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Research Output 2000 2018

  • 1043 Citations
  • 19 h-Index
  • 41 Article
2018
1 Citation (Scopus)

BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice

Okadome, J., Matsumoto, T., Yoshiya, K., Matsuda, D., Tamada, K., Onimaru, M., Nakano, K., Egashira, K., Yonemitsu, Y. & Maehara, Y., Aug 1 2018, In : Journal of Vascular Surgery. 68, 2, p. 576-586.e1

Research output: Contribution to journalArticle

Extremities
Ambulatory Surgical Procedures
Muscles
Ischemia
Vascular Endothelial Growth Factor A
2017
1 Citation (Scopus)

Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease

Murata, K., Motomura, Y., Tanaka, T., Kanno, S., Yano, T., Onimaru, M., Shimoyama, A., Nishio, H., Sakai, Y., Oh-Hora, M., Hara, H., Fukase, K., Takada, H., Masuda, S., Ohga, S., Yamasaki, S. & Hara, T., Oct 2017, In : Clinical and Experimental Immunology. 190, 1, p. 54-67 14 p.

Research output: Contribution to journalArticle

Arteritis
Mucocutaneous Lymph Node Syndrome
Blood Vessels
Severe Combined Immunodeficiency
Coronary Vessels
9 Citations (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones
2016
7 Citations (Scopus)

Activation of Nod1 signaling induces fetal growth restriction and death through fetal and maternal vasculopathy

Inoue, H., Nishio, H., Takada, H., Sakai, Y., Nanishi, E., Ochiai, M., Onimaru, M., Chen, S. J., Matsui, T. & Hara, T., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2779-2787 9 p.

Research output: Contribution to journalArticle

Fetal Death
Fetal Development
Nucleotides
Mothers
Fetus
2 Citations (Scopus)

BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

Ikawa-Yoshida, A., Matsumoto, T., Okano, S., Aoyagi, Y., Matsubara, Y., Furuyama, T., Nakatsu, Y., Tsuzuki, T., Onimaru, M., Ohkusa, T., Nomura, M. & Maehara, Y., Aug 26 2016, In : Scientific reports. 6, 32399.

Research output: Contribution to journalArticle

Liver Regeneration
Hepatectomy
Desmocollins
Hepatocytes
Liver
2 Citations (Scopus)

BUBR1 insufficiency in mice increases their sensitivity to oxidative stress

Matsuda, D., matsumoto, T., Honma, K., Ikawa-Yoshida, A., Onimaru, M., Furuyama, T., Nakatsu, Y., Tsuzuki, T. & Maehara, Y., Nov 1 2016, In : In Vivo. 30, 6, p. 769-776 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Water
Chromosomes
Tumors
11 Citations (Scopus)

Peritoneal dissemination requires an Sp1-dependent CXCR4/CXCL12 signaling axis and extracellular matrix-directed spheroid formation

Kasagi, Y., Harada, Y., Morodomi, Y., Iwai, T., Saito, S., Yoshida, K., Oki, E., Saeki, H., Ohgaki, K., Sugiyama, M., Onimaru, M., Maehara, Y. & Yonemitsu, Y., Jan 15 2016, In : Cancer Research. 76, 2, p. 347-357 11 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Peritoneal Cavity
Neoplasms
Peritoneal Lavage
Gastrointestinal Neoplasms
2015
17 Citations (Scopus)

Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe2/2 mice

Kanno, S., Nishio, H., Tanaka, T., Motomura, Y., Murata, K., Ihara, K., Onimaru, M., Yamasaki, S., Kono, H., Sueishi, K. & Hara, T., Jan 15 2015, In : Journal of Immunology. 194, 2, p. 773-780 8 p.

Research output: Contribution to journalArticle

Apolipoprotein E2
Atherosclerosis
Apolipoproteins E
Knockout Mice
Blood Vessels
8 Citations (Scopus)

BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice

Kyuragi, R., Matsumoto, T., Harada, Y., Saito, S., Onimaru, M., Nakatsu, Y., Tsuzuki, T., Nomura, M., Yonemitsu, Y. & Maehara, Y., Feb 2 2015, In : Arteriosclerosis, thrombosis, and vascular biology. 35, 2, p. 341-347 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Proliferation
Bone Marrow Transplantation
2014
Gingiva
Squamous Cell Carcinoma
Lymph Nodes
Neoplasm Metastasis
Cell Line
6 Citations (Scopus)
Plasminogen
Chondrocytes
Integrins
Transforming Growth Factor beta
Collagen
2013
19 Citations (Scopus)

Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: Results from the Hisayama Study

Nakano, T., Ninomiya, T., Sumiyoshi, S., Onimaru, M., Fujii, H., Itabe, H., Nakashima, Y., Sueishi, K., Tsuruya, K., Oda, Y., Kitazono, T. & Kiyohara, Y., Jan 1 2013, In : Kidney International. 84, 2, p. 373-380 8 p.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Chronic Renal Insufficiency
Coronary Artery Disease
Hemorrhage
Coronary Vessels
34 Citations (Scopus)

DVC1-0101 to treat peripheral arterial disease: A phase I/IIa open-label dose-escalation clinical trial

Yonemitsu, Y., matsumoto, T., Itoh, H., Okazaki, J., Uchiyama, M., Yoshida, K., Onimaru, M., Onohara, T., Inoguchi, H., Kyuragi, R., Shimokawa, M., Ban, H., Tanaka, M., Inoue, M., Shu, T., Hasegawa, M., Nakanishi, Y. & Maehara, Y., Jan 1 2013, In : Molecular Therapy. 21, 3, p. 707-714 8 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Sendai virus
Clinical Trials
Genes
Fibroblast Growth Factor 2
2 Citations (Scopus)

Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood

Saito, S., Harada, Y., Morodomi, Y., Onimaru, M., Yoshida, K., Kyuragi, R., Matsubara, H. & Yonemitsu, Y., Aug 1 2013, In : Human Gene Therapy Methods. 24, 4, p. 241-252 12 p.

Research output: Contribution to journalArticle

Natural Killer Cells
NK Cell Lectin-Like Receptor Subfamily K
Adoptive Immunotherapy
Neoplasms
K562 Cells
2012
16 Citations (Scopus)

BioKnife, a uPA activity-dependent oncolytic sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression

Morodomi, Y., Yano, T., Kinoh, H., Harada, Y., Saito, S., Kyuragi, R., Yoshida, K., Onimaru, M., Shoji, F., Yoshida, T., Ito, K., Shikada, Y., Maruyama, R., Hasegawa, M., Maehara, Y. & Yonemitsu, Y., Jan 1 2012, In : Molecular Therapy. 20, 4, p. 769-777 9 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Sendai virus
Urokinase Plasminogen Activator Receptors
NFI Transcription Factors
Pleural Cavity
13 Citations (Scopus)

Endogenous cardiac troponin T modulates Ca2+-mediated smooth muscle contraction

Kajioka, S., Takahashi-Yanaga, F., Shahab, N., Onimaru, M., Matsuda, M., Takahashi, R., Asano, H., Morita, H., Morimoto, S., Yonemitsu, Y., Hayashi, M., Seki, N., Sasaguri, T., Hirata, M., Nakayama, S. & Naito, S., Dec 1 2012, In : Scientific reports. 2, 979.

Research output: Contribution to journalArticle

Troponin T
Muscle Contraction
Smooth Muscle
Actin Cytoskeleton
Tropomyosin
9 Citations (Scopus)
Urinary Bladder Neck Obstruction
rho-Associated Kinases
Carbachol
Protein Kinase C
Smooth Muscle
3 Citations (Scopus)

Transfection of hypoxia-inducible factor-1 decoy oligodeoxynucleotides suppresses expression of vascular endothelial growth factor in oral squamous cell carcinoma cells

Imai, M., Ishibashi, H., Nariai, Y., Kanno, T., Sekine, J., Onimaru, M. & Mori, Y., Oct 1 2012, In : Journal of Oral Pathology and Medicine. 41, 9, p. 675-681 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Oligodeoxyribonucleotides
Vascular Endothelial Growth Factor A
Transfection
Squamous Cell Carcinoma
2011
18 Citations (Scopus)

Angiogenic and lymphangiogenic cascades in the tumor microenvironment

Onimaru, M. & Yonemitsu, Y., Jan 1 2011, In : Frontiers in Bioscience - Scholar. 3 S, 1, p. 216-225 10 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Tumors
Lymph
Blood
Angiogenesis Inducing Agents
11 Citations (Scopus)

Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites

Sugiyama, M., Kakeji, Y., Tsujitani, S., Harada, Y., Onimaru, M., Yoshida, K., Tanaka, S., Emi, Y., Morita, M., Morodomi, Y., Hasegawa, M., Maehara, Y. & Yonemitsu, Y., Mar 1 2011, In : Molecular Cancer Therapeutics. 10, 3, p. 540-549 10 p.

Research output: Contribution to journalArticle

Ascites
Dendritic Cells
Vascular Endothelial Growth Factor A
Immunity
Phosphotransferases
23 Citations (Scopus)

High podoplanin expression in cancer cells predicts lower incidence of nodal metastasis in patients with lung squamous cell carcinoma

Suzuki, H., Onimaru, M., Koga, T., Takeshita, M., Yano, T., Maehara, Y., Nakamura, S. & Sueishi, K., Feb 15 2011, In : Pathology Research and Practice. 207, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Neoplasm Metastasis
Lung
Incidence
Neoplasms
2010
14 Citations (Scopus)
Angiopoietin-1
Matrix Metalloproteinase 14
Angiopoietin-2
Endothelial Cells
Tissue Inhibitor of Metalloproteinase-3
27 Citations (Scopus)
Lung Neoplasms
Vascular Endothelial Growth Factor C
Lymphangiogenesis
Neoplasms
Squamous Cell Carcinoma
16 Citations (Scopus)

Urokinase-targeted fusion by oncolytic sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-β gene

Hasegawa, Y., Kinoh, H., Iwadate, Y., Onimaru, M., Ueda, Y., Harada, Y., Saito, S., Furuya, A., Saegusa, T., Morodomi, Y., Hasegawa, M., Saito, S., Aoki, I., Saeki, N. & Yonemitsu, Y., Jan 1 2010, In : Molecular Therapy. 18, 10, p. 1778-1786 9 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Sendai virus
Urokinase-Type Plasminogen Activator
Glioblastoma
Interferons
2009
34 Citations (Scopus)

Autocrine Loop between Vascular Endothelial Growth Factor (VEGF)-C and VEGF Receptor-3 Positively Regulates Tumor-Associated Lymphangiogenesis in Oral Squamoid Cancer Cells

Matsuura, M., Onimaru, M., Yonemitsu, Y., Suzuki, H., Nakano, T., Ishibashi, H., Shirasuna, K. & Sueishi, K., Jan 1 2009, In : American Journal of Pathology. 175, 4, p. 1709-1721 13 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-3
Lymphangiogenesis
Vascular Endothelial Growth Factor C
Mouth Neoplasms
Neoplasms
31 Citations (Scopus)

VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B

Onimaru, M., Yonemitsu, Y., Fujii, T., Tanii, M., Nakano, T., Nakagawa, K., Kohno, R. I., Hasegawa, M., Nishikawa, S. I. & Sueishi, K., Nov 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 5, p. H1685-H1696

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-sis
Lymphangiogenesis
Vascular Endothelial Growth Factor C
Fibroblast Growth Factor 2
Endothelial Cells
2008
75 Citations (Scopus)

Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration

murakami, Y., Ikeda, Y., Yonemitsu, Y., Onimaru, M., Nakagawa, K., Kohno, R. I., Miyazaki, M., Hisatomi, T., Nakamura, M., Yabe, T., Hasegawa, M., Ishibashi, T. & Sueishi, K., Jan 1 2008, In : American Journal of Pathology. 173, 5, p. 1326-1338 13 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Retinal Degeneration
Retinitis Pigmentosa
Apoptosis
Animal Models
24 Citations (Scopus)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Angiopathies
Nitric Oxide
Up-Regulation
Extremities
33 Citations (Scopus)

VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis

Fujii, T., Yonemitsu, Y., Onimaru, M., Inoue, M., Hasegawa, M., Kuwano, H. & Sueishi, K., Sep 1 2008, In : Atherosclerosis. 200, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Up-Regulation
Therapeutics
2006
8 Citations (Scopus)

A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia

Kaneko, K., Yonemitsu, Y., Fujii, T., Onimaru, M., Jin, C. H., Inoue, M., Hasegawa, M., Onohara, T., Maehara, Y. & Sueishi, K., Apr 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 4, p. H1484-H1492

Research output: Contribution to journalArticle

Free Radical Scavengers
Fibroblast Growth Factor 2
Hindlimb
Ischemia
Reperfusion
47 Citations (Scopus)

Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors

Tanii, M., Yonemitsu, Y., Fujii, T., Shikada, Y., Kohno, R. I., Onimaru, M., Okano, S., Inoue, M., Hasegawa, M., Onohara, T., Maehara, Y. & Sueishi, K., Jan 1 2006, In : Circulation research. 98, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Diabetic Angiopathies
Angiogenesis Inducing Agents
Protein Kinase C
Extremities
Streptozocin
57 Citations (Scopus)

Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-β gene

Shibata, S., Okano, S., Yonemitsu, Y., Onimaru, M., Sata, S., Nagata-Takeshita, H., Inoue, M., Zhu, T., Hasegawa, M., Moroi, Y., Furue, M. & Sueishi, K., Sep 15 2006, In : Journal of Immunology. 177, 6, p. 3564-3576 13 p.

Research output: Contribution to journalArticle

Sendai virus
Dendritic Cells
Immunity
Genes
Immunotherapy
58 Citations (Scopus)

Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: Critical role of the inflammatory/arteriogenic pathway

Fujii, T., Yonemitsu, Y., Onimaru, M., Tanii, M., Nakano, T., Egashira, K., Takehara, T., Inoue, M., Hasegawa, M., Kuwano, H. & Sueishi, K., Nov 1 2006, In : Arteriosclerosis, thrombosis, and vascular biology. 26, 11, p. 2483-2489 7 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Therapeutics
CCR2 Receptors
32 Citations (Scopus)

The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium

Ikeda, Y., Yonemitsu, Y., Onimaru, M., Nakano, T., Miyazaki, M., Kohno, R. I., Nakagawa, K., Ueno, A., Sueishi, K. & Ishibashi, T., Nov 1 2006, In : Experimental Eye Research. 83, 5, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factors
Vascular Endothelial Growth Factor D
Vascular Endothelial Growth Factor C
Retinal Pigment Epithelium
Vascular Endothelial Growth Factor A
2005
24 Citations (Scopus)

Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques

Baba, H., Yonemitsu, Y., Nakano, T., Onimaru, M., Miyazaki, M., Ikeda, Y., Sumiyoshi, S., Ueda, Y., Hasegawa, M., Yoshino, I., Maehara, Y. & Sueishi, K., Sep 1 2005, In : Arteriosclerosis, thrombosis, and vascular biology. 25, 9, p. 1938-1944 7 p.

Research output: Contribution to journalArticle

Atherosclerotic Plaques
Coronary Vessels
Staining and Labeling
Microvessels
Atherosclerosis
70 Citations (Scopus)

Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas

Shikada, Y., Yonemitsu, Y., Koga, T., Onimaru, M., Nakano, T., Okano, S., Sata, S., Nakagawa, K., Yoshino, I., Maehara, Y. & Sueishi, K., Aug 15 2005, In : Cancer Research. 65, 16, p. 7241-7248 8 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Neoplasms
Cell Line
2004
66 Citations (Scopus)

Essential role of PDGFRα-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo role of PDGFRα during angiogenesis

Tsutsumi, N., Yonemitsu, Y., Shikada, Y., Onimaru, M., Tanii, M., Okano, S., Kaneko, K., Hasegawa, M., Hashizume, M., Maehara, Y. & Sueishi, K., May 14 2004, In : Circulation Research. 94, 9, p. 1186-1194 9 p.

Research output: Contribution to journalArticle

70-kDa Ribosomal Protein S6 Kinases
Platelet-Derived Growth Factor Receptors
Sirolimus
Neoplasms
Vascular Endothelial Growth Factor A
2003
20 Citations (Scopus)

Recombinant Sendai virus vectors for activated T lymphocytes

Okano, S., Yonemitsu, Y., Nagata, S., Sata, S., Onimaru, M., Nakagawa, K., Tomita, Y., Kishihara, K., Hashimoto, S., Nakashima, Y., Sugimachi, K., Hasegawa, M. & Sueishi, K., Aug 1 2003, In : Gene Therapy. 10, 16, p. 1381-1391 11 p.

Research output: Contribution to journalArticle

Sendai virus
T-Lymphocytes
Antigens
Genetic Therapy
Genes
2002
71 Citations (Scopus)

Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs

Onimaru, M., Yonemitsu, Y., Tanii, M., Nakagawa, K., Masaki, I., Okano, S., Ishibashi, H., Shirasuna, K., Hasegawa, M. & Sueishi, K., Nov 15 2002, In : Circulation research. 91, 10, p. 923-930 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Fibroblast Growth Factor 2
Down-Regulation
Extremities
Genes
2001
29 Citations (Scopus)

Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release

Ishibashi, H., Shiratuchi, T., Nakagawa, K., Onimaru, M., Sugiura, T., Sueishi, K. & Shirasuna, K., Jan 1 2001, In : Oral Oncology. 37, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Conditioned Culture Medium
Salivary Glands
Vascular Endothelial Growth Factor A
Carcinoma
2000
95 Citations (Scopus)

Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor/β1, and tissue factor and also cell growth and invasion activities

Ishibashi, H., Nakagawa, K., Onimaru, M., Castellanous, E. J., Kaneda, Y., Nakashima, Y., Shirasuna, K. & Sueishi, K., Dec 7 2000, In : Cancer Research. 60, 22, p. 6531-6536 6 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Thromboplastin
Transforming Growth Factors
Vascular Endothelial Growth Factor A
Carcinoma