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Research Output 2004 2019

  • 714 Citations
  • 11 h-Index
  • 19 Article
  • 1 Chapter
  • 1 Review article
2019

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

Yokoyama, T., Yukuhiro, M., Iwasaki, Y., Tanaka, C., Sankoda, K., Fujiwara, R., Shibuta, A., Higashi, T., Motoyama, K., Arima, H., Yoshida, K., Sugimoto, N., Morimoto, H., Kosako, H., Ohshima, T. & Fujita, M., Dec 1 2019, In : Scientific reports. 9, 1, 16825.

Research output: Contribution to journalArticle

Open Access
Antimitotic Agents
Antineoplastic Agents
polyoxyethylene(10)nonylphenyl ether
Karyopherins
HCT116 Cells
2 Citations (Scopus)

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Morii, I., Iwabuchi, Y., Mori, S., Suekuni, M., Natsume, T., Yoshida, K., Sugimoto, N., Kanemaki, M. T. & Fujita, M., Mar 2019, In : Cancer Science. 110, 3, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Open Access
Cisplatin
Platinum Compounds
Neoplasms
Papillomaviridae
DNA Helicases
2018
11 Citations (Scopus)
Spatio-Temporal Analysis
Replication Origin
Chromatin
Transcription Initiation Site
Genome

Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells

Sugimoto, N., Maehara, K., Yoshida, K., Ohkawa, Y. & Fujita, M., Jul 27 2018, In : Nucleic Acids Research. 46, 13, p. 6683-6696 14 p.

Research output: Contribution to journalArticle

Spatio-Temporal Analysis
Replication Origin
Chromatin
Transcription Initiation Site
Genome
2 Citations (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., Aug 1 2018, In : Journal of Cell Science. 131, 15

Research output: Contribution to journalArticle

Ribosomal Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Glutamic Acid
Down-Regulation
2017
4 Citations (Scopus)

GRWD1, a new player among oncogenesis-related ribosomal/nucleolar proteins

Takafuji, T., Kayama, K., Sugimoto, N. & Fujita, M., Aug 3 2017, In : Cell Cycle. 16, 15, p. 1397-1403 7 p.

Research output: Contribution to journalReview article

Ribosomal Proteins
Nuclear Proteins
Carcinogenesis
Neoplasms
Protein Biosynthesis
11 Citations (Scopus)

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

Glutamic Acid
Carcinogenesis
Ligases
Ubiquitin
WD40 Repeats
2 Citations (Scopus)

Molecular mechanism for chromatin regulation during MCM loading in mammalian cells

Sugimoto, N. & Fujita, M., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 61-78 18 p. (Advances in Experimental Medicine and Biology; vol. 1042).

Research output: Chapter in Book/Report/Conference proceedingChapter

Multicarrier modulation
Chromatin
Nucleosomes
Licensure
Cells
5 Citations (Scopus)

TRF2 recruits ORC through TRFH domain dimerization

Higa, M., Kushiyama, T., Kurashige, S., Kohmon, D., Enokitani, K., Iwahori, S., Sugimoto, N., Yoshida, K. & Fujita, M., Jan 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 1, p. 191-201 11 p.

Research output: Contribution to journalArticle

Origin Recognition Complex
Dimerization
Telomere
DNA Replication
Chromatin
2016
4 Citations (Scopus)
Nucleosomes
Carrier Proteins
Replication Origin
Histones
Chromatin
2015
4 Citations (Scopus)

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

Ohira, M., Iwasaki, Y., Tanaka, C., Kuroki, M., Matsuo, N., Kitamura, T., Yukuhiro, M., Morimoto, H., Pang, N., Liu, B., Kiyono, T., Amemiya, M., Tanaka, K., Yoshida, K., Sugimoto, N., Ohshima, T. & Fujita, M., May 19 2015, In : Biochimica et Biophysica Acta - General Subjects. 1850, 9, p. 1676-1684 9 p.

Research output: Contribution to journalArticle

Cell growth
Microtubules
Tumors
Cells
Growth
19 Citations (Scopus)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y. & Fujita, M., Jan 1 2015, In : Nucleic acids research. 43, 12, p. 5898-5911 14 p.

Research output: Contribution to journalArticle

Histones
Chromatin
Glutamic Acid
Carrier Proteins
Replication Origin
2014
8 Citations (Scopus)

ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication

Iwahori, S., Kohmon, D., Kobayashi, J., Tani, Y., Yugawa, T., Komatsu, K., Kiyono, T., Sugimoto, N. & Fujita, M., Feb 1 2014, In : Cell Cycle. 13, 3, p. 471-481 11 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
S Phase
Double-Stranded DNA Breaks
Genomic Instability
Licensure
2012
25 Citations (Scopus)

Heterocomplex formation by Arp4 and β-actin is involved in the integrity of the Brg1 chromatin remodeling complex

Nishimoto, N., Watanabe, M., Watanabe, S., Sugimoto, N., Yugawa, T., Ikura, T., Koiwai, O., Kiyono, T. & Fujita, M., Aug 15 2012, In : Journal of Cell Science. 125, 16, p. 3870-3882 13 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Actins
Histone Acetyltransferases
Proteins
Mutant Proteins
2011
26 Citations (Scopus)
Replication Origin
DNA Replication
Chromatin
Sucrose
DNA
2010
20 Citations (Scopus)

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells

Yoshida, K., Sugimoto, N., Iwahori, S., Yugawa, T., Narisawa-Saito, M., Kiyono, T. & Fujita, M., Jan 15 2010, In : Journal of Cell Science. 123, 2, p. 225-235 11 p.

Research output: Contribution to journalArticle

Eukaryotic Cells
Xenopus
Phosphorylation
S Phase
Chromatin
2009
22 Citations (Scopus)

Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells

Sugimoto, N., Yoshida, K., Tatsumi, Y., Yugawa, T., Narisawa-Saito, M., Waga, S., Kiyono, T. & Fujita, M., Apr 15 2009, In : Journal of Cell Science. 122, 8, p. 1184-1191 8 p.

Research output: Contribution to journalArticle

Licensure
Cell Line
Telomerase
S Phase
Down-Regulation
2008
43 Citations (Scopus)

Identification of novel human Cdt1-binding proteins by a proteomics approach: Proteolytic regulation by APC/CCdh1

Sugimoto, N., Kitabayashi, I., Osano, S., Tatsumi, Y., Yugawa, T., Narisawa-Saito, M., Matsukage, A., Kiyono, T. & Fujita, M., Mar 1 2008, In : Molecular biology of the cell. 19, 3, p. 1007-1021 15 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Ligases
Ubiquitin
Proteomics
Type II DNA Topoisomerase
2006
85 Citations (Scopus)

Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability

Tatsumi, Y., Sugimoto, N., Yugawa, T., Narisawa-Saito, M., Kiyono, T. & Fujita, M., Aug 1 2006, In : Journal of Cell Science. 119, 15, p. 3128-3140 13 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Telangiectasis
Phosphotransferases
Cyclin A
Human Activities
276 Citations (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., Mar 8 2006, In : EMBO Journal. 25, 5, p. 1126-1136 11 p.

Research output: Contribution to journalArticle

Proteolysis
Ubiquitin-Protein Ligases
G2 Phase
S Phase
Amino Acids
2004
145 Citations (Scopus)

Cdt1 Phosphorylation by Cyclin A-dependent Kinases Negatively Regulates Its Function without Affecting Geminin Binding

Sugimoto, N., Tatsumi, Y., Tsurumi, T., Matsukage, A., Kiyono, T., Nishitani, H. & Fujita, M., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19691-19697 7 p.

Research output: Contribution to journalArticle

Geminin
Cyclin A
Phosphorylation
Cyclin-Dependent Kinases
Phosphotransferases