Mayumi Hirano &ndash; Research Output

2019

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., Aug 15 2019, In : European Journal of Pharmacology. 857, 172405.

Research output: Contribution to journal › Article

Lower Esophageal Sphincter

Dinoprostone

Smooth Muscle

Gastroesophageal Reflux

Muscle Contraction

2 Citations (Scopus)

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

Research output: Contribution to journal › Article

Open Access

PAR-1 Receptor

Pulmonary Hypertension

Monocrotaline

Pulmonary Artery

Right Ventricular Hypertrophy

2018

2 Citations (Scopus)

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na⁺/Ca²⁺ Exchanger

Bai, X., Ihara, E., Hirano, K., Tanaka, Y., Nakano, K., Kita, S., Iwamoto, T., Ogino, H., Hirano, M., Oda, Y., Nakamura, K. & Ogawa, Y., Mar 1 2018, In : CMGH. 5, 3, p. 209-221 13 p.

Research output: Contribution to journal › Article

Cystathionine

Lower Esophageal Sphincter

Hydrogen Sulfide

Swine

Lyases

2017

2 Citations (Scopus)

Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body

Xiaopeng, B., Tanaka, Y., Ihara, E., Hirano, K., Nakano, K., Hirano, M., Oda, Y. & Nakamura, K., Jan 1 2017, In : European Journal of Pharmacology. 797, p. 65-74 10 p.

Research output: Contribution to journal › Article

Muscle Relaxation

Muscle Contraction

Trypsin

Smooth Muscle

Swine

2016

16 Citations (Scopus)

Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption

Hirano, M. & Hirano, K., Feb 11 2016, In : Scientific reports. 6, 20989.

Research output: Contribution to journal › Article

Myosins

Myosin Light Chains

Actins

Phosphorylation

Thrombin

2015

1 Citation (Scopus)

Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter

Tanaka, Y., Ihara, E., Hirano, K., Takahashi, S., Hirano, M., Nakamura, K., Akiho, H., Oda, Y. & Takayanagi, R., Apr 5 2015, In : European Journal of Pharmacology. 752, p. 97-105 9 p.

Research output: Contribution to journal › Article

Lower Esophageal Sphincter

Trypsin

Swine

rho-Associated Kinases

Protein Kinases

2013

20 Citations (Scopus)

Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility

Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K. & Hirano, K., Jan 1 2013, In : Circulation. 127, 1, p. 104-114 11 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Circadian Rhythm

Blood Vessels

Myosin Light Chains

Myofibrils

2012

18 Citations (Scopus)

Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage

Kameda, K., Kikkawa, Y., Hirano, M., Matsuo, S., Sasaki, T. & Hirano, K., Jan 1 2012, In : British Journal of Pharmacology. 165, 1, p. 106-119 14 p.

Research output: Contribution to journal › Article

Subarachnoid Hemorrhage

PAR-1 Receptor

Thrombin

Blood Vessels

Ligands

14 Citations (Scopus)

Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca ²⁺ sensitization after subarachnoid hemorrhage

Kikkawa, Y., Matsuo, S., Kameda, K., Hirano, M., Nakamizo, A., Sasaki, T. & Hirano, K., Feb 1 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 2, p. 341-352 12 p.

Research output: Contribution to journal › Article

Myofibrils

Endothelin-1

Subarachnoid Hemorrhage

Myosin-Light-Chain Phosphatase

Protein Kinase C

2011

24 Citations (Scopus)

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Nishioka, K., Nishida, M., Ariyoshi, M., Jian, Z., Saiki, S., Hirano, M., Michio, N., Sato, Y., Kita, S., Iwamoto, T., Hirano, K., Inoue, R. & Kurose, H., Oct 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2278-2286 9 p.

Research output: Contribution to journal › Article

Cyclic AMP-Dependent Protein Kinases

Vasoconstriction

Angiotensin II

Phosphorylation

Transient Receptor Potential Channels

2010

11 Citations (Scopus)

Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage

Hirano, K. & Hirano, M., Nov 22 2010, In : Journal of Pharmacological Sciences. 114, 2, p. 127-133 7 p.

Research output: Contribution to journal › Article

Thrombin Receptors

Intracranial Vasospasm

PAR-1 Receptor

Subarachnoid Hemorrhage

Thrombin

25 Citations (Scopus)

Impaired feedback regulation of the receptor activity and the myofilament Ca²⁺ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage

Kikkawa, Y., Kameda, K., Hirano, M., Sasaki, T. & Hirano, K., Jan 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 9, p. 1637-1650 14 p.

Research output: Contribution to journal › Article

Myofibrils

Subarachnoid Hemorrhage

Blood Vessels

Thrombin

Intracranial Vasospasm

16 Citations (Scopus)

Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction

Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Dec 1 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 11, p. 1435-1444 10 p.

Research output: Contribution to journal › Article

Vasoconstriction

Thrombin

Reactive Oxygen Species

Phosphorylation

Lung

10 Citations (Scopus)

Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca ²⁺ sensitivity and induces vasoconstriction in porcine pulmonary arteries

Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Feb 1 2010, In : British Journal of Pharmacology. 159, 4, p. 919-927 9 p.

Research output: Contribution to journal › Article

PAR-1 Receptor

Myofibrils

Vasoconstriction

Thrombin

Pulmonary Artery

18 Citations (Scopus)

Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas

aman, M., Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2010, In : Journal of Vascular Research. 47, 6, p. 494-506 13 p.

Research output: Contribution to journal › Article

PAR-2 Receptor

Trypsin

Endothelium

Aorta

Oxidative Stress

2009

20 Citations (Scopus)

Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage

Maeda, Y., Hirano, K., Hirano, M., Kikkawa, Y., Kameda, K., Sasaki, T. & Kanaide, H., Feb 1 2009, In : Stroke. 40, 2, p. 591-596 6 p.

Research output: Contribution to journal › Article

Basilar Artery

Platelet-Derived Growth Factor

Subarachnoid Hemorrhage

Phosphorylation

Intracranial Vasospasm

18 Citations (Scopus)

Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells

Hirano, K., Hirano, M. & Hanada, A., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 499-507 9 p.

Research output: Contribution to journal › Article

PAR-1 Receptor

Endothelial cells

Endothelial Cells

Thrombin

Molecules

2007

26 Citations (Scopus)

Distinct Ca²⁺ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR₁ and PAR₄) in vascular endothelial cells

Hirano, K., Nomoto, N., Hirano, M., Momota, F., Hanada, A. & Kanaide, H., Aug 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 2, p. 668-677 10 p.

Research output: Contribution to journal › Article

PAR-1 Receptor

Endothelial Cells

Phosphotransferases

Thrombin Receptors

Ethane

8 Citations (Scopus)

Involvement of Na ⁺-Ca ²⁺ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice

Karashima, E., Nishimura, J., Iwamoto, T., Hirano, K., Hirano, M., Kita, S., Harada, M. & Kanaide, H., Feb 1 2007, In : British Journal of Pharmacology. 150, 4, p. 434-444 11 p.

Research output: Contribution to journal › Article

Sodium-Calcium Exchanger

Colforsin

Transgenic Mice

Aorta

Thoracic Aorta

4 Citations (Scopus)

Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery

Fujiyoshi, T., Hirano, K., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., Apr 1 2007, In : Arteriosclerosis, thrombosis, and vascular biology. 27, 4, p. 949-954 6 p.

Research output: Contribution to journal › Article

Fibrinolysin

Endothelium

Coronary Vessels

Nitric Oxide

Swine

2 Citations (Scopus)

Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells

Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 10, p. 1500-1510 11 p.

Research output: Contribution to journal › Article

Up-Regulation

Endothelial Cells

rac1 GTP-Binding Protein

Cell Cycle Checkpoints

Cell-Penetrating Peptides

27 Citations (Scopus)

Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage

Maeda, Y., Hirano, K., Kai, Y., Hirano, M., Suzuki, S., Sasaki, T. & Kanaide, H., Dec 1 2007, In : British Journal of Pharmacology. 152, 7, p. 1131-1139 9 p.

Research output: Contribution to journal › Article

PAR-1 Receptor

Subarachnoid Hemorrhage

Thrombin

Up-Regulation

Basilar Artery

2006

12 Citations (Scopus)

Involvement of G _i/o in the PAR-4-induced NO production in endothelial cells

Momota, F., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Apr 7 2006, In : Biochemical and Biophysical Research Communications. 342, 2, p. 365-371 7 p.

Research output: Contribution to journal › Article

Proteinase-Activated Receptors

Ionomycin

Endothelial cells

Endothelial Cells

thrombin receptor peptide SFLLRNP

15 Citations (Scopus)

Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury

Fukunaga, R., Hirano, K., Hirano, M., Niiro, N., Nishimura, J., Maehara, Y. & Kanaide, H., Nov 24 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5

Research output: Contribution to journal › Article

Proteinase-Activated Receptors

Up-Regulation

PAR-1 Receptor

Wounds and Injuries

PAR-2 Receptor

2005

67 Citations (Scopus)

Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga, N., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Mar 13 2005, In : Circulation research. 96, 9, p. 1014-1021 8 p.

Research output: Contribution to journal › Article

Mesenteric Arteries

Simvastatin

Blood Vessels

Rabbits

Endothelial Cells

16 Citations (Scopus)

Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells

Yufu, T., Hirano, K., Bi, D., Hirano, M., Nishimura, J., Iwamoto, Y. & Kanaide, H., Jul 1 2005, In : Arteriosclerosis, thrombosis, and vascular biology. 25, 7, p. 1506-1511 6 p.

Research output: Contribution to journal › Article

PAR-1 Receptor

Vascular Smooth Muscle

Thrombin

Smooth Muscle Myocytes

Simvastatin

2004

12 Citations (Scopus)

A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 149-154 6 p.

Research output: Contribution to journal › Article

Cell Cycle Proteins

Endothelial cells

Endothelial Cells

Proteins

S Phase

21 Citations (Scopus)

Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga, M., Hirano, K., Hirano, M., Nishimura, J., Nakano, H. & Kanaide, H., Nov 5 2004, In : Biochemical and Biophysical Research Communications. 324, 1, p. 321-325 5 p.

Research output: Contribution to journal › Article

Endothelial cells

Estrogens

Endothelial Cells

Cell-Penetrating Peptides

Estradiol

3 Citations (Scopus)

Facilitation of proteasomal degradation of p27^Kip1 by N-terminal cleavage and their sequence requirements

Hirano, K., Ihara, E., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Sep 10 2004, In : FEBS Letters. 574, 1-3, p. 111-115 5 p.

Research output: Contribution to journal › Article

S 10

Proteasome Inhibitors

Adenosine Triphosphate

Degradation

Mutation

9 Citations (Scopus)

Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells

Nakayama, T., Hirano, K., Hirano, M., Nishimura, J., Kuga, H., Nakamura, K., Takahashi, S. & Kanaide, H., Jul 1 2004, In : Biochemical Pharmacology. 68, 1, p. 23-32 10 p.

Research output: Contribution to journal › Article

PAR-1 Receptor

Endothelial cells

Thrombin

Endothelial Cells

Ligands

10 Citations (Scopus)

Transduction of the N-Terminal Fragments of MYPT1 Enhances Myofilament Ca ²⁺ Sensitivity in an Intact Coronary Artery

Hirano, K., Derkach, D. N., Hirano, M., Nishimura, J., Takahashi, S. & Kanaide, H., Mar 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 464-469 6 p.

Research output: Contribution to journal › Article

Myosin-Light-Chain Phosphatase

Myofibrils

Coronary Vessels

Human Immunodeficiency Virus tat Gene Products

Smooth Muscle Myosins

2003

17 Citations (Scopus)

Intracellular alkalinization induces Ca²⁺ influx via non-voltage-operated Ca²⁺ channels in rat aortic smooth muscle cells

Eto, W., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jan 1 2003, In : Cell Calcium. 34, 6, p. 477-484 8 p.

Research output: Contribution to journal › Article

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole

Diltiazem

Smooth Muscle Myocytes

Fluorometry

Fura-2

8 Citations (Scopus)

Sequence requirement for nuclear localization and growth inhibition of p27^Kip1R, a degradation-resistant isoform of p27^Kip1

Hirano, K., Zeng, Y., Hirano, M., Nishimura, J. & Kanaide, H., May 1 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 191-202 12 p.

Research output: Contribution to journal › Article

Cell growth

Protein Isoforms

Fluorescence

Amino Acids

Degradation

2002

26 Citations (Scopus)

Mechanism of down-regulation of L-type Ca²⁺ channel in the proliferating smooth muscle cells of rat aorta

Ihara, E., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. & Kanaide, H., Oct 16 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 242-251 10 p.

Research output: Contribution to journal › Article

Depolarization

Bromodeoxyuridine

Volatile organic compounds

Smooth Muscle Myocytes

Muscle

2001

14 Citations (Scopus)

Cloning and functional expression of a degradation-resistant novel isoform of p27^Kip1

Hirano, K., Hirano, M., Zeng, Y., Nishimura, J., Hara, K., Muta, K., Nawata, H. & Kanaide, H., Jan 1 2001, In : Biochemical Journal. 353, 1, p. 51-57 7 p.

Research output: Contribution to journal › Article

Cloning

Organism Cloning

Protein Isoforms

Degradation

Cells

32 Citations (Scopus)

Transcriptional up-regulation of p27^Kip1 during contact-induced growth arrest in vascular endothelial cells

Hirano, M., Hirano, K., Nishimura, J. & Kanaide, H., Dec 10 2001, In : Experimental Cell Research. 271, 2, p. 356-367 12 p.

Research output: Contribution to journal › Article

Up-Regulation

Endothelial Cells

Cell Cycle

Growth

RNA Stability

2000

9 Citations (Scopus)

Dissociation between the Ca²⁺ signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells

Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Nakatsuka, A., Fujishima, M. & Kanaide, H., Jun 9 2000, In : European Journal of Pharmacology. 398, 1, p. 19-29 11 p.

Research output: Contribution to journal › Article

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole

troglitazone

Vascular Endothelial Growth Factor A

Endothelial Cells

Diltiazem

50 Citations (Scopus)

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

Zeng, Y., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Jul 21 2000, In : Biochemical and Biophysical Research Communications. 274, 1, p. 37-42 6 p.

Research output: Contribution to journal › Article

Cyclin-Dependent Kinases

Green Fluorescent Proteins

Nuclear Localization Signals

Endothelial cells

HeLa Cells

7 Citations (Scopus)

Mitogen-induced up-regulation of non-smooth muscle isoform of α- tropomyosin in rat aortic smooth muscle cells

Hirano, K., Hirano, M., Eto, W., Nishimura, J. & Kanaide, H., Oct 13 2000, In : European Journal of Pharmacology. 406, 2, p. 209-218 10 p.

Research output: Contribution to journal › Article

Tropomyosin

Mitogens

Smooth Muscle Myocytes

Exons

Protein Isoforms

1999

29 Citations (Scopus)

Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells

Hirano, M., Niiro, N., Hirano, K., Nishimura, J., Hartshorne, D. J. & Kanaide, H., Jan 19 1999, In : Biochemical and Biophysical Research Communications. 254, 2, p. 490-496 7 p.

Research output: Contribution to journal › Article

Myosin-Light-Chain Phosphatase

Cloning

Endothelial cells

Organism Cloning

Swine

15 Citations (Scopus)

Troglitazone inhibits the capacitative Ca²⁺ entry in endothelial cells

Kawasaki, J., Hirano, K., Hirano, M., Nishimura, J., Fujishima, M. & Kanaide, H., May 28 1999, In : European Journal of Pharmacology. 373, 1, p. 111-120 10 p.

Research output: Contribution to journal › Article

troglitazone

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole

Endothelial Cells

Thapsigargin

Fura-2

1997

8 Citations (Scopus)

Cloning and characterization of a protein phosphatase type 1-binding subunit from smooth muscle similar to the glycogen-binding subunit of liver

Hirano, K., Hirano, M. & Hartshorne, D. J., May 23 1997, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1339, 2, p. 177-180 4 p.

Research output: Contribution to journal › Article

Avian Gizzard

Protein Phosphatase 1

Liver Glycogen

Cloning

Glycogen

1995

50 Citations (Scopus)

Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo

Erdodi, F., Toth, B., Hirano, K., Hirano, M., Hartshorne, D. J. & Gergely, P., 1995, In : American Journal of Physiology - Cell Physiology. 269, 5 38-5

Research output: Contribution to journal › Article

Protein Phosphatase 1

Protein Phosphatase 2

Cantharidin

Pesticides

Toxicity

1993

18 Citations (Scopus)

Enhancement by captopril of bradykinin-induced calcium transients in cultured endothelial cells of the bovine aorta

Hirano, K., Hirano, M. & Kanaide, H., Jan 15 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 244, 2, p. 133-137 5 p.

Research output: Contribution to journal › Article

Captopril

Bradykinin

Aorta

Cultured Cells

Endothelial Cells