• 4504 Citations
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20002020

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Article
2007

Prenatal exposure to 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) promotes anxiogenic behavior in rats

Orito, K., Gotanda, N., Murakami, M., Ikeda, T., Egashira, N., Mishima, K. & Fujiwara, M., Jun 5 2007, In : Tohoku Journal of Experimental Medicine. 212, 2, p. 151-157 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Repeated treatment with cannabidiol but not Δ9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

Hayakawa, K., Mishima, K., Nozako, M., Ogata, A., Hazekawa, M., Liu, A. X., Fujioka, M., Abe, K., Hasebe, N., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 1 2007, In : Neuropharmacology. 52, 4, p. 1079-1087 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Tokishakuyakusan: Pharmacological evidence for neuroactive and neuroprotective actions

Fujiwara, M., Egashira, N., Mishima, K., Iwasaki, K. & Egashira, N., Jan 1 2007, In : Journal of Traditional Medicines. 24, 5, p. 149-155 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Δ9-tetrahydrocannabinol (Δ9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia

Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Ogata, A., Fujioka, M., Harada, K., Mishima, S., Orito, K., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 27 2007, In : Life Sciences. 80, 16, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2006

Antagonistic effects of methanolic extract of Polygala telephioides on morphine responses in mice

Egashira, N., Li, J. C., Mizuki, A., Yamauchi, K., Matsuda, T., Osajima, M., Matsushita, M., Mishima, K., Iwasaki, K., Hara, S., Ono, N., Nishimura, R., Nohara, T. & Fujiwara, M., Mar 8 2006, In : Journal of Ethnopharmacology. 104, 1-2, p. 193-198 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Antipsychotics improve Δ9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice

Nagai, H., Egashira, N., Sano, K., Ogata, A., Mizuki, A., Mishima, K., Iwasaki, K., Shoyama, Y., Nishimura, R. & Fujiwara, M., Jun 1 2006, In : Pharmacology Biochemistry and Behavior. 84, 2, p. 330-336 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Cerebral ischemia combined with β-amyloid impairs spatial memory in the eight-arm radial maze task in rats

Iwasaki, K., Egashira, N., Hatip-Al-Khatib, I., Akiyoshi, Y., Arai, T., Takagaki, Y., Watanabe, T., Mishima, K. & Fujiwara, M., Jun 30 2006, In : Brain Research. 1097, 1, p. 216-223 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: Neuronal degeneration, memory disturbance, and phenotypic variation

Murakami, T., Paitel, E., Kawarabayashi, T., Ikeda, M., Chishti, M. A., Janus, C., Matsubara, E., Sasaki, A., Kawarai, T., Phinney, A. L., Harigaya, Y., Horne, P., Egashira, N., Mishima, K., Hanna, A., Yang, J., Iwasaki, K., Takahashi, M., Fujiwara, M., Ishiguro, K. & 6 others, Bergeron, C., Carlson, G. A., Abe, K., Westaway, D., St. George-Hyslop, P. & Shoji, M., Oct 2006, In : American Journal of Pathology. 169, 4, p. 1365-1375 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice

Umeda, K., Suemaru, K., Todo, N., Egashira, N., Mishima, K., Iwasaki, K., Fujiwara, M. & Araki, H., Dec 28 2006, In : European Journal of Pharmacology. 553, 1-3, p. 157-162 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice

Umehara, F., Mishima, K., Egashira, N., Ogata, A., Iwasaki, K. & Fujiwara, M., Nov 1 2006, In : Behavioural Brain Research. 174, 1, p. 167-173 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: Involvement of 5-HT1A receptors in the dorsal hippocampus in rats

Egashira, N., Yano, A., Ishigami, N., Mishima, K., Iwasaki, K., Fujioka, M., Matsushita, M., Nishimura, R. & Fujiwara, M., Jan 19 2006, In : Brain Research. 1069, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Involvement of 5-hydroxytryptamine1A receptors in Δ9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice

Egashira, N., Matsuda, T., Koushi, E., Mishima, K., Iwasaki, K., Shoyama, Y. & Fujiwara, M., Nov 21 2006, In : European Journal of Pharmacology. 550, 1-3, p. 117-122 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization

Egashira, N., Matsumoto, Y., Mishima, K., Iwasaki, K., Fujioka, M., Matsushita, M., Shoyama, Y., Nishimura, R. & Fujiwara, M., Jan 1 2006, In : Pharmacology Biochemistry and Behavior. 83, 1, p. 161-167 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats

Ikeda, T., Mishima, K., Aoo, N., Harada, K., An, X. L., Egashira, N., Iwasaki, K., Fujiwara, M. & Ikenoue, T., Jan 1 2006, In : Pediatric Research. 59, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2005

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice

Egashira, N., Iwasaki, K., Takashima, A., Watanabe, T., Kawabe, H., Matsuda, T., Mishima, K., Chidori, S., Nishimura, R. & Fujiwara, M., Oct 12 2005, In : Brain Research. 1059, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism

Mishima, K., Hayakawa, K., Abe, K., Ikeda, T., Egashira, N., Iwasaki, K. & Fujiwara, M., May 1 2005, In : Stroke. 36, 5, p. 1071-1076 6 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats

Ikeda, T., Mishima, K., Aoo, N., Liu, A. X., Egashira, N., Iwasaki, K., Fujiwara, M. & Ikenoue, T., Mar 2005, In : American Journal of Obstetrics and Gynecology. 192, 3, p. 719-726 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Differential effects of buckwheat and kudingcha extract on neuronal damage in cultured hippocampal neurons and spatial memory impairment induced by scopolamine in an eight-arm radial maze

Pu, F., Mishima, K., Irie, K., Egashira, N., Ishibashi, D., Matsumoto, Y., Ikeda, T., Iwasaki, K., Fujii, H., Kosuna, K. & Fujiwara, M., Dec 2005, In : Journal of Health Science. 51, 6, p. 636-644 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: Reversal by antipsychotic drugs

Egashira, N., Tanoue, A., Higashihara, F., Fuchigami, H., Sano, K., Mishima, K., Fukue, Y., Nagai, H., Takano, Y., Tsujimoto, G., Stemmelin, J., Griebel, G., Iwasaki, K., Ikeda, T., Nishimura, R. & Fujiwara, M., Nov 1 2005, In : Neuropsychopharmacology. 30, 11, p. 1996-2005 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats

Hatip-Al-Khatib, I., Iwasaki, K., Yoshimitsu, Y., Arai, T., Egashira, N., Mishima, K., Ikeda, T. & Fujiwara, M., Dec 1 2005, In : British Journal of Pharmacology. 145, 8, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory impairment

Mishima, K., Ikeda, T., Aoo, N., Takai, N., Takahashi, S., Egashira, N., Ikenoue, T., Iwasaki, K. & Fujiwara, M., Mar 16 2005, In : Neuroscience Letters. 376, 3, p. 194-199 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats

Katsuragi, S., Ikeda, T., Date, I., Shingo, T., Yasuhara, T., Mishima, K., Aoo, N., Harada, K., Egashira, N., Iwasaki, K., Fujiwara, M. & Ikenoue, T., Apr 2005, In : American Journal of Obstetrics and Gynecology. 192, 4, p. 1028-1037 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: Implications for obsessive-compulsive disorder

Matsushita, M., Egashira, N., Harada, S., Okuno, R., Mishima, K., Iwasaki, K., Nishimura, R. & Fujiwara, M., Nov 7 2005, In : Journal of Pharmacological Sciences. 99, 2, p. 154-159 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Post-ischemic treatment with Toki-shakuyaku-san (Tang-Gui-Shao-Yao-San) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats

Pu, F., Mishima, K., Egashira, N., Akiyoshi, Y., Liu, A. X., Sano, K., Irie, K., Ishibashi, D., Hatip-Al-Khatib, I., Iwasaki, K., Kurauchi, K., Iwasaki, K. & Fujiwara, M., Jul 13 2005, In : American Journal of Chinese Medicine. 33, 3, p. 475-489 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons

Egashira, N., Iwasaki, K., Akiyoshi, Y., Takagaki, Y., Hatip-Al-Khatib, I., Mishima, K., Kurauchi, K., Ikeda, T. & Fujiwara, M., May 1 2005, In : Phytotherapy Research. 19, 5, p. 450-453 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy

Noor, J. I., Ikeda, T., Mishima, K., Aoo, N., Ohta, S., Egashira, N., Iwasaki, K., Fujiwara, M. & Ikenoue, T., Nov 1 2005, In : Stroke. 36, 11, p. 2468-2474 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2004

Anandamide inhibits the DOI-induced head-twitch response in mice

Egashira, N., Mishima, K., Uchida, T., Hasebe, N., Nagai, H., Mizuki, A., Iwasaki, K., Ishii, H., Nishimura, R., Shoyama, Y. & Fujiwara, M., Feb 1 2004, In : Psychopharmacology. 171, 4, p. 382-389 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism

Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., Ikeda, T., Inui, K., Egashira, N., Iwasaki, K. & Fujiwara, M., Oct 25 2004, In : NeuroReport. 15, 15, p. 2381-2385 5 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Characteristics of behavioral abnormalities in α1d- adrenoceptors deficient mice

Mishima, K., Tanoue, A., Tsuda, M., Hasebe, N., Fukue, Y., Egashira, N., Takano, Y., Kamiya, H. O., Tsujimoto, G., Iwasaki, K. & Fujiwara, M., Jul 9 2004, In : Behavioural Brain Research. 152, 2, p. 365-373 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage

Ikeda, T., Mishima, K., Aoo, N., Egashira, N., Iwasaki, K., Fujiwara, M. & Ikenoue, T., Dec 1 2004, In : American Journal of Obstetrics and Gynecology. 191, 6, p. 2132-2141 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats

Hatip-Al-Khatib, I., Takashi, A., Egashira, N., Iwasaki, K. & Fujiwara, M., Jun 25 2004, In : Brain Research. 1012, 1-2, p. 169-176 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test

Hatip-Al-Khatib, I., Egashira, N., Mishima, K., Iwasaki, K., Iwasaki, K., Kurauchi, K., Inui, K., Ikeda, T. & Fujiwara, M., Sep 1 2004, In : Journal of Pharmacological Sciences. 96, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats

Mishima, K., Ikeda, T., Yoshikawa, T., Aoo, N., Egashira, N., Xia, Y. X., Ikenoue, T., Iwasaki, K. & Fujiwara, M., May 5 2004, In : Behavioural Brain Research. 151, 1-2, p. 209-217 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia

Hatip-Al-Khatib, I., Iwasaki, K., Chung, E. H., Egashira, N., Mishima, K. & Fujiwara, M., Sep 3 2004, In : Life Sciences. 75, 16, p. 1967-1978 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice

Egashira, N., Hayakawa, K., Mishima, K., Kimura, H., Iwasaki, K. & Fujiwara, M., Jun 3 2004, In : Neuroscience Letters. 363, 1, p. 58-61 4 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats

Iwasaki, K., Chung, E. H., Egashira, N., Hatip-Al-Khatib, I., Mishima, K., Egawa, T., Irie, K. & Fujiwara, M., Jan 2 2004, In : Brain Research. 995, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Ovariectomy combined with amyloid β1-42 impairs memory by decreasing acetylcholine release and α7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats

Iwasaki, K., Hatip-Al-Khatib, I., Egashira, N., Akiyoshi, Y., Arai, T., Mishima, K., Takagaki, Y., Inui, K. & Fujiwara, M., Dec 1 2004, In : Neurotoxicity Research. 6, 4, p. 299-309 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Protection by buckwheat polyphenols of cell death induced by glutamate and kainate in cultured hippocampal neurons

Fengling, P., Mishima, K., Irie, K., Egashira, N., Iwasaki, K., Fujiwara, M., Ikeda, T., Fujii, H. & Kosuna, K., Jan 1 2004, In : Journal of Traditional Medicines. 21, 3, p. 143-146 4 p.

Research output: Contribution to journalArticle

Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated with Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia

Pu, F., Mishima, K., Egashira, N., Iwasaki, K., Kaneko, T., Uchida, T., Irie, K., Ishibashi, D., Fujii, H., Kosuna, K. & Fujiwara, M., Apr 1 2004, In : Journal of Pharmacological Sciences. 94, 4, p. 393-402 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Inui, K., Egashira, N., Mishima, K., Yano, A., Matsumoto, Y., Hasebe, N., Abe, K., Hayakawa, K., Ikeda, T., Iwasaki, K. & Fujiwara, M., Dec 1 2004, In : Neurotoxicity Research. 6, 2, p. 153-157 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze

Egashira, N., Tanoue, A., Higashihara, F., Mishima, K., Fukue, Y., Takano, Y., Tsujimoto, G., Iwasaki, K. & Fujiwara, M., Feb 19 2004, In : Neuroscience Letters. 356, 3, p. 195-198 4 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
2003

Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze

Mishima, K., Tsukikawa, H., Miura, I., Inada, K., Abe, K., Matsumoto, Y., Egashira, N., Iwasaki, K. & Fujiwara, M., Mar 2003, In : Neuropharmacology. 44, 4, p. 541-552 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats

Iwasaki, K., Mishima, K., Egashira, N., Al-Khatib, I. H., Ishibashi, D., Irie, K., Kobayashi, H., Egawa, T. & Fujiwara, M., Oct 1 2003, In : Journal of Pharmacological Sciences. 93, 2, p. 188-196 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
8 Citations (Scopus)

Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice

Mishima, K., Tanaka, T., Pu, F., Egashira, N., Iwasaki, K., Hidaka, R., Matsunaga, K., Takata, J., Karube, Y. & Fujiwara, M., Jan 30 2003, In : Neuroscience Letters. 337, 1, p. 56-60 5 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)
2002

Hypoxia enhances β-amyloid-induced apoptosis in rat cultured hippocampal neurons

Egashira, N., Iwasaki, K., Ishibashi, M., Hatip-Al-Khatib, I., Wolozin, B., Mishima, K., Irie, K. & Fujiwara, M., Dec 1 2002, In : Japanese Journal of Pharmacology. 90, 4, p. 321-327 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents

Egawa, T., Mishima, K., Egashira, N., Fukuzawa, M., Abe, K., Yae, T., Iwasaki, K. & Fujiwara, M., Feb 1 2002, In : Behavioural Brain Research. 129, 1-2, p. 31-39 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Intracerebral microinjections of Δ9-tetrahydrocannabinol: Search for the impairment of spatial memory in the eight-arm radial maze in rats

Egashira, N., Mishima, K., Iwasaki, K. & Fujiwara, M., Oct 18 2002, In : Brain Research. 952, 2, p. 239-245 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Involvement of 5-hydroxytryptamine neuronal system in Δ9-tetrahydrocannabinol-induced impairment of spatial memory

Egashira, N., Mishima, K., Katsurabayashi, S., Yoshitake, T., Matsumoto, Y., Ishida, J., Yamaguchi, M., Iwasaki, K. & Fujiwara, M., Jun 12 2002, In : European Journal of Pharmacology. 445, 3, p. 221-229 9 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia

Irie, K., Mishima, K., Ishibashi, D., Egashira, N., Iwasaki, K. & Fujiwara, M., Dec 20 2002, In : Life Sciences. 72, 4-5, p. 621-629 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)