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Research Output 1986 2019

2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles

Germline mutation: De novo mutation in reproductive lineage cells

Sakumi, K., Jan 1 2019, In : Genes and Genetic Systems. 94, 1, p. 3-12 10 p.

Research output: Contribution to journalArticle

Open Access
Germ-Line Mutation
Mutation Rate
Genome
Mutation
Cell Division
2017
17 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Kunihiko, S., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
4 Citations (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Kunihiko, S., Ono, R., Nakabeppu, Y. & Nishigori, C., Feb 1 2017, In : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

Research output: Contribution to journalLetter

Neoplastic Gene Expression Regulation
Chemokine CXCL1
Radiation-Induced Neoplasms
Versicans
DNA Glycosylases
4 Citations (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Kunihiko, S., Nakabeppu, Y. & Toyokuni, S., Nov 1 2017, In : Pathology International. 67, 11, p. 564-574 11 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Carcinogenesis
Kidney
Genotype
Methylation
2016
23 Citations (Scopus)
Mitochondrial DNA
Neurons
Antioxidants
Neurodegenerative Diseases
Cytosine
3 Citations (Scopus)
4 Citations (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., Sep 13 2016, In : Scientific reports. 6, 32849.

Research output: Contribution to journalArticle

DNA
Growth
Deamination
deoxyinosine
triphosphoric acid
12 Citations (Scopus)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Kunihiko, S., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., Nov 29 2016, In : Scientific reports. 6, 37889.

Research output: Contribution to journalArticle

Alzheimer Disease
Mitochondria
Prealbumin
Mitochondrial DNA
Oxidative Stress
16 Citations (Scopus)

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Kunihiko, S., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., Oct 1 2016, In : Free Radical Biology and Medicine. 99, p. 385-391 7 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
Nucleotides
DNA
Transcription
2 Citations (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., Oct 1 2016, In : Genes to Cells. 21, 10, p. 1030-1048 19 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lipid Metabolism
Atherosclerosis
High Fat Diet
Dyslipidemias
2015
Genome
DNA
Research
Genes
2 Citations (Scopus)
DNA Glycosylases
Carcinogenesis
Cell Death
Neoplasms
4-iodo-2,5-dimethoxyphenylisopropylamine
6 Citations (Scopus)

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Kunihiko, S., Kajitani, K., Kadoya, T., Horie, H., Kira, J-I. & Nakabeppu, Y., Feb 1 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

Research output: Contribution to journalArticle

Galectin 1
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Axons
2014
63 Citations (Scopus)

8-Oxoguanine causes spontaneous de novo germline mutations in mice

Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., Gondo, Y. & Nakabeppu, Y., Apr 1 2014, In : Scientific reports. 4, 4689.

Research output: Contribution to journalArticle

Germ-Line Mutation
Mutation
Germ Cells
Exome
DNA
20 Citations (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., Aug 2014, In : GLIA. 62, 8, p. 1284-1298 15 p.

Research output: Contribution to journalArticle

Anaphylatoxin C5a Receptor
Complement C5a
Complement Receptors
Microglia
Kainic Acid
25 Citations (Scopus)

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Kunihiko, S., Oka, S., Nakabeppu, Y. & Nishigori, C., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2610-2619 10 p.

Research output: Contribution to journalArticle

Spirulina
Skin
Carcinogenesis
Tumors
Neoplasms
22 Citations (Scopus)

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

Oka, S., Leon, J., Tsuchimoto, D., Kunihiko, S. & Nakabeppu, Y., Jan 1 2014, In : Oncogenesis. 3, 10, e121.

Research output: Contribution to journalArticle

DNA Glycosylases
Poly(ADP-ribose) Polymerases
Cell Death
Carcinogenesis
DNA Mismatch Repair

What have we learned from cultured adult dorsal root ganglion neurons?

Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T. & Horie, H., Jan 1 2014, Ganglion Cells: Morphology, Functional Development and Role in Disease. Nova Science Publishers, Inc., p. 125-148 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spinal Ganglia
Neurons
Cell culture
Ganglia
Regeneration
2013
1 Citation (Scopus)

Erratum: FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Jun 1 2013, In : Neuropsychopharmacology. 38, 7, p. 1374-1375 2 p.

Research output: Contribution to journalComment/debate

Neurogenesis
Epilepsy
22 Citations (Scopus)

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Apr 1 2013, In : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

Research output: Contribution to journalArticle

Neurogenesis
Epilepsy
Hippocampus
Lateral Ventricles
Depression
22 Citations (Scopus)

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

Takaku, S., Yanagisawa, H., Watabe, K., Horie, H., Kadoya, T., Kunihiko, S., Nakabeppu, Y., Poirier, F. & Sango, K., Feb 1 2013, In : Neurochemistry International. 62, 3, p. 330-339 10 p.

Research output: Contribution to journalArticle

Galectin 1
Glial Cell Line-Derived Neurotrophic Factor
Phosphatidylinositol Phosphates
Spinal Ganglia
Phosphotransferases
2012
66 Citations (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

Research output: Contribution to journalArticle

Microglia
DNA Repair
Carcinogenesis
Oxidative Stress
Apoptosis Inducing Factor
57 Citations (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
obesity
Obesity
Fats
17 Citations (Scopus)

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype

Yogianti, F., Kunisada, M., Ono, R., Sakumi, K., Nakabeppu, Y. & Nishigori, C., Nov 1 2012, In : Mutagenesis. 27, 6, p. 637-643 7 p.

Research output: Contribution to journalArticle

Mutation Rate
Pyrimidine Dimers
Tumors
Skin
Genotype
2011
12 Citations (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., Jun 1 2011, In : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

Research output: Contribution to journalArticle

Nerve Tissue
Guanosine Triphosphate
Nucleotides
Spinal Ganglia
Neoplasms
22 Citations (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., Sep 1 2011, In : Biological Psychiatry. 70, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

Cadherins
Genes
Alleles
Locomotion
Mood Disorders
25 Citations (Scopus)

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Kunihiko, S., Ono, R., Nakabeppu, Y. & Nishigori, C., Dec 1 2011, In : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

Research output: Contribution to journalArticle

Versicans
Knockout Mice
Reactive Oxygen Species
Carcinogenesis
Skin
1 Citation (Scopus)

Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

Tsuzuki, T., Piao, J. S., Isoda, T., Kunihiko, S., Nakabeppu, Y. & Nakatsu, Y., Mar 1 2011, In : Health physics. 100, 3, p. 293-294 2 p.

Research output: Contribution to journalConference article

DNA Mutational Analysis
Bromates
Neoplastic Cell Transformation
Radiation-Induced Neoplasms
DNA Repair-Deficiency Disorders
2010
8 Citations (Scopus)

A comprehensive screening system for damaged nucleotide-binding proteins

Tsuchimoto, D., Iyama, T., Nonaka, M., Abolhassani, N., Ohta, E., Sakumi, K. & Nakabeppu, Y., Nov 28 2010, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

Inosine Triphosphate
Carrier Proteins
Nucleotides
Inosine Monophosphate
Adenosine Triphosphate
26 Citations (Scopus)

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells

Kunihiko, S., Abolhassani, N., Behmanesh, M., Iyama, T., Tsuchimoto, D. & Nakabeppu, Y., Nov 28 2010, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 43-50 8 p.

Research output: Contribution to journalReview article

Inosine Triphosphate
Purine Nucleosides
Enzymes
Proteins
Embryonic Structures
38 Citations (Scopus)

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Abolhassani, N., Iyama, T., Tsuchimoto, D., Sakumi, K., Ohno, M., Behmanesh, M. & Nakabeppu, Y., Jan 15 2010, In : Nucleic acids research. 38, 9, p. 2891-2903 13 p., gkp1250.

Research output: Contribution to journalArticle

Inosine Diphosphate
Inosine Triphosphate
Chromosomal Instability
Mammals
Nucleotides
49 Citations (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
Cell Aging
Mutagenesis
Cell Death
2009
31 Citations (Scopus)

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus

Kajitani, K., Nomaru, H., Ifuku, M., Yutsudo, N., Dan, Y., Miura, T., Tsuchimoto, D., Sakumi, K., Kadoya, T., Horie, H., Poirier, F., Noda, M. & Nakabeppu, Y., Jan 1 2009, In : Cell Death and Differentiation. 16, 3, p. 417-427 11 p.

Research output: Contribution to journalArticle

Galectin 1
Kainic Acid
Dentate Gyrus
Hippocampus
Bromodeoxyuridine
117 Citations (Scopus)

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Fujita, K., Seike, T., Yutsudo, N., Ohno, M., Yamada, H., Yamaguchi, H., Sakumi, K., Yamakawa, Y., Kido, M. A., Takaki, A., Katafuchi, T., Tanaka, Y., Nakabeppu, Y. & Noda, M., Sep 30 2009, In : PloS one. 4, 9, e7247.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Oxidative stress
Parkinson disease
Drinking Water
hydrogen
46 Citations (Scopus)

ITPase-deficient mice show growth retardation and die before weaning

Behmanesh, M., Sakumi, K., Abolhassani, N., Toyokuni, S., Oka, S., Ohnishi, Y. N., Tsuchimoto, D. & Nakabeppu, Y., Jun 9 2009, In : Cell Death and Differentiation. 16, 10, p. 1315-1322 8 p.

Research output: Contribution to journalArticle

Inosine Triphosphate
Weaning
Pyrophosphatases
Purine Nucleosides
Sarcomeres
17 Citations (Scopus)

Mouse RS21-C6 is a mammalian 2′-deoxycytidine 5′-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine

Nonaka, M., Tsuchimoto, D., Sakumi, K. & Nakabeppu, Y., Mar 1 2009, In : FEBS Journal. 276, 6, p. 1654-1666 13 p.

Research output: Contribution to journalArticle

Nucleotides
Inosine Triphosphate
Nucleosides
Adenosine Triphosphate
Mutagenesis
2008
5 Citations (Scopus)

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

Dan, Y., Ohta, Y., Tsuchimoto, D., Mizuki, O., Ide, Y., Sami, M., Kanda, T., Kunihiko, S. & Nakabeppu, Y., Sep 1 2008, In : DNA Repair. 7, 9, p. 1437-1454 18 p.

Research output: Contribution to journalArticle

Thymus
DNA Breaks
Thymocytes
Transcriptome
Gene expression
14 Citations (Scopus)

Antagonistic regulation of cell-matrix adhesion by FosB and ΔFosB/Δ2ΔFosB encoded by alternatively spliced forms of fosB transcripts

Ohnishi, Y. N., Kunihiko, S., Yamazaki, K., Ohnishi, Y. H., Miura, T., Tominaga, Y. & Nakabeppu, Y., Nov 1 2008, In : Molecular biology of the cell. 19, 11, p. 4717-4729 13 p.

Research output: Contribution to journalArticle

Cell-Matrix Junctions
Null Lymphocytes
Alleles
Embryonic Stem Cells
Genes
40 Citations (Scopus)

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

Ichikawa, J., Tsuchimoto, D., Oka, S., Mizuki, O., Furuichi, M., Kunihiko, S. & Nakabeppu, Y., Mar 1 2008, In : DNA Repair. 7, 3, p. 418-430 13 p.

Research output: Contribution to journalArticle

Nitroprusside
Cell death
Null Lymphocytes
Cell Death
Oxidation
142 Citations (Scopus)

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

Oka, S., Ohno, M., Tsuchimoto, D., Sakumi, K., Furuichi, M. & Nakabeppu, Y., Jan 23 2008, In : EMBO Journal. 27, 2, p. 421-432 12 p.

Research output: Contribution to journalArticle

Cell death
Mitochondrial DNA
Cell Death
DNA
DNA Glycosylases
2007
7 Citations (Scopus)

Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A

Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Kunihiko, S., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S. & Aso, T., Apr 1 2007, In : Cell Death and Differentiation. 14, 4, p. 716-726 11 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
Cell Aging
Transcription Factors
Apoptosis
p38 Mitogen-Activated Protein Kinases
95 Citations (Scopus)

MUTYH-null mice are susceptible to spontaneous and oxidative stress-induced intestinal tumorigenesis

Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., Maki, H., Nakabeppu, Y. & Tsuzuki, T., Jul 15 2007, In : Cancer Research. 67, 14, p. 6599-6604 6 p.

Research output: Contribution to journalArticle

Carcinogenesis
Oxidative Stress
Adenoma
Small Intestine
Neoplasms
47 Citations (Scopus)

Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer

Kunisada, M., Kumimoto, H., Ishizaki, K., Sakumi, K., Nakabeppu, Y. & Nishigori, C., Dec 2007, In : Journal of Investigative Dermatology. 127, 12, p. 2865-2871 7 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
Tumors
Skin
Erythema
Knockout Mice
161 Citations (Scopus)

Oxidative damage in nucleic acids and Parkinson's disease

Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H. & Sakumi, K., Apr 1 2007, In : Journal of Neuroscience Research. 85, 5, p. 919-934 16 p.

Research output: Contribution to journalReview article

Mitochondrial DNA
Nucleic Acids
DNA Glycosylases
Parkinson Disease
Dopaminergic Neurons

Prevention of the Mutagenecity and Cytotoxicity of Oxidized Purine Nucleotides

Nakabeppu, Y., Behmanesh, M., Ymaguchi, H., Tsuchimoto, D. & Kunihiko, S., 2007, Oxidative Damage to Nucleic Acids. Evans, MD. & Cooke, MS. (eds.). Landes Bioscience, Springer Science+Business Media, p. 40-53

Research output: Chapter in Book/Report/Conference proceedingChapter

2006
54 Citations (Scopus)
Human Genome
Genetic Recombination
Single Nucleotide Polymorphism
Genome
Metaphase
32 Citations (Scopus)

Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis

Akatsuka, S., Aung, T. T., Dutta, K. K., Jiang, L., Lee, W. H., Liu, Y. T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T. & 2 others, Yamada, Y. & Toyokuni, S., Oct 2006, In : American Journal of Pathology. 169, 4, p. 1328-1342 15 p.

Research output: Contribution to journalArticle

Acrolein
Adenine
Carcinogenesis
Oxidative Stress
Genome
57 Citations (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopaminergic Neurons
Nucleic Acids
179 Citations (Scopus)

Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.

Nakabeppu, Y., Kunihiko, S., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T. & Nakatsu, Y., Jan 1 2006, In : Biological chemistry. 387, 4, p. 373-379 7 p.

Research output: Contribution to journalConference article

DNA Glycosylases
Mutagenesis
Nucleic Acids
Carcinogenesis
Genes