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Research Output 2005 2017

  • 919 Citations
  • 15 h-Index
  • 24 Article
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Article
2017
79 Citations (Scopus)

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

Ikenaga, N., Peng, Z. W., Vaid, K. A., Liu, S. B., Yoshida, S., Sverdlov, D. Y., Mikels-Vigdal, A., Smith, V., Schuppan, D. & Popov, Y. V., Sep 1 2017, In : Gut. 66, 9, p. 1697-1708 12 p.

Research output: Contribution to journalArticle

Open Access
Protein-Lysine 6-Oxidase
Fibrosis
Liver
Hepatocytes
Collagen
2016
36 Citations (Scopus)

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

Peng, Z. W., Ikenaga, N., Liu, S. B., Sverdlov, D. Y., Vaid, K. A., Dixit, R., Weinreb, P. H., Violette, S., Sheppard, D., Schuppan, D. & Popov, Y., Jan 1 2016, In : Hepatology. 63, 1, p. 217-232 16 p.

Research output: Contribution to journalArticle

Open Access
Integrins
Transforming Growth Factor beta
Hepatocytes
Carcinogenesis
Fibrosis
55 Citations (Scopus)

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

Liu, S. B., Ikenaga, N., Peng, Z. W., Sverdlov, D. Y., Greenstein, A., Smith, V., Schuppan, D. & Popov, Y., Apr 1 2016, In : FASEB Journal. 30, 4, p. 1599-1609 11 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Aminopropionitrile
Liver Cirrhosis
Liver
Fibrosis
2015
21 Citations (Scopus)

A new mdr2-/- mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer

Ikenaga, N., Liu, S. B., Sverdlov, D. Y., Yoshida, S., Nasser, I., Ke, Q., Kang, P. M. & Popov, Y., Jan 1 2015, In : American Journal of Pathology. 185, 2, p. 325-334 10 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Portal Hypertension
Liver Neoplasms
Fibrosis
Tumor Burden
2014
54 Citations (Scopus)

Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice

Yoshida, S., Ikenaga, N., Liu, S. B., Peng, Z. W., Chung, J., Sverdlov, D. Y., Miyamoto, M., Kim, Y. O., Ogawa, S., Arch, R. H., Schuppan, D. & Popov, Y., Dec 1 2014, In : Gastroenterology. 147, 6, p. 1378-1392 15 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Platelet-Derived Growth Factor
Proto-Oncogene Proteins c-sis
Platelet Activation
Fibrosis
9 Citations (Scopus)

Mass spectrometry-based metabolic profiling of gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer cells

Fujimura, Y., Ikenaga, N., Ouchida, K., Setoyama, D., Irie, M., Miura, D., Wariishi, H., Murata, M., Mizumoto, K., Hashizume, M. & Tanaka, M., Mar 1 2014, In : Pancreas. 43, 2, p. 311-318 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Mass Spectrometry
Cell Line
Metabolome
5 Citations (Scopus)

Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer

Akagawa, S., Ohuchida, K., Torata, N., Hattori, M., Eguchi, D., Fujiwara, K., Kozono, S., Cui, L., Ikenaga, N., Ohtsuka, T., Aishima, S., Mizumoto, K., Oda, Y. & Tanaka, M., Jul 2014, In : International journal of oncology. 45, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

Myofibroblasts
Pancreatic Neoplasms
Peritoneal Cavity
Neoplasms
Green Fluorescent Proteins
2013
26 Citations (Scopus)

Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor

Eguchi, D., Ikenaga, N., Ohuchida, K., Kozono, S., Cui, L., Fujiwara, K., Fujino, M., Ohtsuka, T., Mizumoto, K. & Tanaka, M., May 15 2013, In : Journal of Surgical Research. 181, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Connective Tissue Growth Factor
Pancreatic Neoplasms
Neoplasms
Hypoxia
15 Citations (Scopus)

Kindlin-1 expression is involved in migration and invasion of pancreatic cancer

Mahawithitwong, P., Ohuchida, K., Ikenaga, N., Fujita, H., Zhao, M., Kozono, S., Shindo, K., Ohtsuka, T., Aishima, S., Mizumoto, K. & Tanaka, M., Apr 1 2013, In : International journal of oncology. 42, 4, p. 1360-1366 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epithelial Cells
Fibroblasts
Cell Line
Messenger RNA
13 Citations (Scopus)

Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma

Mahawithitwong, P., Ohuchida, K., Ikenaga, N., Fujita, H., Zhao, M., Kozono, S., Shindo, K., Ohtsuka, T., Mizumoto, K. & Tanaka, M., May 1 2013, In : Pancreas. 42, 4, p. 663-669 7 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatectomy
Focal Adhesions
Survival
Stomach Neoplasms
10 Citations (Scopus)

MAL2 expression predicts distant metastasis and short survival in pancreatic cancer

Eguchi, D., Ohuchida, K., Kozono, S., Ikenaga, N., Shindo, K., Cui, L., Fujiwara, K., Akagawa, S., Ohtsuka, T., Takahata, S., Tokunaga, S., Mizumoto, K. & Tanaka, M., Sep 1 2013, In : Surgery (United States). 154, 3, p. 573-582 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Survival
Microarray Analysis
Cell Line
12 Citations (Scopus)

Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells

Fujiwara, K., Ohuchida, K., Ohtsuka, T., Mizumoto, K., Shindo, K., Ikenaga, N., Cui, L., Takahata, S., Aishima, S. & Tanaka, M., Nov 1 2013, In : Pancreas. 42, 8, p. 1283-1290 8 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Pancreatic Neoplasms
Polymerase Chain Reaction
Messenger RNA
Epithelial-Mesenchymal Transition
74 Citations (Scopus)

Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells

Kozono, S., Ohuchida, K., Eguchi, D., Ikenaga, N., Fujiwara, K., Cui, L., Mizumoto, K. & Tanaka, M., Apr 1 2013, In : Cancer Research. 73, 7, p. 2345-2356 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
gemcitabine
Neoplasms
Collagen Type I
Pancreatic Stellate Cells
59 Citations (Scopus)

Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma

Yoshida, S., Kornek, M., Ikenaga, N., Schmelzle, M., Masuzaki, R., Csizmadia, E., Wu, Y., Robson, S. C. & Schuppan, D., Nov 1 2013, In : Hepatology. 58, 5, p. 1667-1680 14 p.

Research output: Contribution to journalArticle

Open Access
Epithelial-Mesenchymal Transition
Hepatocellular Carcinoma
Hot Temperature
Therapeutics
Nude Mice
2012
Pancreatic Neoplasms
Epidemiology
Neoplasms
Pancreatic Carcinoma
11 Citations (Scopus)

CD271+ Subpopulation of Pancreatic Stellate Cells Correlates with Prognosis of Pancreatic Cancer and Is Regulated by Interaction with Cancer Cells

Fujiwara, K., Ohuchida, K., Mizumoto, K., Shindo, K., Eguchi, D., Kozono, S., Ikenaga, N., Ohtsuka, T., Takahata, S., Aishima, S. & Tanaka, M., Dec 27 2012, In : PloS one. 7, 12, e52682.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
pancreatic neoplasms
Pancreatic Neoplasms
prognosis
Cells
24 Citations (Scopus)

Pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition

Ikenaga, N., Ohuchida, K., Mizumoto, K., Akagawa, S., Fujiwara, K., Eguchi, D., Kozono, S., Ohtsuka, T., Takahata, S. & Tanaka, M., Jul 5 2012, In : PloS one. 7, 7, e40434.

Research output: Contribution to journalArticle

pancreatic neoplasms
Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
collagen
Collagen
2011
101 Citations (Scopus)

MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis

Nakata, K., Ohuchida, K., Mizumoto, K., Kayashima, T., Ikenaga, N., Sakai, H., Lin, C., Fujita, H., Otsuka, T., Aishima, S., Nagai, E., Oda, Y. & Tanaka, M., Nov 1 2011, In : Surgery. 150, 5, p. 916-922 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Pancreatic Neoplasms
Cell Line
Paraffin
Formaldehyde
2010
104 Citations (Scopus)

CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer

Ikenaga, N., Ohuchida, K., Mizumoto, K., Cui, L., Kayashima, T., Morimatsu, K., Moriyama, T., Nakata, K., Fujita, H. & Tanaka, M., Sep 2010, In : Gastroenterology. 139, 3, p. 1041-1051.e8

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Pancreatic Neoplasms
Matrix Metalloproteinase 3
Adenocarcinoma
27 Citations (Scopus)

Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas

Ikenaga, N., Ohuchida, K., Mizumoto, K., Yu, J., Kayashima, T., Hayashi, A., Nakata, K. & Tanaka, M., Oct 1 2010, In : Human Pathology. 41, 10, p. 1466-1474 9 p.

Research output: Contribution to journalArticle

Pancreatic Ductal Carcinoma
Mucinous Adenocarcinoma
Papillary Carcinoma
Pancreatic Neoplasms
Carcinoma, Intraductal, Noninfiltrating
51 Citations (Scopus)

Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells

Moriyama, T., Ohuchida, K., Mizumoto, K., Cui, L., Ikenaga, N., Sato, N. & Tanaka, M., Jul 15 2010, In : Cancer. 116, 14, p. 3357-3368 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Pancreatic Neoplasms
Cell Movement
Aptitude
Neoplastic Stem Cells
94 Citations (Scopus)

MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma

Ikenaga, N., Ohuchida, K., Mizumoto, K., Yu, J., Kayashima, T., Sakai, H., Fujita, H., Nakata, K. & Tanaka, M., Dec 1 2010, In : Annals of Surgical Oncology. 17, 12, p. 3120-3128 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Adenocarcinoma
Chronic Pancreatitis
Pancreas
Survival
2009
31 Citations (Scopus)

S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma

Ikenaga, N., Ohuchida, K., Mizumoto, K., Yu, J., Fujita, H., Nakata, K., Ueda, J., Sato, N., Nagai, E. & Tanaka, M., Sep 1 2009, In : Journal of Gastrointestinal Surgery. 13, 10, p. 1852-1858 7 p.

Research output: Contribution to journalArticle

Messenger RNA
Pancreatic Neoplasms
Ductal Carcinoma
Neoplasms
Paraffin
2005
8 Citations (Scopus)

A minute nonfunctioning islet cell tumor demonstrating malignant features

Ikenaga, N., Yamaguchi, K., Konomi, H., Fujii, K., Sugitani, A. & Tanaka, M., Feb 1 2005, In : Journal of Hepato-Biliary-Pancreatic Surgery. 12, 1, p. 84-87 4 p.

Research output: Contribution to journalArticle

Islet Cell Carcinoma
Islet Cell Adenoma
Neoplasms
Pancreatic Hormones
Pancreatectomy