Research Output per year
Research Output 1993 2019
Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body
Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., Aug 15 2019, In : European Journal of Pharmacology. 857, 172405.Research output: Contribution to journal › Article
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension
Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.Research output: Contribution to journal › Article
Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger
Bai, X., Ihara, E., Hirano, K., Tanaka, Y., Nakano, K., Kita, S., Iwamoto, T., Ogino, H., Hirano, M., Oda, Y., Nakamura, K. & Ogawa, Y., Mar 2018, In : CMGH. 5, 3, p. 209-221 13 p.Research output: Contribution to journal › Article
Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body
Xiaopeng, B., Tanaka, Y., Ihara, E., Hirano, K., Nakano, K., Hirano, M., Oda, Y. & Nakamura, K., Jan 1 2017, In : European Journal of Pharmacology. 797, p. 65-74 10 p.Research output: Contribution to journal › Article
Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption
Hirano, M. & Hirano, K., Feb 11 2016, In : Scientific reports. 6, 20989.Research output: Contribution to journal › Article
Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter
Tanaka, Y., Ihara, E., Hirano, K., Takahashi, S., Hirano, M., Nakamura, K., Akiho, H., Oda, Y. & Takayanagi, R., Apr 5 2015, In : European Journal of Pharmacology. 752, p. 97-105 9 p.Research output: Contribution to journal › Article
Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility
Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K. & Hirano, K., Jan 1 2013, In : Circulation. 127, 1, p. 104-114 11 p.Research output: Contribution to journal › Article
Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage
Kameda, K., Kikkawa, Y., Hirano, M., Matsuo, S., Sasaki, T. & Hirano, K., Jan 1 2012, In : British Journal of Pharmacology. 165, 1, p. 106-119 14 p.Research output: Contribution to journal › Article
Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca 2+ sensitization after subarachnoid hemorrhage
Kikkawa, Y., Matsuo, S., Kameda, K., Hirano, M., Nakamizo, A., Sasaki, T. & Hirano, K., Feb 1 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 2, p. 341-352 12 p.Research output: Contribution to journal › Article
Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel
Nishioka, K., Nishida, M., Ariyoshi, M., Jian, Z., Saiki, S., Hirano, M., Nakaya, M., Sato, Y., Kita, S., Iwamoto, T., Hirano, K., Inoue, R. & Kurose, H., Oct 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2278-2286 9 p.Research output: Contribution to journal › Article
Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage
Hirano, K. & Hirano, M., Nov 22 2010, In : Journal of Pharmacological Sciences. 114, 2, p. 127-133 7 p.Research output: Contribution to journal › Article
Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage
Kikkawa, Y., Kameda, K., Hirano, M., Sasaki, T. & Hirano, K., Jan 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 9, p. 1637-1650 14 p.Research output: Contribution to journal › Article
Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction
Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Dec 1 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 11, p. 1435-1444 10 p.Research output: Contribution to journal › Article
Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca 2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Feb 1 2010, In : British Journal of Pharmacology. 159, 4, p. 919-927 9 p.Research output: Contribution to journal › Article
Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas
aman, M., Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2010, In : Journal of Vascular Research. 47, 6, p. 494-506 13 p.Research output: Contribution to journal › Article
Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage
Maeda, Y., Hirano, K., Hirano, M., Kikkawa, Y., Kameda, K., Sasaki, T. & Kanaide, H., Feb 1 2009, In : Stroke. 40, 2, p. 591-596 6 p.Research output: Contribution to journal › Article
Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells
Hirano, K., Hirano, M. & Hanada, A., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 499-507 9 p.Research output: Contribution to journal › Article
Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells
Hirano, K., Nomoto, N., Hirano, M., Momota, F., Hanada, A. & Kanaide, H., Aug 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 2, p. 668-677 10 p.Research output: Contribution to journal › Article
Involvement of Na +-Ca 2+ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice
Karashima, E., Nishimura, J., Iwamoto, T., Hirano, K., Hirano, M., Kita, S., Harada, M. & Kanaide, H., Feb 1 2007, In : British Journal of Pharmacology. 150, 4, p. 434-444 11 p.Research output: Contribution to journal › Article
Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery
Fujiyoshi, T., Hirano, K., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., Apr 1 2007, In : Arteriosclerosis, thrombosis, and vascular biology. 27, 4, p. 949-954 6 p.Research output: Contribution to journal › Article
Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells
Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 10, p. 1500-1510 11 p.Research output: Contribution to journal › Article
Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage
Maeda, Y., Hirano, K., Kai, Y., Hirano, M., Suzuki, S. O., Sasaki, T. & Kanaide, H., Dec 1 2007, In : British Journal of Pharmacology. 152, 7, p. 1131-1139 9 p.Research output: Contribution to journal › Article
Involvement of G i/o in the PAR-4-induced NO production in endothelial cells
Momota, F., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Apr 7 2006, In : Biochemical and Biophysical Research Communications. 342, 2, p. 365-371 7 p.Research output: Contribution to journal › Article
Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury
Fukunaga, R., Hirano, K., Hirano, M., Niiro, N., Nishimura, J., Maehara, Y. & Kanaide, H., Nov 24 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5, p. H2388-H2395Research output: Contribution to journal › Article
Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery
Shiga, N., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Mar 13 2005, In : Circulation research. 96, 9, p. 1014-1021 8 p.Research output: Contribution to journal › Article
Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells
Yufu, T., Hirano, K., Bi, D., Hirano, M., Nishimura, J., Iwamoto, Y. & Kanaide, H., Jul 1 2005, In : Arteriosclerosis, thrombosis, and vascular biology. 25, 7, p. 1506-1511 6 p.Research output: Contribution to journal › Article
A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells
Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 149-154 6 p.Research output: Contribution to journal › Article
Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells
Koga, M., Hirano, K., Hirano, M., Nishimura, J., Nakano, H. & Kanaide, H., Nov 5 2004, In : Biochemical and Biophysical Research Communications. 324, 1, p. 321-325 5 p.Research output: Contribution to journal › Article
Facilitation of proteasomal degradation of p27Kip1 by N-terminal cleavage and their sequence requirements
Hirano, K., Ihara, E., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Sep 10 2004, In : FEBS Letters. 574, 1-3, p. 111-115 5 p.Research output: Contribution to journal › Article
Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells
Nakayama, T., Hirano, K., Hirano, M., Nishimura, J., Kuga, H., Nakamura, K., Takahashi, S. & Kanaide, H., Jul 1 2004, In : Biochemical Pharmacology. 68, 1, p. 23-32 10 p.Research output: Contribution to journal › Article
Transduction of the N-Terminal Fragments of MYPT1 Enhances Myofilament Ca2+ Sensitivity in an Intact Coronary Artery
Hirano, K., Derkach, D. N., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., Mar 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 464-469 6 p.Research output: Contribution to journal › Article
Intracellular alkalinization induces Ca2+ influx via non-voltage-operated Ca2+ channels in rat aortic smooth muscle cells
Eto, W., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Dec 2003, In : Cell Calcium. 34, 6, p. 477-484 8 p.Research output: Contribution to journal › Article
Sequence requirement for nuclear localization and growth inhibition of p27Kip1R, a degradation-resistant isoform of p27Kip1
Hirano, K., Zeng, Y., Hirano, M., Nishimura, J. & Kanaide, H., May 1 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 191-202 12 p.Research output: Contribution to journal › Article
Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta
Ihara, E., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Oct 16 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 242-251 10 p.Research output: Contribution to journal › Article
Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1
Hirano, K., Hirano, M., Zeng, Y., Nishimura, J., Hara, K., Muta, K., Nawata, H. & Kanaide, H., Jan 1 2001, In : Biochemical Journal. 353, 1, p. 51-57 7 p.Research output: Contribution to journal › Article
Transcriptional up-regulation of p27Kip1 during contact-induced growth arrest in vascular endothelial cells
Hirano, M., Hirano, K., Nishimura, J. & Kanaide, H., Dec 10 2001, In : Experimental Cell Research. 271, 2, p. 356-367 12 p.Research output: Contribution to journal › Article
Dissociation between the Ca2+ signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells
Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Nakatsuka, A., Fujishima, M. & Kanaide, H., Jun 9 2000, In : European Journal of Pharmacology. 398, 1, p. 19-29 11 p.Research output: Contribution to journal › Article
Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor
Zeng, Y., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jul 21 2000, In : Biochemical and Biophysical Research Communications. 274, 1, p. 37-42 6 p.Research output: Contribution to journal › Article
Mitogen-induced up-regulation of non-smooth muscle isoform of α- tropomyosin in rat aortic smooth muscle cells
Hirano, K., Hirano, M., Eto, W., Nishimura, J. & Kanaide, H., Oct 13 2000, In : European Journal of Pharmacology. 406, 2, p. 209-218 10 p.Research output: Contribution to journal › Article
Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells
Hirano, M., Niiro, N., Hirano, K., Nishimura, J., Hartshorne, D. J. & Kanaide, H., Jan 19 1999, In : Biochemical and Biophysical Research Communications. 254, 2, p. 490-496 7 p.Research output: Contribution to journal › Article
Troglitazone inhibits the capacitative Ca2+ entry in endothelial cells
Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Fujishima, M. & Kanaide, H., May 28 1999, In : European Journal of Pharmacology. 373, 1, p. 111-120 10 p.Research output: Contribution to journal › Article
Cloning and characterization of a protein phosphatase type 1-binding subunit from smooth muscle similar to the glycogen-binding subunit of liver
Hirano, K., Hirano, M. & Hartshorne, D. J., May 23 1997, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1339, 2, p. 177-180 4 p.Research output: Contribution to journal › Article
Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo
Erdodi, F., Toth, B., Hirano, K., Hirano, M., Hartshorne, D. J. & Gergely, P., 1995, In : American Journal of Physiology - Cell Physiology. 269, 5 38-5Research output: Contribution to journal › Article
Enhancement by captopril of bradykinin-induced calcium transients in cultured endothelial cells of the bovine aorta
Hirano, K., Hirano, M. & Kanaide, H., Jan 15 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 244, 2, p. 133-137 5 p.Research output: Contribution to journal › Article