrocytes
Maintenance
Stem Cells
Oligodendroglia
374 Citations (Scopus)

L1 retrotransposition in neurons is modulated by MeCP2

Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K. & Gage, F. H., Nov 18 2010, In : Nature. 468, 7322, p. 443-446 4 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Retroelements
TCF Transcription Factors
Neurons
Brain
172 Citations (Scopus)

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury

Abematsu, M., Tsujimura, K., Yamano, M., Saito, M., Kohno, K., Kohyama, J., Namihira, M., Komiya, S. & Nakashima, K., Sep 1 2010, In : Journal of Clinical Investigation. 120, 9, p. 3255-3266 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Spinal Cord Injuries
Neurons
Valproic Acid
Extremities
246 Citations (Scopus)

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

Mira, H., Andreu, Z., Suh, H., Chichung Lie, D., Jessberger, S., Consiglio, A., Emeterio, J. S., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., Colak, D., Götz, M., Fariñas, I. & Gage, F. H., Jan 1 2010, In : Cell stem cell. 7, 1, p. 78-89 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Hippocampus
Bone Morphogenetic Proteins
Neurogenesis
Stem Cells
2009
69 Citations (Scopus)

Astrocyte differentiation of neural precursor cells is enhanced by retinoic acid through a change in epigenetic modification

Asano, H., Aonuma, M., Sanosaka, T., Kohyama, J., Namihira, M. & Nakashima, K., Nov 1 2009, In : STEM CELLS. 27, 11, p. 2744-2752 9 p.

Research output: Contribution to journalArticle

Tretinoin
Epigenomics
Astrocytes
Leukemia Inhibitory Factor
STAT3 Transcription Factor
200 Citations (Scopus)

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

Namihira, M., Kohyama, J., Semi, K., Sanosaka, T., Deneen, B., Taga, T. & Nakashima, K., Feb 17 2009, In : Developmental Cell. 16, 2, p. 245-255 11 p.

Research output: Contribution to journalArticle

Astrocytes
Neurons
Genes
NFI Transcription Factors
Telencephalon
2 Citations (Scopus)

Epigenetic mechanisms regulating neural cell fate determination

Nakashima, K., Kohyama, J., Namihira, M., Gage, F. H., Okano, H. & Sawamoto, K., 2009, In : No To Hattatsu. 41, 6, p. 411-414 4 p.

Research output: Contribution to journalArticle

Epigenomics
Astrocytes
Oligodendroglia
Cues
Cytokines