• 4545 Citations
  • 39 h-Index
20002020

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Article
2006

Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization

Egashira, N., Matsumoto, Y., Mishima, K., Iwasaki, K., Fujioka, M., Matsushita, M., Shoyama, Y., Nishimura, R. & Fujiwara, M., Jan 1 2006, In : Pharmacology Biochemistry and Behavior. 83, 1, p. 161-167 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats

Ikeda, T., Mishima, K., Aoo, N., Harada, K., An, X. L., Egashira, N., Iwasaki, K., Fujiwara, M. & Ikenoue, T., Jan 1 2006, In : Pediatric Research. 59, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2007

2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Δ9- tetrahydrocannabinol-induced catalepsy-like immobilization in mice

Egashira, N., Koushi, E., Mishima, K., Iwasaki, K., Oishi, R. & Fujiwara, M., Dec 1 2007, In : Journal of Pharmacological Sciences. 105, 4, p. 361-366 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion

Hatip-Al-Khatib, I., Iwasaki, K., Egashira, N., Ishibashi, D., Mishima, K. & Fujiwara, M., Feb 2 2007, In : Journal of Pharmacological Sciences. 103, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism

Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Irie, K., Fujioka, M., Orito, K., Abe, K., Hasebe, N., Egashira, N., Iwasaki, K. & Fujiwara, M., Sep 1 2007, In : Journal of Neurochemistry. 102, 5, p. 1488-1496 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Effect of Toki-Shakuyaku-San on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats

Hatip-Al-Khatib, I., Hatip, F. B., Yoshimitsu, Y., Iwasaki, K., Egashira, N., Liu, A. X., Mishima, K. & Fujiwara, M., Mar 1 2007, In : Phytotherapy Research. 21, 3, p. 291-294 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor

Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Aoyama, Y., Ogata, A., Harada, K., Fujioka, M., Abe, K., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 6 2007, In : Neuroscience Letters. 414, 2, p. 183-187 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice

Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., Mishima, K., Iwasaki, K. & Fujiwara, M., Mar 12 2007, In : Behavioural Brain Research. 178, 1, p. 123-127 5 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Involvement of both tumor necrosis factor-α-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin

Yano, T., Itoh, Y., Matsuo, M., Kawashiri, T., Egashira, N. & Oishi, R., Oct 1 2007, In : Apoptosis. 12, 10, p. 1901-1909 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Egashira, N., Hayakawa, K., Osajima, M., Mishima, K., Iwasaki, K., Oishi, R. & Fujiwara, M., Nov 20 2007, In : Journal of Pharmacological Sciences. 105, 2, p. 211-214 4 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: Comparison with paroxetine

Egashira, N., Harada, S., Okuno, R., Matsushita, M., Nishimura, R., Mishima, K., Iwasaki, K., Orito, K. & Fujiwara, M., Jun 1 2007, In : European Journal of Pharmacology. 563, 1-3, p. 149-154 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats

Egashira, N., Manome, N., Kurauchi, K., Matsumoto, Y., Iwasaki, K., Mishima, K., Shoyama, Y. & Fujiwara, M., Feb 1 2007, In : Phytotherapy Research. 21, 2, p. 126-129 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats

Pu, F., Mishima, K., Irie, K., Motohashi, K., Tanaka, Y., Orito, K., Egawa, T., Kitamura, Y., Egashira, N., Iwasaki, K. & Fujiwara, M., Sep 13 2007, In : Journal of Pharmacological Sciences. 104, 4, p. 329-334 6 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats

Iwasaki, K., Egashira, N., Takagaki, Y., Yoshimitsu, Y., Hatip-Al-Khatib, I., Mishima, K. & Fujiwara, M., Apr 1 2007, In : Biological and Pharmaceutical Bulletin. 30, 4, p. 698-701 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Prenatal exposure to 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) promotes anxiogenic behavior in rats

Orito, K., Gotanda, N., Murakami, M., Ikeda, T., Egashira, N., Mishima, K. & Fujiwara, M., Jun 5 2007, In : Tohoku Journal of Experimental Medicine. 212, 2, p. 151-157 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Repeated treatment with cannabidiol but not Δ9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

Hayakawa, K., Mishima, K., Nozako, M., Ogata, A., Hazekawa, M., Liu, A. X., Fujioka, M., Abe, K., Hasebe, N., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 1 2007, In : Neuropharmacology. 52, 4, p. 1079-1087 9 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Tokishakuyakusan: Pharmacological evidence for neuroactive and neuroprotective actions

Fujiwara, M., Egashira, N., Mishima, K., Iwasaki, K. & Egashira, N., Jan 1 2007, In : Journal of Traditional Medicines. 24, 5, p. 149-155 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Δ9-tetrahydrocannabinol (Δ9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia

Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Ogata, A., Fujioka, M., Harada, K., Mishima, S., Orito, K., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 27 2007, In : Life Sciences. 80, 16, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2008

Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms

Egashira, N., Okuno, R., Matsushita, M., Abe, M., Mishima, K., Iwasaki, K., Nishimura, R., Oishi, R. & Fujiwara, M., Sep 11 2008, In : European Journal of Pharmacology. 592, 1-3, p. 103-108 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Calcium-channel antagonists inhibit marble-burying behavior in mice

Egashira, N., Okuno, R., Abe, M., Matsushita, M., Mishima, K., Iwasaki, K., Oishi, R., Nishimura, R., Matsumoto, Y. & Fujiwara, M., Oct 6 2008, In : Journal of Pharmacological Sciences. 108, 1, p. 140-143 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cannabidiol potentiates pharmacological effects of Δ9-tetrahydrocannabinol via CB1 receptor-dependent mechanism

Hayakawa, K., Mishima, K., Hazekawa, M., Sano, K., Irie, K., Orito, K., Egawa, T., Kitamura, Y., Uchida, N., Nishimura, R., Egashira, N., Iwasaki, K. & Fujiwara, M., Jan 10 2008, In : Brain Research. 1188, 1, p. 157-164 8 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism

Hayakawa, K., Mishima, K., Irie, K., Hazekawa, M., Mishima, S., Fujioka, M., Orito, K., Egashira, N., Katsurabayashi, S., Takasaki, K., Iwasaki, K. & Fujiwara, M., Dec 1 2008, In : Neuropharmacology. 55, 8, p. 1280-1286 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Characteristics of gabexate mesilate-induced cell injury in porcine aorta endothelial cells

Aki, T., Egashira, N., Hama, M., Yamauchi, Y., Yano, T., Itoh, Y. & Oishi, R., Apr 8 2008, In : Journal of Pharmacological Sciences. 106, 3, p. 415-422 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells

Yano, T., Itoh, Y., Yamada, M., Egashira, N. & Oishi, R., Apr 1 2008, In : Apoptosis. 13, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism

Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Mishima, S., Fujioka, M., Orito, K., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 1 2008, In : Stroke. 39, 3, p. 951-958 8 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Effects of glutamate-related drugs on marble-burying behavior in mice: Implications for obsessive-compulsive disorder

Egashira, N., Okuno, R., Harada, S., Matsushita, M., Mishima, K., Iwasaki, K., Nishimura, R., Oishi, R. & Fujiwara, M., May 31 2008, In : European Journal of Pharmacology. 586, 1-3, p. 164-170 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs

Orito, K., Saito, M., Fukunaga, K., Matsuo, E., Takikawa, S., Muto, M., Mishima, K., Egashira, N. & Fujiwara, M., Jun 1 2008, In : Journal of Veterinary Pharmacology and Therapeutics. 31, 3, p. 259-264 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Protection against the extravasation of anticancer drugs by standardization of the management system

Watanabe, H., Ikesue, H., Yoshida, M., Yamamoto, N., Sakamoto, S., Koga, T., Sueyasu, M., Egashira, N., Inoshima, I., Nakanishi, Y. & Oishi, R., Jul 1 2008, In : Hospital Pharmacy. 43, 7, p. 571-576 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Protective effects of amino acids against Gabexate mesilate-induced cell injury in porcine-aorta endothelial cells

Aki, T., Egashira, N., Yamauchi, Y., Hama, M., Yano, T., Itoh, Y., Yamada, T. & Oishi, R., Jul 28 2008, In : Journal of Pharmacological Sciences. 107, 3, p. 238-245 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex

Egashira, N., Iwasaki, K., Ishibashi, A., Hayakawa, K., Okuno, R., Abe, M., Uchida, N., Mishima, K., Takasaki, K., Nishimura, R., Oishi, R. & Fujiwara, M., Aug 1 2008, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32, 6, p. 1516-1520 5 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Schizandrin reverses memory impairment in rats

Egashira, N., Kurauchi, K., Iwasaki, K., Mishima, K., Orito, K., Oishi, R. & Fujiwara, M., Jan 1 2008, In : Phytotherapy Research. 22, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats

Watanabe, T., Iwasaki, K., Ishikane, S., Naitou, T., Yoshimitsu, Y., Yamagata, N., Ozdemir, M. B., Takasaki, K., Egashira, N., Mishima, K. & Fujiwara, M., Feb 1 2008, In : Journal of Pharmacological Sciences. 106, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

Egashira, N., Ishigami, N., Pu, F., Mishima, K., Iwasaki, K., Orito, K., Oishi, R. & Fujiwara, M., Jan 1 2008, In : Phytotherapy Research. 22, 1, p. 65-68 4 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Δ9-Tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons

Sano, K., Mishima, K., Koushi, E., Orito, K., Egashira, N., Irie, K., Takasaki, K., Katsurabayashi, S., Iwasaki, K., Uchida, N., Egawa, T., Kitamura, Y., Nishimura, R. & Fujiwara, M., Jan 24 2008, In : Neuroscience. 151, 2, p. 320-328 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Δ9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats

Egashira, N., Ishigami, N., Mishima, K., Iwasaki, K., Oishi, R. & Fujiwara, M., Feb 15 2008, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32, 2, p. 499-506 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Δ9-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: Involvement of cannabinoid CB1 receptor and serotonergic system

Egashira, N., Matsuda, T., Koushi, E., Higashihara, F., Mishima, K., Chidori, S., Hasebe, N., Iwasaki, K., Nishimura, R., Oishi, R. & Fujiwara, M., Jul 28 2008, In : European Journal of Pharmacology. 589, 1-3, p. 117-121 5 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2009
31 Citations (Scopus)

Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease

Watanabe, T., Yamagata, N., Takasaki, K., Sano, K., Hayakawa, K., Katsurabayashi, S., Egashira, N., Mishima, K., Iwasaki, K. & Fujiwara, M., Jan 16 2009, In : Brain Research. 1249, p. 222-228 7 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress

Sano, K., Koushi, E., Irie, K., Higuchi, S., Tsuchihashi, R., Kinjo, J., Egashira, N., Oishi, R., Uchida, N., Nagai, H., Nishimura, R., Tanaka, H., Morimoto, S., Mishima, K., Iwasaki, K. & Fujiwara, M., Dec 1 2009, In : Biological and Pharmaceutical Bulletin. 32, 12, p. 2065-2067 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats

Pu, F., Motohashi, K., Kaneko, T., Tanaka, Y., Manome, N., Irie, K., Takata, J., Egashira, N., Oishi, R., Okamoto, T., Sei, Y., Yokozawa, T., Mishima, K., Iwasaki, K. & Fujiwara, M., Jun 22 2009, In : Journal of Pharmacological Sciences. 109, 3, p. 424-430 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy

Kawashiri, T., Egashira, N., Itoh, Y., Shimazoe, T., Ikegami, Y., Yano, T., Yoshimura, M. & Oishi, R., Jan 1 2009, In : European Journal of Cancer. 45, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Oxaliplatin-induced neuropathy in the rat: Involvement of oxalate in cold hyperalgesia but not mechanical allodynia

Sakurai, M., Egashira, N., kawashiri, T., Yano, T., Ikesue, H. & Oishi, R., Dec 15 2009, In : Pain. 147, 1-3, p. 165-174 10 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Reduced motor and sensory functions and emotional response in GM3-only mice: Emergence from early stage of life and exacerbation with aging

Tajima, O., Egashira, N., Ohmi, Y., Fukue, Y., Mishima, K., Iwasaki, K., Fujiwara, M., Inokuchi, J., Sugiura, Y., Furukawa, K. & Furukawa, K., Mar 2 2009, In : Behavioural Brain Research. 198, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents

Uchida, N., Egashira, N., Iwasaki, K., Ishibashi, A., Tashiro, R., Nogami, A., Manome, N., Abe, M., Takasaki, K., Mishima, K., Takata, J., Oishi, R., Nishimura, R. & Fujiwara, M., Mar 1 2009, In : Biological and Pharmaceutical Bulletin. 32, 3, p. 372-375 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2010

Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia

Pu, F., Kaneko, T., Enoki, M., Irie, K., Okamoto, T., Sei, Y., Egashira, N., Oishi, R., Mishima, K., Kamimura, H., Iwasaki, K. & Fujiwara, M., Apr 1 2010, In : Journal of Natural Medicines. 64, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse

Egashira, N., Koushi, E., Okuno, R., Shirakawa, A., Mishima, K., Iwasaki, K., Oishi, R. & Fujiwara, M., May 1 2010, In : Behavioural Brain Research. 209, 1, p. 142-147 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells

Maeda, A., Yano, T., Itoh, Y., Kakumori, M., Kubota, T., Egashira, N. & Oishi, R., Jan 1 2010, In : Atherosclerosis. 208, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice

Tajima, O., Egashira, N., Ohmi, Y., Fukue, Y., Mishima, K., Iwasaki, K., Fujiwara, M., Sugiura, Y., Furukawa, K. & Furukawa, K., Jan 5 2010, In : Behavioural Brain Research. 206, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats

Egashira, N., Hirakawa, S., Kawashiri, T., Yano, T., Ikesue, H. & Oishi, R., Apr 16 2010, In : Journal of Pharmacological Sciences. 112, 4, p. 473-476 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion

Hazekawa, M., Kataoka, A., Hayakawa, K., Uchimasu, T., Furuta, R., Irie, K., Akitake, Y., Yoshida, M., Fujioka, T., Egashira, N., Oishi, R., Mishima, K., Mishima, K., Uchida, T., Iwasaki, K. & Fujiwara, M., Jun 1 2010, In : Journal of Health Science. 56, 3, p. 296-303 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)