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Research Output

2020

Mitochondrial dynamics in exercise physiology

Tanaka, T., Nishimura, A., Nishiyama, K., Goto, T., Numaga-Tomita, T. & Nishida, M., Feb 1 2020, In : Pflugers Archiv European Journal of Physiology. 472, 2, p. 137-153 17 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice

Shimoda, K., Nishimura, A., Sunggip, C., Ito, T., Nishiyama, K., Kato, Y., Tanaka, T., Tozaki-Saitoh, H., Tsuda, M. & Nishida, M., Dec 1 2020, In : Scientific reports. 10, 1, 13926.

Research output: Contribution to journalArticle

Open Access
2019

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Kenichi, Y. & Uchida, K., Jan 25 2019, In : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., 2019, In : Science Signaling. 12, 587, eaaw1920.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., Sep 1 2019, In : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., Dec 1 2019, In : Scientific reports. 9, 1, 9785.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., Sep 1 2019, In : FASEB Journal. 33, 9, p. 9785-9796 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

TRPC channels in exercise-mimetic therapy

Numaga-Tomita, T., Oda, S., Nishiyama, K., Tanaka, T., Nishimura, A. & Nishida, M., Mar 7 2019, In : Pflugers Archiv European Journal of Physiology. 471, 3, p. 507-517 11 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)
2018

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., Nov 13 2018, In : Science Signaling. 11, 556, eaat5185.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Masuda, K., Tsutsuki, H., Kasamatsu, S., Ida, T., Takata, T., Sugiura, K., Nishida, M., Watanabe, Y., Sawa, T., Akaike, T. & Ihara, H., Jan 15 2018, In : Biochemical and Biophysical Research Communications. 495, 3, p. 2165-2170 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Lifestyle inspires future pharmacotherapy and drug discovery

Miyamoto, L. & Nishida, M., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1255-1256 2 p.

Research output: Contribution to journalEditorial

New strategies for exercise-mimetic medication

Oda, S., Numaga-Tomita, T. & Nishida, M., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Nov 2018, In : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

Sawa, T., Ono, K., Tsutsuki, H., Zhang, T., Ida, T., Nishida, M. & Akaike, T., Jan 1 2018, Nitric Oxide and Other Small Signalling Molecules. Poole, R. K. (ed.). Academic Press, p. 1-28 28 p. (Advances in Microbial Physiology; vol. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

Yamaguchi, Y., Iribe, G., Kaneko, T., Takahashi, K., Numaga-Tomita, T., Nishida, M., Birnbaumer, L. & Naruse, K., Mar 1 2018, In : Journal of Physiological Sciences. 68, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy

Sunggip, C., Shimoda, K., Oda, S., Tanaka, T., Nishiyama, K., Mangmool, S., Nishimura, A., Numaga-Tomita, T. & Nishida, M., May 22 2018, In : Frontiers in Pharmacology. 9, MAY, 523.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy

Guan, Y., Nakano, D., Zhang, Y., Li, L., Liu, W., Nishida, M., Kuwabara, T., Morishita, A., Hitomi, H., Mori, K., Mukoyama, M., Masaki, T., Hirano, K. & Nishiyama, A., Oct 2017, In : Journal of Pharmacological Sciences. 135, 2, p. 81-88 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S. & 6 others, Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M. & Motohashi, H., Dec 1 2017, In : Nature communications. 8, 1, 1177.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Eco-pharma of approved drug focused on mitochondria fission

Shimauchi, T., Nishimura, A., Ishikawa, T. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 6, p. 269-273 5 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Exposure to electrophiles impairs reactive persulfide-dependent redox signaling in neuronal cells

Ihara, H., Kasamatsu, S., Kitamura, A., Nishimura, A., Tsutsuki, H., Ida, T., Ishizaki, K., Toyama, T., Yoshida, E., Hamid, H. A., Jung, M., Matsunaga, T., Fujii, S., Sawa, T., Nishida, M., Kumagai, Y. & Akaike, T., 2017, In : Chemical Research in Toxicology. 30, 9, p. 1673-1684 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

MiR30-GALNT1/2 axis-mediated glycosylation contributes to the increased secretion of inactive human prohormone for brain natriuretic peptide (proBNP) from failing hearts

Nakagawa, Y., Nishikimi, T., Kuwahara, K., Fujishima, A., Oka, S., Tsutamoto, T., Kinoshita, H., Nakao, K., Cho, K., Inazumi, H., Okamoto, H., Nishida, M., Kato, T., Fukushima, H., Yamashita, J. K., Wijnen, W. J., Creemers, E. E., Kangawa, K., Minamino, N., Nakao, K. & 1 others, Kimura, T., 2017, In : Journal of the American Heart Association. 6, 2, e003601.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Sunggip, C., Nishimura, A., Shimoda, K., Numaga-Tomita, T., Tsuda, M. & Nishida, M., Jun 1 2017, In : Pharmacological Research. 120, p. 51-59 9 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Nishimura, A., Sunggip, C., Oda, S., Numaga-Tomita, T., Tsuda, M. & Nishida, M., Dec 2017, In : Pharmacology and Therapeutics. 180, p. 113-128 16 p.

Research output: Contribution to journalReview article

25 Citations (Scopus)

Purinergic signaling in cardiovascular system

Nishimura, A. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 2, p. 84-90 7 p.

Research output: Contribution to journalArticle

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Nishida, M., Nishimura, A., Matsunaga, T., Motohashi, H., Kasamatsu, S. & Akaike, T., Aug 2017, In : Free Radical Biology and Medicine. 109, p. 132-140 9 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology

Yamaguchi, Y., Iribe, G., Nishida, M. & Naruse, K., Nov 2017, In : Progress in Biophysics and Molecular Biology. 130, p. 264-272 9 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac Fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway

Phosri, S., Arieyawong, A., Bunrukchai, K., Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Jun 30 2017, In : Frontiers in Pharmacology. 8, JUN, 428.

Research output: Contribution to journalArticle

25 Citations (Scopus)

TRPC3 Channels in Cardiac Fibrosis

Numaga-Tomita, T., Oda, S., Shimauchi, T., Nishimura, A., Mangmool, S. & Nishida, M., Sep 7 2017, In : Frontiers in Cardiovascular Medicine. 4, 56.

Research output: Contribution to journalReview article

Open Access
13 Citations (Scopus)

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Shimauchi, T., Numaga-Tomita, T., Ito, T., Nishimura, A., Matsukane, R., Oda, S., Hoka, S., Ide, T., Koitabashi, N., Uchida, K., Sumimoto, H., Mori, Y. & Nishida, M., Aug 3 2017, In : JCI Insight. 2, 15

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Oda, S., Numaga-Tomita, T., Kitajima, N., Toyama, T., Harada, E., Shimauchi, T., Nishimura, A., Ishikawa, T., Kumagai, Y., Birnbaumer, L. & Nishida, M., Dec 1 2017, In : Scientific reports. 7, 1, 7511.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T. & Kumagai, Y., Jun 30 2016, In : Scientific reports. 6, 28944.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides

Fujii, S., Sawa, T., Nishida, M., Ihara, H., Ida, T., Motohashi, H. & Akaike, T., Apr 1 2016, In : Archives of Biochemistry and Biophysics. 595, p. 140-146 7 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

Redox signaling regulated by electrophiles and reactive sulfur species

Nishida, M., Kumagai, Y., Ihara, H., Fujii, S., Motohashi, H. & Akaike, T., Mar 2016, In : Journal of Clinical Biochemistry and Nutrition. 58, 2, p. 91-98 8 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compoundss

Sawamura, S., Hatano, M., Takada, Y., Hino, K., Kawamura, T., Tanikawa, J., Nakagawa, H., Hase, H., Nakao, A., Hirano, M., Rotrattanadumrong, R., Kiyonaka, S., Mori, M. X., Nishida, M., Hu, Y., Inoue, R., Nagata, R. & Mori, Y., Mar 2016, In : Molecular Pharmacology. 89, 3, p. 348-363 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner

Mangmool, S., Denkaew, T., Phosri, S., Pinthong, D., Parichatikanond, W., Shimauchi, T. & Nishida, M., Jan 2016, In : Molecular Endocrinology. 30, 1, p. 118-132 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor

Hagimori, M., Murakami, T., Shimizu, K., Nishida, M., Ohshima, T. & Mukai, T., 2016, In : MedChemComm. 7, 5, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation

Numaga-Tomita, T., Nishida, M., Putney, J. W. & Mori, Y., Jan 15 2016, In : Biochemical Journal. 473, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Dec 19 2016, In : Scientific reports. 6, 39383.

Research output: Contribution to journalArticle

22 Citations (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Nov 11 2016, In : Scientific reports. 6, 37001.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2015

Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological potentiality

Mori, Y., Mori, M. X. & Nishida, M., Jan 1 2015, In : Clinical calcium. 25, 1, p. 47-58 12 p.

Research output: Contribution to journalReview article

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases

Gentry, L. R., Nishimura, A., Cox, A. D., Martin, T. D., Tsygankov, D., Nishida, M., Elston, T. C. & Der, C. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22851-22861 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress

Shinkai, Y., Abiko, Y., Ida, T., Miura, T., Kakehashi, H., Ishii, I., Nishida, M., Sawa, T., Akaike, T. & Kumagai, Y., May 18 2015, In : Chemical Research in Toxicology. 28, 5, p. 838-847 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2014

Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species

Nishida, M., Toyama, T., Kumagai, Y. & Numaga-Tomita, T., Jan 1 2014, In : Yakugaku Zasshi. 134, 12, p. 1239-1243 5 p.

Research output: Contribution to journalArticle

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

Yamada, Y., Kinoshita, H., Kuwahara, K., Nakagawa, Y., Kuwabara, Y., Minami, T., Yamada, C., Shibata, J., Nakao, K., Cho, K., Arai, Y., Yasuno, S., Nishikimi, T., Ueshima, K., Kamakura, S., Nishida, M., Kiyonaka, S., Mori, Y., Kimura, T., Kangawa, K. & 1 others, Nakao, K., Oct 1 2014, In : Cardiovascular research. 104, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling

Nishida, M., Toyama, T. & Akaike, T., Aug 2014, In : Journal of Molecular and Cellular Cardiology. 73, p. 10-17 8 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
2013

[Function and role of transient receptor potential channels].

Nishida, M., Sumita, M. & Kitajima, N., Jan 1 2013, In : Clinical calcium. 23, 4, p. 561-568 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase i and TRPC6 channels

Chen, W., Oberwinkler, H., Werner, F., Ganer, B., Nakagawa, H., Feil, R., Hofmann, F., Schlossmann, J., Dietrich, A., Gudermann, T., Nishida, M., Del Galdo, S., Wieland, T. & Kuhn, M., Sep 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 9, p. 2121-2129 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Chemical biology of hydrogen sulfide

Kitajima, N. & Nishida, M., 2013, In : Folia Pharmacologica Japonica. 141, 6, p. 350-351 2 p.

Research output: Contribution to journalComment/debate