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Research Output 2004 2017

  • 3695 Citations
  • 22 h-Index
  • 28 Article
  • 1 Review article
2017
34 Citations (Scopus)

Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota

Nagashima, K., Sawa, S., Nitta, T., Tsutsumi, M., Okamura, T., Penninger, J. M., Nakashima, T. & Takayanagi, H., May 18 2017, In : Nature Immunology. 18, 6, p. 675-682 8 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Lymphoid Tissue
Helper-Inducer T-Lymphocytes
Cell Communication
Dendritic Cells
38 Citations (Scopus)

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis

Onder, L., Mörbe, U., Pikor, N., Novkovic, M., Cheng, H. W., Hehlgans, T., Pfeffer, K., Becher, B., Waisman, A., Rülicke, T., Gommerman, J., Mueller, C. G., Sawa, S., Scandella, E. & Ludewig, B., Jul 18 2017, In : Immunity. 47, 1, p. 80-92.e4

Research output: Contribution to journalArticle

Open Access
Organogenesis
Lymphoid Tissue
Endothelial Cells
Lymph Nodes
Helper-Inducer T-Lymphocytes
59 Citations (Scopus)

Osteoimmunology: The conceptual framework unifying the immune and skeletal systems

Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T. & Takayanagi, H., Oct 1 2017, In : Physiological Reviews. 97, 4, p. 1295-1349 55 p.

Research output: Contribution to journalArticle

Immune System
Bone and Bones
Hematopoietic Stem Cells
Helper-Inducer T-Lymphocytes
Rheumatoid Arthritis
2 Citations (Scopus)

Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver

Nagashima, K., Sawa, S., Nitta, T., Prados, A., Koliaraki, V., Kollias, G., Nakashima, T. & Takayanagi, H., Nov 4 2017, In : Biochemical and Biophysical Research Communications. 493, 1, p. 437-443 7 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Tissue
Immunoglobulin A
Antigen-antibody reactions
Lymphoid Tissue
2016
62 Citations (Scopus)

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

Danks, L., Komatsu, N., Guerrini, M. M., Sawa, S., Armaka, M., Kollias, G., Nakashima, T. & Takayanagi, H., Jun 1 2016, In : Annals of the Rheumatic Diseases. 75, 6, p. 1187-1195 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Fibroblasts
Experimental Arthritis
Erosion
Bone
12 Citations (Scopus)

SLAM-associated protein favors the development of iNKT2 over iNKT17 cells

Michel, M. L., Lenoir, C., Massot, B., Diem, S., Pasquier, B., Sawa, S., Rignault-Bricard, R., Lehuen, A., Eberl, G., Veillette, A., Leite-de-Moraes, M. & Latour, S., Sep 1 2016, In : European Journal of Immunology. 46, 9, p. 2162-2174 13 p.

Research output: Contribution to journalArticle

Open Access
Lymphocyte Activation
Natural Killer T-Cells
Proteins
Interleukin-4
Transcription Factor 3
2015
46 Citations (Scopus)

Immune complexes regulate bone metabolism through FcRγ signalling

Negishi-Koga, T., Gober, H. J., Matsumoto, E., Komatsu, N., Okamoto, K., Sawa, S., Suematsu, A., Suda, T., Sato, K., Takai, T. & Takayanagi, H., Mar 31 2015, In : Nature communications. 6, 6637.

Research output: Contribution to journalArticle

Open Access
metabolism
Antigen-Antibody Complex
Metabolism
bones
Bone
23 Citations (Scopus)

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System

Guerrini, M. M., Okamoto, K., Komatsu, N., Sawa, S., Danks, L., Penninger, J. M., Nakashima, T. & Takayanagi, H., Jan 1 2015, In : Immunity. 43, 6, p. 1174-1185 12 p.

Research output: Contribution to journalArticle

Open Access
Central Nervous System
Cytokines
Inflammation
T-Lymphocytes
Autoimmune Experimental Encephalomyelitis
2014
412 Citations (Scopus)

Pathogenic conversion of Foxp3 + T cells into TH17 cells in autoimmune arthritis

Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Ohora, M., Kodama, T., Tanaka, S., Bluestone, J. A. & Takayanagi, H., Jan 1 2014, In : Nature medicine. 20, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

Th17 Cells
T-cells
Arthritis
T-Lymphocytes
Interleukin-17
2013
1 Citation (Scopus)

Roles of RORγt+ innate lymphoid cells in mucosal tissues of mouse and human

Sawa, S., Jan 1 2013, In : Japanese Journal of Clinical Immunology. 36, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

Open Access
Mucous Membrane
Lymphocytes
Crohn Disease
Intestines
Antigen Receptors
2012
159 Citations (Scopus)

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells

Cherrier, M., Sawa, S. & Eberl, G., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

Open Access
Lymphoid Tissue
Fetal Development
Helper-Inducer T-Lymphocytes
Lymphoid Progenitor Cells
Peyer's Patches
2011
32 Citations (Scopus)

Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity

Ohnmacht, C., Marques, R., Presley, L., Sawa, S., Lochner, M. & Eberl, G., May 1 2011, In : Cellular Microbiology. 13, 5, p. 653-659 7 p.

Research output: Contribution to journalReview article

Open Access
Immune System
Immunity
Intestines
Dysbiosis
Th17 Cells
26 Citations (Scopus)

Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells

Satoh-Takayama, N., Lesjean-Pottier, S., Sawa, S., Vosshenrich, C. A. J., Eberl, G. & Di Santo, J. P., Mar 1 2011, In : European Journal of Immunology. 41, 3, p. 780-786 7 p.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Lymphocytes
Lymphoid Tissue
Natural Cytotoxicity Triggering Receptor 1
Citrobacter rodentium
137 Citations (Scopus)

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

Lochner, M., Ohnmacht, C., Presley, L., Bruhns, P., Si-Tahar, M., Sawa, S. & Eberl, G., Jan 17 2011, In : Journal of Experimental Medicine. 208, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Lymphoid Tissue
Helper-Inducer T-Lymphocytes
B-Lymphocytes
Immunoglobulin G
57 Citations (Scopus)

Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells

Lochner, M., Bérard, M., Sawa, S., Hauer, S., Gaboriau-Routhiau, V., Fernandez, T. D., Snel, J., Bousso, P., Cerf-Bensussan, N. & Eberl, G., Feb 1 2011, In : Journal of Immunology. 186, 3, p. 1531-1537 7 p.

Research output: Contribution to journalArticle

Open Access
Th17 Cells
Microbiota
Antigens
Interleukin-17
T-Lymphocytes
354 Citations (Scopus)

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

Sawa, S., Lochner, M., Satoh-Takayama, N., Dulauroy, S., Bérard, M., Kleinschek, M., Cua, D., Di Santo, J. P. & Eberl, G., Apr 1 2011, In : Nature Immunology. 12, 4, p. 320-328 9 p.

Research output: Contribution to journalArticle

Microbiota
Homeostasis
Lymphocytes
Th17 Cells
Interleukin-17
2010
225 Citations (Scopus)

IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors

Satoh-Takayama, N., Lesjean-Pottier, S., Vieira, P., Sawa, S., Eberl, G., Vosshenrich, C. A. J. & Di Santo, J. P., Feb 15 2010, In : Journal of Experimental Medicine. 207, 2, p. 273-280 8 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-15
Interleukin-7
Natural Killer Cells
Lymphoid Tissue
Natural Cytotoxicity Triggering Receptor 1
324 Citations (Scopus)

Lineage relationship analysis of RORγt+ innate lymphoid cells

Sawa, S., Cherrier, M., Lochner, M., Satoh-Takayama, N., Fehling, H. J., Langa, F., Di Santo, J. P. & Eberl, G., Oct 29 2010, In : Science. 330, 6004, p. 665-669 5 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Helper-Inducer T-Lymphocytes
Lymphocytes
T-Lymphocytes
Interleukin-17
19 Citations (Scopus)

Opening the crypt: current facts and hypotheses on the function of cryptopatches

Eberl, G. & Sawa, S., Feb 1 2010, In : Trends in Immunology. 31, 2, p. 50-55 6 p.

Research output: Contribution to journalArticle

Lymphocytes
Th17 Cells
Lymphoid Tissue
Allergy and Immunology
Dendritic Cells
2008
331 Citations (Scopus)

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Langa, F., Varona, R., Riethmacher, D., Si-Tahar, M., Di Santo, J. P. & Eberl, G., Jun 9 2008, In : Journal of Experimental Medicine. 205, 6, p. 1381-1393 13 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-17
T-Cell Antigen Receptor
Interleukin-10
Interleukin-6
Inflammation
681 Citations (Scopus)

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

Satoh-Takayama, N., Vosshenrich, C. A. J., Lesjean-Pottier, S., Sawa, S., Lochner, M., Rattis, F., Mention, J. J., Thiam, K., Cerf-Bensussan, N., Mandelboim, O., Eberl, G. & Di Santo, J. P., Dec 19 2008, In : Immunity. 29, 6, p. 958-970 13 p.

Research output: Contribution to journalArticle

Open Access
Natural Killer Cells
Natural Cytotoxicity Triggering Receptor 1
Citrobacter rodentium
Lymphocytes
Perforin
2007
54 Citations (Scopus)

Homeostatically proliferating CD4+ T cells are involved in the pathogenesis of an Omenn syndrome murine model

Khiong, K., Murakami, M., Kitabayashi, C., Ueda, N., Sawa, S., Sakamoto, A., Kotzin, B. L., Rozzo, S. J., Ishihara, K., Verella-Garcia, M., Kappler, J., Marrack, P. & Hirano, T., May 1 2007, In : Journal of Clinical Investigation. 117, 5, p. 1270-1281 12 p.

Research output: Contribution to journalArticle

Open Access
Severe Combined Immunodeficiency
T-Lymphocytes
Immunoglobulin E
Mutation
Eosinophilia
2006
125 Citations (Scopus)

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4 + T cells

Sawa, S. I., Kamimura, D., Jin, G. H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K., Murakami, M. & Hirano, T., Jun 12 2006, In : Journal of Experimental Medicine. 203, 6, p. 1459-1470 12 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-6 Receptors
Interleukin-7
Arthritis
T-Lymphocytes
Interleukin-6
17 Citations (Scopus)

CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4

Ueda, N., Kuki, H., Kamimura, D., Sawa, S., Seino, K., Tashiro, T., Fushuku, K. I., Taniguchi, M., Hirano, T. & Murakami, M., Sep 1 2006, In : International Immunology. 18, 9, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

Open Access
Natural Killer T-Cells
Interleukin-4
T-Lymphocytes
Cell Proliferation
Cytokines
2005

Hyperactivation of gp130-mediated STAT3 signaling induces a rheumatoid arthritis-like disease that is dependent on MHC class II restricted CD4+ T cells

Murakami, M., Sawa, S., Kamimura, D., Kamon, H., Kitamura, H., Kawabe, T., Sung-Joo, P., Ishihara, K. & Hirano, T., Nov 1 2005, In : International Congress Series. 1285, p. 207-211 5 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
T-Lymphocytes
Dendritic Cells
Arthritis
Interleukin-6
135 Citations (Scopus)

IL-6-STAT3 controls intracellular MHC class II αβ dimer level through cathepsin S activity in Dendritic Cells

Kitamura, H., Kamon, H., Sawa, S., Park, S. J., Katunuma, N., Ishihara, K., Murakami, M. & Hirano, T., Nov 1 2005, In : Immunity. 23, 5, p. 491-502 12 p.

Research output: Contribution to journalArticle

Open Access
cathepsin S
Dendritic Cells
Interleukin-6
Cystatin C
Cathepsins
2004
26 Citations (Scopus)

Evidence of a novel IL-2/15Rβ-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells

Kamimura, D., Ueda, N., Sawa, Y., Hachida, S., Atsumi, T., Nakagawa, T., Sawa, S., Jin, G. H., Suzuki, H., Ishihara, K., Murakami, M. & Hirano, T., Nov 15 2004, In : Journal of Immunology. 173, 10, p. 6041-6049 9 p.

Research output: Contribution to journalArticle

Interleukin-2
Cytokines
T-Lymphocytes
Interleukin-15
Knockout Mice
290 Citations (Scopus)

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation

Park, S. J., Nakagawa, T., Kitamura, H., Atsumi, T., Kamon, H., Sawa, S., Kamimura, D., Ueda, N., Iwakura, Y., Ishihara, K., Murakami, M. & Hirano, T., Sep 15 2004, In : Journal of Immunology. 173, 6, p. 3844-3854 11 p.

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Cell Differentiation
Interleukin-6
Knockout Mice
SH2 Domain-Containing Protein Tyrosine Phosphatases
14 Citations (Scopus)

The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis

Ishihara, K., Sawa, S. I., Ikushima, H., Hirota, S., Atsumi, T., Kamimura, D., Park, S. J., Murakami, M., Kitamura, Y., Iwakura, Y. & Hirano, T., Mar 1 2004, In : International Immunology. 16, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

Open Access
Cytokine Receptor gp130
Human T-lymphotropic virus 1
Point Mutation
Arthritis
Tyrosine