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Research Output 1993 2019

  • 878 Citations
  • 18 h-Index
  • 44 Article
  • 5 Review article
  • 1 Short survey
2019

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., Aug 15 2019, In : European Journal of Pharmacology. 172405.

Research output: Contribution to journalArticle

Lower Esophageal Sphincter
Dinoprostone
Smooth Muscle
Gastroesophageal Reflux
Muscle Contraction
2 Citations (Scopus)

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
PAR-1 Receptor
Pulmonary Hypertension
Monocrotaline
Pulmonary Artery
Right Ventricular Hypertrophy
2018
2 Citations (Scopus)

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger

Bai, X., Ihara, E., Hirano, K., Tanaka, Y., Nakano, K., Kita, S., Iwamoto, T., Ogino, H., Hirano, M., Oda, Y., Nakamura, K. & Ogawa, Y., Mar 1 2018, In : CMGH. 5, 3, p. 209-221 13 p.

Research output: Contribution to journalArticle

Cystathionine
Lower Esophageal Sphincter
Hydrogen Sulfide
Swine
Lyases
2017
2 Citations (Scopus)

Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body

Xiaopeng, B., Tanaka, Y., Ihara, E., Hirano, K., Nakano, K., Hirano, M., Oda, Y. & Nakamura, K., Jan 1 2017, In : European Journal of Pharmacology. 797, p. 65-74 10 p.

Research output: Contribution to journalArticle

Muscle Relaxation
Muscle Contraction
Trypsin
Smooth Muscle
Swine
2016
16 Citations (Scopus)
Myosins
Myosin Light Chains
Actins
Phosphorylation
Thrombin
2015
1 Citation (Scopus)

Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter

Tanaka, Y., Ihara, E., Hirano, K., Takahashi, S., Hirano, M., Nakamura, K., Akiho, H., Oda, Y. & Takayanagi, R., Apr 5 2015, In : European Journal of Pharmacology. 752, p. 97-105 9 p.

Research output: Contribution to journalArticle

Lower Esophageal Sphincter
Trypsin
Swine
rho-Associated Kinases
Protein Kinases
2013
20 Citations (Scopus)

Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility

Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K. & Hirano, K., Jan 1 2013, In : Circulation. 127, 1, p. 104-114 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Circadian Rhythm
Blood Vessels
Myosin Light Chains
Myofibrils
2012
18 Citations (Scopus)

Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage

Kameda, K., Kikkawa, Y., Hirano, M., Matsuo, S., Sasaki, T. & Hirano, K., Jan 1 2012, In : British Journal of Pharmacology. 165, 1, p. 106-119 14 p.

Research output: Contribution to journalArticle

Subarachnoid Hemorrhage
PAR-1 Receptor
Thrombin
Blood Vessels
Ligands
14 Citations (Scopus)

Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca 2+ sensitization after subarachnoid hemorrhage

Kikkawa, Y., Matsuo, S., Kameda, K., Hirano, M., Nakamizo, A., Sasaki, T. & Hirano, K., Feb 1 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 2, p. 341-352 12 p.

Research output: Contribution to journalArticle

Myofibrils
Endothelin-1
Subarachnoid Hemorrhage
Myosin-Light-Chain Phosphatase
Protein Kinase C
2011

[Molecular mechanisms underlying the increased contractility of smooth muscle in cerebral artery after subarachnoid hemmorhage].

Kikkawa, Y., Sasaki, T., Hirano, M. & Hirano, K., Dec 1 2011, In : Fukuoka igaku zasshi = Hukuoka acta medica. 102, 12, p. 325-332 8 p.

Research output: Contribution to journalReview article

Calcium-Sensing Receptors
Cerebral Arteries
Subarachnoid Hemorrhage
Muscle Contraction
Vasoconstriction
24 Citations (Scopus)

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Nishioka, K., Nishida, M., Ariyoshi, M., Jian, Z., Saiki, S., Hirano, M., Michio, N., Sato, Y., Kita, S., Iwamoto, T., Hirano, K., Inoue, R. & Kurose, H., Oct 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2278-2286 9 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Vasoconstriction
Angiotensin II
Phosphorylation
Transient Receptor Potential Channels
2010
11 Citations (Scopus)

Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage

Hirano, K. & Hirano, M., Nov 22 2010, In : Journal of Pharmacological Sciences. 114, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

Thrombin Receptors
Intracranial Vasospasm
PAR-1 Receptor
Subarachnoid Hemorrhage
Thrombin
25 Citations (Scopus)
Myofibrils
Subarachnoid Hemorrhage
Blood Vessels
Thrombin
Intracranial Vasospasm
16 Citations (Scopus)

Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction

Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Dec 1 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 11, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

Vasoconstriction
Thrombin
Reactive Oxygen Species
Phosphorylation
Lung
10 Citations (Scopus)
PAR-1 Receptor
Myofibrils
Vasoconstriction
Thrombin
Pulmonary Artery
18 Citations (Scopus)

Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas

aman, M., Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2010, In : Journal of Vascular Research. 47, 6, p. 494-506 13 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Trypsin
Endothelium
Aorta
Oxidative Stress
2009
20 Citations (Scopus)

Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage

Maeda, Y., Hirano, K., Hirano, M., Kikkawa, Y., Kameda, K., Sasaki, T. & Kanaide, H., Feb 1 2009, In : Stroke. 40, 2, p. 591-596 6 p.

Research output: Contribution to journalArticle

Basilar Artery
Platelet-Derived Growth Factor
Subarachnoid Hemorrhage
Phosphorylation
Intracranial Vasospasm
18 Citations (Scopus)

Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells

Hirano, K., Hirano, M. & Hanada, A., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endothelial cells
Endothelial Cells
Thrombin
Molecules
2007
26 Citations (Scopus)

Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells

Hirano, K., Nomoto, N., Hirano, M., Momota, F., Hanada, A. & Kanaide, H., Aug 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 2, p. 668-677 10 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endothelial Cells
Phosphotransferases
Thrombin Receptors
Ethane
8 Citations (Scopus)

Involvement of Na +-Ca 2+ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice

Karashima, E., Nishimura, J., Iwamoto, T., Hirano, K., Hirano, M., Kita, S., Harada, M. & Kanaide, H., Feb 1 2007, In : British Journal of Pharmacology. 150, 4, p. 434-444 11 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
Colforsin
Transgenic Mice
Aorta
Thoracic Aorta
4 Citations (Scopus)

Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery

Fujiyoshi, T., Hirano, K., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., Apr 1 2007, In : Arteriosclerosis, thrombosis, and vascular biology. 27, 4, p. 949-954 6 p.

Research output: Contribution to journalArticle

Fibrinolysin
Endothelium
Coronary Vessels
Nitric Oxide
Swine
2 Citations (Scopus)

Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells

Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 10, p. 1500-1510 11 p.

Research output: Contribution to journalArticle

Up-Regulation
Endothelial Cells
rac1 GTP-Binding Protein
Cell Cycle Checkpoints
Cell-Penetrating Peptides
27 Citations (Scopus)

Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage

Maeda, Y., Hirano, K., Kai, Y., Hirano, M., Suzuki, S., Sasaki, T. & Kanaide, H., Dec 1 2007, In : British Journal of Pharmacology. 152, 7, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Subarachnoid Hemorrhage
Thrombin
Up-Regulation
Basilar Artery
2006
12 Citations (Scopus)

Involvement of G i/o in the PAR-4-induced NO production in endothelial cells

Momota, F., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Apr 7 2006, In : Biochemical and Biophysical Research Communications. 342, 2, p. 365-371 7 p.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
Ionomycin
Endothelial cells
Endothelial Cells
thrombin receptor peptide SFLLRNP
15 Citations (Scopus)

Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury

Fukunaga, R., Hirano, K., Hirano, M., Niiro, N., Nishimura, J., Maehara, Y. & Kanaide, H., Nov 24 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
Up-Regulation
PAR-1 Receptor
Wounds and Injuries
PAR-2 Receptor
2005
67 Citations (Scopus)

Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga, N., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Mar 13 2005, In : Circulation research. 96, 9, p. 1014-1021 8 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Simvastatin
Blood Vessels
Rabbits
Endothelial Cells
16 Citations (Scopus)

Physiology and pathophysiology of proteinase-activated receptors (PARs): Regulation of the expression of PARs

Hirano, K., Yufu, T., Hirano, M., Nishimura, J. & Kanaide, H., Jan 1 2005, In : Journal of Pharmacological Sciences. 97, 1, p. 31-37 7 p.

Research output: Contribution to journalShort survey

Proteinase-Activated Receptors
Genetic Promoter Regions
Transcription Factors
Phosphorylation
16 Citations (Scopus)

Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells

Yufu, T., Hirano, K., Bi, D., Hirano, M., Nishimura, J., Iwamoto, Y. & Kanaide, H., Jul 1 2005, In : Arteriosclerosis, thrombosis, and vascular biology. 25, 7, p. 1506-1511 6 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Vascular Smooth Muscle
Thrombin
Smooth Muscle Myocytes
Simvastatin
2004
12 Citations (Scopus)

A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 149-154 6 p.

Research output: Contribution to journalArticle

Cell Cycle Proteins
Endothelial cells
Endothelial Cells
Proteins
S Phase
21 Citations (Scopus)

Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga, M., Hirano, K., Hirano, M., Nishimura, J., Nakano, H. & Kanaide, H., Nov 5 2004, In : Biochemical and Biophysical Research Communications. 324, 1, p. 321-325 5 p.

Research output: Contribution to journalArticle

Endothelial cells
Estrogens
Endothelial Cells
Cell-Penetrating Peptides
Estradiol
3 Citations (Scopus)

Facilitation of proteasomal degradation of p27Kip1 by N-terminal cleavage and their sequence requirements

Hirano, K., Ihara, E., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Sep 10 2004, In : FEBS Letters. 574, 1-3, p. 111-115 5 p.

Research output: Contribution to journalArticle

S 10
Proteasome Inhibitors
Adenosine Triphosphate
Degradation
Mutation
9 Citations (Scopus)

Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells

Nakayama, T., Hirano, K., Hirano, M., Nishimura, J., Kuga, H., Nakamura, K., Takahashi, S. & Kanaide, H., Jul 1 2004, In : Biochemical Pharmacology. 68, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endothelial cells
Thrombin
Endothelial Cells
Ligands
60 Citations (Scopus)

Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle

Hirano, K., Hirano, M. & Kanaide, H., Dec 1 2004, In : Journal of Smooth Muscle Research. 40, 6, p. 219-236 18 p.

Research output: Contribution to journalReview article

Myosin Light Chains
Myofibrils
Myosin-Light-Chain Phosphatase
Myosins
Vascular Smooth Muscle
10 Citations (Scopus)

Transduction of the N-Terminal Fragments of MYPT1 Enhances Myofilament Ca 2+ Sensitivity in an Intact Coronary Artery

Hirano, K., Derkach, D. N., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., Mar 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 464-469 6 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Phosphatase
Myofibrils
Coronary Vessels
Human Immunodeficiency Virus tat Gene Products
Smooth Muscle Myosins
2003
17 Citations (Scopus)

Intracellular alkalinization induces Ca2+ influx via non-voltage-operated Ca2+ channels in rat aortic smooth muscle cells

Eto, W., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jan 1 2003, In : Cell Calcium. 34, 6, p. 477-484 8 p.

Research output: Contribution to journalArticle

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Diltiazem
Smooth Muscle Myocytes
Fluorometry
Fura-2
70 Citations (Scopus)
Smooth Muscle Myosins
Myosin Light Chains
Phosphorylation
Protein Kinases
Myosins
70 Citations (Scopus)
Smooth Muscle Myosins
Myosin Light Chains
Phosphorylation
Protein Kinases
Myosins
70 Citations (Scopus)

Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain

Hirano, K., Derkach, D. N., Hirano, M., Nishimura, J. & Kanaide, H., Jun 1 2003, In : Molecular and cellular biochemistry. 248, 1-2, p. 105-114 10 p.

Research output: Contribution to journalReview article

Smooth Muscle Myosins
Myosin Light Chains
Phosphorylation
Protein Kinases
Myosins
8 Citations (Scopus)

Sequence requirement for nuclear localization and growth inhibition of p27Kip1R, a degradation-resistant isoform of p27Kip1

Hirano, K., Zeng, Y., Hirano, M., Nishimura, J. & Kanaide, H., May 1 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 191-202 12 p.

Research output: Contribution to journalArticle

Cell growth
Protein Isoforms
Fluorescence
Amino Acids
Degradation
2002
26 Citations (Scopus)

Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta

Ihara, E., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Oct 16 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

Depolarization
Bromodeoxyuridine
Volatile organic compounds
Smooth Muscle Myocytes
Muscle
2001
14 Citations (Scopus)

Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1

Hirano, K., Hirano, M., Zeng, Y., Nishimura, J., Hara, K., Muta, K., Nawata, H. & Kanaide, H., Jan 1 2001, In : Biochemical Journal. 353, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Protein Isoforms
Degradation
Cells
32 Citations (Scopus)

Transcriptional up-regulation of p27Kip1 during contact-induced growth arrest in vascular endothelial cells

Hirano, M., Hirano, K., Nishimura, J. & Kanaide, H., Dec 10 2001, In : Experimental Cell Research. 271, 2, p. 356-367 12 p.

Research output: Contribution to journalArticle

Up-Regulation
Endothelial Cells
Cell Cycle
Growth
RNA Stability
2000
9 Citations (Scopus)

Dissociation between the Ca2+ signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells

Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Nakatsuka, A., Fujishima, M. & Kanaide, H., Jun 9 2000, In : European Journal of Pharmacology. 398, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
troglitazone
Vascular Endothelial Growth Factor A
Endothelial Cells
Diltiazem
50 Citations (Scopus)

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

Zeng, Y., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jul 21 2000, In : Biochemical and Biophysical Research Communications. 274, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Green Fluorescent Proteins
Nuclear Localization Signals
Endothelial cells
HeLa Cells
7 Citations (Scopus)

Mitogen-induced up-regulation of non-smooth muscle isoform of α- tropomyosin in rat aortic smooth muscle cells

Hirano, K., Hirano, M., Eto, W., Nishimura, J. & Kanaide, H., Oct 13 2000, In : European Journal of Pharmacology. 406, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

Tropomyosin
Mitogens
Smooth Muscle Myocytes
Exons
Protein Isoforms
1999
29 Citations (Scopus)

Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells

Hirano, M., Niiro, N., Hirano, K., Nishimura, J., Hartshorne, D. J. & Kanaide, H., Jan 19 1999, In : Biochemical and Biophysical Research Communications. 254, 2, p. 490-496 7 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Phosphatase
Cloning
Endothelial cells
Organism Cloning
Swine
15 Citations (Scopus)

Troglitazone inhibits the capacitative Ca2+ entry in endothelial cells

Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Fujishima, M. & Kanaide, H., May 28 1999, In : European Journal of Pharmacology. 373, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

troglitazone
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Endothelial Cells
Thapsigargin
Fura-2
1997
8 Citations (Scopus)
Avian Gizzard
Protein Phosphatase 1
Liver Glycogen
Cloning
Glycogen
1995
50 Citations (Scopus)

Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo

Erdodi, F., Toth, B., Hirano, K., Hirano, M., Hartshorne, D. J. & Gergely, P., 1995, In : American Journal of Physiology - Cell Physiology. 269, 5 38-5

Research output: Contribution to journalArticle

Protein Phosphatase 1
Protein Phosphatase 2
Cantharidin
Pesticides
Toxicity
1993
18 Citations (Scopus)

Enhancement by captopril of bradykinin-induced calcium transients in cultured endothelial cells of the bovine aorta

Hirano, K., Hirano, M. & Kanaide, H., Jan 15 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 244, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

Captopril
Bradykinin
Aorta
Cultured Cells
Endothelial Cells