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19972020

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Article
2020

Activation of invariant natural killer T cells by alpha-galactosylceramide ameliorates doxorubicin-induced cardiotoxicity in mice

Obata, Y., Ishimori, N., Saito, A., Kinugawa, S., Yokota, T., Takada, S., Nakano, I., Kakutani, N., Yamanashi, K. & Anzai, T., Jan 1 2020, (Accepted/In press) In : European Journal of Preventive Cardiology.

Research output: Contribution to journalArticle

Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure

Nambu, H., Takada, S., Fukushima, A., Matsumoto, J., Kakutani, N., Maekawa, S., Shirakawa, R., Nakano, I., Furihata, T., Katayama, T., Yamanashi, K., Obata, Y., Saito, A., Yokota, T. & Kinugawa, S., Jan 5 2020, In : European Journal of Pharmacology. 866, 172810.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Heterogeneity in the vasodilatory function of individual extremities

Kadoguchi, T., Horiuchi, M., Kinugawa, S. & Okita, K., Feb 1 2020, In : Vascular. 28, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure

Nakano, I., Tsuda, M., Kinugawa, S., Fukushima, A., Kakutani, N., Takada, S. & Yokota, T., Jan 1 2020, (Accepted/In press) In : Journal of Cardiology.

Research output: Contribution to journalArticle

Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle: Complex II function is comparable to that of complex I

Maekawa, S., Takada, S., Furihata, T., Fukushima, A., Yokota, T. & Kinugawa, S., Mar 2020, In : Biochemistry and Biophysics Reports. 21, 100717.

Research output: Contribution to journalArticle

Open Access

Serum brain-derived neurotrophic factor levels are associated with skeletal muscle function but not with muscle mass in patients with heart failure

Nakano, I., Kinugawa, S., Hori, H., Fukushima, A., Yokota, T., Takada, S., Kakutani, N., Obata, Y., Yamanashi, K. & Anzai, T., Jan 1 2020, In : International heart journal. 61, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice

Takahashi, M., Kinugawa, S., Takada, S., Kakutani, N., Furihata, T., Sobirin, M. A., Fukushima, A., Obata, Y., Saito, A., Ishimori, N., Iwabuchi, K. & Tsutsui, H., Jan 1 2020, (Accepted/In press) In : Experimental Physiology.

Research output: Contribution to journalArticle

2019

A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells

Katayama, T., Kinugawa, S., Takada, S., Furihata, T., Fukushima, A., Yokota, T., Anzai, T., Hibino, M., Harashima, H. & Yamada, Y., Nov 2019, In : Mitochondrion. 49, p. 66-72 7 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure

Nakano, I., Hori, H., Fukushima, A., Yokota, T., Kinugawa, S., Takada, S., Yamanashi, K., Obata, Y., Kitaura, Y., Kakutani, N., Abe, T. & Anzai, T., Jan 1 2019, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis

Nakajima, T., Yokota, T., Shingu, Y., Yamada, A., Iba, Y., Ujihira, K., Wakasa, S., Ooka, T., Takada, S., Shirakawa, R., Katayama, T., Furihata, T., Fukushima, A., Matsuoka, R., Nishihara, H., Dela, F., Nakanishi, K., Matsui, Y. & Kinugawa, S., Dec 1 2019, In : Scientific reports. 9, 1, 3535.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure ― digest version ―

behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 10, p. 2084-2184 101 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure

Maekawa, S., Takada, S., Nambu, H., Furihata, T., Kakutani, N., Setoyama, D., Ueyanagi, Y., Kang, D., Sabe, H. & Kinugawa, S., Oct 16 2019, In : Cell Communication and Signaling. 17, 1, 128.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients

Shirakawa, R., Yokota, T., Nakajima, T., Takada, S., Yamane, M., Furihata, T., Maekawa, S., Nambu, H., Katayama, T., Fukushima, A., Saito, A., Ishimori, N., Dela, F., Kinugawa, S. & Anzai, T., Dec 1 2019, In : Scientific reports. 9, 1, 14709.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Rapidly progressive heart failure in a female carrier of Becker muscular dystrophy with no skeletal muscle symptoms

Komoriyama, H., Fukushima, A., Takahashi, Y., Kinugawa, S., Sera, F., Ohtani, T., Nakamura, A., Sakata, Y. & Anzai, T., Jan 1 2019, In : Internal Medicine. 58, 17, p. 2545-2549 5 p.

Research output: Contribution to journalArticle

Open Access

Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort

Okita, K., Takada, S., Morita, N., Takahashi, M., Hirabayashi, K., Yokota, T. & Kinugawa, S., Jan 1 2019, In : Applied Physiology, Nutrition and Metabolism. 44, 7, p. 759-764 6 p.

Research output: Contribution to journalArticle

Standard cardiac rehabilitation program for heart failure

Izawa, H., Yoshida, T., Ikegame, T., Izawa, K. P., Ito, Y., Okamura, H., Osada, N., Kinugawa, S., Kubozono, T., Kono, Y., Kobayashi, K., Nishigaki, K., Higo, T., Hirashiki, A., Miyazawa, Y., Morio, Y., Yanase, M., Yamada, S., Ikeda, H., Momomura, S. I. & 4 others, Kihara, Y., Yamamoto, K., Goto, Y. & Makita, S., Jan 1 2019, In : Circulation Journal. 83, 12, p. 2394-2398 5 p.

Research output: Contribution to journalArticle

Open Access

Tolerability, efficacy, and safety of bisoprolol vs. Carvedilol in japanese patients with heart failure and reduced ejection fraction: The CIBIS-J trial

CIBIS-J Investigators, Jan 1 2019, In : Circulation Journal. 83, 6, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Open Access

Triglyceride deposit cardiomyovasculopathy: A rare cardiovascular disorder

Li, M., Hirano, K. I., Ikeda, Y., Higashi, M., Hashimoto, C., Zhang, B., Kozawa, J., Sugimura, K., Miyauchi, H., Suzuki, A., Hara, Y., Takagi, A., Ikeda, Y., Kobayashi, K., Futsukaichi, Y., Zaima, N., Yamaguchi, S., Shrestha, R., Nakamura, H., Kawaguchi, K. & 18 others, Sai, E., Hui, S. P., Nakano, Y., Sawamura, A., Inaba, T., Sakata, Y., Yasui, Y., Nagasawa, Y., Kinugawa, S., Shimada, K., Yamada, S., Hao, H., Nakatani, D., Ide, T., Amano, T., Naito, H., Nagasaka, H. & Kobayashi, K., Jun 11 2019, In : Orphanet Journal of Rare Diseases. 14, 1, 134.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy

Kadoguchi, T., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Mizushima, W., Fukushima, A., Okita, K. & Kinugawa, S., Jan 1 2018, In : BioMed Research International. 2018, 3194917.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Elucidation of the Strongest Predictors of Cardiovascular Events in Patients with Heart Failure

Fukuda, H., Shindo, K., Sakamoto, M., Ide, T., Kinugawa, S., Fukushima, A., Tsutsui, H., Ito, S., Ishii, A., Washio, T. & Kitakaze, M., Jul 2018, In : EBioMedicine. 33, p. 185-195 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Impact of high respiratory exchange ratio during submaximal exercise on adverse clinical outcome in heart failure

Kakutani, N., Fukushima, A., Yokota, T., Katayama, T., Nambu, H., Shirakawa, R., Maekawa, S., Abe, T., Takada, S., Furihata, T., Ono, K., Okita, K., Kinugawa, S. & Anzai, T., Jan 1 2018, In : Circulation Journal. 82, 11, p. 2753-2760 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

Tsuda, M., Fukushima, A., Matsumoto, J., Takada, S., Kakutani, N., Nambu, H., Yamanashi, K., Furihata, T., Yokota, T., Okita, K., Kinugawa, S. & Anzai, T., Oct 2018, In : Journal of Cachexia, Sarcopenia and Muscle. 9, 5, p. 844-859 16 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Randomized trial of effect of urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia (LEAF-CHF) study design

Yokota, T., Fukushima, A., Kinugawa, S., Okumura, T., Murohara, T. & Tsutsui, H., Jan 1 2018, In : International heart journal. 59, 5, p. 976-982 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The impact of creating mathematical formula to predict cardiovascular events in patients with heart failure

Sakamoto, M., Fukuda, H., Kim, J., Ide, T., Kinugawa, S., Fukushima, A., Tsutsui, H., Ishii, A., Ito, S., Asanuma, H., Asakura, M., Washio, T. & Kitakaze, M., Dec 1 2018, In : Scientific reports. 8, 1, 3986.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure

Sawatari, H., Nishizaka, M. K., Miyazono, M., Ando, S. I., Inoue, S., Takemoto, M., Sakamoto, T., Goto, D., Furumoto, T., Kinugawa, S., Hashiguchi, N., Rahmawati, A., Chishaki, H., Ohkusa, T., Magota, C., Tsutsui, H. & Chishaki, A., Feb 1 2018, In : Heart and Vessels. 33, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome

Yokota, T., Kinugawa, S., Hirabayashi, K., Suga, T., Takada, S., Omokawa, M., Kadoguchi, T., Takahashi, M., Fukushima, A., Matsushima, S., Yamato, M., Okita, K. & Tsutsui, H., Jul 2017, In : Journal of Diabetes Investigation. 8, 4, p. 535-541 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling

Takada, S., Masaki, Y., Kinugawa, S., Matsumoto, J., Furihata, T., Mizushima, W., Kadoguchi, T., Fukushima, A., Homma, T., Takahashi, M., Harashima, S., Matsushima, S., Yokota, T., Tanaka, S., Okita, K. & Tsutsui, H., Sep 1 2016, In : Cardiovascular research. 111, 4, p. 338-347 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice

Fukushima, A., Kinugawa, S., Takada, S., Matsumoto, J., Furihata, T., Mizushima, W., Tsuda, M., Yokota, T., Matsushima, S., Okita, K. & Tsutsui, H., May 15 2016, In : European Journal of Pharmacology. 779, p. 147-156 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Furihata, T., Kinugawa, S., Fukushima, A., Takada, S., Homma, T., Masaki, Y., Abe, T., Yokota, T., Oba, K., Okita, K. & Tsutsui, H., Oct 1 2016, In : International Journal of Cardiology. 220, p. 483-487 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice

Furihata, T., Kinugawa, S., Takada, S., Fukushima, A., Takahashi, M., Homma, T., Masaki, Y., Tsuda, M., Matsumoto, J., Mizushima, W., Matsushima, S., Yokota, T. & Tsutsui, H., Jun 1 2016, In : IJC Heart and Vasculature. 11, p. 24-28 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., Nov 1 2016, In : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling

Matsushima, S., Kuroda, J., Zhai, P., Liu, T., Ikeda, S., Nagarajan, N., Oka, S. I., Yokota, T., Kinugawa, S., Hsu, C. P., Li, H., Tsutsui, H. & Sadoshima, J., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3403-3416 14 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2015

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

Kadoguchi, T., Kinugawa, S., Takada, S., Fukushima, A., Furihata, T., Homma, T., Masaki, Y., Mizushima, W., Nishikawa, M., Takahashi, M., Yokota, T., Matsushima, S., Okita, K. & Tsutsui, H., Mar 1 2015, In : Experimental Physiology. 100, 3, p. 312-322 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress

Nishikawa, M., Ishimori, N., Takada, S., Saito, A., Kadoguchi, T., Furihata, T., Fukushima, A., Matsushima, S., Yokota, T., Kinugawa, S. & Tsutsui, H., Jun 1 2015, In : Nephrology Dialysis Transplantation. 30, 6, p. 934-942 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Curcumin ameliorates skeletal muscle atrophy in type 1 diabetic mice by inhibiting protein ubiquitination

Ono, T., Takada, S., Kinugawa, S. & Tsutsui, H., Sep 1 2015, In : Experimental Physiology. 100, 9, p. 1052-1063 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Low-intensity exercise under ischemic conditions enhances metabolic stress in patients with heart failure

Takahashi, M., Kinugawa, S., Takada, S., Hirabayashi, K., Yokota, T., Matsushima, S., Saito, A., Okita, K. & Tsutsui, H., Oct 10 2015, In : International Journal of Cardiology. 201, p. 142-144 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure

Fukushima, A., Kinugawa, S., Homma, T., Masaki, Y., Furihata, T., Yokota, T., Matsushima, S., Takada, S., Kadoguchi, T., Oba, K., Okita, K. & Tsutsui, H., Apr 1 2015, In : Journal of Cardiac Failure. 21, 4, p. 300-306 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes

Takada, S., Kinugawa, S., Matsushima, S., Takemoto, D., Furihata, T., Mizushima, W., Fukushima, A., Yokota, T., Ono, Y., Shibata, H., Okita, K. & Tsutsui, H., Nov 1 2015, In : Experimental Physiology. 100, 11, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014

(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice

Fukushima, A., Kinugawa, S., Takada, S., Matsushima, S., Sobirin, M. A., Ono, T., Takahashi, M., Suga, T., Homma, T., Masaki, Y., Furihata, T., Kadoguchi, T., Yokota, T., Okita, K. & Tsutsui, H., Sep 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 6, p. E503-E514

Research output: Contribution to journalArticle

20 Citations (Scopus)

Assessment of quality of life during long-term treatment of tolvaptan in refractory heart failure: Design and rationale of the AQUA-TLV study

Imamura, T., Kinugawa, K., Ohtani, T., Sakata, Y., Higo, T., Kinugawa, S., Tsutsui, H., Sunagawa, K. & Komuro, I., 2014, In : International heart journal. 55, 3, p. 264-267 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Clinical characteristics and CHADS2 score in patients with heart failure and atrial fibrillation: Insights from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Kinugawa, S., Matsushima, S., Fukushima, A., Yokota, T., Sakakibara, M., Yokoshiki, H., Tsuchihashi-Makaya, M. & Tsutsui, H., Jan 1 2014, In : International Journal of Cardiology. 176, 1, p. 239-242 4 p.

Research output: Contribution to journalArticle

Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice

Suga, T., Kinugawa, S., Takada, S., Kadoguchi, T., Fukushima, A., Homma, T., Masaki, Y., Furihata, T., Takahashi, M., Sobirin, M. A., Ono, T., Hirabayashi, K., Yokota, T., Tanaka, S., Okita, K. & Tsutsui, H., Jan 1 2014, In : Endocrinology. 155, 1, p. 68-80 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Hyponatremia is an independent predictor of adverse clinical outcomes in hospitalized patients due to worsening heart failure

Hamaguchi, S., Kinugawa, S., Tsuchihashi-Makaya, M., Matsushima, S., Sakakibara, M., Ishimori, N., Goto, D. & Tsutsui, H., Mar 1 2014, In : Journal of Cardiology. 63, 3, p. 182-188 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Intramyocellular lipid is increased in the skeletal muscle of patients with dilated cardiomyopathy with lowered exercise capacity

Hirabayashi, K., Kinugawa, S., Yokota, T., Takada, S., Fukushima, A., Suga, T., Takahashi, M., Ono, T., Morita, N., Omokawa, M., Harada, K., Oyama-Manabe, N., Shirato, H., Matsushima, S., Okita, K. & Tsutsui, H., Oct 20 2014, In : International Journal of Cardiology. 176, 3, p. 1110-1112 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, S., Hirabayashi, K., Kinugawa, S., Yokota, T., Matsushima, S., Suga, T., Kadoguchi, T., Fukushima, A., Homma, T., Mizushima, W., Masaki, Y., Furihata, T., Katsuyama, R., Okita, K. & Tsutsui, H., Oct 5 2014, In : European Journal of Pharmacology. 740, p. 690-696 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Report of the American Heart Association (AHA) scientific sessions 2013, Dallas

Ishimori, N., Kinugawa, S., Yamada, S., Yokoshiki, H., Mitsuyama, H. & Tsutsui, H., Jan 1 2014, In : Circulation Journal. 78, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
11 Citations (Scopus)
2013

[Multidisciplinary management for heart failure --prevention, diagnosis and updated treatment].

Yokoshiki, H., Tsutsui, H., Goto, D., Kinugawa, S. & Ooka, T., Jan 1 2013, In : Unknown Journal. 88, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice

Homma, T., Kinugawa, S., Takahashi, M., Sobirin, M. A., Saito, A., Fukushima, A., Suga, T., Takada, S., Kadoguchi, T., Masaki, Y., Furihata, T., Taniguchi, M., Nakayama, T., Ishimori, N., Iwabuchi, K. & Tsutsui, H., Sep 1 2013, In : Journal of Molecular and Cellular Cardiology. 62, p. 179-188 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, S., Kinugawa, S., Hirabayashi, K., Suga, T., Yokota, T., Takahashi, M., Fukushima, A., Homma, T., Ono, T., Sobirin, M. A., Masaki, Y., Mizushima, W., Kadoguchi, T., Okita, K. & Tsutsui, H., Apr 1 2013, In : Journal of Applied Physiology. 114, 7, p. 844-857 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)