• 2564 Citations
  • 21 h-Index
19962020

Research output per year

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Research Output

  • 2564 Citations
  • 21 h-Index
  • 34 Article
  • 14 Chapter
  • 4 Review article
  • 1 Book
2020

Recent insights into peroxisome biogenesis and associated diseases

Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A. J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W. K. & Kuroiwa, T., May 2020, In : Journal of cell science. 133, 9, jcs236943.

Research output: Contribution to journalReview article

Open Access

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway

Dubreuil, M. M., Morgens, D. W., Okumoto, K., Honsho, M., Contrepois, K., Lee-McMullen, B., Traber, G. M. A., Sood, R. S., Dixon, S. J., Snyder, M. P., Fujiki, Y. & Bassik, M. C., Feb 4 2020, In : Cell Reports. 30, 5, p. 1417-1433.e7

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase

Exner, T., Romero-Brey, I., Yifrach, E., Rivera-Monroy, J., Schrul, B., Zouboulis, C. C., Stremmel, W., Honsho, M., Bartenschlager, R., Zalckvar, E., Poppelreuther, M. & Fullekrug, J., Mar 1 2019, In : Journal of cell science. 132, 6, 223016.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum

Honsho, M., Dorninger, F., Abe, Y., Setoyama, D., Ohgi, R., Uchiumi, T., Kang, D., Berger, J. & Fujiki, Y., Aug 15 2019, In : Journal of biochemistry. 166, 4, p. 353-361 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Plasmalogen mediates integration of adherens junction

Takahashi, T., Honsho, M., Abe, Y. & Fujiki, Y., Nov 1 2019, In : Journal of biochemistry. 166, 5, p. 423-432 10 p.

Research output: Contribution to journalArticle

2018

Biological functions of organelles and failure mechanism in diseases Regulation of peroxisome homeostasis and functions

Honsho, M. & Fujiki, Y., Jan 1 2018, In : Seikagaku. 90, 1, p. 5-13 9 p.

Research output: Contribution to journalReview article

Homeostasis of plasmalogens in mammals

Honsho, M. & Fujiki, Y., Jan 1 2018, Encyclopedia of Food Chemistry. Elsevier, p. 218-223 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T. & Fujiki, Y., Dec 1 2018, In : Nature communications. 9, 1, 4634.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., 2018, In : Life Science Alliance. 1, 6

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Analysis of plasmalogen synthesis in cultured cells

Honsho, M. & Fujiki, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 55-61 7 p. (Methods in Molecular Biology; vol. 1595).

Research output: Chapter in Book/Report/Conference proceedingChapter

Defining the dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae

Imoto, Y., Abe, Y., Okumoto, K., Honsho, M., Kuroiwa, H., Kuroiwa, T. & Fujiki, Y., Jan 1 2017, In : Journal of cell science. 130, 5, p. 853-867 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

In vitro PMP import analysis using cell-free synthesized PMP and isolated peroxisomes

Liu, Y., Honsho, M. & Fujiki, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 207-212 6 p. (Methods in Molecular Biology; vol. 1595).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomal membrane and matrix protein import using a semi-intact mammalian cell system

Okumoto, K., Honsho, M., Liu, Y. & Fujiki, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 213-219 7 p. (Methods in Molecular Biology; vol. 1595).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes

Honsho, M., Abe, Y. & Fujiki, Y., Mar 8 2017, In : Scientific reports. 7, 43936.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Plasmalogen homeostasis – regulation of plasmalogen biosynthesis and its physiological consequence in mammals

Honsho, M. & Fujiki, Y., Sep 2017, In : FEBS Letters. 591, 18, p. 2720-2729 10 p.

Research output: Contribution to journalReview article

Open Access
19 Citations (Scopus)

Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation

Hossain, M. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y. & Katafuchi, T., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4074-4092 19 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

ペキソファジー:ペルオキシソームの機能・形成と分解

Fujiki, Y., Honsho, M., OKUMOTO, K. & Yamashita, S., Jun 2017, 実験医学. p. 1824-1831 (実験医学 7月号特集; vol. 35, no. 11).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Peroxisome homeostasis: Mechanisms of division and selective degradation of peroxisomes in mammals

Honsho, M., Yamashita, S. I. & Fujiki, Y., May 1 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 5, p. 984-991 8 p.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)

エーテルリン脂質プラスマローゲンの生合成とその障害

Fujiki, Y. & Honsho, M., Feb 2016, 機能性食品と薬理栄養 . p. 322-327 (機能性食品と薬理栄養; vol. 9, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

ペルオキシソーム形成異常と疾患. (別冊・医学のあゆみ)

Fujiki, Y., OKUMOTO, K. & Honsho, M., Jul 2016, 別冊・医学のあゆみ. p. 75-79 (別冊・医学のあゆみ).

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis

Honsho, M., Abe, Y. & Fujiki, Y., Nov 27 2015, In : Journal of Biological Chemistry. 290, 48, p. 28822-28833 12 p.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Pex11mediates peroxisomal proliferation by promoting deformation of the lipid membrane

Yoshida, Y., Niwa, H., Honsho, M., Itoyama, A. & Fujiki, Y., Jun 15 2015, In : Biology Open. 4, 6, p. 710-721 12 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Protein Import into Peroxisomes: the principles and methods of studying

Fujiki, Y., Okumoto, K. & Honsho, M., Apr 14 2015

Research output: Book/ReportBook

Open Access

ペルオキシソーム形成異常と疾患

Fujiki, Y., OKUMOTO, K. & Honsho, M., Aug 2015, 医学のあゆみ. p. 397-401 (医学のあゆみ; vol. 254, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: Functional characterization of a novel mutation

Noguchi, M., Honsho, M., Abe, Y., Toyama, R., Niwa, H., Sato, Y., Ghaedi, K., Rahmanifar, A., Shafeghati, Y. & Fujiki, Y., Jul 2014, In : Journal of Human Genetics. 59, 7, p. 387-392 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Molecular complex coordinating peroxisome morphogenesis in mammalian cells

Fujiki, Y., Itoyama, A., Abe, Y. & Honsho, M., Feb 1 2014, Molecular Machines Involved in Peroxisome Biogenesis and Maintenance. Springer-Verlag Wien, p. 391-401 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Peroxisome biogenesis in mammalian cells

Fujiki, Y., Okumoto, K., Mukai, S., Honsho, M. & Tamura, S., 2014, In : Frontiers in Physiology. 5 AUG, Article 307.

Research output: Contribution to journalReview article

65 Citations (Scopus)
30 Citations (Scopus)

ペルオキシソームの脂質代謝

Fujiki, Y. & Honsho, M., Mar 2014, 医学のあゆみ. p. 1143-1149 (医学のあゆみ; vol. 248, no. 13).

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Mff functions with Pex11pβ and DLP1 in peroxisomal fission

Itoyama, A., Michiyuki, S., Honsho, M., Yamamoto, T., Moser, A., Yoshida, Y. & Fujiki, Y., Oct 15 2013, In : Biology Open. 2, 10, p. 998-1006 9 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Topogenesis and homeostasis of fatty Acyl-CoA reductase 1

Honsho, M., Asaoku, S., Fukumoto, K. & Fujiki, Y., Nov 29 2013, In : Journal of Biological Chemistry. 288, 48, p. 34588-34598 11 p.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)
2012

Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division

Itoyama, A., Honsho, M., Abe, Y., Moser, A., Yoshida, Y. & Fujiki, Y., Feb 1 2012, In : Journal of cell science. 125, 3, p. 589-602 14 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

ペルオキシソームの形成・制御とその障害

Fujiki, Y., Miyata, N., OKUMOTO, K., Tamura, S., Itoyama, A. & Honsho, M., Oct 2012, 生体の化学. (生体の化学; vol. 63, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals

Honsho, M., Hashiguchi, Y., Ghaedi, K. & Fujiki, Y., Feb 1 2011, In : Journal of biochemistry. 149, 2, p. 203-210 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2010

Posttranslational regulation of fatty acyl-CoA reductase 1, Far1, controls ether glycerophospholipid synthesis

Honsho, M., Asaoku, S. & Fujiki, Y., Mar 19 2010, In : Journal of Biological Chemistry. 285, 12, p. 8537-8542 6 p.

Research output: Contribution to journalArticle

Open Access
64 Citations (Scopus)

ペルオキシソームの形成・制御とその障害による高次機能の破綻

Fujiki, Y., Miyata, N., Matsuzono, Y., Matsuzaki, T. & Honsho, M., Aug 2010, 実験医学. p. 2094-2101 (実験医学; vol. 28, no. 13).

Research output: Chapter in Book/Report/Conference proceedingChapter

2008

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons

Schneider, A., Rajendran, L., Honsho, M., Gralle, M., Donnert, G., Wouters, F., Hell, S. W. & Simons, M., Mar 12 2008, In : Journal of Neuroscience. 28, 11, p. 2874-2882 9 p.

Research output: Contribution to journalArticle

Open Access
149 Citations (Scopus)
Open Access
44 Citations (Scopus)
2006

Alzheimer's disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P. & Simons, K., Jul 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 30, p. 11172-11177 6 p.

Research output: Contribution to journalArticle

Open Access
685 Citations (Scopus)

Detergent-Resistant Membranes and the Use of Cholesterol Depletion

Schuck, S., Honsho, M. & Simons, K., Dec 1 2006, Cell Biology, Four-Volume Set. Elsevier Inc., Vol. 2. p. 5-9 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2004

Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference

Schuck, S., Manninen, A., Honsho, M., Füllekrug, J. & Simons, K., Apr 6 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 14, p. 4912-4917 6 p.

Research output: Contribution to journalArticle

Open Access
81 Citations (Scopus)
2003

Dual subcellular distribution of cytochrome b5 in plant, cauliflower, cells

Zhao, J., Onduka, T., Kinoshita, J. Y., Honsho, M., Kinoshita, T., Shimazaki, K. I. & Ito, A., Jan 1 2003, In : Journal of biochemistry. 133, 1, p. 115-121 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Involvement of caveolin-2 in caveolar biogenesis in MDCK cells

Lahtinen, U., Honsho, M., Parton, R. G., Simons, K. & Verkade, P., Mar 13 2003, In : FEBS Letters. 538, 1-3, p. 85-88 4 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Resistance of cell membranes to different detergents

Schuck, S., Honsho, M., Ekroos, K., Shevchenko, A. & Simons, K., May 13 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 10, p. 5795-5800 6 p.

Research output: Contribution to journalArticle

Open Access
509 Citations (Scopus)

ペルオキシソーム形成の分子基盤

Fujiki, Y., Mukai, S. & Honsho, M., Sep 2003, 実験医学増刊. p. 1904-1911 (実験医学増刊; vol. 21, no. 14).

Research output: Chapter in Book/Report/Conference proceedingChapter

2002

The membrane biogenesis peroxin Pex16p: Topogenesis and functional roles in peroxisomal membrane assembly

Honsho, M., Hiroshige, T. & Fujiki, Y., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44513-44524 12 p.

Research output: Contribution to journalArticle

Open Access
62 Citations (Scopus)
2001
Open Access
51 Citations (Scopus)
2000

PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G

Ghaedi, K., Honsho, M., Shimozawa, N., Suzuki, Y., Kondo, N. & Fujiki, Y., 2000, In : American journal of human genetics. 67, 4, p. 976-981 6 p.

Research output: Contribution to journalArticle

Open Access
48 Citations (Scopus)

The mammalian peroxin Pex5pl, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p·PTS2 protein complex into peroxisomes via its initial docking site, Pex14p

Otera, H., Harano, T., Honsho, M., Ghaedi, K., Mukai, S., Tanaka, A., Kawai, A., Shimizu, N. & Fujiki, Y., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21703-21714 12 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)
1998

Charged amine acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b5

Kuroda, R., Ikenoue, T., Honsho, M., Tsujimoto, S., Mitoma, J. Y. & Ito, A., Nov 20 1998, In : Journal of Biological Chemistry. 273, 47, p. 31097-31102 6 p.

Research output: Contribution to journalArticle

Open Access
97 Citations (Scopus)