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Research Output 2005 2019

  • 542 Citations
  • 15 h-Index
  • 43 Article
  • 3 Chapter
  • 1 Review article
2019

Brain-transportable dipeptides across the blood-brain barrier in mice

Tanaka, M., Dohgu, S., Komabayashi, G., Kiyohara, H., Takata, F., Kataoka, Y., Nirasawa, T., Maebuchi, M. & Matsui, T., Dec 1 2019, In : Scientific reports. 9, 1, 5769.

Research output: Contribution to journalArticle

Open Access
Dipeptides
Blood-Brain Barrier
tyrosyl-proline
Brain
Peptides

Detection and visualization of food-derived polyphenols by matrix-assisted laser desorption/ionization mass spectrometry imaging

Nguyen, H. N., Ham, T. H., Matsui, T. & Tanaka, M., Jan 1 2019, In : Sensors and Materials. 31, 7, p. 2333-2346 14 p.

Research output: Contribution to journalArticle

Open Access
biochemistry
Biochemistry
Histology
histology
flow visualization
3 Citations (Scopus)

Novel in situ visualisation of rat intestinal absorption of polyphenols via matrix-assisted laser desorption/ionisation mass spectrometry imaging

Nguyen, H. N., Tanaka, M., Li, B., Ueno, T., Matsuda, H. & Matsui, T., Dec 1 2019, In : Scientific reports. 9, 1, 3166.

Research output: Contribution to journalArticle

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Intestinal Absorption
Polyphenols
Jejunum
Monocarboxylic Acid Transporters
2018

Research of the cancer-odor

Sonoda, H., Oki, E., Tanaka, M., Matsui, T., Onodera, T., Toko, K., Satoh, Y. & Maehara, Y., Jun 1 2018, In : Japanese Journal of Cancer and Chemotherapy. 45, 6, p. 911-915 5 p.

Research output: Contribution to journalArticle

Research
Neoplasms
Smell
Odorants
Happiness
3 Citations (Scopus)

Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain

Shimizu, A., Mitani, T., Tanaka, S., Fujii, H., Maebuchi, M., Amiya, Y., Tanaka, M., Matsui, T., Nakamura, S. & Katayama, S., Aug 1 2018, In : Journal of Agricultural and Food Chemistry. 66, 30, p. 7935-7941 7 p.

Research output: Contribution to journalArticle

Glycine (Fabaceae)
neurotrophins
dipeptides
Dipeptides
Brain-Derived Neurotrophic Factor
2017

Analytical evaluation of bioactive small peptides on their intestinal absorption and bioavailability

Tanaka, M., Jan 1 2017, In : Bunseki Kagaku. 66, 9, p. 677-685 9 p.

Research output: Contribution to journalArticle

Mass spectrometry
Peptides
Phytic Acid
Dipeptides
Liquid chromatography
7 Citations (Scopus)

Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats

Hanh, V. T., Shen, W., Tanaka, M., Siltari, A., Korpela, R. & Matsui, T., Jul 26 2017, In : Journal of Agricultural and Food Chemistry. 65, 29, p. 5935-5943 9 p.

Research output: Contribution to journalArticle

Inbred SHR Rats
Rats
Sarcosine
Aging of materials
peptides

Study on the physiological benefits of food compounds on vascular health and their underlying mechanisms

Tanaka, M., Jan 1 2017, In : Nippon Shokuhin Kagaku Kogaku Kaishi. 64, 6, p. 285-293 9 p.

Research output: Contribution to journalReview article

blood vessels
Blood Vessels
vasodilation
Vasodilation
peptides
2016
2 Citations (Scopus)

Adenine attenuates the Ca2+ contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells

Fukuda, T., Kuroda, T., Kono, M., Hyoguchi, M., Tajiri, S., Tanaka, M., Mine, Y. & Matsui, T., Sep 1 2016, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 389, 9, p. 999-1007 9 p.

Research output: Contribution to journalArticle

Adenine
Vascular Smooth Muscle
Smooth Muscle Myocytes
Myosin Light Chains
Phosphorylation
2 Citations (Scopus)

An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration

Mizokami, A., Wang, D. G., Tanaka, M., Gao, J., Takeuchi, H., Matsui, T. & Hirata, M., Jan 1 2016, In : Bioscience, Biotechnology and Biochemistry. 80, 11, p. 2176-2183 8 p.

Research output: Contribution to journalArticle

Osteocalcin
Metabolism
Oral Administration
Bone
Bone and Bones
9 Citations (Scopus)

Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells

Zhao, J., Suyama, A., Chung, H., Fukuda, T., Tanaka, M. & Matsui, T., Jan 15 2016, In : Life Sciences. 145, p. 224-232 9 p.

Research output: Contribution to journalArticle

ferulic acid
Argininosuccinate Synthase
Endothelial cells
Nitric Oxide
Up-Regulation
2 Citations (Scopus)

Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity

Kumrungsee, T., Akiyama, S., Guo, J., Tanaka, M. & Matsui, T., Dec 15 2016, In : Food Chemistry. 213, p. 329-335 7 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
wheat germ
calmodulin
hydrolysates
protein kinases

Paracellular transport of sulforaphane across caco-2 cell monolayers

Ushida, Y., Boonyapichest, C., Suganuma, H., Tanaka, M. & Matsui, T., Jan 1 2016, In : Food Science and Technology Research. 22, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

tight junctions
Caco-2 Cells
Monolayers
epigallocatechin
broccoli
7 Citations (Scopus)

Quantitative mass spectrometric analysis of dipeptides in protein hydrolysate by a TNBS derivatization-aided standard addition method

Hanh, V. T., Kobayashi, Y., Maebuchi, M., Nakamori, T., Tanaka, M. & Matsui, T., Jun 3 2016, In : Food Chemistry. 190, p. 345-350 6 p.

Research output: Contribution to journalArticle

Trinitrobenzenesulfonic Acid
Protein Hydrolysates
dipeptides
sulfonates
Dipeptides
11 Citations (Scopus)

Structural Design of Oligopeptides for Intestinal Transport Model

Hong, S. M., Tanaka, M., Koyanagi, R., Shen, W. & Matsui, T., Mar 16 2016, In : Journal of Agricultural and Food Chemistry. 64, 10, p. 2072-2079 8 p.

Research output: Contribution to journalArticle

Sarcosine
oligopeptides
tripeptides
Oligopeptides
Structural design
2 Citations (Scopus)

The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem

Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T. & Furuya, S., Jan 1 2016, In : International Journal of Peptides. 2016, 6020786.

Research output: Contribution to journalArticle

isoleucyl-tyrosine
tyrosyl-proline
Dipeptides
Metabolism
Brain Stem
5 Citations (Scopus)
Polyphenols
Nifedipine
Ionization
Mass spectrometry
Desorption
2015
5 Citations (Scopus)

Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats

Fukuda, T., Kuroda, T., Kono, M., Hyoguchi, M., Tanaka, M. & Matsui, T., Oct 1 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 10, p. 1113-1117 5 p., 1171.

Research output: Contribution to journalArticle

ferulic acid
Inbred SHR Rats
Thoracic Aorta
Vasodilation
Inbred WKY Rats
5 Citations (Scopus)

Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain

Ichinose, T., Moriyasu, K., Nakahata, A., Tanaka, M., Matsui, T. & Furuya, S., Jan 1 2015, In : Bioscience, Biotechnology and Biochemistry. 79, 9, p. 1542-1547 6 p.

Research output: Contribution to journalArticle

isoleucyl-tyrosine
tyrosyl-proline
Dipeptides
Brain
Cerebral Cortex
40 Citations (Scopus)
Camellia
Claudin-1
Flavins
Occludin
AMP-Activated Protein Kinases
2 Citations (Scopus)
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
alpha-Tocopherol
tocopherols
films (materials)
desorption
17 Citations (Scopus)

Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses

Tanaka, M., Hong, S. M., Akiyama, S., Hu, Q. Q. & Matsui, T., Jan 1 2015, In : Molecular Nutrition and Food Research. 59, 8, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

tryptophyl-histidine
dipeptides
matrix-assisted laser desorption-ionization mass spectrometry
Dipeptides
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
2014
12 Citations (Scopus)
L-Type Calcium Channels
Inbred SHR Rats
aorta
Aorta
Rats
18 Citations (Scopus)
ferulic acid
Vasodilator Agents
tryptophyl-histidine
Aorta
Rats
4 Citations (Scopus)

Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells

Kumrungsee, T., Wang, Z. Q., Matsumura, S., Saiki, T., Tanaka, M. & Matsui, T., Jun 1 2014, In : Food Chemistry. 152, p. 218-224 7 p.

Research output: Contribution to journalArticle

glycinin
Soybean Proteins
soy protein
Vascular Smooth Muscle
blood vessels
9 Citations (Scopus)

Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses

Kumrungsee, T., Saiki, T., Akiyama, S., Nakashima, K., Tanaka, M., Kobayashi, Y. & Matsui, T., Jan 1 2014, In : Biochimica et Biophysica Acta - General Subjects. 1840, 10, p. 3073-3078 6 p.

Research output: Contribution to journalArticle

Dipeptides
Calmodulin
Vasodilator Agents
Computer Simulation
Calcium
15 Citations (Scopus)

In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementation

Kovacs-Nolan, J., Rupa, P., Matsui, T., Tanaka, M., Konishi, T., Sauchi, Y., Sato, K., Ono, S. & Mine, Y., Oct 1 2014, In : Journal of Agricultural and Food Chemistry. 62, 39, p. 9499-9506 8 p.

Research output: Contribution to journalArticle

Intestinal Mucosa
intestinal mucosa
Glutathione
glutathione
mouth

低分子ペプチドを高感度に測る・視る

福田俊彦, 田中充 & 松井利郎, 2014, In : 食品加工技術 : 日本食品機械研究会誌. 34, 2, p. 66-71 6 p.

Research output: Contribution to journalArticle

2013
22 Citations (Scopus)

Enhanced visualization of small peptides absorbed in rat small intestine by phytic-acid-aided matrix-assisted laser desorption/ionization-imaging mass spectrometry

Hong, S. M., Tanaka, M., Yoshii, S., Mine, Y. & Matsui, T., Nov 5 2013, In : Analytical Chemistry. 85, 21, p. 10033-10039 7 p.

Research output: Contribution to journalArticle

Phytic Acid
Ionization
Mass spectrometry
Rats
Desorption
23 Citations (Scopus)
Trinitrobenzenesulfonic Acid
Electrospray ionization
Advanced Glycosylation End Products
Liquid chromatography
Mass spectrometry
8 Citations (Scopus)

Improved detection of di-peptides by liquid chromatography-tandem mass spectrometry with 2,4,6-trinitrobenzene sulfonate conversion

Nakashima, E. M. N., Qing, H. Q., Tanaka, M. & Matsui, T., Nov 4 2013, In : Bioscience, Biotechnology and Biochemistry. 77, 10, p. 2094-2099 6 p.

Research output: Contribution to journalArticle

Trinitrobenzenesulfonic Acid
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
2012
5 Citations (Scopus)
Adenine
Thoracic Aorta
Endothelium
Sprague Dawley Rats
Aorta
6 Citations (Scopus)
tryptophyl-histidine
dipeptides
vasodilation
Dipeptides
epigallocatechin
16 Citations (Scopus)
tryptophyl-histidine
Phosphorylation
Calmodulin
Vascular Smooth Muscle
Smooth Muscle Myocytes
2011
25 Citations (Scopus)

Application of 13C stable isotope labeling liquid chromatography-multiple reaction monitoring-tandem mass spectrometry method for determining intact absorption of bioactive dipeptides in rats

Nakashima, E. M. N., Kudo, A., Iwaihara, Y., Tanaka, M., Matsumoto, K. & Matsui, T., Jul 1 2011, In : Analytical Biochemistry. 414, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

valyltyrosine
Isotope Labeling
Dipeptides
Liquid chromatography
Tandem Mass Spectrometry
1 Citation (Scopus)

Vascular regulation by small peptides

Matsui, T., Wang, Z. & Tanaka, M., Jan 1 2011, Bioactive Natural Products: Opportunities and Challenges in Medicinal Chemistry. World Scientific Publishing Co., p. 201-221 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

blood vessels
Peptides
Blood Vessels
peptides
antihypertensive effect

血管機能とペプチド

松井利郎 & 田中充, Mar 2011, In : ニューフードインダストリー. 53, 3, p. 22-30 9 p.

Research output: Contribution to journalArticle

2010
10 Citations (Scopus)

Antihypertensive Peptides and Their Underlying Mechanisms

Matsui, T. & Tanaka, M., Jun 29 2010, Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals. Wiley-Blackwell, p. 43-54 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

antihypertensive agents
Antihypertensive Agents
peptides
Peptides
34 Citations (Scopus)

Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca 2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like l-type Ca2+ channels

Wang, Z., Watanabe, S., Kobayashi, Y., Tanaka, M. & Matsui, T., Nov 1 2010, In : Peptides. 31, 11, p. 2060-2066 7 p.

Research output: Contribution to journalArticle

tryptophyl-histidine
Vasodilator Agents
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
42 Citations (Scopus)

Vasodilating dipeptide Trp-His can prevent atherosclerosis in apo E-deficient mice

Matsui, T., Sato, M., Tanaka, M., Yamada, Y., Watanabe, S., Fujimoto, Y., Imaizumi, K. & Matsumoto, K., Feb 1 2010, In : British Journal of Nutrition. 103, 3, p. 309-313 5 p.

Research output: Contribution to journalArticle

tryptophyl-histidine
Dipeptides
Apolipoproteins E
Atherosclerosis
Peptides
2009
20 Citations (Scopus)

His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx

Tanaka, M., Watanabe, S., Wang, Z., Matsumoto, K. & Matsui, T., Aug 1 2009, In : Peptides. 30, 8, p. 1502-1507 6 p.

Research output: Contribution to journalArticle

Thoracic Aorta
Sprague Dawley Rats
Rats
Peptides
Vasodilation
2008
33 Citations (Scopus)

Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta

Ushida, Y., Matsui, T., Tanaka, M., Matsumoto, K., Hosoyama, H., Mitomi, A., Sagesaka, Y. & Kakuda, T., Oct 1 2008, In : Journal of Nutritional Biochemistry. 19, 10, p. 700-707 8 p.

Research output: Contribution to journalArticle

Fagopyrum
Rutin
Phenylephrine
Thoracic Aorta
Vasodilation
43 Citations (Scopus)

Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of Sprague-Dawley rats

Tanaka, M., Tokuyasu, M., Matsui, T. & Matsumoto, K., Apr 9 2008, In : Life Sciences. 82, 15-16, p. 869-875 7 p.

Research output: Contribution to journalArticle

Thoracic Aorta
Vasodilation
Endothelium
Sprague Dawley Rats
Rats
2006
22 Citations (Scopus)

Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Tanaka, M., Matsui, T., Ushida, Y. & Matsumoto, K., Oct 2 2006, In : Bioscience, Biotechnology and Biochemistry. 70, 9, p. 2292-2295 4 p.

Research output: Contribution to journalArticle

Inbred SHR Rats
isoleucyl-tyrosine
Thoracic Aorta
valyltyrosine
Blood Vessels

ペプチドの高血圧抑制の新たなメカニズム

Tanaka, M., 2006, 日本食品機械研究会. 1, Vol. 26. p. 29-33 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2005
41 Citations (Scopus)
valyltyrosine
Peptidyl-Dipeptidase A
Vascular Smooth Muscle
Smooth Muscle Myocytes
Peptides
11 Citations (Scopus)
High performance liquid chromatography
Antihypertensive Agents
Peptides
Trifluoroacetic Acid
Plasmas