• 2438 Citations
  • 28 h-Index
1980 …2020

Research output per year

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Research Output

  • 2438 Citations
  • 28 h-Index
  • 74 Article
  • 6 Review article
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Article
2020

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Le Douce, J., Maugard, M., Veran, J., Matos, M., Jégo, P., Vigneron, P. A., Faivre, E., Toussay, X., Vandenberghe, M., Balbastre, Y., Piquet, J., Guiot, E., Tran, N. T., Taverna, M., Marinesco, S., Koyanagi, A., Furuya, S., Gaudin-Guérif, M., Goutal, S., Ghettas, A. & 16 others, Pruvost, A., Bemelmans, A. P., Gaillard, M. C., Cambon, K., Stimmer, L., Sazdovitch, V., Duyckaerts, C., Knott, G., Hérard, A. S., Delzescaux, T., Hantraye, P., Brouillet, E., Cauli, B., Oliet, S. H. R., Panatier, A. & Bonvento, G., Mar 3 2020, In : Cell metabolism. 31, 3, p. 503-517.e8

Research output: Contribution to journalArticle

2 Citations (Scopus)

Molecular survey of the phosphoserine phosphatase involved in L-serine synthesis by silkworms (Bombyx mori)

Haque, M. R., Hirowatari, A., Saruta, F., Furuya, S. & Yamamoto, K., Feb 1 2020, In : Insect Molecular Biology. 29, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

Tyr-Trp administration facilitates brain norepinephrine metabolism and ameliorates a short-term memory deficit in a mouse model of Alzheimer’s disease

Ichinose, T., Murasawa, H., Ishijima, T., Okada, S., Abe, K., Matsumoto, S., Matsui, T. & Furuya, S., May 2020, In : PloS one. 15, 5, e0232233.

Research output: Contribution to journalArticle

Open Access
2019

Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2

Koshimizu, H., Hirata, N., Takao, K., Toyama, K., Ichinose, T., Furuya, S. & Miyakawa, T., Mar 2019, In : Neuropsychopharmacology Reports. 39, 1, p. 56-60 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Molecular characterization and expression analysis of a phosphoserine aminotransferase involving l-serine synthesis from silkworm, Bombyx mori

Haque, M. R., Hirowatari, A., Koyanagi, A., Ichinose, T., Abiru, M., Mohri, S., Furuya, S. & Yamamoto, K., Jun 2019, In : Archives of insect biochemistry and physiology. 101, 2, e21553.

Research output: Contribution to journalArticle

Molecular structure of a 5,10-methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori

Haque, M. R., Higashiura, A., Nakagawa, A., Hirowatari, A., Furuya, S. & Yamamoto, K., Apr 2019, In : FEBS Open Bio. 9, 4, p. 618-628 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
1 Citation (Scopus)
2018

Comparison of the effect of soy and casein-derived peptide administration on tyrosine and catecholamine metabolism in the mouse brain

Hino, Y., Koyanagi, A., Maebuchi, M., Ichinose, T. & Furuya, S., 2018, In : Journal of Nutritional Science and Vitaminology. 64, 5, p. 329-334 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice

Takai, Y., Kawai, M., Ogo, T., Ichinose, T., Furuya, S., Takaki, N., Tone, Y., Udo, H., Furuse, M. & Yasuo, S., Mar 15 2018, In : Neuroscience. 374, p. 133-143 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Enhanced vulnerability to oxidative stress and induction of inflammatory gene expression in 3-phosphoglycerate dehydrogenase-deficient fibroblasts

Hamano, M., Haraguchi, Y., Sayano, T., Zyao, C., Arimoto, Y., Kawano, Y., Moriyasu, K., Udono, M., Katakura, Y., Ogawa, T., Kato, H. & Furuya, S., Jun 2018, In : FEBS Open Bio. 8, 6, p. 914-922 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Vandekeere, S., Dubois, C., Kalucka, J., Sullivan, M. R., García-Caballero, M., Goveia, J., Chen, R., Diehl, F. F., Bar-Lev, L., Souffreau, J., Pircher, A., Kumar, S., Vinckier, S., Hirabayashi, Y., Furuya, S., Schoonjans, L., Eelen, G., Ghesquière, B., Keshet, E., Li, X. & 3 others, Vander Heiden, M. G., Dewerchin, M. & Carmeliet, P., Jul 12 2018, In : Cell Metabolism. 28, 4, p. in press

Research output: Contribution to journalArticle

30 Citations (Scopus)
2017

Soy peptide ingestion augments the synthesis and metabolism of noradrenaline in the mouse brain

Imai, H., Moriyasu, K., Nakahata, A., Maebuchi, M., Ichinose, T. & Furuya, S., 2017, In : Bioscience, Biotechnology and Biochemistry. 81, 5, p. 1007-1013 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Adaptive response to l-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts

Sayano, T., Kawano, Y., Kusada, W., Arimoto, Y., Esaki, K., Hamano, M., Udono, M., Katakura, Y., Ogawa, T., Kato, H., Hirabayashi, Y. & Furuya, S., Apr 1 2016, In : FEBS Open Bio. 6, 4, p. 303-316 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
3 Citations (Scopus)

Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by L-serine depletion

Hamano, M., Sayano, T., Kusada, W., Kato, H. & Furuya, S., Jun 1 2016, In : Data in Brief. 7, p. 1598-1601 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem

Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T. & Furuya, S., 2016, In : International Journal of Peptides. 2016, 6020786.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxysphingolipids and lipid body formation

Esaki, K., Sayano, T., Sonoda, C., Akagi, T., Suzuki, T., Ogawa, T., Okamoto, M., Yoshikawa, T., Hirabayashi, Y. & Furuya, S., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14595-14609 15 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain

Ichinose, T., Moriyasu, K., Nakahata, A., Tanaka, M., Matsui, T. & Furuya, S., Jan 1 2015, In : Bioscience, Biotechnology and Biochemistry. 79, 9, p. 1542-1547 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia

Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., Koshimizu, H., Umemori, J., Toyama, K., Nakamura, H. K., Kuroiwa, M., Maeda, J., Atsuzawa, K., Esaki, K., Yamaguchi, S., Furuya, S., Takagi, T., Walton, N. M., Hayashi, N., Suzuki, H. & 7 others, Higuchi, M., Usuda, N., Suhara, T., Nishi, A., Matsumoto, M., Ishii, S. & Miyakawa, T., Jul 2013, In : Neuropsychopharmacology. 38, 8, p. 1409-1425 17 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

D-Serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase

Ehmsen, J. T., Ma, T. M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S. H. & Wolosker, H., 2013, In : Journal of Neuroscience. 33, 30, p. 12464-12469 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

Esaki, K., Ohmori, T., Maebuchi, M., Nakamori, T., Ohshima, T. & Furuya, S., 2013, In : Bioscience, Biotechnology and Biochemistry. 77, 4, p. 847-849 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

L-Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system

Sayano, T., Kawakami, Y., Kusada, W., Suzuki, T., Kawano, Y., Watanabe, A., Takashima, K., Arimoto, Y., Esaki, K., Wada, A., Yoshizawa, F., Watanabe, M., Okamoto, M., Hirabayashi, Y. & Furuya, S., Mar 2013, In : FEBS Journal. 280, 6, p. 1502-1517 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
10 Citations (Scopus)
2012

Type 1 diabetes mellitus in mice increases hippocampal d-serine in the acute phase after streptozotocin injection

Suzuki, M., Sasabe, J., Furuya, S., Mita, M., Hamase, K. & Aiso, S., Jul 23 2012, In : Brain Research. 1466, p. 167-176 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2010

Brain-specific Phgdh deletion reveals a pivotal role for l-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain

Yang, J. H., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, M. O., Tomonaga, S., Azuma, N., Watanabe, M., Hamase, K., Zaitsu, K., MacHida, T., Messing, A., Itohara, S., Hirabayashi, Y. & Furuya, S., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41380-41390 11 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2009

Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathways

Jin, H. K., Bae, J. S., Furuya, S. & Carter, J. E., Oct 2009, In : Cell Proliferation. 42, 5, p. 571-586 16 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model

Kawakami, Y., Yoshida, K., Yang, J. H., Suzuki, T., Azuma, N., Sakai, K., Hashikawa, T., Watanabe, M., Yasuda, K., Kuhara, S., Hirabayashi, Y. & Furuya, S., Mar 1 2009, In : Neuroscience Research. 63, 3, p. 184-193 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors

Kinoshita, M. O., Furuya, S., Ito, S., Shinoda, Y., Yamazaki, Y., Greimel, P., Ito, Y., Hashikawa, T., Machida, T., Nagatsuka, Y. & Hirabayashi, Y., May 1 2009, In : Biochemical Journal. 419, 3, p. 565-575 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Selective upregulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche

Kinoshita, M. O., Shinoda, Y., Sakai, K., Hashikawa, T., Watanabe, M., Machida, T., Hirabayashi, Y. & Furuya, S., Mar 27 2009, In : Neuroscience Letters. 453, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2008

Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: Changes in gene expression and associated regulatory networks resulting from serine deficiency

Furuya, S., Yoshida, K., Kawakami, Y., Yang, J. H., Sayano, T., Azuma, N., Tanaka, H., Kuhara, S. & Hirabayashi, Y., Aug 1 2008, In : Functional and Integrative Genomics. 8, 3, p. 235-249 15 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2007

Cell-specific expression of neutral glycosphingolipids in vertebrate brain: Immunochemical localization of 3-O-acetyl-sphingosine-series glycolipid(s) in myelin and oligodendrocytes

Dasgupta, S., Bhat, N. R., Spicer, S. S., Hogan, E. L., Furuya, S. & Hirabayashi, Y., Oct 1 2007, In : Journal of Neuroscience Research. 85, 13, p. 2856-2862 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The microtubule destabilizer stathmin mediates the development of dendritic arbors in neuronal cells

Ohkawa, N., Fujitani, K., Tokunaga, E., Furuya, S. & Inokuchi, K., Apr 15 2007, In : Journal of cell science. 120, 8, p. 1447-1456 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2005

Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis

Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N., Akiguchi, I., Furuya, S., Hirabayashi, Y. & Okazaki, T., Jan 1 2005, In : Neuroscience. 130, 3, p. 657-666 10 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Bae, J. S., Furuya, S., Shinoda, Y., Endo, S., Schuchman, E. H., Hirabayashi, Y. & Jin, H. K., Aug 1 2005, In : Human Gene Therapy. 16, 8, p. 1006-1011 6 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells

Bae, J. S., Furuya, S., Ahn, S. J., Yi, S. J., Hirabayashi, Y. & Jin, H. K., Jun 24 2005, In : Neuroscience Letters. 381, 3, p. 234-236 3 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2004

Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain

Shimizu, M., Furuya, S., Shinoda, Y., Mitoma, J., Okamura, T., Miyoshi, I., Kasai, N., Hirabayashi, Y. & Suzuki, Y., Jun 1 2004, In : Journal of Neuroscience Research. 76, 5, p. 623-632 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture

Yamamoto, T., Nishizaki, I., Nukada, T., Kamegaya, E., Furuya, S., Hirabayashi, Y., Ikeda, K., Hata, H., Kobayashi, H., Sora, I. & Yamamoto, H., May 1 2004, In : Neuroscience Research. 49, 1, p. 101-111 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Mouse 3-phosphoglycerate dehydrogenase gene: Genomic organization, chromosomal localization, and promoter analysis

Mitoma, J., Furuya, S., Shimizu, M., Shinoda, Y., Yoshida, K., Azuma, N., Tanaka, H., Suzuki, Y. & Hirabayashi, Y., Jun 9 2004, In : Gene. 334, 1-2, p. 15-22 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Targeted Disruption of the Mouse 3-Phosphoglycerate Dehydrogenase Gene Causes Severe Neurodevelopmental Defects and Results in Embryonic Lethality

Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S. & Hirabayashi, Y., Jan 30 2004, In : Journal of Biological Chemistry. 279, 5, p. 3573-3577 5 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2003

Characterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary culture

Yamamoto, T., Nishizaki, I., Furuya, S., Hirabayashi, Y., Takahashi, K., Okuyama, S. & Yamamoto, H., Jul 31 2003, In : FEBS Letters. 548, 1-3, p. 69-73 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization

Chen, N., Furuya, S., Shinoda, Y., Yumoto, M., Ohtake, A., Sato, K., Doi, H., Hashimoto, Y., Kudo, Y. & Higashi, H., Jan 1 2003, In : Neuroscience. 122, 4, p. 985-995 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Ganglioside/calmodulin kinase II signal inducing cdc42-mediated neuronal actin reorganization

Chen, N., Furuya, S., Doi, H., Hashimoto, Y., Kudo, Y. & Higashi, H., Aug 4 2003, In : Neuroscience. 120, 1, p. 163-176 14 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries

Sakai, K., Shimizu, H., Koike, T., Furuya, S. & Watanabe, M., Jan 15 2003, In : Journal of Neuroscience. 23, 2, p. 550-560 11 p.

Research output: Contribution to journalArticle

Open Access
82 Citations (Scopus)

Oxidative Stress is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice

Chen, P., Peng, C., Luff, J., Spring, K., Watters, D., Bottle, S., Furuya, S. & Lavin, M. F., Dec 10 2003, In : Journal of Neuroscience. 23, 36, p. 11453-11460 8 p.

Research output: Contribution to journalArticle

Open Access
99 Citations (Scopus)
14 Citations (Scopus)
2001

3-Phosphoglycerate dehydrogenase, a key enzyme for L-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain

Yamasaki, M., Yamada, K., Furuya, S., Mitoma, J., Hirabayashi, Y. & Watanabe, M., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7691-7704 14 p.

Research output: Contribution to journalArticle

Open Access
141 Citations (Scopus)

Intercellular action of nitric oxide increases cGMP in cerebellar Purkinje cells

Hartell, N. A., Furuya, S., Jacoby, S. & Okada, D., Jan 22 2001, In : NeuroReport. 12, 1, p. 25-28 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

L-serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate dehydrogenase, an enzyme for L-serine biosynthesis

Sugishita, H., Kuwabara, Y., Toku, K., Doi, L., Yang, L., Mitoma, J., Furuya, S., Hirabayashi, Y., Maeda, N., Sakanaka, M. & Tanaka, J., May 15 2001, In : Journal of Neuroscience Research. 64, 4, p. 392-401 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2000

A reliable method for culture of dissociated mouse cerebellar cells enriched for Purkinje neurons

Tabata, T., Sawada, S., Araki, K., Bono, Y., Furuya, S. & Kano, M., Dec 15 2000, In : Journal of Neuroscience Methods. 104, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)