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Research Output 1999 2019

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2019

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K-I. & Uchida, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., Jan 1 2019, In : Science Signaling. 12, 587, eaaw1920.

Research output: Contribution to journalArticle

Filamins
Hemodynamics
Cardiac Myocytes
Oxidation-Reduction
Rats

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., Sep 1 2019, In : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Doxorubicin
Tobacco Smoke Pollution
Proteins
Pharmaceutical Preparations

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., Dec 1 2019, In : Scientific reports. 9, 1, 9785.

Research output: Contribution to journalArticle

Open Access
Cardiac Myocytes
Malnutrition
Atrophy
Adenosine Triphosphate
Reactive Oxygen Species

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., Sep 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 9785-9796 12 p.

Research output: Contribution to journalArticle

Cell membranes
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Muscle
2018
8 Citations (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., Nov 13 2018, In : Science Signaling. 11, 556, eaat5185.

Research output: Contribution to journalArticle

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins
3 Citations (Scopus)

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Masuda, K., Tsutsuki, H., Kasamatsu, S., Ida, T., Takata, T., Sugiura, K., Nishida, M., Watanabe, Y., Sawa, T., Akaike, T. & Ihara, H., Jan 15 2018, In : Biochemical and Biophysical Research Communications. 495, 3, p. 2165-2170 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenylpyridinium
PC12 Cells
Neurons
Rats
Reactive Oxygen Species

New strategies for exercise-mimetic medication

Oda, S., Numaga-Tomita, T. & Nishida, M., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

Exercise Therapy
Exercise
Reactive Oxygen Species
NADP
Vascular Smooth Muscle

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Nov 1 2018, In : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Insulin
Glucose
Smooth Muscle Myocytes
9 Citations (Scopus)

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

Yamaguchi, Y., Iribe, G., Kaneko, T., Takahashi, K., Numaga-Tomita, T., Nishida, M., Birnbaumer, L. & Naruse, K., Mar 1 2018, In : Journal of Physiological Sciences. 68, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Cardiac Myocytes
Angiotensin II Type 1 Receptor Blockers
Type C Phospholipases
Knockout Mice
5 Citations (Scopus)

TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy

Sunggip, C., Shimoda, K., Oda, S., Tanaka, T., Nishiyama, K., Mangmool, S., Nishimura, A., Numaga-Tomita, T. & Nishida, M., May 22 2018, In : Frontiers in Pharmacology. 9, MAY, 523.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hypertrophy
Adenosine Triphosphate
NFATC Transcription Factors
Cyclic GMP-Dependent Protein Kinases
2017
6 Citations (Scopus)

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy

Guan, Y., Nakano, D., Zhang, Y., Li, L., Liu, W., Nishida, M., Kuwabara, T., Morishita, A., Hitomi, H., Mori, K., Mukoyama, M., Masaki, T., Hirano, K. & Nishiyama, A., Oct 1 2017, In : Journal of Pharmacological Sciences. 135, 2, p. 81-88 8 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Podocytes
Doxorubicin
Wounds and Injuries
Kidney
77 Citations (Scopus)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S. & 6 others, Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M. & Motohashi, H., Dec 1 2017, In : Nature communications. 8, 1, 1177.

Research output: Contribution to journalArticle

cysteinyl-tRNA synthetase
cysteine
Energy Metabolism
Cysteine
Cysteine Synthase
9 Citations (Scopus)

Exposure to electrophiles impairs reactive persulfide-dependent redox signaling in neuronal cells

Ihara, H., Kasamatsu, S., Kitamura, A., Nishimura, A., Tsutsuki, H., Ida, T., Ishizaki, K., Toyama, T., Yoshida, E., Hamid, H. A., Jung, M., Matsunaga, T., Fujii, S., Sawa, T., Nishida, M., Kumagai, Y. & Akaike, T., Jan 1 2017, In : Chemical Research in Toxicology. 30, 9, p. 1673-1684 12 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Chemical activation
Wounds and Injuries
Metabolites
Sulfhydryl Compounds
15 Citations (Scopus)

MiR30-GALNT1/2 axis-mediated glycosylation contributes to the increased secretion of inactive human prohormone for brain natriuretic peptide (proBNP) from failing hearts

Nakagawa, Y., Nishikimi, T., Kuwahara, K., Fujishima, A., Oka, S., Tsutamoto, T., Kinoshita, H., Nakao, K., Cho, K., Inazumi, H., Okamoto, H., Nishida, M., Kato, T., Fukushima, H., Yamashita, J. K., Wijnen, W. J., Creemers, E. E., Kangawa, K., Minamino, N., Nakao, K. & 1 others, Kimura, T., Jan 1 2017, In : Journal of the American Heart Association. 6, 2, e003601.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Glycosylation
Heart Failure
MicroRNAs
Cyclic GMP

Purinergic signaling in cardiovascular system

Nishimura, A. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 2, p. 84-90 7 p.

Research output: Contribution to journalArticle

Uracil
Cardiovascular System
Adenosine
Signal Transduction
Hypertension
17 Citations (Scopus)

Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac Fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway

Phosri, S., Arieyawong, A., Bunrukchai, K., Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Jun 30 2017, In : Frontiers in Pharmacology. 8, JUN, 428.

Research output: Contribution to journalArticle

Endothelin A Receptors
Phosphatidylinositol 3-Kinases
Adenosine
Endothelin-1
Smooth Muscle
8 Citations (Scopus)

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Shimauchi, T., Numaga-Tomita, T., Ito, T., Nishimura, A., Matsukane, R., Oda, S., Hoka, S., Ide, T., Koitabashi, N., Uchida, K., Sumimoto, H., Mori, Y. & Nishida, M., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
NADPH Oxidase
Doxorubicin
Atrophy
Cardiac Myocytes
Compliance
3 Citations (Scopus)

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Oda, S., Numaga-Tomita, T., Kitajima, N., Toyama, T., Harada, E., Shimauchi, T., Nishimura, A., Ishikawa, T., Kumagai, Y., Birnbaumer, L. & Nishida, M., Dec 1 2017, In : Scientific reports. 7, 1, 7511.

Research output: Contribution to journalArticle

NADPH Oxidase
Hyperglycemia
Heart Failure
Proteins
Reactive Oxygen Species
2016
18 Citations (Scopus)

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T. & Kumagai, Y., Jun 30 2016, In : Scientific reports. 6, 28944.

Research output: Contribution to journalArticle

Signal Transduction
Cell Survival
Apoptosis Regulatory Proteins
Neuroblastoma
Phosphatidylinositol 3-Kinases
27 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
7 Citations (Scopus)

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compoundss

Sawamura, S., Hatano, M., Takada, Y., Hino, K., Kawamura, T., Tanikawa, J., Nakagawa, H., Hase, H., Nakao, A., Hirano, M., Rotrattanadumrong, R., Kiyonaka, S., Mori, M. X., Nishida, M., Hu, Y., Inoue, R., Nagata, R. & Mori, Y., Mar 1 2016, In : Molecular Pharmacology. 89, 3, p. 348-363 16 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Diglycerides
Brain-Derived Neurotrophic Factor
Cations
Neurons
13 Citations (Scopus)

Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner

Mangmool, S., Denkaew, T., Phosri, S., Pinthong, D., Parichatikanond, W., Shimauchi, T. & Nishida, M., Jan 1 2016, In : Molecular Endocrinology. 30, 1, p. 118-132 15 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Cyclic AMP-Dependent Protein Kinases
Insulin
Cardiac Myocytes
3 Citations (Scopus)

Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor

Hagimori, M., Murakami, T., Shimizu, K., Nishida, M., Ohshima, T. & Mukai, T., Jan 1 2016, In : MedChemComm. 7, 5, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

Therapeutic Human Experimentation
HEK293 Cells
Treatment Failure
Heart Failure
Cell Membrane
2 Citations (Scopus)

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation

Numaga-Tomita, T., Nishida, M., Putney, J. W. & Mori, Y., Jan 15 2016, In : Biochemical Journal. 473, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
B-Lymphocytes
Chemical activation
Cells
Lymphocytes
18 Citations (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Dec 19 2016, In : Scientific reports. 6, 39383.

Research output: Contribution to journalArticle

Cardiac Myocytes
Fibrosis
Microtubules
Pressure
Fibroblasts
31 Citations (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Nov 11 2016, In : Scientific reports. 6, 37001.

Research output: Contribution to journalArticle

NADPH Oxidase
Reactive Oxygen Species
Physiological Adaptation
Proteasome Endopeptidase Complex
Cardiac Myocytes
2015
17 Citations (Scopus)

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases

Gentry, L. R., Nishimura, A., Cox, A. D., Martin, T. D., Tsygankov, D., Nishida, M., Elston, T. C. & Der, C. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22851-22861 11 p.

Research output: Contribution to journalArticle

Endopeptidases
GTP Phosphohydrolases
Post Translational Protein Processing
Protein Isoforms
Cell Membrane
11 Citations (Scopus)

Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress

Shinkai, Y., Abiko, Y., Ida, T., Miura, T., Kakehashi, H., Ishii, I., Nishida, M., Sawa, T., Akaike, T. & Kumagai, Y., May 18 2015, In : Chemical Research in Toxicology. 28, 5, p. 838-847 10 p.

Research output: Contribution to journalArticle

Sulfenic Acids
Oxidative stress
Sulfur
Oxidative Stress
Chemical activation
2014

Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species

Nishida, M., Toyama, T., Kumagai, Y. & Numaga-Tomita, T., Jan 1 2014, In : Yakugaku Zasshi. 134, 12, p. 1239-1243 5 p.

Research output: Contribution to journalArticle

Sulfur
Oxidation-Reduction
Nitric Oxide
Homeostasis
Heart Failure
16 Citations (Scopus)

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

Yamada, Y., Kinoshita, H., Kuwahara, K., Nakagawa, Y., Kuwabara, Y., Minami, T., Yamada, C., Shibata, J., Nakao, K., Cho, K., Arai, Y., Yasuno, S., Nishikimi, T., Ueshima, K., Kamakura, S., Nishida, M., Kiyonaka, S., Mori, Y., Kimura, T., Kangawa, K. & 1 others, Nakao, K., Oct 1 2014, In : Cardiovascular research. 104, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

Autonomic Pathways
Cardiac Arrhythmias
Heart Failure
Sudden Death
Nitrendipine
2013
17 Citations (Scopus)

Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca 2+ and permeability response to histamine involves cGMP-dependent protein kinase i and TRPC6 channels

Chen, W., Oberwinkler, H., Werner, F., Ganer, B., Nakagawa, H., Feil, R., Hofmann, F., Schlossmann, J., Dietrich, A., Gudermann, T., Nishida, M., Del Galdo, S., Wieland, T. & Kuhn, M., Sep 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 9, p. 2121-2129 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinase Type I
Cyclic GMP-Dependent Protein Kinases
Atrial Natriuretic Factor
Histamine
Permeability
30 Citations (Scopus)

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Michio, N., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., Nishida, M., Taniguchi, H., Sato, Y., Matsumoto, M., Makoto, T., Kuroda, M., Inoue, K. & Kurose, H., Mar 11 2013, In : Nature communications. 4, 1532.

Research output: Contribution to journalArticle

clearances
Autoimmune Diseases
mice
Cells
proteins
8 Citations (Scopus)

Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice

Nishida, M., Ishikawa, T., Saiki, S., Sunggip, C., Aritomi, S., Harada, E., Kuwahara, K., Hirano, K., Mori, Y. & Kim-Mitsuyama, S., May 3 2013, In : Biochemical and Biophysical Research Communications. 434, 2, p. 210-216 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Endothelial cells
Angiotensin II
Oxidative Stress
Endothelial Cells
28 Citations (Scopus)

β-arrestin2 in Infiltrated Macrophages Inhibits Excessive Inflammation after Myocardial Infarction

Watari, K., Michio, N., Nishida, M., Kim, K. M. & Kurose, H., Jul 8 2013, In : PloS one. 8, 7, e68351.

Research output: Contribution to journalArticle

Macrophages
myocardial infarction
Knockout Mice
macrophages
inflammation
2012
175 Citations (Scopus)

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Nishida, M., Sawa, T., Kitajima, N., Ono, K., Inoue, H., Ihara, H., Motohashi, H., Yamamoto, M., Suematsu, M., Kurose, H., Van Der Vliet, A., Freeman, B. A., Shibata, T., Uchida, K., Kumagai, Y. & Akaike, T., Jan 1 2012, In : Nature Chemical Biology. 8, 8, p. 714-724 11 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Oxidation-Reduction
Anions
Myocardial Infarction
Cell Aging
33 Citations (Scopus)

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent signaling pathways

Michio, N., Chikura, S., Watari, K., Mizuno, N., Mochinaga, K., Mangmool, S., Satoru, K., Ohdo, S., Sato, Y., Ide, T., Nishida, M. & Kurose, H., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35669-35677 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 5
Metoprolol
GTP-Binding Proteins
Fibrosis
Arrestin
35 Citations (Scopus)

Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis

Kan-O, M., Takeya, R., Abe, T., Kitajima, N., Nishida, M., Tominaga, R., Kurose, H. & Sumimoto, H., Sep 15 2012, In : Biology Open. 1, 9, p. 889-896 8 p.

Research output: Contribution to journalArticle

Muscle Development
muscle development
Actins
heart
Myofibrils
17 Citations (Scopus)

Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D. & Sunagawa, K., Jul 1 2012, In : Mitochondrion. 12, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Cardiac Myocytes
Hypertrophy
Mitochondrial DNA
Proteins
2011
25 Citations (Scopus)

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Nishioka, K., Nishida, M., Ariyoshi, M., Jian, Z., Saiki, S., Hirano, M., Michio, N., Sato, Y., Kita, S., Iwamoto, T., Hirano, K., Inoue, R. & Kurose, H., Oct 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2278-2286 9 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Vasoconstriction
Angiotensin II
Phosphorylation
Transient Receptor Potential Channels

Determining the activation of rho as an index of receptor coupling to G12/13 proteins

Michio, N., Ohba, M., Nishida, M. & Kurose, H., Jan 1 2011, In : Methods in Molecular Biology. 746, p. 317-327 11 p.

Research output: Contribution to journalArticle

G12-G13 GTP-Binding Protein alpha Subunits
GTP-Binding Proteins
Heterotrimeric GTP-Binding Proteins
Rho Guanine Nucleotide Exchange Factors
Guanine Nucleotide Exchange Factors
4 Citations (Scopus)

Dual signaling pathways of arterial constriction by extracellular uridine 5′-triphosphate in the rat

Sugihara, M., Morita, H., Matsuda, M., Umebayashi, H., Kajioka, S., Ito, S., Nishida, M., Inoue, R., Futatsuki, T., Yamazaki, J., Mori, Y., Inoue, R., Ito, Y., Abe, K. & Hirata, M., Mar 24 2011, In : Journal of Pharmacological Sciences. 115, 3, p. 293-308 16 p.

Research output: Contribution to journalArticle

Uridine Triphosphate
Constriction
Purinergic P2X1 Receptors
Adenosine Triphosphate
Muscle Cells
37 Citations (Scopus)

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-κB

Nishida, M., Ogushi, M., Suda, R., Toyotaka, M., Saiki, S., Kitajima, N., Michio, N., Kim, K. M., Ide, T., Sato, Y., Inoue, K. & Kurose, H., Apr 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 16, p. 6662-6667 6 p.

Research output: Contribution to journalArticle

Purinergic P2Y2 Receptors
Angiotensin Type 1 Receptor
Down-Regulation
Adenosine Triphosphate
Arrestins
8 Citations (Scopus)

Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity

Tomonari, M., To, H., Nishida, M., Mishima, T., Sasaki, H. & Kurose, H., Mar 24 2011, In : Journal of Pharmacological Sciences. 115, 3, p. 336-345 10 p.

Research output: Contribution to journalArticle

docetaxel
Doxorubicin
Poisons
Cardiotoxicity
Pharmacokinetics
15 Citations (Scopus)

Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB

Nishida, M., Kitajima, N., Saiki, S., Michio, N. & Kurose, H., Aug 1 2011, In : Nitric Oxide - Biology and Chemistry. 25, 2, p. 112-117 6 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Cysteine
Reactive Oxygen Species
Angiotensin II
Reactive Nitrogen Species
40 Citations (Scopus)

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

Kitajima, N., Watanabe, K., Morimoto, S., Sato, Y., Kiyonaka, S., Hoshijima, M., Ikeda, Y., Michio, N., Ide, T., Mori, Y., Kurose, H. & Nishida, M., May 27 2011, In : Biochemical and Biophysical Research Communications. 409, 1, p. 108-113 6 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Calcium-Calmodulin-Dependent Protein Kinases
Reactive Oxygen Species
NADPH Oxidase
Calmodulin
2010
48 Citations (Scopus)

Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells

Numaga, T., Nishida, M., Kiyonaka, S., Kato, K., Katano, M., Mori, E., Kurosaki, T., Inoue, R., Hikida, M., Putney, J. W. & Mori, Y., Mar 15 2010, In : Journal of Cell Science. 123, 6, p. 927-938 12 p.

Research output: Contribution to journalArticle

Diglycerides
Extracellular Signal-Regulated MAP Kinases
Protein Kinase C
B-Lymphocytes
Cell Membrane
90 Citations (Scopus)

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-a signaling in the heart

Kinoshita, H., Kuwahara, K., Nishida, M., Jian, Z., Rong, X., Kiyonaka, S., Kuwabara, Y., Kurose, H., Inoue, R., Mori, Y., Li, Y., Nakagawa, Y., Usami, S., Fujiwara, M., Yamada, Y., Minami, T., Ueshima, K. & Nakao, K., Jun 25 2010, In : Circulation research. 106, 12, p. 1849-1860 12 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Guanylate Cyclase
Atrial Natriuretic Factor
Cardiomegaly
NFATC Transcription Factors
30 Citations (Scopus)

Pertussis toxin up-regulates angiotensin type 1 receptors through toll-like receptor 4-mediated Rac activation

Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Michio, N., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y. & Kurose, H., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15268-15277 10 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Toll-Like Receptor 4
Pertussis Toxin
Up-Regulation
Chemical activation
62 Citations (Scopus)

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

Nishida, M., Watanabe, K., Sato, Y., Michio, N., Kitajima, N., Ide, T., Inoue, R. & Kurose, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13244-13253 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Phosphorylation
Cyclic GMP-Dependent Protein Kinases
Cardiomegaly
Chemical activation