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Research Output 2010 2019

  • 240 Citations
  • 10 h-Index
  • 22 Article
  • 3 Review article
  • 1 Comment/debate
2019

Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level

Kataoka, Y., Iimori, M., Niimi, S., Tsukihara, H., Wakasa, T., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., May 28 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Trifluridine
thymidine kinase 1
Colorectal Neoplasms
DNA
Clustered Regularly Interspaced Short Palindromic Repeats
2018
1 Citation (Scopus)

Changes in HER2 expression and amplification status following preoperative chemotherapy for gastric cancer

Shu, S., Iimori, M., Nakanishi, R., Jogo, T., Saeki, H., Oki, E. & Maehara, Y., Nov 1 2018, In : In Vivo. 32, 6, p. 1491-1498 8 p.

Research output: Contribution to journalArticle

Chemotherapy
Stomach Neoplasms
Amplification
Drug Therapy
Epidermal Growth Factor Receptor
17 Citations (Scopus)

Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability

Korehisa, S., Oki, E., Iimori, M., Nakaji, Y., Shimokawa, M., Saeki, H., Okano, S., Oda, Y. & Maehara, Y., Feb 15 2018, In : International Journal of Cancer. 142, 4, p. 822-832 11 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Colorectal Neoplasms
Cell Death
Ligands
CD274 Antigen
9 Citations (Scopus)

DNA replication stress and cancer chemotherapy

Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., Feb 1 2018, In : Cancer Science. 109, 2, p. 264-271 8 p.

Research output: Contribution to journalReview article

DNA Replication
Drug Therapy
Neoplasms
Biological Phenomena
Genomic Instability
10 Citations (Scopus)

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer

Yamashita, N., Tokunaga, E., Iimori, M., Inoue, Y., Tanaka, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Oct 1 2018, In : Clinical Breast Cancer. 18, 5, p. e1003-e1009

Research output: Contribution to journalArticle

Vimentin
Cadherins
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
1 Citation (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., Dec 1 2018, In : Scientific reports. 8, 1, 10888.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
Methyltransferases
Methylation
Lysine
DNA Damage
2 Citations (Scopus)

Thymidine kinase 1 loss confers trifluridine resistance without affecting 5-fluorouracil metabolism and cytotoxicity

Edahiro, K., Iimori, M., Kobunai, T., Morikawa-Ichinose, T., Miura, D., Kataoka, Y., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Oct 2018, In : Molecular Cancer Research. 16, 10, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

Trifluridine
Fluorouracil
Pyrimidine Nucleotides
Pharmaceutical Preparations
Cell Line
2017
6 Citations (Scopus)

High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer

Nishimura, S., Oki, E., Ando, K., Iimori, M., Nakaji, Y., Nakashima, Y., Saeki, H., Oda, Y. & Maehara, Y., Jun 2017, In : Cancer Medicine. 6, 6, p. 1453-1464 12 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Aneuploidy
Stomach Neoplasms
DNA
Chromosomal Instability
6 Citations (Scopus)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest

Tsuda, Y., Iimori, M., Nakashima, Y., Nakanishi, R., Andou, K., Ohgaki, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2017, In : Scientific reports. 7, 1, 16762.

Research output: Contribution to journalArticle

Tubulin
Microtubules
eribulin
Aurora Kinase B
Endoreduplication
1 Citation (Scopus)

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Nakanishi, R., Kitao, H., Kiniwa, M., Morodomi, Y., Iimori, M., Kurashige, J., Sugiyama, M., Nakashima, Y., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2017, In : Scientific reports. 7, 1, 16969.

Research output: Contribution to journalArticle

Trifluridine
Colorectal Neoplasms
Blood Cells
Antibodies
DNA
10 Citations (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., Jan 1 2017, In : Cancer Medicine. 6, 1, p. 258-266 9 p.

Research output: Contribution to journalArticle

Neoplasms
Survival
Pyrophosphatases
Messenger RNA
Neoadjuvant Therapy
2016

Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)

Kitao, H., Matsuoka, K., Iimori, M., Tokunaga, E., Saeki, H., Oki, E., Miyamoto, Y., Baba, H. & Maehara, Y., Jan 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 1, p. 8-14 7 p.

Research output: Contribution to journalReview article

Trifluridine
Colorectal Neoplasms
Drug Therapy
Salvage Therapy
Japan

Evolving 5-fluorouracil therapy to achieve enhanced efficacy-past and current efforts of researchers

Maehara, Y., Oki, E., Saeki, H., Tokunaga, E., Kitao, H., Iimori, M., Niimi, S., Kataoka, Y., Emi, Y., Kakeji, Y., Baba, H. & Shirasaka, T., Jul 1 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 7, p. 845-854 10 p.

Research output: Contribution to journalReview article

Fluorouracil
Research Personnel
Tegafur
Prodrugs
Pharmaceutical Preparations
14 Citations (Scopus)

Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis

otsu, H., Iimori, M., Andou, K., Saeki, H., Aishima, S., Oda, Y., Morita, M., Matsuo, K., Kitao, H., Oki, E. & Maehara, Y., Jul 1 2016, In : Oncology (Switzerland). 91, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Aneuploidy
Stomach Neoplasms
DNA
Ploidies
Neoplasms
12 Citations (Scopus)

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Iimori, M., Watanabe, S., Kiyonari, S., Matsuoka, K., Sakasai, R., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Mar 31 2016, In : Nature communications. 7, 11117.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
genome
Genomic Instability
progressions
12 Citations (Scopus)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Kitao, H., Morodomi, Y., Niimi, S., Kiniwa, M., Shigeno, K., Matsuoka, K., Kataoka, Y., Iimori, M., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., May 3 2016, In : Scientific reports. 6, 25286.

Research output: Contribution to journalArticle

Trifluridine
Bromodeoxyuridine
Antibodies
DNA
Nucleoside Transport Proteins

The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU

Kitao, H., Kiyonari, S., Iimori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., Jun 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 707-714 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Platinum
Fluorouracil
Leucovorin
Combination Drug Therapy
2015
3 Citations (Scopus)

Intensive immunofluorescence staining methods for low expression protein: Detection of intestinal stem cell marker LGR5

Yamazaki, M., Kato, A., Zaitsu, Y., Watanabe, T., Iimori, M., Funahashi, S., Kitao, H., Saeki, H., Oki, E. & Suzuki, M., Oct 29 2015, In : Acta Histochemica et Cytochemica. 48, 5, p. 159-164 6 p.

Research output: Contribution to journalComment/debate

Stem cells
Fluorescent Antibody Technique
Stem Cells
Staining and Labeling
Proteins
15 Citations (Scopus)

The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis

Kiyonari, S., Iimori, M., Matsuoka, K., Watanabe, S., Morikawa-Ichinose, T., Miura, D., Niimi, S., Saeki, H., Tokunaga, E., Oki, E., Morita, M., Kadomatsu, K., Maehara, Y. & Kitao, H., Oct 1 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2332-2342 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Ligands
Deoxyuridine
Fluorouracil
Platinum
31 Citations (Scopus)

Trifluridine induces p53-dependent sustained G2 phase arrest with its massive misincorporation into DNA and few DNA strand breaks

Matsuoka, K., Iimori, M., Niimi, S., Tsukihara, H., Watanabe, S., Kiyonari, S., Kiniwa, M., Ando, K., Tokunaga, E., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Trifluridine
DNA Breaks
G2 Phase
Cyclin B1
Deoxyuridine
2014
10 Citations (Scopus)

Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers

Honma, K., Nakanishi, R., Nakanoko, T., Andou, K., Saeki, H., Oki, E., Iimori, M., Kitao, H., Kakeji, Y. & Maehara, Y., Mar 1 2014, In : Surgery Today. 44, 3, p. 454-461 8 p.

Research output: Contribution to journalArticle

Aneuploidy
Stomach Neoplasms
Microsatellite Instability
DNA
Cell Division
2013
12 Citations (Scopus)

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Tuul, M., Kitao, H., Iimori, M., Matsuoka, K., Kiyonari, S., Saeki, H., Oki, E., Morita, M. & Maehara, Y., Feb 1 2013, In : PloS one. 8, 2, e55361.

Research output: Contribution to journalArticle

heat tolerance
phosphotransferases (kinases)
Phosphotransferases
Hot Temperature
Chemical activation
2012
16 Citations (Scopus)

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

Fujinaka, Y., Matsuoka, K., Iimori, M., Tuul, M., Sakasai, R., Yoshinaga, K., Saeki, H., Morita, M., Kakeji, Y., Gillespie, D. A., Yamamoto, K. I., Takata, M., Kitao, H. & Maehara, Y., Mar 1 2012, In : DNA Repair. 11, 3, p. 247-258 12 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Cytotoxicity
Fluorouracil
Repair
Phosphotransferases
4 Citations (Scopus)

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication

Sakasai, R., Sakai, A., Iimori, M., Kiyonari, S., Matsuoka, K., Kakeji, Y., Kitao, H. & Maehara, Y., Dec 1 2012, In : Genes to Cells. 17, 12, p. 962-970 9 p.

Research output: Contribution to journalArticle

Camptothecin
DNA Breaks
Double-Stranded DNA Breaks
DNA Replication
S Phase Cell Cycle Checkpoints
9 Citations (Scopus)

FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer

Nakanishi, R., Kitao, H., Fujinaka, Y., Yamashita, N., Iimori, M., Tokunaga, E., Yamashita, N., Morita, M., Kakeji, Y. & Maehara, Y., Oct 1 2012, In : Annals of Surgical Oncology. 19, 11, p. 3627-3635 9 p.

Research output: Contribution to journalArticle

Fluorouracil
Colorectal Neoplasms
Drug Therapy
Neoplasms
DNA Mismatch Repair
2010
39 Citations (Scopus)

High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer

Andou, K., Kakeji, Y., Kitao, H., Iimori, M., Zhao, Y., Yoshida, R., Oki, E., Yoshinaga, K., Matumoto, T., Morita, M., Sakaguchi, Y. & Maehara, Y., Mar 1 2010, In : Cancer Science. 101, 3, p. 639-645 7 p.

Research output: Contribution to journalArticle

Aneuploidy
Stomach Neoplasms
DNA
Ploidies
Cell Line