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Research Output 1999 2019

2019

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K-I. & Uchida, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., Jan 1 2019, In : Science Signaling. 12, 587, eaaw1920.

Research output: Contribution to journalArticle

Filamins
Hemodynamics
Cardiac Myocytes
Oxidation-Reduction
Rats

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., Sep 1 2019, In : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Doxorubicin
Tobacco Smoke Pollution
Proteins
Pharmaceutical Preparations
1 Citation (Scopus)

Mitochondrial dynamics in exercise physiology

Tanaka, T., Nishimura, A., Nishiyama, K., Goto, T., Numaga-Tomita, T. & Nishida, M., Jan 1 2019, In : Pflugers Archiv European Journal of Physiology.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Physiology
Organelle Biogenesis
Post Translational Protein Processing
Homeostasis

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., Dec 1 2019, In : Scientific reports. 9, 1, 9785.

Research output: Contribution to journalArticle

Open Access
Cardiac Myocytes
Malnutrition
Atrophy
Adenosine Triphosphate
Reactive Oxygen Species

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., Sep 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 9785-9796 12 p.

Research output: Contribution to journalArticle

Cell membranes
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Muscle
2 Citations (Scopus)

TRPC channels in exercise-mimetic therapy

Numaga-Tomita, T., Oda, S., Nishiyama, K., Tanaka, T., Nishimura, A. & Nishida, M., Mar 7 2019, In : Pflugers Archiv European Journal of Physiology. 471, 3, p. 507-517 11 p.

Research output: Contribution to journalReview article

Exercise Therapy
Muscle
Mechanical Stress
Proteins
Oxidative stress
2018
8 Citations (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., Nov 13 2018, In : Science Signaling. 11, 556, eaat5185.

Research output: Contribution to journalArticle

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins
3 Citations (Scopus)

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Masuda, K., Tsutsuki, H., Kasamatsu, S., Ida, T., Takata, T., Sugiura, K., Nishida, M., Watanabe, Y., Sawa, T., Akaike, T. & Ihara, H., Jan 15 2018, In : Biochemical and Biophysical Research Communications. 495, 3, p. 2165-2170 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenylpyridinium
PC12 Cells
Neurons
Rats
Reactive Oxygen Species

Lifestyle inspires future pharmacotherapy and drug discovery

Miyamoto, L. & Nishida, M., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1255-1256 2 p.

Research output: Contribution to journalEditorial

Drug Discovery
Life Style
Drug Therapy

New strategies for exercise-mimetic medication

Oda, S., Numaga-Tomita, T. & Nishida, M., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

Exercise Therapy
Exercise
Reactive Oxygen Species
NADP
Vascular Smooth Muscle

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Nov 1 2018, In : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Insulin
Glucose
Smooth Muscle Myocytes
4 Citations (Scopus)

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

Sawa, T., Ono, K., Tsutsuki, H., Zhang, T., Ida, T., Nishida, M. & Akaike, T., Jan 1 2018, Nitric Oxide and Other Small Signalling Molecules. Poole, R. K. (ed.). Academic Press, p. 1-28 28 p. (Advances in Microbial Physiology; vol. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter

Antioxidants
Sulfur
Cysteine
Homocysteine
Coenzyme A
9 Citations (Scopus)

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

Yamaguchi, Y., Iribe, G., Kaneko, T., Takahashi, K., Numaga-Tomita, T., Nishida, M., Birnbaumer, L. & Naruse, K., Mar 1 2018, In : Journal of Physiological Sciences. 68, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Cardiac Myocytes
Angiotensin II Type 1 Receptor Blockers
Type C Phospholipases
Knockout Mice
5 Citations (Scopus)

TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy

Sunggip, C., Shimoda, K., Oda, S., Tanaka, T., Nishiyama, K., Mangmool, S., Nishimura, A., Numaga-Tomita, T. & Nishida, M., May 22 2018, In : Frontiers in Pharmacology. 9, MAY, 523.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hypertrophy
Adenosine Triphosphate
NFATC Transcription Factors
Cyclic GMP-Dependent Protein Kinases
2017
6 Citations (Scopus)

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy

Guan, Y., Nakano, D., Zhang, Y., Li, L., Liu, W., Nishida, M., Kuwabara, T., Morishita, A., Hitomi, H., Mori, K., Mukoyama, M., Masaki, T., Hirano, K. & Nishiyama, A., Oct 1 2017, In : Journal of Pharmacological Sciences. 135, 2, p. 81-88 8 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Podocytes
Doxorubicin
Wounds and Injuries
Kidney
77 Citations (Scopus)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S. & 6 others, Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M. & Motohashi, H., Dec 1 2017, In : Nature communications. 8, 1, 1177.

Research output: Contribution to journalArticle

cysteinyl-tRNA synthetase
cysteine
Energy Metabolism
Cysteine
Cysteine Synthase
1 Citation (Scopus)

Eco-pharma of approved drug focused on mitochondria fission

Shimauchi, T., Nishimura, A., Ishikawa, T. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 6, p. 269-273 5 p.

Research output: Contribution to journalComment/debate

Drug Repositioning
Mitochondrial Dynamics
Drug Approval
Cell Aging
Mitochondria
9 Citations (Scopus)

Exposure to electrophiles impairs reactive persulfide-dependent redox signaling in neuronal cells

Ihara, H., Kasamatsu, S., Kitamura, A., Nishimura, A., Tsutsuki, H., Ida, T., Ishizaki, K., Toyama, T., Yoshida, E., Hamid, H. A., Jung, M., Matsunaga, T., Fujii, S., Sawa, T., Nishida, M., Kumagai, Y. & Akaike, T., Jan 1 2017, In : Chemical Research in Toxicology. 30, 9, p. 1673-1684 12 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Chemical activation
Wounds and Injuries
Metabolites
Sulfhydryl Compounds
15 Citations (Scopus)

MiR30-GALNT1/2 axis-mediated glycosylation contributes to the increased secretion of inactive human prohormone for brain natriuretic peptide (proBNP) from failing hearts

Nakagawa, Y., Nishikimi, T., Kuwahara, K., Fujishima, A., Oka, S., Tsutamoto, T., Kinoshita, H., Nakao, K., Cho, K., Inazumi, H., Okamoto, H., Nishida, M., Kato, T., Fukushima, H., Yamashita, J. K., Wijnen, W. J., Creemers, E. E., Kangawa, K., Minamino, N., Nakao, K. & 1 others, Kimura, T., Jan 1 2017, In : Journal of the American Heart Association. 6, 2, e003601.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Glycosylation
Heart Failure
MicroRNAs
Cyclic GMP
5 Citations (Scopus)

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Sunggip, C., Nishimura, A., Shimoda, K., Numaga-Tomita, T., Makoto, T. & Nishida, M., Jun 1 2017, In : Pharmacological Research. 120, p. 51-59 9 p.

Research output: Contribution to journalReview article

Purinergic Receptors
Hypertension
Angiotensin Type 1 Receptor
clopidogrel
Purinergic P2Y12 Receptors
14 Citations (Scopus)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Nishimura, A., Sunggip, C., Oda, S., Numaga-Tomita, T., Makoto, T. & Nishida, M., Dec 1 2017, In : Pharmacology and Therapeutics. 180, p. 113-128 16 p.

Research output: Contribution to journalReview article

Purinergic P2Y Receptors
G-Protein-Coupled Receptors
Cardiovascular System
Cardiovascular Diseases
Uracil Nucleotides

Purinergic signaling in cardiovascular system

Nishimura, A. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 2, p. 84-90 7 p.

Research output: Contribution to journalArticle

Uracil
Cardiovascular System
Adenosine
Signal Transduction
Hypertension
6 Citations (Scopus)

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Nishida, M., Nishimura, A., Matsunaga, T., Motohashi, H., Kasamatsu, S. & Akaike, T., Aug 1 2017, In : Free Radical Biology and Medicine. 109, p. 132-140 9 p.

Research output: Contribution to journalReview article

Metabolism
Oxidation-Reduction
Nitric Oxide
Cardiovascular Physiological Phenomena
Cell signaling
9 Citations (Scopus)

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology

Yamaguchi, Y., Iribe, G., Nishida, M. & Naruse, K., Nov 1 2017, In : Progress in Biophysics and Molecular Biology. 130, p. 264-272 9 p.

Research output: Contribution to journalReview article

Transient Receptor Potential Channels
Cardiomegaly
Heart Failure
NFATC Transcription Factors
Mechanical Stress
17 Citations (Scopus)

Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac Fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway

Phosri, S., Arieyawong, A., Bunrukchai, K., Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Jun 30 2017, In : Frontiers in Pharmacology. 8, JUN, 428.

Research output: Contribution to journalArticle

Endothelin A Receptors
Phosphatidylinositol 3-Kinases
Adenosine
Endothelin-1
Smooth Muscle
8 Citations (Scopus)

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Shimauchi, T., Numaga-Tomita, T., Ito, T., Nishimura, A., Matsukane, R., Oda, S., Hoka, S., Ide, T., Koitabashi, N., Uchida, K., Sumimoto, H., Mori, Y. & Nishida, M., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
NADPH Oxidase
Doxorubicin
Atrophy
Cardiac Myocytes
Compliance
3 Citations (Scopus)

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Oda, S., Numaga-Tomita, T., Kitajima, N., Toyama, T., Harada, E., Shimauchi, T., Nishimura, A., Ishikawa, T., Kumagai, Y., Birnbaumer, L. & Nishida, M., Dec 1 2017, In : Scientific reports. 7, 1, 7511.

Research output: Contribution to journalArticle

NADPH Oxidase
Hyperglycemia
Heart Failure
Proteins
Reactive Oxygen Species
2016
18 Citations (Scopus)

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T. & Kumagai, Y., Jun 30 2016, In : Scientific reports. 6, 28944.

Research output: Contribution to journalArticle

Signal Transduction
Cell Survival
Apoptosis Regulatory Proteins
Neuroblastoma
Phosphatidylinositol 3-Kinases
27 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
13 Citations (Scopus)

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides

Fujii, S., Sawa, T., Nishida, M., Ihara, H., Ida, T., Motohashi, H. & Akaike, T., Apr 1 2016, In : Archives of Biochemistry and Biophysics. 595, p. 140-146 7 p.

Research output: Contribution to journalReview article

Cyclic Nucleotides
Metabolism
Oxidation-Reduction
Oxidants
Reactive Oxygen Species
20 Citations (Scopus)

Redox signaling regulated by electrophiles and reactive sulfur species

Nishida, M., Kumagai, Y., Ihara, H., Fujii, S., Motohashi, H. & Akaike, T., Mar 1 2016, In : Journal of Clinical Biochemistry and Nutrition. 58, 2, p. 91-98 8 p.

Research output: Contribution to journalReview article

Sulfur
Oxidative stress
Oxidation-Reduction
Cell signaling
Metabolism
7 Citations (Scopus)

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compoundss

Sawamura, S., Hatano, M., Takada, Y., Hino, K., Kawamura, T., Tanikawa, J., Nakagawa, H., Hase, H., Nakao, A., Hirano, M., Rotrattanadumrong, R., Kiyonaka, S., Mori, M. X., Nishida, M., Hu, Y., Inoue, R., Nagata, R. & Mori, Y., Mar 1 2016, In : Molecular Pharmacology. 89, 3, p. 348-363 16 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Diglycerides
Brain-Derived Neurotrophic Factor
Cations
Neurons
13 Citations (Scopus)

Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner

Mangmool, S., Denkaew, T., Phosri, S., Pinthong, D., Parichatikanond, W., Shimauchi, T. & Nishida, M., Jan 1 2016, In : Molecular Endocrinology. 30, 1, p. 118-132 15 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Cyclic AMP-Dependent Protein Kinases
Insulin
Cardiac Myocytes
3 Citations (Scopus)

Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor

Hagimori, M., Murakami, T., Shimizu, K., Nishida, M., Ohshima, T. & Mukai, T., Jan 1 2016, In : MedChemComm. 7, 5, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

Therapeutic Human Experimentation
HEK293 Cells
Treatment Failure
Heart Failure
Cell Membrane
2 Citations (Scopus)

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation

Numaga-Tomita, T., Nishida, M., Putney, J. W. & Mori, Y., Jan 15 2016, In : Biochemical Journal. 473, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
B-Lymphocytes
Chemical activation
Cells
Lymphocytes
18 Citations (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Dec 19 2016, In : Scientific reports. 6, 39383.

Research output: Contribution to journalArticle

Cardiac Myocytes
Fibrosis
Microtubules
Pressure
Fibroblasts
31 Citations (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Nov 11 2016, In : Scientific reports. 6, 37001.

Research output: Contribution to journalArticle

NADPH Oxidase
Reactive Oxygen Species
Physiological Adaptation
Proteasome Endopeptidase Complex
Cardiac Myocytes
2015

Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological potentiality

Mori, Y., Mori, M. X. & Nishida, M., Jan 1 2015, In : Clinical calcium. 25, 1, p. 47-58 12 p.

Research output: Contribution to journalReview article

Calcium Signaling
Ions
Calcium
Biological Phenomena
Bone and Bones
17 Citations (Scopus)

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases

Gentry, L. R., Nishimura, A., Cox, A. D., Martin, T. D., Tsygankov, D., Nishida, M., Elston, T. C. & Der, C. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22851-22861 11 p.

Research output: Contribution to journalArticle

Endopeptidases
GTP Phosphohydrolases
Post Translational Protein Processing
Protein Isoforms
Cell Membrane
11 Citations (Scopus)

Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress

Shinkai, Y., Abiko, Y., Ida, T., Miura, T., Kakehashi, H., Ishii, I., Nishida, M., Sawa, T., Akaike, T. & Kumagai, Y., May 18 2015, In : Chemical Research in Toxicology. 28, 5, p. 838-847 10 p.

Research output: Contribution to journalArticle

Sulfenic Acids
Oxidative stress
Sulfur
Oxidative Stress
Chemical activation
2014

Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species

Nishida, M., Toyama, T., Kumagai, Y. & Numaga-Tomita, T., Jan 1 2014, In : Yakugaku Zasshi. 134, 12, p. 1239-1243 5 p.

Research output: Contribution to journalArticle

Sulfur
Oxidation-Reduction
Nitric Oxide
Homeostasis
Heart Failure
16 Citations (Scopus)

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

Yamada, Y., Kinoshita, H., Kuwahara, K., Nakagawa, Y., Kuwabara, Y., Minami, T., Yamada, C., Shibata, J., Nakao, K., Cho, K., Arai, Y., Yasuno, S., Nishikimi, T., Ueshima, K., Kamakura, S., Nishida, M., Kiyonaka, S., Mori, Y., Kimura, T., Kangawa, K. & 1 others, Nakao, K., Oct 1 2014, In : Cardiovascular research. 104, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

Autonomic Pathways
Cardiac Arrhythmias
Heart Failure
Sudden Death
Nitrendipine
8 Citations (Scopus)

Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling

Nishida, M., Toyama, T. & Akaike, T., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 73, p. 10-17 8 p.

Research output: Contribution to journalReview article

Cardiovascular System
Reactive Oxygen Species
Nitric Oxide
Gasotransmitters
Cardiovascular Diseases
2013
1 Citation (Scopus)

[Function and role of transient receptor potential channels].

Nishida, M., Sumita, M. & Kitajima, N., Jan 1 2013, In : Clinical calcium. 23, 4, p. 561-568 8 p.

Research output: Contribution to journalReview article

Transient Receptor Potential Channels
Cations
Intracellular Signaling Peptides and Proteins
Heart Failure
Proteins
Gene Knockdown Techniques
Hydrogen Sulfide
Cardiac Myocytes
Oxidation-Reduction
Anions
17 Citations (Scopus)

Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca 2+ and permeability response to histamine involves cGMP-dependent protein kinase i and TRPC6 channels

Chen, W., Oberwinkler, H., Werner, F., Ganer, B., Nakagawa, H., Feil, R., Hofmann, F., Schlossmann, J., Dietrich, A., Gudermann, T., Nishida, M., Del Galdo, S., Wieland, T. & Kuhn, M., Sep 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 9, p. 2121-2129 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinase Type I
Cyclic GMP-Dependent Protein Kinases
Atrial Natriuretic Factor
Histamine
Permeability

Chemical biology of hydrogen sulfide

Kitajima, N. & Nishida, M., Jan 1 2013, In : Folia Pharmacologica Japonica. 141, 6, p. 350-351 2 p.

Research output: Contribution to journalComment/debate

Hydrogen Sulfide
34 Citations (Scopus)

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide

Sawa, T., Ihara, H., Ida, T., Fujii, S., Nishida, M. & Akaike, T., Jan 1 2013, In : Nitric Oxide - Biology and Chemistry. 34, p. 10-18 9 p.

Research output: Contribution to journalReview article

Cyclic Nucleotides
Metabolism
Protein S
Proteins
Cell signaling
30 Citations (Scopus)

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Michio, N., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., Nishida, M., Taniguchi, H., Sato, Y., Matsumoto, M., Makoto, T., Kuroda, M., Inoue, K. & Kurose, H., Mar 11 2013, In : Nature communications. 4, 1532.

Research output: Contribution to journalArticle

clearances
Autoimmune Diseases
mice
Cells
proteins