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Research Output 1990 2014

  • 2401 Citations
  • 29 h-Index
  • 70 Article
  • 4 Review article
  • 1 Comment/debate
2014

Computer simulation as an alternative to animal use in pharmacology education

Oike, M., Jan 1 2014, In : Folia Pharmacologica Japonica. 144, 2, p. 95-97 3 p.

Research output: Contribution to journalComment/debate

Animal Use Alternatives
Animal Testing Alternatives
Vital Signs
Computer Simulation
Pharmacology
3 Citations (Scopus)

Development of vascular smooth muscle contractility by endothelium-derived transforming growth factor β proteins

Kimura, C., Konishi, S., Hasegawa, M. & Oike, M., Feb 1 2014, In : Pflugers Archiv European Journal of Physiology. 466, 2, p. 369-380 12 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Vascular Smooth Muscle
Endothelium
Muscle
Endothelial cells
2013
10 Citations (Scopus)

Endothelium-dependent epithelial-mesenchymal transition of tumor cells: Exclusive roles of transforming growth factor β1 and β2

Kimura, C., Hayashi, M., Mizuno, Y. & Oike, M., Jul 3 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 10, p. 4470-4481 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Endothelial cells
Transforming Growth Factors
Endothelium
Tumors
25 Citations (Scopus)

Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia

Matsunaga, Y., Fukuyama, S., Okuno, T., Sasaki, F., Matsunobu, T., Asai, Y., Matsumoto, K., Saeki, K., Oike, M., Sadamura, Y., Machida, K., Nakanishi, Y., Kubo, M., Yokomizo, T. & Inoue, H., Aug 1 2013, In : FASEB Journal. 27, 8, p. 3306-3314 9 p.

Research output: Contribution to journalArticle

Leukotriene B4 Receptors
T-cells
Ovalbumin
Eosinophilia
Interleukin-13
2012

Effect of superoxide anion on contractility of aortic smooth muscle cells

Cheng, W., Koyama, T. & Oike, M., Sep 2012, In : Chinese Pharmacological Bulletin. 28, 9, p. 1215-1217 3 p.

Research output: Contribution to journalArticle

Superoxides
Smooth Muscle Myocytes
Calcimycin
Collagen
Gels
2010
9 Citations (Scopus)

Transforming growth factor β1 alters calcium mobilizing properties and endogenous ATP release in A549 cells: Possible implications for cell migration

Miki, K., Tanaka, H., Nagai, Y., Kimura, C. & Oike, M., Jul 23 2010, In : Journal of Pharmacological Sciences. 113, 4, p. 387-394 8 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Cell Movement
Adenosine Triphosphate
Calcium
A549 Cells
2009
17 Citations (Scopus)

Hypergravity induces ATP release and actin reorganization via tyrosine phosphorylation and RhoA activation in bovine endothelial cells

Koyama, T., Kimura, C., Hayashi, M., Watanabe, M., Karashima, Y. & Oike, M., Feb 1 2009, In : Pflugers Archiv European Journal of Physiology. 457, 4, p. 711-719 9 p.

Research output: Contribution to journalArticle

Hypergravity
Phosphorylation
Endothelial cells
rho-Associated Kinases
Tyrosine
34 Citations (Scopus)

The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles

Braunstein, T. H., Inoue, R., Cribbs, L., Oike, M., Ito, Y., Holstein-Rathlou, N. H. & Jensen, L. J., Feb 1 2009, In : Journal of Vascular Research. 46, 2, p. 138-151 14 p.

Research output: Contribution to journalArticle

T-Type Calcium Channels
L-Type Calcium Channels
Arterioles
Calcium
Vasoconstriction
2008
24 Citations (Scopus)

Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production

Ohta, Y., Hayashi, M., Kanemaru, T., Abe, K., Ito, Y. & Oike, M., Mar 15 2008, In : Journal of Immunology. 180, 6, p. 4191-4199 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 1
Muscle Contraction
Smooth Muscle
Gels
Cytokines
4 Citations (Scopus)
Heparan Sulfate Proteoglycans
heparitinsulfate lyase
Thrombin
Nitric Oxide
Endothelial Cells
5 Citations (Scopus)

Involvement of heparan sulfate proteoglycan in sensing hypotonic stress in bovine aortic endothelial cells

Oike, M., Watanabe, M. & Chiwaka, K., Oct 1 2008, In : Biochimica et Biophysica Acta - General Subjects. 1780, 10, p. 1148-1155 8 p.

Research output: Contribution to journalArticle

heparitinsulfate lyase
Heparan Sulfate Proteoglycans
Endothelial cells
Osmotic Pressure
Endothelial Cells
2007
5 Citations (Scopus)

Long-term treatment with TGFβ 1 impairs mechanotransduction in bovine aortic endothelial cells

Watanabe, M., Oike, M., Ohta, Y. & Ito, Y., Feb 1 2007, In : British Journal of Pharmacology. 150, 4, p. 424-433 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Endothelial Cells
Osmotic Pressure
Membranes
Tyrosine
5 Citations (Scopus)

Proapoptotic nitric oxide production in amyloid β protein-treated cerebral microvascular endothelial cells

Kimura, C., Oike, M., Watanabe, M. & Ito, Y., Feb 1 2007, In : Microcirculation. 14, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Nitric Oxide
Endothelial Cells
Brain
Apoptosis
17 Citations (Scopus)

Protein kinase A inhibits lysophosphatidic acid-induced migration of airway smooth muscle cells

Hirakawa, M., Karashima, Y., Watanabe, M., Kimura, C., Ito, Y. & Oike, M., Jun 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 1102-1108 7 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Smooth Muscle Myocytes
Actins
Cell Movement
Airway Remodeling
2006
15 Citations (Scopus)

Pivotal role of integrin α5β1 in hypotonic stress-induced responses of human endothelium

Hirakawa, M., Oike, M., Watanabe, M., Karashima, Y. & Ito, Y., Oct 1 2006, In : FASEB Journal. 20, 12, p. 1992-1999 8 p.

Research output: Contribution to journalArticle

Osmotic Pressure
Integrins
Endothelium
Actins
Umbilical Cord
8 Citations (Scopus)

Sustained contraction and loss of NO production in TGFβ 1- treated endothelial cells

Watanabe, M., Oike, M., Ohta, Y., Nawata, H. & Ito, Y., Oct 11 2006, In : British Journal of Pharmacology. 149, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Endothelial Cells
Adenosine Triphosphate
Gels
Collagen
2005
5 Citations (Scopus)

Excess L-arginine restores endothelium-dependent relaxation impaired by monocrotaline pyrrole

Cheng, W., Oike, M., Hirakawa, M., Keizo, O., Koyama, T. & Ito, Y., Sep 15 2005, In : Toxicology and Applied Pharmacology. 207, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

Endothelium
Arginine
Acetylcholine
Gels
Endothelial cells
25 Citations (Scopus)

Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling

Harada, K., Takeuchi, H., Oike, M., Matsuda, M., Kanematsu, T., Yagisawa, H., Nakayama, K. I. I., Maeda, K., Erneux, C. & Hirata, M., Feb 1 2005, In : Journal of cellular physiology. 202, 2, p. 422-433 12 p.

Research output: Contribution to journalArticle

Carrier Proteins
Inositol
Polyphosphates
Enzyme activity
Phosphoric Monoester Hydrolases
2004
8 Citations (Scopus)

ATP release pathways in vascular endothelial cells

Oike, M., Droogmans, G. & Ito, Y., Jul 14 2004, In : Folia Pharmacologica Japonica. 123, 6, p. 403-411 9 p.

Research output: Contribution to journalReview article

Endothelial Cells
Adenosine Triphosphate
Anions
Exocytosis
Endothelium
45 Citations (Scopus)

Constitutive nitric oxide production in bovine aortic and brain microvascular endothelial cells: A comparative study

Kimura, C., Oike, M., Keizo, O., Nose, Y. & Ito, Y., Feb 1 2004, In : Journal of Physiology. 554, 3, p. 721-730 10 p.

Research output: Contribution to journalArticle

Nitric Oxide
Endothelial Cells
Brain
Acetylcholine
Adenosine Triphosphate
52 Citations (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Osmotic Pressure
Endothelium
Human Umbilical Vein Endothelial Cells
Paxillin
2003

Analysis of airway hyperresponsiveness using in vitro contraction model

Oike, M. & Ito, Y., Dec 1 2003, In : Folia Pharmacologica Japonica. 122, SUPPL. 1

Research output: Contribution to journalArticle

Gels
Theophylline
Smooth Muscle Myocytes
rho-Associated Kinases
Adenosine Triphosphate
19 Citations (Scopus)

Calcium-dependent injury of human microvascular endothelial cells induced by a variety of iodinated radiographic contrast media

Sumimura, T., Sendo, T., Itoh, Y., Oka, M., Oike, M., Ito, Y. & Oishi, R., Jun 1 2003, In : Investigative Radiology. 38, 6, p. 366-374 9 p.

Research output: Contribution to journalArticle

Contrast Media
Endothelial Cells
Calcium
Wounds and Injuries
Diatrizoate
90 Citations (Scopus)

DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, in T cells

Sanui, T., Inayoshi, A., Noda, M., Iwata, E., Oike, M., Sasazuki, T. & Fukui, Y., Jul 1 2003, In : Immunity. 19, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
T-Lymphocytes
Actin Cytoskeleton
Lipids
Antigens
32 Citations (Scopus)

Involvement of proteinase-activated receptor-2 in mast cell tryptase-induced barrier dysfunction in bovine aortic endothelial cells

Sendo, T., Sumimura, T., Itoh, Y., Goromaru, T., Aki, K., Yano, T., Oike, M., Ito, Y., Mori, S., Nishibori, M. & Oishi, R., Aug 1 2003, In : Cellular Signalling. 15, 8, p. 773-781 9 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Tryptases
Endothelial Cells
Ioxaglic Acid
Mast Cells

Regulatory role of mechanical stress response in cellular function: Development of new drugs and tissue engineering

Momose, K., Matsuda, T., Oike, M., Obara, K., Laher, I., Sugiura, S., Ohata, H. & Nakayama, K., Feb 27 2003, In : Folia Pharmacologica Japonica. 121, 2, p. 103-111 9 p.

Research output: Contribution to journalReview article

Mechanical Stress
Tissue Engineering
Blood Vessels
Pharmaceutical Preparations
Contractile Proteins
19 Citations (Scopus)

Theophylline and cAMP inhibit lysophosphatidic acid-induced hyperresponsiveness of bovine tracheal smooth muscle cells

Sakai, J., Oike, M., Hirakawa, M. & Ito, Y., May 15 2003, In : Journal of Physiology. 549, 1, p. 171-180 10 p.

Research output: Contribution to journalArticle

Theophylline
Smooth Muscle Myocytes
Gels
rho-Associated Kinases
Colforsin
2002
24 Citations (Scopus)

Functional implications of Ca2+ mobilizing properties for nitric oxide production in aortic endothelium

Koyama, T., Kimura, C., Park, S. J., Oike, M. & Ito, Y., Dec 20 2002, In : Life Sciences. 72, 4-5, p. 511-520 10 p.

Research output: Contribution to journalArticle

Endothelium
Nitric Oxide
Adenosine Triphosphate
Fura-2
Fluorescence
10 Citations (Scopus)

Propofol prevents endothelial dysfunction induced by glucose overload

Karashima, Y., Oike, M., Takahashi, S. & Ito, Y., Nov 2002, In : British Journal of Pharmacology. 137, 5, p. 683-691 9 p.

Research output: Contribution to journalArticle

Propofol
Glucose
Xanthine
Xanthine Oxidase
Inhibitory Concentration 50
31 Citations (Scopus)

Superoxide anion impairs contractility in cultured aortic smooth muscle cells

Kimura, C., Cheng, W., Hisadome, K., Wang, Y. P., Koyama, T., Karashima, Y., Oike, M. & Ito, Y., Jul 10 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 1 52-1

Research output: Contribution to journalArticle

Xanthine
Xanthine Oxidase
Superoxides
Smooth Muscle Myocytes
Thapsigargin
18 Citations (Scopus)

Tumor cell apoptosis by irradiation-induced nitric oxide production in vascular endothelium

Hirakawa, M., Oike, M., Masuda, K. & Ito, Y., Mar 1 2002, In : Cancer Research. 62, 5, p. 1450-1457 8 p.

Research output: Contribution to journalArticle

Vascular Endothelium
Nitric Oxide
Endothelial Cells
Apoptosis
Nitric Oxide Synthase
112 Citations (Scopus)

Volume-regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells

Hisadome, K., Koyama, T., Kimura, C., Droogmans, G., Ito, Y. & Oike, M., Jun 20 2002, In : Journal of General Physiology. 119, 6, p. 511-520 10 p.

Research output: Contribution to journalArticle

Anions
Nucleotides
Endothelial Cells
Adenosine Triphosphate
Osmotic Pressure
2001
34 Citations (Scopus)

Alterations of Ca2+ mobilizing properties in migrating endothelial cells

Kimura, C., Oike, M., Koyama, T. & Ito, Y., Aug 29 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 281, 2 50-2

Research output: Contribution to journalArticle

Endothelial Cells
Thapsigargin
Adenosine Triphosphate
Pathologic Neovascularization

Effects of monocrotaline pyrrole on morphology, number and production of nitric oxide of cultured artery endothelial cells

Cheng, W., Li, Z., Koyama, T., Oike, M. & Ito, Y., Jan 1 2001, In : Chinese Journal of Pharmacology and Toxicology. 15, 3, p. 169-171 3 p.

Research output: Contribution to journalArticle

Endothelial cells
Nitric Oxide
Endothelial Cells
Arteries
Pulmonary Hypertension
332 Citations (Scopus)

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T. & Sasazuki, T., Aug 23 2001, In : Nature. 412, 6849, p. 826-831 6 p.

Research output: Contribution to journalArticle

Myoblasts
Lymphocytes
Chemokines
Cell Movement
Actins
43 Citations (Scopus)

Impairment of endothelial nitric oxide production by acute glucose overload

Kimura, C., Oike, M., Koyama, T. & Ito, Y., Jun 11 2001, In : American Journal of Physiology - Endocrinology and Metabolism. 280, 1 43-1

Research output: Contribution to journalArticle

Nitric Oxide
Glucose
Adenosine Triphosphate
Fluorescence
Endothelial Cells
82 Citations (Scopus)

Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells

Koyama, T., Oike, M. & Ito, Y., May 1 2001, In : Journal of Physiology. 532, 3, p. 759-769 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Osmotic Pressure
Protein-Tyrosine Kinases
Endothelial Cells
Adenosine Triphosphate
2000
16 Citations (Scopus)

Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo

Fukuyama, S., Inoue, H., Aizawa, H., Oike, M., Kitaura, M., Yoshie, O. & Hara, N., Jan 1 2000, In : American Journal of Respiratory and Critical Care Medicine. 161, 6, p. 1844-1849 6 p.

Research output: Contribution to journalArticle

Platelet Activating Factor
Eosinophils
Guinea Pigs
Inflammation
Bronchoalveolar Lavage Fluid
41 Citations (Scopus)

Hypotonic stress-induced dual Ca2+ responses in bovine aortic endothelial cells

Oike, M., Kimura, C., Koyama, T., Yoshikawa, M. & Yushi, I. T. O., Sep 14 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 2 48-2

Research output: Contribution to journalArticle

Osmotic Pressure
Endothelial Cells
Adenosine Triphosphate
Apyrase
Suramin
36 Citations (Scopus)

Hypotonic stress-induced NO production in endothelium depends on endogenous ATP

Kimura, C., Koyama, T., Oike, M. & Ito, Y., Aug 11 2000, In : Biochemical and Biophysical Research Communications. 274, 3, p. 736-740 5 p.

Research output: Contribution to journalArticle

Osmotic Pressure
Endothelium
Nitric Oxide
Adenosine Triphosphate
Endothelial cells
31 Citations (Scopus)
Endothelial Cells
Thenoyltrifluoroacetone
Brain
Rotenone
Adenosine Triphosphate
52 Citations (Scopus)

Inhibition of Ca2+ signalling by p130, a phospholipase-C-related catalytically inactive protein: Critical role of the p130 pleckstrin homology domain

Takeuchi, H., Oike, M., Paterson, H. F., Allen, V., Kanematsu, T., Ito, Y., Erneux, C., Katan, M. & Hirata, M., Jul 1 2000, In : Biochemical Journal. 349, 1, p. 357-368 12 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Ligands
COS Cells
Proteins
Phospholipases
Nitric Oxide Donors
Metabolic Diseases
Vascular Endothelium
Superoxides
Arginine
1999
3 Citations (Scopus)

Effects of superoxide anion on intracellular Ca2+ concentration in rabbit pulmonary arterial smooth muscle cells

Wang, Y. P., Oike, M. & Ito, Y., Jan 27 1999, In : Acta Pharmacologica Sinica. 20, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Superoxides
Smooth Muscle Myocytes
Adenosine Triphosphate
Rabbits
Lung
3 Citations (Scopus)

Superoxide anion impairs Ca2+ mobilization in cultured human nasal epithelial cells

Koyama, T., Oike, M., Komiyama, S. & Ito, Y., Dec 1 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 6 21-6

Research output: Contribution to journalArticle

Nose
Superoxides
Xanthine Oxidase
Epithelial Cells
Adenosine Triphosphate
1998
40 Citations (Scopus)

Acute glucose overload abolishes Ca2+ oscillation in cultured endothelial cells from bovine aorta: A possible role of superoxide anion

Kimura, C., Oike, M. & Ito, Y., Apr 6 1998, In : Circulation research. 82, 6, p. 677-685 9 p.

Research output: Contribution to journalArticle

Superoxides
Aorta
Cultured Cells
Endothelial Cells
Glucose
9 Citations (Scopus)

Effects of acute glucose overload on histamine H2 receptor-mediated Ca2+ mobilization in bovine cerebral endothelial cells

Kimura, C., Oike, M., Kashiwagi, S. & Ito, Y., Jan 1 1998, In : Diabetes. 47, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Histamine H2 Receptors
Histamine
Endothelial Cells
Glucose
Extracellular Space

Impairing effects of acute glucose overload on calcium homeostasis in vascular endothelial cells

Oike, M. & Kimura, C., Jan 1 1998, In : Korean Journal of Physiology and Pharmacology. 2, 6, p. 653-659 7 p.

Research output: Contribution to journalReview article

Homeostasis
Endothelial Cells
Calcium
Glucose
7 Citations (Scopus)

Increase in calcium in smooth muscle cells of the rabbit bladder induced by acetylcholine and ATP

Oike, M., Creed, K. E., Onoue, H., Tanaka, H. & Ito, Y., Apr 30 1998, In : Journal of the Autonomic Nervous System. 69, 2-3, p. 141-147 7 p.

Research output: Contribution to journalArticle

Acetylcholine
Smooth Muscle Myocytes
Urinary Bladder
Adenosine Triphosphate
Rabbits
1997
13 Citations (Scopus)

Dynamic regulation of intracellular Ca2+ concentration in arotic endothelial cells

Oike, M. & Ito, Y., Jan 29 1997, In : European Journal of Pharmacology. 319, 2-3, p. 291-298 8 p.

Research output: Contribution to journalArticle

Endothelial Cells
Adenosine Triphosphate
Thapsigargin
Fura-2
Coloring Agents