If you made any changes in Pure these will be visible here soon.

Research Output 2003 2019

  • 2880 Citations
  • 26 h-Index
  • 91 Article
  • 6 Review article
  • 2 Chapter
  • 1 Short survey
2019
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., Aug 1 2019, In : Development (Cambridge). 146, 15, dev174243.

Research output: Contribution to journalArticle

Open Access
Telencephalon
Homeobox Genes
Gene Dosage
Olfactory Bulb
Neurogenesis

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Makoto, T., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
spinal cord injuries
macrophages
healing
interferon
lesions
1 Citation (Scopus)

Pathological changes of distal motor neurons after complete spinal cord injury

Yokota, K., Kubota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Maeda, T., Katoh, H., Ohkawa, Y., Nakashima, Y. & Okada, S., Jan 9 2019, In : Molecular Brain. 12, 1, 4.

Research output: Contribution to journalArticle

Motor Neurons
Spinal Cord Injuries
Spinal Cord
Microdissection
Thoracic Injuries
Heavy Ion Radiotherapy
Spontaneous Fractures
Single-Photon Emission-Computed Tomography
Bone and Bones
Bone Remodeling
Arm Injuries
Ossification of Posterior Longitudinal Ligament
Pectoralis Muscles
Prone Position
Brachial Plexus

The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury

Kijima, K., Kubota, K., Hara, M., Kobayakawa, K., Yokota, K., Saito, T., Yoshizaki, S., Maeda, T., Konno, D., Matsumoto, Y., Nakashima, Y. & Okada, S., Mar 1 2019, In : EBioMedicine. 41, p. 659-669 11 p.

Research output: Contribution to journalArticle

Open Access
Biomarkers
Spinal Cord Injuries
Zinc
Serum
Patient treatment

Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury

Yoshizaki, S., Kijima, K., Hara, M., Saito, T., Tamaru, T., Tanaka, M., Konno, D., Nakashima, Y. & Okada, S., Jul 29 2019, In : Journal of neuroinflammation. 16, 1, 160.

Research output: Contribution to journalArticle

Open Access
Tranexamic Acid
Toll-Like Receptor 4
Heme
Spinal Cord Injuries
Tumor Necrosis Factor-alpha
2018
28 Citations (Scopus)

Astrocyte reactivity and astrogliosis after spinal cord injury

Okada, S., Hara, M., Kobayakawa, K., Matsumoto, Y. & Nakashima, Y., Jan 1 2018, In : Neuroscience Research. 126, p. 39-43 5 p.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Astrocytes
Cicatrix
Neuroglia
Central Nervous System

Clinical outcome and prognostic factors of malignant spinal dumbbell tumors

Matsumoto, Y., Kawaguchi, K., Fukushi, J. I., Endo, M., Setsu, N., Iida, K., Baba, S., Saiwai, H., Matsushita, A., Hayashida, M., Okada, S. & Nakashima, Y., Jan 1 2018, In : Spine Surgery and Related Research. 2, 4, p. 317-323 7 p.

Research output: Contribution to journalArticle

Open Access
Recurrence
Neoplasms
Neurilemmoma
Multivariate Analysis
2 Citations (Scopus)

Cutting edge: B cells expressing cyclic citrullinated peptide-specific antigen receptor are tolerized in normal conditions

Yamada, H., Ozawa, T., Kishi, H., Okada, S., Nakashima, Y., Muraguchi, A. & Yoshikai, Y., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3492-3496 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
B-Lymphocytes
Transgenic Mice
Immunoglobulin M
Rheumatoid Arthritis
1 Citation (Scopus)

Effect of cartilaginous endplates on extruded disc resorption in lumbar disc herniation

Kawaguchi, K., Harimaya, K., Matsumoto, Y., Hayashida, M., Okada, S., Iida, K., Kato, G., Tsuchiya, K., Doi, T., Oda, Y., Iwamoto, Y. & Nakashima, Y., Apr 1 2018, In : PloS one. 13, 4, e0195946.

Research output: Contribution to journalArticle

granulation tissue
Intervertebral Disc Displacement
Granulation
Cartilage
resorption

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

Harada, A., Maehara, K., Ono, Y., Taguchi, H., Yoshioka, K., Kitajima, Y., Xie, Y., Sato, Y., Iwasaki, T., Nogami, J., Okada, S., Komatsu, T., Semba, Y., Takemoto, T., Kimura, H., Kurumizaka, H. & Ohkawa, Y., Dec 1 2018, In : Nature communications. 9, 1, 1400.

Research output: Contribution to journalArticle

skeletal muscle
chromatin
Nucleosomes
regeneration
Histones

Periostin Promotes Fibroblast Migration and Inhibits Muscle Repair After Skeletal Muscle Injury

Hara, M., Yokota, K., Saito, T., Kobayakawa, K., Kijima, K., Yoshizaki, S., Okazaki, K., Yoshida, S., Matsumoto, Y., Harimaya, K., Nakashima, Y. & Okada, S., Aug 15 2018, In : The Journal of bone and joint surgery. American volume. 100, 16, p. e108

Research output: Contribution to journalArticle

Skeletal Muscle
Fibroblasts
Muscles
Wounds and Injuries
Fibrosis
Open Access
Spondylosis
Spondylarthropathies
Spinal Cord Diseases
Dialysis
Dilatation and Curettage
1 Citation (Scopus)
Spinal Cord Injuries
Knee
Sensitivity and Specificity
Cervical Cord
Leg
Spinal Cord Compression
Spinal Cord Diseases
Radiotherapy
Radiation
Therapeutics
1 Citation (Scopus)
Open Access
Scoliosis
Thorax
X-Rays
Prone Position
Supine Position
2017
2 Citations (Scopus)

Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells

Yokoyama, N., Matsunobu, T., Matsumoto, Y., Fukushi, J-I., Endo, M., Hatano, M., Nabeshima, A., Fukushima, S., Okada, S. & Iwamoto, Y., Mar 28 2017, In : Scientific reports. 7, 45332.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 6
Synovial Sarcoma
Down-Regulation
Clone Cells
Mitogen-Activated Protein Kinase Kinases

A radiographic evaluation of facet sagittal angle in cervical spinal cord injury without major fracture or dislocation

Takao, T., Kubota, K., Maeda, T., Okada, S., Morishita, Y., Mori, E., Yugue, I., Kawano, O., Sakai, H., Ueta, T. & Shiba, K., May 1 2017, In : Spinal Cord. 55, 5, p. 515-517 3 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Joints
Spine
Cervical Cord
Fracture Dislocation
8 Citations (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones

Clinical features and surgical management of rare cases of thoracic intraspinal cysts: Report of 3 cases

Saiwai, H., Okada, S., Miyazaki, K., Nakano, R., Iwamoto, Y. & Tsuchiya, K., May 1 2017, In : Journal of Orthopaedic Science. 22, 3, p. 578-582 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Heavy Ion Radiotherapy
Compression Fractures
Radiotherapy
Sarcoma
Carbon
3 Citations (Scopus)

Experimental mouse model of lumbar ligamentum flavum hypertrophy

Saito, T., Yokota, K., Kobayakawa, K., Hara, M., Kubota, K., Harimaya, K., Kawaguchi, K., Hayashida, M., Matsumoto, Y., Doi, T., Shiba, K., Nakashima, Y. & Okada, S., Jan 1 2017, In : PloS one. 12, 1, e0169717.

Research output: Contribution to journalArticle

Ligamentum Flavum
hypertrophy
Hypertrophy
Canals
Theoretical Models
76 Citations (Scopus)

Interaction of reactive astrocytes with type i collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury

Hara, M., Kobayakawa, K., Ohkawa, Y., Kumamaru, H., Yokota, K., Saito, T., Kijima, K., Yoshizaki, S., Harimaya, K., Nakashima, Y. & Okada, S., Jul 1 2017, In : Nature medicine. 23, 7, p. 818-828 11 p.

Research output: Contribution to journalArticle

Cadherins
Spinal Cord Injuries
Integrins
Astrocytes
Cicatrix

Macrophage Infiltration Is a Causative Factor for Ligamentum Flavum Hypertrophy through the Activation of Collagen Production in Fibroblasts

Saito, T., Hara, M., Kumamaru, H., Kobayakawa, K., Yokota, K., Kijima, K., Yoshizaki, S., Harimaya, K., Matsumoto, Y., Kawaguchi, K., Hayashida, M., Inagaki, Y., Shiba, K., Nakashima, Y. & Okada, S., Dec 1 2017, In : American Journal of Pathology. 187, 12, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

Ligamentum Flavum
Hypertrophy
Collagen
Fibroblasts
Macrophages
1 Citation (Scopus)
Tumor Burden
Tumors
Spine
Glycolysis
Disease-Free Survival
16 Citations (Scopus)

Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury

Yokota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Ohkawa, Y., Harada, A., Okazaki, K., Ishihara, K., Yoshida, S., Kudo, A., Iwamoto, Y. & Okada, S., Mar 1 2017, In : American Journal of Pathology. 187, 3, p. 639-653 15 p.

Research output: Contribution to journalArticle

Pericytes
Spinal Cord Injuries
Cicatrix
Monocytes
Macrophages
20 Citations (Scopus)

Regulation of RhoA by STAT3 coordinates glial scar formation

Renault-Mihara, F., Mukaino, M., Shinozaki, M., Kumamaru, H., Kawase, S., Baudoux, M., Ishibashi, T., Kawabata, S., Nishiyama, Y., Sugai, K., Yasutake, K., Okada, S., Nakamura, M. & Okano, H., Jan 1 2017, In : Journal of Cell Biology. 216, 8, p. 2533-2550 18 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Neuroglia
Cicatrix
Astrocytes
Nestin
2016
2 Citations (Scopus)

Bone and soft tissue tumors presenting as sciatic notch dumbbell masses: A critical differential diagnosis of sciatica

Matsumoto, Y., Matsunobu, T., Harimaya, K., Kawaguchi, K., Hayashida, M., Okada, S., Doi, T. & Iwamoto, Y., Oct 10 2016, In : World Journal of Clinical Oncology. 7, 5, p. 414-419 6 p.

Research output: Contribution to journalArticle

Sciatica
Differential Diagnosis
Bone and Bones
Neoplasms
Buttocks
8 Citations (Scopus)

Clinical influence of cervical spinal canal stenosis on neurological outcome after traumatic cervical spinal cord injury without major fracture or dislocation

Takao, T., Okada, S., Morishita, Y., Maeda, T., Kubota, K., Ideta, R., Mori, E., Yugue, I., Kawano, O., Sakai, H., Ueta, T. & Shiba, K., Jan 1 2016, In : Asian Spine Journal. 10, 3, p. 536-542 7 p.

Research output: Contribution to journalArticle

Spinal Stenosis
Spinal Canal
Spinal Cord Injuries
Cerebrospinal Fluid
Decompression
10 Citations (Scopus)

Dumbbell scoring system a new method for the differential diagnosis of malignant and benign spinal dumbbell tumors

Matsumoto, Y., Harimaya, K., Kawaguchi, K., Hayashida, M., Okada, S., Doi, T. & Iwamoto, Y., Oct 15 2016, In : Spine. 41, 20, p. E1230-E1236

Research output: Contribution to journalArticle

Differential Diagnosis
Neoplasms
Neurilemmoma
Myoepithelioma
Hemangioendothelioma
5 Citations (Scopus)

Risk factors for adjacent segment pathology requiring additional surgery after single-level spinal fusion: impact of pre-existing spinal stenosis demonstrated by preoperative myelography

Yugué, I., Okada, S., Masuda, M., Ueta, T., Maeda, T. & Shiba, K., May 1 2016, In : European Spine Journal. 25, 5, p. 1542-1549 8 p.

Research output: Contribution to journalArticle

Spinal Stenosis
Spinal Fusion
Myelography
Pathology
Spinal Canal
5 Citations (Scopus)

The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury

Yokota, K., Saito, T., Kobayakawa, K., Kubota, K., Hara, M., Murata, M., Ohkawa, Y., Iwamoto, Y. & Okada, S., May 9 2016, In : Scientific reports. 6, 25673.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Blood Cells
Neutrophils
Wounds and Injuries
4 Citations (Scopus)

The position of the aorta relative to the vertebrae in patients with Lenke type 1 adolescent idiopathic scoliosis

Bekki, H., Harimaya, K., Matsumoto, Y., Hayashida, M., Okada, S., Doi, T. & Iwamoto, Y., Jan 1 2016, In : Spine. 41, 7, p. 585-590 6 p.

Research output: Contribution to journalArticle

Scoliosis
Aorta
Spine
Thorax
Tomography
2 Citations (Scopus)

Venous hypertensive myelopathy associated with cervical spondylosis

Okada, S., Chang, C., Chang, G. & Yue, J. J., Nov 1 2016, In : Spine Journal. 16, 11, p. e751-e754

Research output: Contribution to journalArticle

Spondylosis
Spinal Cord Diseases
Magnetic Resonance Imaging
Vascular Malformations
Transverse Myelitis
1 Citation (Scopus)

“Knee-up test” for easy detection of postoperative motor deficits following spinal surgery

Yugué, I., Okada, S., Masuda, M., Ueta, T., Maeda, T. & Shiba, K., Dec 1 2016, In : Spine Journal. 16, 12, p. 1437-1444 8 p.

Research output: Contribution to journalArticle

Knee
Airway Extubation
Neurologic Manifestations
Muscles
Leg
2015
1 Citation (Scopus)

A new sagittal parameter to estimate pelvic tilt using the iliac cortical density line and iliac tilt: A retrospective X-ray measurement study

Doi, T., Tono, O., Tarukado, K., Harimaya, K., Matsumoto, Y., Hayashida, M., Okada, S. & Iwamoto, Y., Jul 22 2015, In : Journal of Orthopaedic Surgery and Research. 10, 1, 115.

Research output: Contribution to journalArticle

Thigh
X-Rays
Kyphosis
Ilium
Pelvis
8 Citations (Scopus)

Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone

Hatano, M., Matsumoto, Y., Fukushi, J. I., Matsunobu, T., Endo, M., Okada, S., Iura, K., Kamura, S., Fujiwara, T., Iida, K., Fujiwara, Y., Nabeshima, A., Yokoyama, N., Fukushima, S., Oda, Y. & Iwamoto, Y., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 579-591 13 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Neoplasm Metastasis
Bone and Bones
osteoblast cadherin
Cell Movement
28 Citations (Scopus)

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

Yokota, K., Kobayakawa, K., Kubota, K., Miyawaki, A., Okano, H., Ohkawa, Y., Iwamoto, Y. & Okada, S., Jan 1 2015, In : Stem Cell Reports. 5, 2, p. 264-277 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Spinal Cord Injuries
Synapses
Neurons
6 Citations (Scopus)

Scoliosis in patients with multiple hereditary exostoses

Matsumoto, Y., Matsumoto, K., Harimaya, K., Okada, S., Doi, T. & Iwamoto, Y., Jul 27 2015, In : European Spine Journal. 24, 7, p. 1568-1573 6 p.

Research output: Contribution to journalArticle

Multiple Hereditary Exostoses
Scoliosis
Inborn Genetic Diseases
Spine
15 Citations (Scopus)

Spatial re-organization of myogenic regulatory sequences temporally controls gene expression

Harada, A., Mallappa, C., Okada, S., Butler, J. T., Baker, S. P., Lawrence, J. B., Ohkawa, Y. & Imbalzano, A. N., Feb 27 2015, In : Nucleic acids research. 43, 4, p. 2008-2021 14 p.

Research output: Contribution to journalArticle

Gene Expression
Genes
Muscle Development
Myogenin
Chromatin Assembly and Disassembly
2014
21 Citations (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
1 Citation (Scopus)

A shallow chest correlates with the aortic position in the normal spine: Features resembling those observed in structural scoliosis

Doi, T., Matsumoto, Y., Tono, O., Tarukado, K., Harimaya, K., Okada, S., Kubota, K., Hayashida, M. & Iwamoto, Y., Aug 30 2014, In : Scoliosis. 9, 1, 14.

Research output: Contribution to journalArticle

Scoliosis
Spine
Thorax
Rib Cage

Blockade of interleukin-6 effects on cytokine profiles and macrophage activation after spinal cord injury in mice

Guerrero, A. R., Uchida, K., Nakajima, H., Watanabe, S., Nakamura, M., Okada, S., Johnson, W. E. B. & Baba, H., Nov 1 2014, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 203-212 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Macrophage Activation
Spinal Cord Injuries
Interleukin-6 Receptors
Interleukin-6
Cytokines
CCAAT-Enhancer-Binding Proteins
Monoclonal Antibodies
Protein Isoforms
Leucine Zippers
DNA
8 Citations (Scopus)
Quadriplegia
Spinal Cord Diseases
Paraplegia
Spinal Cord Injuries
Nervous System

The mechanism behind functional recovery after the incomplete spinal cord injury

Okada, S., Nov 1 2014, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 3-10 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spinal Cord Injuries
Research
Astrocytes
Rodentia
Central Nervous System
2013
16 Citations (Scopus)

Clinical relationship between cervical spinal canal stenosis and traumatic cervical spinal cord injury without major fracture or dislocation

Takao, T., Morishita, Y., Okada, S., Maeda, T., Katoh, F., Ueta, T., Mori, E., Yugue, I., Kawano, O. & Shiba, K., Oct 1 2013, In : European Spine Journal. 22, 10, p. 2228-2231 4 p.

Research output: Contribution to journalArticle

Spinal Stenosis
Spinal Canal
Spinal Cord Injuries
Incidence
Cerebrospinal Fluid
6 Citations (Scopus)

Dedifferentiated chondrosarcoma of the cervical spine: A case report

Matsumoto, Y., Takahashi, Y., Harimaya, K., Nakagawa, T., Kawaguchi, K., Okada, S., Hayashida, M., Doi, T., Sakamoto, A., Matsunobu, T., Oda, Y. & Iwamoto, Y., Feb 2 2013, In : World Journal of Surgical Oncology. 11, 32.

Research output: Contribution to journalArticle

Chondrosarcoma
Spine
Neoplasms
Fibrosarcoma
Magnetic Resonance Imaging