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Research Output 1985 2018

2018
5 Citations (Scopus)

Insecticidal activity of the metalloprotease AprA occurs through suppression of host cellular and humoral immunity

Lee, S. A., Jang, S. H., Kim, B. H., Shibata, T., Yoo, J., Jung, Y., Kawabata, S-I. & Lee, B. L., Apr 1 2018, In : Developmental and Comparative Immunology. 81, p. 116-126 11 p.

Research output: Contribution to journalArticle

Metalloproteases
Humoral Immunity
Cellular Immunity
Insects
Innate Immunity
1 Citation (Scopus)
Enzyme Precursors
Serine Proteases
Lipopolysaccharides
Chemical activation
Molecules
2 Citations (Scopus)

Pluripotency and a secretion mechanism of Drosophila transglutaminase

Shibata, T. & Kawabata, S-I., Mar 1 2018, In : Journal of biochemistry. 163, 3, p. 165-176 12 p.

Research output: Contribution to journalReview article

Transglutaminases
Drosophila
Glutamine
Exosomes
Acylation
2017
7 Citations (Scopus)

Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations

Shibata, T., Hadano, J., Kawasaki, D., Dong, X., Kawabata, S-I. & Sllner, T., Jan 1 2017, In : Journal of Biological Chemistry. 292, 25, p. 10723-10734 12 p.

Research output: Contribution to journalArticle

Exosomes
Acylation
Transglutaminases
Drosophila
Lipoylation
2 Citations (Scopus)

Genetic engineering approach to develop next-generation reagents for endotoxin quantification

Mizumura, H., Ogura, N., Aketagawa, J., Aizawa, M., Kobayashi, Y., Kawabata, S-I. & Oda, T., Jan 1 2017, In : Innate Immunity. 23, 2, p. 136-146 11 p.

Research output: Contribution to journalArticle

Genetic Engineering
Endotoxins
Horseshoe Crabs
Insects
Peptide Hydrolases
2 Citations (Scopus)
Takifugu
Saxitoxin
Tetraodontiformes
Tetrodotoxin
Denaturation
3 Citations (Scopus)
Transglutaminases
Polyamines
Masks
Transcription Factors
DNA
2016
4 Citations (Scopus)

RNA interference directed against the Transglutaminase gene triggers dysbiosis of gut microbiota in Drosophila

Sekihara, S., Shibata, T., Hyakkendani, M. & Kawabata, S-I., Nov 25 2016, In : Journal of Biological Chemistry. 291, 48, p. 25077-25087 11 p.

Research output: Contribution to journalArticle

Dysbiosis
Transglutaminases
Acetobacter
RNA Interference
Diptera
5 Citations (Scopus)

Transglutaminase in Invertebrates

Shibata, T. & Kawabata, S-I., Jan 1 2016, Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, p. 117-127 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transglutaminases
Invertebrates
Horseshoe Crabs
Antigen-antibody reactions
Genetic Techniques
2015
14 Citations (Scopus)

Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

Shibata, T., Maki, K., Hadano, J., Fujikawa, T., Kitazaki, K., Koshiba, T. & Kawabata, S-I., Jan 1 2015, In : PLoS Pathogens. 11, 10, e1005244.

Research output: Contribution to journalArticle

Exotoxins
Transglutaminases
Epithelium
Diptera
Proteins
3 Citations (Scopus)

Factor B is the second lipopolysaccharide-binding protease zymogen in the horseshoe crab coagulation cascade

Kobayashi, Y., Takahashi, T., Shibata, T., Ikeda, S., Koshiba, T., Mizumura, H., Oda, T. & Kawabata, S-I., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 19379-19386 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Enzyme Precursors
Complement Factor B
Coagulation
Lipopolysaccharides

First Asian Invertebrate Immunity Symposium (Busan, Korea). Preface to the Special Issue

Lee, B. L. U., Kawabata, S-I., Wang, C. & Kim, Y., Jan 1 2015, In : Archives of insect biochemistry and physiology. 88, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

Animals
Cytokines
Invertebrates
2014
65 Citations (Scopus)

Influenza a virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S-I., Mihara, K. & Koshiba, T., Aug 20 2014, In : Nature communications. 5, 4713.

Research output: Contribution to journalArticle

influenza
Mitochondria
mitochondria
immunity
viruses
37 Citations (Scopus)

Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide

Kushibiki, T., Kamiya, M., Aizawa, T., Kumaki, Y., Kikukawa, T., Mizuguchi, M., Demura, M., Kawabata, S-I. & Kawano, K., Mar 1 2014, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 3, p. 527-534 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Lipopolysaccharides
Peptides
Tryptophan
Fluorescence
8 Citations (Scopus)

The N-terminal Arg residue is essential for autocatalytic activation of a lipopolysaccharide-responsive protease zymogen

Kobayashi, Y., Shiga, T., Shibata, T., Sako, M., Maenaka, K., Koshiba, T., Mizumura, H., Oda, T. & Kawabata, S-I., Sep 12 2014, In : Journal of Biological Chemistry. 289, 37, p. 25987-25995 9 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Lipopolysaccharides
Peptide Hydrolases
Chemical activation
Molecules
2013
13 Citations (Scopus)

A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer

Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S-I. & Koshiba, T., May 1 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Energy Transfer
Mitochondrial Membranes
Antiviral Agents
RNA Virus Infections
Mitochondria
4 Citations (Scopus)

Expression and functional characterization of recombinant tributyltin-binding protein type 2

Satone, H., Akahoshi, E., Nakamura, A., Lee, M., Honda, M., Shimasaki, Y., Kawabata, S-I., Kusakabe, T. & Oshima, Y., Nov 18 2013, In : Journal of Toxicological Sciences. 38, 6, p. 885-890 6 p.

Research output: Contribution to journalLetter

Lipocalins
Carrier Proteins
Bombyx
Baculoviridae
Fish

Limulus Clotting Enzyme

Kawabata, S-I., Muta, T. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3064-3066 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Horseshoe Crabs
clotting enzyme

Limulus Coagulation Factor B

Kawabata, S-I., Muta, T. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3063-3064 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Horseshoe Crabs
Blood Coagulation Factors

Limulus Coagulation Factor C

Kawabata, S-I., Muta, T. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3060-3063 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood Coagulation Factors
Limulus clotting factor C

Limulus Coagulation Factor G

Kawabata, S-I., Muta, T. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3066-3067 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Horseshoe Crabs
Blood Coagulation Factors

Limulus Kexin

Kawabata, S-I. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3277-3278 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Horseshoe Crabs
25 Citations (Scopus)

Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-κB-like transcription factor relish

Shibata, T., Sekihara, S., Fujikawa, T., Miyaji, R., Maki, K., Ishihara, T., Koshiba, T. & Kawabata, S-I., Jul 23 2013, In : Science Signaling. 6, 285, ra61.

Research output: Contribution to journalArticle

Transglutaminases
Transcription Factors
Diptera
RNA Interference
Proteins

Trimerelysin I

Kawabata, S-I. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 1. p. 1044-1046 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Trimerelysin II

Kawabata, S-I. & Iwanaga, S., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 1. p. 1046-1047 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012
13 Citations (Scopus)

Microbe-specific C3b deposition in the horseshoe crab complement system in a C2/factor B-dependent or -independent manner

Tagawa, K., Yoshihara, T., Shibata, T., Kitazaki, K., Endo, Y., Fujita, T., Koshiba, T. & Kawabata, S-I., May 7 2012, In : PloS one. 7, 5, e36783.

Research output: Contribution to journalArticle

Merostomata
Horseshoe Crabs
Complement Factor B
Lectins
lectins
2011
18 Citations (Scopus)

Mitochondria and antiviral innate immunity

Koshiba, T., Bashiruddin, N. & Kawabata, S-I., 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 3, p. 257-262 6 p.

Research output: Contribution to journalReview article

Mitochondria
Innate Immunity
Antiviral Agents
Immunity
Signal transduction
110 Citations (Scopus)

Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

Koshiba, T., Yasukawa, K., Yanagi, Y. & Kawabata, S-I., Feb 1 2011, In : Science Signaling. 4, 158, ra7.

Research output: Contribution to journalArticle

Mitochondrial Membrane Potential
Antiviral Agents
Membranes
Mitochondria
Innate Immunity
30 Citations (Scopus)

Peptidoglycan activation of the proPO-system without a peptidoglycan receptor protein (PGRP)?

Liu, H., Wu, C., Matsuda, Y., Kawabata, S-I., Lee, B. L., Söderhäll, K. & Söderhäll, I., Jan 1 2011, In : Developmental and Comparative Immunology. 35, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Peptidoglycan
Lysine
Lipopolysaccharides
Astacoidea
Proteins
8 Citations (Scopus)

Purification and characterization of tributyltin-binding protein of tiger puffer, Takifugu rubripes

Oba, Y., Yamauchi, A., Hashiguchi, Y., Satone, H., Miki, S., Nassef, M., Shimasaki, Y., Kitano, T., Nakao, M., Kawabata, S-I., Honjo, T. & Oshima, Y., Jan 1 2011, In : Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 153, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Takifugu
Tetraodontiformes
Purification
Carrier Proteins
Electrophoresis
22 Citations (Scopus)

Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: Implications for mitochondrial inheritance

Koshiba, T., Holman, H. A., Kubara, K., Yasukawa, K., Kawabata, S-I., Okamoto, K., Macfarlane, J. & Shaw, J. M., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 354-362 9 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Mitochondrial Genes
GTP Phosphohydrolases
EF Hand Motifs
Yeast
8 Citations (Scopus)

Tributyltin-binding protein type 1, a lipocalin, prevents inhibition of osteoblastic activity by tributyltin in fish scales

Satone, H., Lee, M., Oba, Y., Kusakabe, T., Akahoshi, E., Miki, S., Suzuki, N., Sasayama, Y., Nassef, M., Shimasaki, Y., Kawabata, S-I., Honjo, T. & Oshima, Y., May 1 2011, In : Aquatic Toxicology. 103, 1-2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Lipocalin 1
tributyltin
binding proteins
Carrier Proteins
Fishes
2010
26 Citations (Scopus)

Immunocompetent molecules and their response network in horseshoe crabs

Kawabata, S-I., Dec 1 2010, Invertebrate Immunity. p. 122-136 15 p. (Advances in Experimental Medicine and Biology; vol. 708).

Research output: Chapter in Book/Report/Conference proceedingChapter

Horseshoe Crabs
Lipopolysaccharides
Hemocytes
Molecules
Transglutaminases
30 Citations (Scopus)

Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila

Shibata, T., Ariki, S., Shinzawa, N., Miyaji, R., Suyama, H., Sako, M., Inomata, N., Koshiba, T., Kanuka, H. & Kawabata, S-I., Nov 17 2010, In : PloS one. 5, 10, e13477.

Research output: Contribution to journalArticle

Transglutaminases
protein-glutamine gamma-glutamyltransferase
crosslinking
Morphogenesis
Crosslinking
191 Citations (Scopus)

Proteolytic cascades and their involvement in invertebrate immunity

Cerenius, L., Kawabata, S-I., Lee, B. L., Nonaka, M. & Söderhäll, K., Oct 1 2010, In : Trends in Biochemical Sciences. 35, 10, p. 575-583 9 p.

Research output: Contribution to journalReview article

Invertebrates
Immunity
Complement Receptors
Immune system
Toll-Like Receptors
19 Citations (Scopus)
Hemocytes
Glucans
Hemolymph
Invertebrates
Coagulation
2009
10 Citations (Scopus)

A novel β-defensin structure: Big defensin changes its N-terminal structure to associate with the target membrane

Kouno, T., Mizuguchi, M., Aizawa, T., Shinoda, H., Demura, M., Kawabata, S-I. & Kawano, K., Aug 18 2009, In : Biochemistry. 48, 32, p. 7629-7635 7 p.

Research output: Contribution to journalArticle

Defensins
Membranes
Micelles
Nuclear magnetic resonance
Horseshoe Crabs
1 Citation (Scopus)

Biological and immunological aspects of innate defence mechanisms activated by (1,3)----lucans and related polysaccharides in invertebrates

Cerenius, L., Kawabata, S-I. & Soöerhäll, K., Dec 1 2009, Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharides. Elsevier Inc., p. 563-577 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Invertebrates
Polysaccharides
Antigen-antibody reactions
Oomycetes
Pathogens
45 Citations (Scopus)

Factor C acts as a lipopolysaccharide-responsive C3 convertase in horseshoe crab complement activation

Ariki, S., Takahara, S., Shibata, T., Fukuoka, T., Ozaki, A., Endo, Y., Fujita, T., Koshiba, T. & Kawabata, S-I., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7994-8001 8 p.

Research output: Contribution to journalArticle

Complement C3-C5 Convertases
Horseshoe Crabs
Complement Activation
Lipopolysaccharides
Gram-Negative Bacteria
6 Citations (Scopus)

Factor G utilizes a carbohydrate-binding cleft that is conserved between horseshoe crab and bacteria for the recognition of β-1,3-D-glucans

Ueda, Y., Ohwada, S., Abe, Y., Shibata, T., Iijima, M., Yoshimitsu, Y., Koshiba, T., Nakata, M., Ueda, T. & Kawabata, S-I., Sep 15 2009, In : Journal of Immunology. 183, 6, p. 3810-3818 9 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Carbohydrates
Bacteria
Endo-1,4-beta Xylanases
Cellvibrio
140 Citations (Scopus)

Mitofusin 2 inhibits mitochondrial antiviral signaling

Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S-I. & Koshiba, T., Aug 18 2009, In : Science Signaling. 2, 84

Research output: Contribution to journalArticle

Antiviral Agents
Mitochondrial Dynamics
Genes
Chemical activation
Interferon Regulatory Factor-3
2008
24 Citations (Scopus)

A novel β-defensin structure: A potential strategy of big defensin for overcoming resistance by gram-positive bacteria

Kouno, T., Fujitani, N., Mizuguchi, M., Osaki, T., Nishimura, S. I., Kawabata, S-I., Aizawa, T., Demura, M., Nitta, K. & Kawano, K., Oct 7 2008, In : Biochemistry. 47, 40, p. 10611-10619 9 p.

Research output: Contribution to journalArticle

Defensins
Gram-Positive Bacteria
Bacteria
Micelles
Gram-Negative Bacteria
17 Citations (Scopus)

Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus

Satone, H., Oshima, Y., Shimasaki, Y., Tawaratsumida, T., Oba, Y., Takahashi, E., Kitano, T., Kawabata, S-I., Kakuta, Y. & Honjo, T., Dec 11 2008, In : Aquatic Toxicology. 90, 4, p. 292-299 8 p.

Research output: Contribution to journalArticle

Lipocalins
Flounder
Paralichthys olivaceus
tributyltin
excretion
2007
20 Citations (Scopus)

A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites

Matsuda, Y., Osaki, T., Hashii, T., Koshiba, T. & Kawabata, S-I., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33545-33552 8 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Hemocytes
Transglutaminases
Cysteine
Bacteria
17 Citations (Scopus)

An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh

Matsuda, Y., Koshiba, T., Osaki, T., Suyama, H., Arisaka, F., Toh, Y. & Kawabata, S-I., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37316-37324 9 p.

Research output: Contribution to journalArticle

Transglutaminases
Chitin
Arthropods
Carrier Proteins
Horseshoe Crabs
39 Citations (Scopus)
Gram-Negative Bacteria
Lipopolysaccharides
Bacteria
Innate Immunity
Horseshoe Crabs
30 Citations (Scopus)

Purification and characterization of tributyltin-binding protein type 2 from plasma of Japanese flounder, Paralichthys olivaceus

Oba, Y., Shimasaki, Y., Oshima, Y., Satone, H., Kitano, T., Nakao, M., Kawabata, S-I. & Honjo, T., Aug 1 2007, In : Journal of biochemistry. 142, 2, p. 229-238 10 p.

Research output: Contribution to journalArticle

Flounder
Purification
Carrier Proteins
Plasmas
Electrophoresis
142 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S-I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
13 Citations (Scopus)

The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif

Fujitani, N., Kouno, T., Nakahara, T., Takaya, K., Osaki, T., Kawabata, S-I., Mizuguchi, M., Aizawa, T., Demura, M., Nishimura, S. I. & Kawano, K., Apr 1 2007, In : Journal of Peptide Science. 13, 4, p. 269-279 11 p.

Research output: Contribution to journalArticle

Cystine Knot Motifs
Horseshoe Crabs
Cystine
Chitin
Peptides