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Research Output 2000 2019

  • 2440 Citations
  • 24 h-Index
  • 31 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Book
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Article
2019
4 Citations (Scopus)

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI99751.

Research output: Contribution to journalArticle

Chromosome Segregation
Mutation
HEK293 Cells
Chromatin
Apoptosis

Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation

Aktar, S., Sasaki, H. & Unoki, M., Nov 1 2019, In : Genes to Cells. 24, 11, p. 746-755 10 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Heterochromatin
Zinc Fingers
AT-Hook Motifs
Transcriptional Activation
2018
7 Citations (Scopus)

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotou, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalArticle

Open Access
2017
18 Citations (Scopus)

Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos

Maenohara, S., Unoki, M., Toh, H., Ohishi, H., Sharif, J., Koseki, H. & Sasaki, H., Oct 2017, In : PLoS genetics. 13, 10, e1007042.

Research output: Contribution to journalArticle

methylation
Blastocyst
DNA methylation
DNA Methylation
Methylation
2015
45 Citations (Scopus)

Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome

Thijssen, P. E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R. J. L. F., De Greef, J. C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Güngör, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B. & 9 others, Iwai, T., Kondo, I., Kubota, T., Van Ostaijen-Ten Dam, M. M., Van Tol, M. J. D., Weemaes, C., Francastel, C., Van Der Maarel, S. M. & Sasaki, H., Jul 28 2015, In : Nature communications. 6, 7870.

Research output: Contribution to journalArticle

mutations
genes
Genes
anomalies
Mutation
2013
72 Citations (Scopus)

Lysyl 5-hydroxylation, a novel histone modification, by jumonji domain containing 6 (JMJD6)

Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6053-6062 10 p.

Research output: Contribution to journalArticle

Histone Code
Hydroxylation
Histones
Hydroxylysine
Acetylation
20 Citations (Scopus)

Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients

Nitta, H., Unoki, M., Ichiyanagi, K., Kosho, T., Shigemura, T., Takahashi, H., Velasco, G., Francastel, C., Picard, C., Kubota, T. & Sasaki, H., Jul 1 2013, In : Journal of Human Genetics. 58, 7, p. 455-460 6 p.

Research output: Contribution to journalArticle

Mutation
Zinc Fingers
Nonsense Codon
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 9
2012
88 Citations (Scopus)

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1

Arita, K., Isogai, S., Oda, T., Unoki, M., Sugita, K., Sekiyama, N., Kuwata, K., Hamamoto, R., Tochio, H., Sato, M., Ariyoshi, M. & Shirakawa, M., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32, p. 12950-12955 6 p.

Research output: Contribution to journalArticle

Epigenomics
Histones
DNA Methylation
Fingers
Histone Code
23 Citations (Scopus)

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer

Kofunato, Y., Kumamoto, K., Saitou, K., Hayase, S., Okayama, H., Miyamoto, K., Sato, Y., Katakura, K., Nakamura, I., Ohki, S., Koyama, Y., Unoki, M. & Takenoshita, S., Dec 1 2012, In : Oncology reports. 28, 6, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Cell Proliferation
Colonic Neoplasms
Neoplasms
Tumor Suppressor Protein p14ARF
2011
24 Citations (Scopus)
Drug Delivery Systems
Epigenomics
Histone Code
DNA Methylation
Neoplasms
113 Citations (Scopus)

Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells

Cho, H. S., Suzuki, T., Dohmae, N., Hayami, S., Unoki, M., Yoshimatsu, M., Toyokawa, G., Takawa, M., Chen, T., Kurash, J. K., Field, H. I., Ponder, B. A. J., Nakamura, Y. & Hamamoto, R., Feb 1 2011, In : Cancer Research. 71, 3, p. 655-660 6 p.

Research output: Contribution to journalArticle

Histone Demethylases
Methylation
Cell Cycle
Neoplasms
Histone-Lysine N-Methyltransferase
174 Citations (Scopus)

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

Yoshimatsu, M., Toyokawa, G., Hayami, S., Unoki, M., Tsunoda, T., Field, H. I., Kelly, J. D., Neal, D. E., Maehara, Y., Ponder, B. A. J., Nakamura, Y. & Hamamoto, R., Feb 1 2011, In : International Journal of Cancer. 128, 3, p. 562-573 12 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Neoplasms
Gene Expression
Post Translational Protein Processing
DNA Replication
285 Citations (Scopus)

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

Hayami, S., Kelly, J. D., Cho, H. S., Yoshimatsu, M., Unoki, M., Tsunoda, T., Field, H. I., Neal, D. E., Yamaue, H., Ponder, B. A. J., Nakamura, Y. & Hamamoto, R., Feb 1 2011, In : International Journal of Cancer. 128, 3, p. 574-586 13 p.

Research output: Contribution to journalArticle

Lysine
Chromatin
Carcinogenesis
Chromatin Assembly and Disassembly
Neoplasms
2010
132 Citations (Scopus)

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway

Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., Field, H. I., Kelly, J. D., Neal, D. E., Yamaue, H., Ponder, B. A. J., Nakamura, Y. & Hamamoto, R., Mar 13 2010, In : Molecular cancer. 9, 59.

Research output: Contribution to journalArticle

Histone Demethylases
Carcinogenesis
Cell Proliferation
Neoplasms
Microarray Analysis
78 Citations (Scopus)

UHRF1 is a novel diagnostic marker of lung cancer

Unoki, M., Daigo, Y., Koinuma, J., Tsuchiya, E., Hamamoto, R. & Nakamura, Y., Jul 13 2010, In : British journal of cancer. 103, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Ubiquitin
Cell Nucleus
2009
31 Citations (Scopus)

ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression

Kumamoto, K., Fujita, K., Kurotani, R., Saito, M., Unoki, M., Hagiwara, N., Shiga, H., Bowman, E. D., Yanaihara, N., Okamura, S., Nagashima, M., Miyamoto, K., Takenoshita, S., Yokota, J. & Harris, C. C., Sep 15 2009, In : International Journal of Cancer. 125, 6, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 13
Growth Inhibitors
Colonic Neoplasms
Up-Regulation
Neoplasm Metastasis
75 Citations (Scopus)

UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer

Unoki, M., Kelly, J. D., Neal, D. E., Ponder, B. A. J., Nakamura, Y. & Hamamoto, R., Jul 7 2009, In : British journal of cancer. 101, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Kidney Neoplasms
Neoplasms
Immunohistochemistry
Muscle Neoplasms
2008
20 Citations (Scopus)

A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis

Unoki, M., Kumamoto, K., Robles, A. I., Shen, J. C., Zheng, Z. M. & Harris, C. C., Nov 26 2008, In : FEBS Letters. 582, 28, p. 3868-3874 7 p.

Research output: Contribution to journalArticle

Cell growth
Cell Cycle Checkpoints
Protein Isoforms
Cells
Apoptosis
47 Citations (Scopus)

Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation

Brunet, J., Pfaff, A. W., Abidi, A., Unoki, M., Nakamura, Y., Guinard, M., Klein, J. P., Candolfi, E. & Mousli, M., Apr 1 2008, In : Cellular Microbiology. 10, 4, p. 908-920 13 p.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Toxoplasma
Parasites
G2 Phase
Cyclin B1
2007
97 Citations (Scopus)

Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin α

Shen, J. C., Unoki, M., Ythier, D., Duperray, A., Varticovski, L., Kumamoto, K., Pedeux, R. & Harris, C. C., Mar 15 2007, In : Cancer Research. 67, 6, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Cell Movement
RNA Interference
Vinculin
Proteins
2006
80 Citations (Scopus)

Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility

Unoki, M., Shen, J. C., Zheng, Z. M. & Harris, C. C., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34677-34686 10 p.

Research output: Contribution to journalArticle

Cell growth
Cell Movement
Nuclear Localization Signals
Cell proliferation
Growth
2004
196 Citations (Scopus)

ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

Unoki, M., Nishidate, T. & Nakamura, Y., Oct 7 2004, In : Oncogene. 23, 46, p. 7601-7610 10 p.

Research output: Contribution to journalArticle

RING Finger Domains
Tumor Suppressor Genes
Tumor Suppressor Protein p14ARF
Type II DNA Topoisomerase
Genetic Promoter Regions
2003
65 Citations (Scopus)

EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK

Unoki, M. & Nakamura, Y., Apr 10 2003, In : Oncogene. 22, 14, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Apoptosis
Cell Line
Caspase 8
Mitochondrial Membranes
26 Citations (Scopus)

Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia.

Unoki, M., Okutsu, J. & Nakamura, Y., Jan 1 2003, In : International journal of oncology. 22, 6, p. 1217-1223 7 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Genes
Zinc Fingers
Apoptosis
Drug Therapy
51 Citations (Scopus)

Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity

Unoki, M. & Nakamura, Y., Nov 6 2003, In : FEBS Letters. 554, 1-2, p. 67-72 6 p.

Research output: Contribution to journalArticle

CpG Islands
Methylation
Introns
Tumors
Genes
2001
17 Citations (Scopus)

Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children

Takeoka, S., Unoki, M., Onouchi, Y., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Inoue, I., Nakamura, Y. & Tamari, M., Apr 2 2001, In : Journal of Human Genetics. 46, 2, p. 57-63 7 p.

Research output: Contribution to journalArticle

Amino Acid Substitution
Asthma
Haplotypes
Single Nucleotide Polymorphism
Genes
74 Citations (Scopus)

Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease

Yamada, R., Tanaka, T., Unoki, M., Nagai, T., Sawada, T., Ohnishi, Y., Tsunoda, T., Yukioka, M., Maeda, A., Suzuki, K., Tateishi, H., Ochi, T., Nakamura, Y. & Yamamoto, K., Jan 1 2001, In : American journal of human genetics. 68, 3, p. 674-685 12 p.

Research output: Contribution to journalArticle

Genetic Loci
Interleukin-3
Disease Susceptibility
Single Nucleotide Polymorphism
Rheumatoid Arthritis
72 Citations (Scopus)

Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous pten

Matsushima-Nishiu, M., Unoki, M., Ono, K., Tsunoda, T., Minaguchi, T., Kuramoto, H., Nishida, M., Satoh, T., Tanaka, T. & Nakamura, Y., May 1 2001, In : Cancer Research. 61, 9, p. 3741-3749 9 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Transcriptome
Growth
Genes
Cell Proliferation
255 Citations (Scopus)

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

Unoki, M. & Nakamura, Y., Jul 27 2001, In : Oncogene. 20, 33, p. 4457-4465 9 p.

Research output: Contribution to journalArticle

Growth
Genes
Neoplasms
Antisense Oligonucleotides
Cell Cycle
8 Citations (Scopus)

Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes

Suzuki, C., Unoki, M. & Nakamura, Y., Apr 23 2001, In : Journal of Human Genetics. 46, 3, p. 155-157 3 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genes
Loss of Heterozygosity
Disease Susceptibility
Endometrial Neoplasms
2000
79 Citations (Scopus)

Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: Positive association of a T924C polymorphism in the thromboxane A2 receptor gene

Unoki, M., Furuta, S., Onouchi, Y., Watanabe, O., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Tamari, M. & Nakamura, Y., Jan 1 2000, In : Human Genetics. 106, 4, p. 440-446 7 p.

Research output: Contribution to journalArticle

Prostaglandin H2 Receptors Thromboxane A2
Single Nucleotide Polymorphism
Asthma
Genes
Medical Genetics