If you made any changes in Pure these will be visible here soon.

Research Output 2006 2019

2019
6 Citations (Scopus)

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

Iwamoto, M., Saso, W., Sugiyama, R., Ishii, K., Ohki, M., Nagamori, S., Suzuki, R., Aizaki, H., Ryo, A., Yun, J. H., Park, S. Y., Ohtani, N., Muramatsu, M., Iwami, S., Tanaka, Y., Sureau, C., Wakita, T. & Watashi, K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 17, p. 8487-8492 6 p.

Research output: Contribution to journalArticle

Virus Internalization
Epidermal Growth Factor Receptor
Hepatitis B virus
Virus Diseases
Peptides
1 Citation (Scopus)

Mathematical Analysis of a Transformed ODE from a PDE Multiscale Model of Hepatitis C Virus Infection

Kitagawa, K., Kuniya, T., Nakaoka, S., Asai, Y., Watashi, K. & Iwami, S., May 15 2019, In : Bulletin of Mathematical Biology. 81, 5, p. 1427-1441 15 p.

Research output: Contribution to journalArticle

mathematical analysis
hepatitis
Multiscale Model
Hepatitis C virus
Virus Diseases

Revealing uninfected and infected target cell dynamics from peripheral blood data in highly and less pathogenic simian/human immunodeficiency virus infected Rhesus macaque

Hara, A., Iwanami, S., Ito, Y., Miura, T., Nakaoka, S. & Iwami, S., Oct 21 2019, In : Journal of Theoretical Biology. 479, p. 29-36 8 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus
Macaca mulatta
Viruses
2018
1 Citation (Scopus)

A PDE multiscale model of hepatitis C virus infection can be transformed to a system of ODEs

Kitagawa, K., Nakaoka, S., Asai, Y., Watashi, K. & Iwami, S., Jul 7 2018, In : Journal of Theoretical Biology. 448, p. 80-85 6 p.

Research output: Contribution to journalArticle

Multiscale Model
Hepatitis C virus
Virus Diseases
Viruses
System of Ordinary Differential Equations

Dynamics of HIV-1 coinfection in different susceptible target cell populations during cell-free infection

Ito, Y., Tauzin, A., Remion, A., Ejima, K., Mammano, F. & Iwami, S., Oct 14 2018, In : Journal of Theoretical Biology. 455, p. 39-46 8 p.

Research output: Contribution to journalArticle

Health Services Needs and Demand
Cell Population
Human immunodeficiency virus 1
Coinfection
mixed infection
9 Citations (Scopus)

Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo

Yamada, E., Nakaoka, S., Klein, L., Reith, E., Langer, S., Hopfensperger, K., Iwami, S., Schreiber, G., Kirchhoff, F., Koyanagi, Y., Sauter, D. & Sato, K., Jan 10 2018, In : Cell Host and Microbe. 23, 1, p. 110-120.e7

Research output: Contribution to journalArticle

HIV-1
Interferons
HIV Infections
Mutation
Proteins
2 Citations (Scopus)

Malaria incidences in South Africa linked to a climate mode in southwestern Indian Ocean

Behera, S. K., Morioka, Y., Ikeda, T., Doi, T., Ratnam, J. V., Nonaka, M., Tsuzuki, A., Imai, C., Kim, Y., Hashizume, M., Iwami, S., Kruger, P., Maharaj, R., Sweijd, N. & Minakawa, N., Sep 1 2018, In : Environmental Development. 27, p. 47-57 11 p.

Research output: Contribution to journalArticle

Indian Ocean
malaria
incidence
climate
district
23 Citations (Scopus)

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

Mahgoub, M., Yasunaga, J. I., Iwami, S., Nakaoka, S., Koizumi, Y., Shimura, K. & Matsuoka, M., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. E1269-E1278

Research output: Contribution to journalArticle

Deltaretrovirus
Viruses
Population
Infection
Single-Cell Analysis
2017
26 Citations (Scopus)

A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation

Fujiu, K., Shibata, M., Nakayama, Y., Ogata, F., Matsumoto, S., Noshita, K., Iwami, S., Nakae, S., Komuro, I., Nagai, R. & Manabe, I., May 1 2017, In : Nature medicine. 23, 5, p. 611-622 12 p.

Research output: Contribution to journalArticle

Macrophage Activation
Macrophages
Brain
Chemical activation
Tissue
3 Citations (Scopus)

A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture

Iwanami, S., Kakizoe, Y., Morita, S., Miura, T., Nakaoka, S. & Iwami, S., Apr 21 2017, In : Theoretical Biology and Medical Modelling. 14, 1, 9.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Cell Culture
Viruses
Cell culture
Virion
7 Citations (Scopus)
Antiviral Agents
Normal Distribution
HIV
Viruses
Infection

Erratum: Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation (PLoS pathogens (2017) 13 5 (e1006348))

Nakano, Y., Misawa, N., Juarez-Fernandez, G., Moriwaki, M., Nakaoka, S., Funo, T., Yamada, E., Soper, A., Yoshikawa, R., Ebrahimi, D., Tachiki, Y., Iwami, S., Harris, R. S., Koyanagi, Y. & Sato, K., Sep 1 2017, In : PLoS pathogens. 13, 9, p. e1006606

Research output: Contribution to journalComment/debate

Open Access
HIV-1
Viruses
5 Citations (Scopus)

Hepatitis C virus entry inhibitors for optimally boosting direct-Acting antiviral-based treatments

Ohashi, H., Koizumi, Y., Fukano, K., Wakita, T., Perelson, A. S., Iwami, S. & Watashi, K., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4527-E4529

Research output: Contribution to journalLetter

14 Citations (Scopus)

HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

Nakano, Y., Misawa, N., Juarez-Fernandez, G., Moriwaki, M., Nakaoka, S., Funo, T., Yamada, E., Soper, A., Yoshikawa, R., Ebrahimi, D., Tachiki, Y., Iwami, S., Harris, R. S., Koyanagi, Y. & Sato, K., May 2017, In : PLoS pathogens. 13, 5, e1006348.

Research output: Contribution to journalArticle

HIV-1
Viruses
Cytosine Deaminase
RNA Sequence Analysis
Viral RNA
4 Citations (Scopus)

Number of infection events per cell during HIV-1 cell-free infection

Ito, Y., Remion, A., Tauzin, A., Ejima, K., Nakaoka, S., Iwasa, Y., Iwami, S. & Mammano, F., Dec 1 2017, In : Scientific reports. 7, 1, 6559.

Research output: Contribution to journalArticle

HIV-1
Infection
Genetic Recombination
Binomial Distribution
Coinfection
14 Citations (Scopus)

Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection

Koizumi, Y., Ohashi, H., Nakajima, S., Tanaka, Y., Wakita, T., Perelson, A. S., Iwami, S. & Watashi, K., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 1922-1927 6 p.

Research output: Contribution to journalArticle

Virus Diseases
Drug Combinations
Hepacivirus
Antiviral Agents
danoprevir
2016
5 Citations (Scopus)

(In)validating experimentally derived knowledge about influenza A defective interfering particles

Liao, L. E., Iwami, S. & Beauchemin, C. A. A., Nov 1 2016, In : Journal of the Royal Society Interface. 13, 124, 20160412.

Research output: Contribution to journalArticle

Defective Viruses
Viruses
Human Influenza
Virion
Influenza A virus
10 Citations (Scopus)

Dynamics of HIV infection in lymphoid tissue network

Nakaoka, S., Iwami, S. & Sato, K., Mar 1 2016, In : Journal of Mathematical Biology. 72, 4, p. 909-938 30 p.

Research output: Contribution to journalArticle

HIV infections
Lymphoid Tissue
Virus Diseases
Viruses
Virus
1 Citation (Scopus)

Impact of asymptomatic infections on the early spread of malaria

Funo, T., Inaba, H., Jusup, M., Tsuzuki, A., Minakawa, N. & Iwami, S., Dec 1 2016, In : Japan Journal of Industrial and Applied Mathematics. 33, 3, p. 671-681 11 p.

Research output: Contribution to journalArticle

Malaria
Infection
Mathematical models
Elimination
Proportion
6 Citations (Scopus)

Modelling Ebola virus dynamics: Implications for therapy

Martyushev, A., Nakaoka, S., Sato, K., Noda, T. & Iwami, S., Nov 1 2016, In : Antiviral Research. 135, p. 62-73 12 p.

Research output: Contribution to journalArticle

Ebolavirus
Ebola Hemorrhagic Fever
Antiviral Agents
Therapeutics
Uganda
5 Citations (Scopus)

Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model

Ikeda, H., Nakaoka, S., Boer, R. J., Morita, S., Misawa, N., Koyanagi, Y., Aihara, K., Sato, K. & Iwami, S., Apr 18 2016, In : Retrovirology. 13, 1, 23.

Research output: Contribution to journalArticle

HIV-1
Basic Reproduction Number
Viral Load
HIV Infections
Theoretical Models
2015
8 Citations (Scopus)

A conservation law for virus infection kinetics in vitro

Kakizoe, Y., Morita, S., Nakaoka, S., Takeuchi, Y., Sato, K., Miura, T., Beauchemin, C. A. A. & Iwami, S., Jul 7 2015, In : Journal of Theoretical Biology. 376, p. 39-47 9 p.

Research output: Contribution to journalArticle

Virus Diseases
Viruses
Conservation Laws
Virus
Infection
19 Citations (Scopus)

A method to determine the duration of the eclipse phase for in vitro infection with a highly pathogenic SHIV strain

Kakizoe, Y., Nakaoka, S., Beauchemin, C. A. A., Morita, S., Mori, H., Igarashi, T., Aihara, K., Miura, T. & Iwami, S., May 21 2015, In : Scientific reports. 5, 10371.

Research output: Contribution to journalArticle

Viruses
Infection
Theoretical Models
Virus Diseases
In Vitro Techniques
42 Citations (Scopus)

Cell-to-cell infection by HIV contributes over half of virus infection

Iwami, S., Takeuchi, J. S., Nakaoka, S., Mammano, F., Clavel, F., Inaba, H., Kobayashi, T., Misawa, N., Aihara, K., Koyanagi, Y. & Sato, K., Oct 6 2015, In : eLife. 4, OCTOBER2015, e08150.

Research output: Contribution to journalArticle

Virus Diseases
Viruses
HIV Infections
Infection
HIV-1
5 Citations (Scopus)

Dynamically rich, yet parameter-sparse models for spatial epidemiology: Comment on "Coupled disease-behavior dynamics on complex networks: A review" by Z. Wang et al.

Jusup, M., Iwami, S., Podobnik, B. & Stanley, H. E., Dec 1 2015, In : Physics of Life Reviews. 15, p. 43-46 4 p.

Research output: Contribution to journalComment/debate

epidemiology
Epidemiology
Nonlinear Dynamics
Complex networks
Theoretical Models
1 Citation (Scopus)

Erratum: Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture (Scientific Reports (2015) 5 (11761) DOI:10.1038/srep11761)

Ikeda, H., Godinho-Santos, A., Rato, S., Vanwalscappel, B., Clavel, F., Aihara, K., Iwami, S. & Mammano, F., Oct 22 2015, In : Scientific reports. 5, 15679.

Research output: Contribution to journalComment/debate

Exploring the conserved quantity of viral infection model with periodical cell removal

Kakizoe, Y. & Iwami, S., Nov 1 2015, In : Japan Journal of Industrial and Applied Mathematics. 32, 3, p. 749-757 9 p.

Research output: Contribution to journalArticle

Conserved Quantity
Infection
Cell Culture
Cell culture
Cell
6 Citations (Scopus)

Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin

Iwami, S., Sato, K., Morita, S., Inaba, H., Kobayashi, T., Takeuchi, J. S., Kimura, Y., Misawa, N., Ren, F., Iwasa, Y., Aihara, K. & Koyanagi, Y., Jul 17 2015, In : Scientific reports. 5, 12256.

Research output: Contribution to journalArticle

Herd Immunity
Pandemics
HIV-1
HIV
Intrinsic Factor
3 Citations (Scopus)

Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture

Ikeda, H., Godinho-Santos, A., Rato, S., Vanwalscappel, B., Clavel, F., Aihara, K., Iwami, S. & Mammano, F., Jun 29 2015, In : Scientific reports. 5, 11761.

Research output: Contribution to journalArticle

Interferons
Antiviral Agents
HIV-1
Cell Culture Techniques
HIV
2014
50 Citations (Scopus)

APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

Sato, K., Takeuchi, J. S., Misawa, N., Izumi, T., Kobayashi, T., Kimura, Y., Iwami, S., Takaori-Kondo, A., Hu, W. S., Aihara, K., Ito, M., An, D. S., Pathak, V. K. & Koyanagi, Y., Jan 1 2014, In : PLoS Pathogens. 10, 10

Research output: Contribution to journalArticle

HIV-1
Proteins
Viral Genome
Viral RNA
Proteasome Endopeptidase Complex
6 Citations (Scopus)

Improving the estimation of the death rate of infected cells from time course data during the acute phase of virus infections: Application to acute HIV-1 infection in a humanized mouse model

Ikeda, H., De Boer, R. J., Sato, K., Morita, S., Misawa, N., Koyanagi, Y., Aihara, K. & Iwami, S., May 21 2014, In : Theoretical Biology and Medical Modelling. 11, 1, 22.

Research output: Contribution to journalArticle

Virus Diseases
Viruses
Acute
Virus
HIV Infections
16 Citations (Scopus)
Drug therapy
Drug Combinations
Viruses
Mathematical Modeling
Therapy
21 Citations (Scopus)

Quantification of deaminase activity-dependent and -independent restriction of HIV-1 replication mediated by APOBEC3F and APOBEC3G through experimental-mathematical investigation

Kobayashi, T., Koizumi, Y., Takeuchi, J. S., Misawa, N., Kimura, Y., Morita, S., Aihara, K., Koyanagi, Y., Iwami, S. & Sato, K., Jan 1 2014, In : Journal of virology. 88, 10, p. 5881-5887 7 p.

Research output: Contribution to journalArticle

Virus Replication
Human immunodeficiency virus 1
Antiviral Agents
HIV-1
Cytidine Deaminase
2013
28 Citations (Scopus)

HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo

Sato, K., Misawa, N., Iwami, S., Satou, Y., Matsuoka, M., Ishizaka, Y., Ito, M., Aihara, K., An, D. S. & Koyanagi, Y., Jan 1 2013, In : PLoS pathogens. 9, 12, p. 1-12 12 p., e1003812.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus vpr Gene Products
vpr Gene Products
HIV-1
T-Lymphocytes
Infection
10 Citations (Scopus)

Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation

Fukuhara, M., Iwami, S., Sato, K., Nishimura, Y., Shimizu, H., Aihara, K. & Koyanagi, Y., Jan 1 2013, In : Journal of virology. 87, 1, p. 701-705 5 p.

Research output: Contribution to journalArticle

Enterovirus Infections
Enterovirus
hand, foot and mouth disease
Hand, Foot and Mouth Disease
infection
8 Citations (Scopus)

Quantification of viral infection dynamics in animal experiments

Iwami, S., Koizumi, Y., Ikeda, H. & Kakizoe, Y., Jan 1 2013, In : Frontiers in Microbiology. 4, SEP

Research output: Contribution to journalShort survey

Virus Diseases
Infection
Theoretical Models
Animal Models
2012
8 Citations (Scopus)

A race between tumor immunoescape and genome maintenance selects for optimum levels of (epi)genetic instability

Iwami, S., Haeno, H. & Michor, F., Feb 1 2012, In : PLoS Computational Biology. 8, 2, e1002370.

Research output: Contribution to journalArticle

tumor
Tumors
Tumor
Maintenance
Genome
18 Citations (Scopus)

Identifying viral parameters from in vitro cell cultures

Iwami, S., Sato, K., De Boer, R. J., Aihara, K., Miura, T. & Koyanagi, Y., Jan 1 2012, In : Frontiers in Microbiology. 3, SEP

Research output: Contribution to journalArticle

Virus Diseases
Cell Culture Techniques
Virology
Virion
Cell Death
66 Citations (Scopus)

Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy

Horiike, M., Iwami, S., Kodama, M., Sato, A., Watanabe, Y., Yasui, M., Ishida, Y., Kobayashi, T., Miura, T. & Igarashi, T., Feb 20 2012, In : Virology. 423, 2, p. 107-118 12 p.

Research output: Contribution to journalArticle

Viremia
Viral RNA
Macaca
Lymph Nodes
Lymphoid Tissue

Potential risks of vaccination against avian flu epidemics

Iwami, S. & Takeuchi, Y., 2012, Avian Influenza: Etiology, Pathogenesis and Interventions. Nova Science Publishers, Inc., p. 167-194 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Influenza in Birds
Vaccination
Vaccines
Birds
H5N1 Subtype Influenza A Virus
19 Citations (Scopus)

Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model

Iwami, S., Holder, B. P., Beauchemin, C. A. A., Morita, S., Tada, T., Sato, K., Igarashi, T. & Miura, T., Feb 25 2012, In : Retrovirology. 9, 18.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Theoretical Models
Viral Load
HIV
Viruses
46 Citations (Scopus)

Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice

Sato, K., Misawa, N., Fukuhara, M., Iwami, S., An, D. S., Ito, M. & Koyanagi, Y., May 1 2012, In : Journal of virology. 86, 9, p. 5000-5013 14 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
Down-Regulation
mice
cells
2010
7 Citations (Scopus)

Global stability of a generalized epidemic model

Iwami, S. & Hara, T., Feb 15 2010, In : Journal of Mathematical Analysis and Applications. 362, 2, p. 286-300 15 p.

Research output: Contribution to journalArticle

Epidemiology
Epidemic Model
System theory
Lyapunov functions
Global Stability
2009
24 Citations (Scopus)

A geographical spread of vaccine-resistance in avian influenza epidemics

Iwami, S., Takeuchi, Y., Liu, X. & Nakaoka, S., Jul 21 2009, In : Journal of Theoretical Biology. 259, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

Influenza in Birds
Vaccines
Vaccination
Vaccine
Influenza
11 Citations (Scopus)

A mathematical design of vector vaccine against autoimmune disease

Iwami, S., Takeuchi, Y., Iwamoto, K., Naruo, Y. & Yasukawa, M., Feb 7 2009, In : Journal of Theoretical Biology. 256, 3, p. 382-392 11 p.

Research output: Contribution to journalArticle

vector vaccines
Vaccines
autoimmune diseases
Vaccine
Autoimmune Diseases
39 Citations (Scopus)

Avian flu pandemic: Can we prevent it?

Iwami, S., Takeuchi, Y. & Liu, X., Mar 7 2009, In : Journal of Theoretical Biology. 257, 1, p. 181-190 10 p.

Research output: Contribution to journalArticle

Influenza in Birds
avian influenza
Pandemics
pandemic
Viruses
4 Citations (Scopus)

Dynamical adaptation of parental care

Takeuchi, Y., Wang, W., Nakaoka, S. & Iwami, S., May 1 2009, In : Bulletin of Mathematical Biology. 71, 4, p. 931-951 21 p.

Research output: Contribution to journalArticle

parental care
immatures
Population
Dichlorodiphenyl Dichloroethylene
DDE
24 Citations (Scopus)

Immune impairment in HIV infection: Existence of risky and immunodeficiency thresholds

Iwami, S., Miura, T., Nakaoka, S. & Takeuchi, Y., Oct 21 2009, In : Journal of Theoretical Biology. 260, 4, p. 490-501 12 p.

Research output: Contribution to journalArticle

HIV Infection
immunosuppression
HIV infections
HIV Infections
Immune system
13 Citations (Scopus)

Immune impairment thresholds in HIV infection

Iwami, S., Nakaoka, S., Takeuchi, Y., Miura, Y. & Miura, T., Apr 27 2009, In : Immunology Letters. 123, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

HIV Infections
Acquired Immunodeficiency Syndrome
HIV
Disease Progression
Immune System
54 Citations (Scopus)

Optimal control strategy for prevention of avian influenza pandemic

Jung, E., Iwami, S., Takeuchi, Y. & Jo, T. C., Sep 21 2009, In : Journal of Theoretical Biology. 260, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Influenza in Birds
Influenza
avian influenza
Pandemics
pandemic