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Research Output 2003 2019

  • 1532 Citations
  • 20 h-Index
  • 43 Article
  • 3 Review article
  • 1 Editorial
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Article
2019
2 Citations (Scopus)

Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect: A possible role of SGLT2 in mesangial cells

Maki, T., Maeno, S., Maeda, Y., Yamato, M., Sonoda, N., Ogawa, Y., Wakisaka, M. & Inoguchi, T., Dec 1 2019, In : Scientific reports. 9, 1, 4703.

Research output: Contribution to journalArticle

Open Access
Sodium-Glucose Transport Proteins
Mesangial Cells
Diabetic Nephropathies
Glucose
Protein Kinase C

Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines

Takei, R., Inoue, T., Sonoda, N., Kohjima, M., Okamoto, M., Sakamoto, R., Inoguchi, T. & Ogawa, Y., Jan 1 2019, In : PloS one. 14, 10, e0223302.

Research output: Contribution to journalArticle

Open Access
Abdominal Obesity
bilirubin
Bilirubin
insulin resistance
Insulin Resistance
2 Citations (Scopus)

Dynamic nuclear polarization magnetic resonance imaging and the oxygen-sensitive paramagnetic agent OX63 provide a noninvasive quantitative evaluation of kidney hypoxia in diabetic mice

Kodama, Y., Hyodo, F., Yamato, M., Yasukawa, K., Minami, Y., Sonoda, N., Ogawa, Y., Ichikawa, K. & Inoguchi, T., Sep 1 2019, In : Kidney International. 96, 3, p. 787-792 6 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Oxygen
Kidney
Streptozocin
Type 1 Diabetes Mellitus
Hypoglycemia
Pancreatitis
C-Peptide
Pancreas

Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

Inoguchi, Y., Ichiyanagi, K., Ohishi, H., Maeda, Y., Sonoda, N., Ogawa, Y., Inoguchi, T. & Sasaki, H., Dec 1 2019, In : Scientific reports. 9, 1, 10181.

Research output: Contribution to journalArticle

Open Access
Glucose Intolerance
Streptozocin
Lactation
Pregnancy
Gluconeogenesis
2018
7 Citations (Scopus)

DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue

Iwaya, C., Kitajima, H., Yamamoto, K., Maeda, Y., Sonoda, N., Shibata, H. & Inoguchi, T., Mar 11 2018, In : Biochemical and Biophysical Research Communications. 497, 3, p. 908-915 8 p.

Research output: Contribution to journalArticle

DNA Methylation
Type 2 Diabetes Mellitus
Adipose Tissue
Medical problems
Blood Cells
5 Citations (Scopus)

P66Shc Signaling Mediates Diabetes-Related Cognitive Decline

Minami, Y., Sonoda, N., Hayashida, E., Makimura, H., Ide, M., Ikeda, N., Ohgidani, M., Kato, T., Seki, Y., Maeda, Y., Kanba, S., Takayanagi, R., Ogawa, Y. & Inoguchi, T., Dec 1 2018, In : Scientific reports. 8, 1, 3213.

Research output: Contribution to journalArticle

Oxidative Stress
Alzheimer Disease
Brain
Pathology
Microglia
2 Citations (Scopus)

Serum Bilirubin Concentration is Associated with Left Ventricular Remodeling in Patients with Type 2 Diabetes Mellitus: A Cohort Study

Inoue, T., Sonoda, N., Hiramatsu, S., Kimura, S., Ogawa, Y. & Inoguchi, T., Feb 1 2018, In : Diabetes Therapy. 9, 1, p. 331-338 8 p.

Research output: Contribution to journalArticle

Ventricular Remodeling
Bilirubin
Type 2 Diabetes Mellitus
Cohort Studies
Serum
2017
10 Citations (Scopus)

Arterial pressure lability is improved by sodium-glucose cotransporter 2 inhibitor in streptozotocin-induced diabetic rats

Yoshikawa, T., Kishi, T., shinohara, K., Takesue, K., Shibata, R., Sonoda, N., Inoguchi, T., Sunagawa, K., Tsutsui, H. & Hirooka, Y., Jul 1 2017, In : Hypertension Research. 40, 7, p. 646-651 6 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Streptozocin
Arterial Pressure
Insulin
Diabetes Mellitus
11 Citations (Scopus)

Renoprotective effect of a novel selective PPARα modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD(P)H oxidase pathway

Maki, T., Maeda, Y., Sonoda, N., Makimura, H., Kimura, S., Maeno, S., Takayanagi, R. & Inoguchi, T., Jun 1 2017, In : Metabolism: Clinical and Experimental. 71, p. 33-45 13 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Peroxisome Proliferator-Activated Receptors
NADPH Oxidase
Protein Kinase C
Kidney
2016
20 Citations (Scopus)

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Kimura, S., Inoguchi, T., Yamasaki, T., Yamato, M., Ide, M., Sonoda, N., Yamada, K-I. & Takayanagi, R., Mar 1 2016, In : Metabolism: Clinical and Experimental. 65, 3, p. 138-145 8 p.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Electron Spin Resonance Spectroscopy
Hydroxyl Radical
Dipeptidyl Peptidase 4
Experimental Diabetes Mellitus
5 Citations (Scopus)
Hyperinsulinism
Left Ventricular Dysfunction
Type 2 Diabetes Mellitus
Blood Glucose
Insulin
2015
5 Citations (Scopus)

Clinical significance of barriers to blood glucose control in type 2 diabetes patients with insufficient glycemic control

Suzuki, T., Takei, R., Inoguchi, T., Sonoda, N., Sasaki, S., Kaise, T. & Takayanagi, R., Jun 25 2015, In : Patient Preference and Adherence. 9, p. 837-845 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
chronic illness
Blood Glucose
physician
exercise therapy

Clinical significance of the laparoscopic bariatric surgeries for morbid obesity: initial 30 cases at a single institution in Japan

Ikeda, T., Akahoshi, T., Tomikawa, M., Sozaki, R., Nomura, M., Sonoda, N., Nakayama, R., Morita, C., Yamaguchi, S., Hashimoto, K., Maehara, Y. & Hashizume, M., Feb 1 2015, In : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 2, p. 33-40 8 p.

Research output: Contribution to journalArticle

Bariatric Surgery
Morbid Obesity
Laparoscopy
Japan
Blood Glucose
40 Citations (Scopus)

GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats

Inoue, T., Inoguchi, T., Sonoda, N., Hendarto, H., Makimura, H., Sasaki, S., Yokomizo, H., Fujimura, Y., Miura, D. & Takayanagi, R., May 1 2015, In : Atherosclerosis. 240, 1, p. 250-259 10 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Streptozocin
Oxidative Stress
Apoptosis
AMP-Activated Protein Kinases
2014
25 Citations (Scopus)

Association of borderline ankle-brachial index with mortality and the incidence of peripheral artery disease in diabetic patients

Natsuaki, C., Inoguchi, T., Maeda, Y., Yamada, T., Sasaki, S., Sonoda, N., Shimabukuro, M., Nawata, H. & Takayanagi, R., Jan 1 2014, In : Atherosclerosis. 234, 2, p. 360-365 6 p.

Research output: Contribution to journalArticle

Ankle Brachial Index
Peripheral Arterial Disease
Mortality
Incidence
Cause of Death
46 Citations (Scopus)

Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: The Kyushu prevention study of atherosclerosis

Maeda, Y., Inoguchi, T., Etoh, E., Kodama, Y., Sasaki, S., Sonoda, N., Nawata, H., Shimabukuro, M. & Takayanagi, R., Jan 1 2014, In : Diabetes care. 37, 8, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Ankle
Atherosclerosis
Arm
Mortality
44 Citations (Scopus)

Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice

Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., Fukuda, K., Sasaki, H. & Takayanagi, R., May 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 10

Research output: Contribution to journalArticle

High Fat Diet
Sex Characteristics
Insulin Resistance
Mothers
Oxidative Stress
74 Citations (Scopus)

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

Batchuluun, B., Inoguchi, T., Sonoda, N., Sasaki, S., Inoue, T., Fujimura, Y., Miura, D. & Takayanagi, R., Jan 1 2014, In : Atherosclerosis. 232, 1, p. 156-164 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Metformin
Protein Kinase C
Oxidative Stress
Endothelial Cells
2013
21 Citations (Scopus)

CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues

Fujii, M., Inoguchi, T., Batchuluun, B., Sugiyama, N., Kobayashi, K., Sonoda, N. & Takayanagi, R., Aug 16 2013, In : Biochemical and Biophysical Research Communications. 438, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

T-cells
Macrophages
Cytotoxic T-Lymphocytes
Immunotherapy
Insulin Resistance
13 Citations (Scopus)

Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice

Inoue, T., Kobayashi, K., Inoguchi, T., Sonoda, N., Maeda, Y., Hirata, E., Fujimura, Y., Miura, D., Hirano, K. I. & Takayanagi, R., Aug 16 2013, In : Biochemical and Biophysical Research Communications. 438, 1, p. 224-229 6 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Lipase
Triglycerides
Down-Regulation
Genes
65 Citations (Scopus)

Phycocyanin and phycocyanobilin from spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress

Zheng, J., Inoguchi, T., Sasaki, S., Maeda, Y., Mccarty, M. F., Fujii, M., Ikeda, N., Kobayashi, K., Sonoda, N. & Takayanagi, R., Jan 15 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 2

Research output: Contribution to journalArticle

Phycocyanin
Spirulina
Diabetic Nephropathies
Biliverdine
Oxidative Stress
2012
2 Citations (Scopus)

[Role of oxidative stress in pathogenesis of diabetic complications].

Sonoda, N. & Inoguchi, T., Jan 1 2012, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 5, p. 231-235 5 p.

Research output: Contribution to journalArticle

Diabetes Complications
Oxidative Stress
108 Citations (Scopus)

GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases

Hendarto, H., Inoguchi, T., Maeda, Y., Ikeda, N., Zheng, J., Takei, R., Yokomizo, H., Hirata, E., Sonoda, N. & Takayanagi, R., Oct 1 2012, In : Metabolism: Clinical and Experimental. 61, 10, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Albuminuria
Streptozocin
Cyclic AMP-Dependent Protein Kinases
Oxidative Stress
20 Citations (Scopus)

Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy

Kimura, S., Inoguchi, T., Yokomizo, H., Maeda, Y., Sonoda, N. & Takayanagi, R., Jan 1 2012, In : Diabetes, Obesity and Metabolism. 14, 7, p. 666-669 4 p.

Research output: Contribution to journalArticle

Pravastatin
Diabetic Nephropathies
Albumins
Creatinine
Albuminuria
2011
45 Citations (Scopus)

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia

Kato, T. A., Monji, A., Yasukawa, K., Mizoguchi, Y., Horikawa, H., Seki, Y., Hashioka, S., Han, Y. H., Kasai, M., Sonoda, N., Hirata, E., Maeda, Y., Inoguchi, T., Utsumi, H. & Kanba, S., Jul 1 2011, In : Schizophrenia research. 129, 2-3, p. 172-182 11 p.

Research output: Contribution to journalArticle

Microglia
Tetradecanoylphorbol Acetate
Superoxides
Antipsychotic Agents
Schizophrenia
31 Citations (Scopus)

Biliverdin protects against the deterioration of glucose tolerance in db/db mice

Ikeda, N., Inoguchi, T., Sonoda, N., Fujii, M., Takei, R., Hirata, E., Yokomizo, H., Zheng, J., Maeda, Y., Kobayashi, K. & Takayanagi, R., Aug 1 2011, In : Diabetologia. 54, 8, p. 2183-2191 9 p.

Research output: Contribution to journalArticle

Biliverdine
Glucose
Bilirubin
Insulin
Oxidative Stress
23 Citations (Scopus)

Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor α-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-κB

Inoue, T., Kobayashi, K., Inoguchi, T., Sonoda, N., Fujii, M., Maeda, Y., Fujimura, Y., Miura, D., Hirano, K. I. & Takayanagi, R., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 32045-32053 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Intercellular Adhesion Molecule-1
Lipase
Protein Kinase C
Endothelial Cells
2007
3 Citations (Scopus)

Fulminant type 1 diabetes during pregnancy: A case report and review of the literature

Yamamoto, N., Fujita, Y., Satoh, S., Nakanami, N., Sonoda, N. & Nakano, H., Aug 1 2007, In : Journal of Obstetrics and Gynaecology Research. 33, 4, p. 552-556 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Pregnancy
Diabetic Ketoacidosis
Mothers
Ketosis
14 Citations (Scopus)

Therapeutic angiogenesis by ex vivo expanded erythroid progenitor cells

Sasaki, S., Inoguchi, T., Muta, K., Abe, Y., Zhang, M., Hiasa, K., Egashira, K., Sonoda, N., Kobayashi, K., Takayanagi, R. & Nawata, H., Jan 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 1, p. H657-H665

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Vascular Endothelial Growth Factor A
Fibroblast Growth Factor 2
Erythroid Cells
Hindlimb
2005
73 Citations (Scopus)

Adenovirus-mediated high expression of resistin causes dyslipidemia in mice

Sato, N., Kobayashi, K., Inoguchi, T., Sonoda, N., Imamura, M., Sekiguchi, N., Nakashima, N. & Nawata, H., Jan 1 2005, In : Endocrinology. 146, 1, p. 273-279 7 p.

Research output: Contribution to journalArticle

Resistin
Dyslipidemias
Adenoviridae
Insulin
Lipoproteins
16 Citations (Scopus)

Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan

Kobayashi, K., Inoguchi, T., Sonoda, N., Sekiguchi, N. & Nawata, H., Sep 16 2005, In : Biochemical and Biophysical Research Communications. 335, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

Biglycan
Adiponectin
Proteoglycans
LDL Lipoproteins
Blood Vessels
16 Citations (Scopus)

Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells

Sekiguchi, N., Inoguchi, T., Kobayashi, K., Sonoda, N. & Nawata, H., Aug 19 2005, In : Biochemical and Biophysical Research Communications. 334, 1, p. 218-222 5 p.

Research output: Contribution to journalArticle

Endothelial cells
Erythropoietin
Endothelial Cells
Apoptosis
Glucose

Incidence of latent depression associated with diabetic retinopathy and utility of SRQ-D in diagnosis

Sasaki, S., Tsuru, N. E., Inoguchi, T., Nakayama, M., Tsubouchi, H., Sato, N., Sonta, T., Sonoda, N., Sekiguchi, N., Kobayashi, K., Nawata, H. & Sugimoto, H., Jun 1 2005, In : Folia Ophthalmologica Japonica. 56, 6, p. 401-405 5 p.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Incidence
Diabetic Neuropathies
Interviews
Cohort Studies
88 Citations (Scopus)

Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist

Nakayama, M., Inoguchi, T., Sonta, T., Maeda, Y., Sasaki, S., Sawada, F., Tsubouchi, H., Sonoda, N., Kobayashi, K., Sumimoto, H. & Nawata, H., Jul 15 2005, In : Biochemical and Biophysical Research Communications. 332, 4, p. 927-933 7 p.

Research output: Contribution to journalArticle

Oxidative stress
NADPH Oxidase
Medical problems
Type 2 Diabetes Mellitus
Animals
52 Citations (Scopus)

In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker

Sonta, T., Inoguchi, T., Matsumoto, S., Yasukawa, K., Inuo, M., Tsubouchi, H., Sonoda, N., Kobayashi, K., Utsumi, H. & Nawata, H., May 6 2005, In : Biochemical and Biophysical Research Communications. 330, 2, p. 415-422 8 p.

Research output: Contribution to journalArticle

Angiotensin II Type 1 Receptor Blockers
Oxidative stress
Oxidative Stress
Paramagnetic resonance
Kidney
16 Citations (Scopus)

Lemierre's syndrome: Porphyromonas asaccharolytica as a putative pathogen

Morizono, S., Enjoji, M., Sonoda, N., Fukushima, M., Kuniyoshi, M., Kotoh, K., Nakamuta, M. & Nawata, H., Apr 1 2005, In : Internal Medicine. 44, 4, p. 350-353 4 p.

Research output: Contribution to journalArticle

Lemierre Syndrome
Porphyromonas
Pharyngitis
Jugular Veins
Fusobacterium
20 Citations (Scopus)

Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD(P)H oxidase activity in cultured mesangial cells.

Yu, H. Y., Inoguchi, T., Nakayama, M., Tsubouchi, H., Sato, N., Sonoda, N., Sasaki, S., Kobayashi, K. & Nawata, H., Jan 1 2005, In : Medicinal chemistry. 1, 5, p. 461-466 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mesangial Cells
NADPH Oxidase
Angiotensin II
Cultured Cells

Two cases of type 1 diabetes mellitus with subclinical Sjögren syndrome

Sasaki, S., Inoguchi, T., Ohtsuka, R., Sonta, T., Tsubouchi, H., Sato, N., Etoh, T., Sonoda, N., Sekiguchi, N., Kobayashi, K. & Nawata, H., Apr 25 2005, In : Journal of the Japan Diabetes Society. 48, 2, p. 109-114 6 p.

Research output: Contribution to journalArticle

Sjogren's Syndrome
Type 1 Diabetes Mellitus
2004
17 Citations (Scopus)

Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

Nawata, H., Shirasawa, S., Nakashima, N., Araki, E., Hashiguchi, J., Miyake, S., Yamauchi, T., Hamaguchi, K., Yoshimatsu, H., Takeda, H., Fukushima, H., Sasahara, T., Yamaguchi, K., Sonoda, N., Sonoda, T., Matsumoto, M., Tanaka, Y., Sugimoto, H., Tsubouchi, H., Inoguchi, T. & 25 others, Yanase, T., Wake, N., Narazaki, K., Eto, T., Umeda, F., Nakazaki, M., Ono, J., Asano, T., Ito, Y., Akazawa, S., Hazegawa, I., Takasu, N., Shinohara, M., Nishikawa, T., Nagafuchi, S., Okeda, T., Eguchi, K., Iwase, M., Ishikawa, M., Aoki, M., Keicho, N., Kato, N., Yasuda, K., Yamamoto, K. & Sasazuki, T., Nov 1 2004, In : Journal of Human Genetics. 49, 11, p. 629-634 6 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Genome
Causality
Insulin Resistance
Insulin
37 Citations (Scopus)

Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6-a role of NAD(P)H oxidase in β-cells

Tsubouchi, H., Inoguchi, T., Inuo, M., Kakimoto, M., Sonta, T., Sonoda, N., Sasaki, S., Kobayashi, K., Sumimoto, H. & Nawata, H., Dec 31 2004, In : Biochemical and Biophysical Research Communications. 326, 1, p. 60-65 6 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Reactive Oxygen Species
Glyburide
Cells
Glucose
2003
201 Citations (Scopus)

Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

Etoh, T., Inoguchi, T., Kakimoto, M., Sonoda, N., Kobayashi, K., Kuroda, J., Sumimoto, H. & Nawata, H., Oct 1 2003, In : Diabetologia. 46, 10, p. 1428-1437 10 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Streptozocin
Insulin
Kidney
Reactive Oxygen Species
311 Citations (Scopus)

Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: Role of vascular NAD(P)H oxidase

Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H. & Nawata, H., Aug 1 2003, In : Journal of the American Society of Nephrology. 14, SUPPL. 3

Research output: Contribution to journalArticle

NADPH Oxidase
Protein Kinase C
Blood Vessels
Reactive Oxygen Species
Oxidative Stress