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Research Output 1985 2018

Article
11 Citations (Scopus)

A characteristic property of vitamin K-dependent plasma protein Z

Morita, T., Kaetsu, H., Mizuguchi, J., Kawabata, S-I. & Iwanaga, S., Jan 1 1988, In : Journal of biochemistry. 104, 3, p. 368-374 7 p.

Research output: Contribution to journalArticle

Vitamin K
Calcium
Binding Sites
Proteolysis
Thrombin
1 Citation (Scopus)

A cryptic fimbrial gene in Serratia marcescens

Moriya, T., Kawabata, S-I., Mizunoe, Y. & Amako, K., Jan 1 1989, In : Journal of bacteriology. 171, 12, p. 6629-6636 8 p.

Research output: Contribution to journalArticle

Serratia marcescens
Mannose
Genes
Escherichia coli
Cosmids
30 Citations (Scopus)

Activated phenoloxidase from Tenebrio molitor larvae enhances the synthesis of melanin by using a vitellogenin-like protein in the presence of dopamine

Lee, K. M., Lee, K. Y., Choi, H. W., Cho, M. Y., Kwon, T. H., Kawabata, S-I. & Lee, B. L., Jul 12 2000, In : European Journal of Biochemistry. 267, 12, p. 3695-3703 9 p.

Research output: Contribution to journalArticle

Tenebrio
Vitellogenins
Monophenol Monooxygenase
Melanins
Larva
40 Citations (Scopus)

Activation Peptide of Human Factor IX Has Oligosaccharides O-Glycosidically Linked to Threonine Residues at 159 and 169

Agarwala, K. L., Kawabata, S-I., Nishimura, H., Iwanaga, S., Takao, T., Murata, H. & Shimonishi, Y., May 1 1994, In : Biochemistry. 33, 17, p. 5167-5171 5 p.

Research output: Contribution to journalArticle

Factor IX
Threonine
Human engineering
Oligosaccharides
Chemical activation
35 Citations (Scopus)

A cysteine protease inhibitor stored in the large granules of horseshoe crab hemocytes: Purification, characterization, cDNA cloning and tissue localization

Agarwala, K. L., Kawabata, S-I., Hirata, M., Miyagi, M., Tsunasawa, S. & Iwanaga, S., Jan 1996, In : Journal of Biochemistry. 119, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

Cystatins
Cysteine Proteinase Inhibitors
Horseshoe Crabs
Hemocytes
Cloning
20 Citations (Scopus)

A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites

Matsuda, Y., Osaki, T., Hashii, T., Koshiba, T. & Kawabata, S-I., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33545-33552 8 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Hemocytes
Transglutaminases
Cysteine
Bacteria
12 Citations (Scopus)

A horseshoe crab receptor structurally related to Drosophila Toll

Inamori, K. I., Koori, K., Mishima, C., Muta, T. & Kawabata, S-I., Dec 1 2000, In : Journal of Endotoxin Research. 6, 5, p. 397-399 3 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Toll-Like Receptors
Drosophila
Lipopolysaccharides
Interleukin-1 Receptors
59 Citations (Scopus)

A limulus intracellular coagulation inhibitor type 2: Purification, characterization, cDNA cloning, and tissue localization

Miura, Y., Kawabata, S-I., Wakamiya, Y., Nakamura, T. & Iwanaga, S., Jan 13 1995, In : Journal of Biological Chemistry. 270, 2, p. 558-565 8 p.

Research output: Contribution to journalArticle

Serpins
Horseshoe Crabs
Cloning
Coagulation
Purification
67 Citations (Scopus)
Serpins
Horseshoe Crabs
Cloning
Serine Proteases
Coagulation
128 Citations (Scopus)

A link between blood coagulation and prophenol oxidase activation in arthropod host defense

Nagai, T. & Kawabata, S-I., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29264-29267 4 p.

Research output: Contribution to journalArticle

Arthropods
Blood Coagulation
Coagulation
Blood
Horseshoe Crabs
25 Citations (Scopus)
Endopeptidases
Vitamin K
Substrate Specificity
Liver
Blood Proteins
85 Citations (Scopus)

Amino acid sequence of a coagulant enzyme, flavoxobin, from Trimeresurus flavoviridis venom

Shieh, T. C., Kawabata, S-I., Kihara, H., Ohno, M. & Iwanaga, S., Jan 1 1988, In : Journal of Biochemistry. 103, 4, p. 596-605 10 p.

Research output: Contribution to journalArticle

Coagulants
Venoms
Batroxobin
Amino Acid Sequence
lysyl endopeptidase
18 Citations (Scopus)

A mutant rat strain defficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes

Hashimoto, T., Matsumoto, T., Nishizawa, M., Kawabata, S-I., Morohashi, K-I., Handa, S. & Omura, T., Jan 1 1988, In : Journal of Biochemistry. 103, 3, p. 487-492 6 p.

Research output: Contribution to journalArticle

Mutant Strains Rats
Liver Microsomes
Phenobarbital
Liver
Cytochrome P-450 Enzyme System
17 Citations (Scopus)

An abnormal fibrinogen Fukuoka II (Gly-Bβ15 → Cys) characterized by defective fibrin lateral association and mixed disulfide formation

Kamura, T., Tsuda, H., Yae, Y., Hattori, S., Ohga, S., Shibata, Y., Kawabata, S-I. & Hamasaki, N., Jan 1 1995, In : Journal of Biological Chemistry. 270, 49, p. 29392-29399 8 p.

Research output: Contribution to journalArticle

Abnormal Fibrinogens
Fibrin
Disulfides
Fibrinogen
Association reactions
17 Citations (Scopus)

An antimicrobial peptide tachyplesin acts as a secondary secretagogue and amplifies lipopolysaccharide-induced hemocyte exocytosis

Ozaki, A., Ariki, S. & Kawabata, S. I., Aug 1 2005, In : FEBS Journal. 272, 15, p. 3863-3871 9 p.

Research output: Contribution to journalArticle

Hemocytes
Exocytosis
Lipopolysaccharides
GTP-Binding Proteins
Peptides
17 Citations (Scopus)

An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh

Matsuda, Y., Koshiba, T., Osaki, T., Suyama, H., Arisaka, F., Toh, Y. & Kawabata, S-I., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37316-37324 9 p.

Research output: Contribution to journalArticle

Transglutaminases
Chitin
Arthropods
Carrier Proteins
Horseshoe Crabs
84 Citations (Scopus)

A newly identified horseshoe crab lectin with binding specificity to O- antigen of bacterial lipopolysaccharides

Saito, T., Hatada, M., Iwanaga, S. & Kawabata, S-I., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30703-30708 6 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
O Antigens
Lectins
Lipopolysaccharides
Hemocytes
56 Citations (Scopus)

A newly identified horseshoe crab lectin with specificity for blood group A antigen recognizes specific O-antigens of bacterial lipopolysaccharides

Inamori, K. I., Saito, T., Iwaki, D., Nagira, T., Iwanaga, S., Arisaka, F. & Kawabata, S. I., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3272-3278 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
O Antigens
Blood Group Antigens
Lectins
Lipopolysaccharides
82 Citations (Scopus)

A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulation factors VII and IX

Hase, S., Kawabata, S-I., Nishimura, H., Takeya, H., Sueyoshi, T., Miyata, T., Iwanaga, S., Takao, T., Shimonishi, Y. & Ikenaka, T., Jan 1 1988, In : Journal of Biochemistry. 104, 6, p. 867-868 2 p.

Research output: Contribution to journalArticle

Trisaccharides
Factor VII
Factor IX
Sugars
Serine
10 Citations (Scopus)

A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z

Iwanaga, S., Nishimura, H., Kawabata, S., Kisiel, W., Hase, S. & Ikenaka, T., Jun 12 1991, In : Advances in experimental medicine and biology. 281, p. 121-131 11 p.

Research output: Contribution to journalArticle

243 Citations (Scopus)

An immune-responsive Serpin regulates the melanization cascade in Drosophila

De Gregorio, E., Han, S. J., Lee, W. J., Baek, M. J., Osaki, T., Kawabata, S. I., Lee, B. L., Iwanaga, S., Lemaitre, B. & Brey, P. T., Oct 1 2002, In : Developmental Cell. 3, 4, p. 581-592 12 p.

Research output: Contribution to journalArticle

Serpins
Arthropods
Drosophila
Serine Proteinase Inhibitors
Monophenol Monooxygenase
12 Citations (Scopus)

Annexin V is localized in association with Z-line of rat cardiac myocytes

Wang, L., Rahman, M. M., Iida, H., Inai, T., Kawabata, S-I., Iwanaga, S. & Shibata, Y., Jan 1 1995, In : Cardiovascular research. 30, 3, p. 363-371 9 p.

Research output: Contribution to journalArticle

Annexin A5
Cardiac Myocytes
Actins
Annexins
Fluorescence Microscopy
143 Citations (Scopus)

A novel big defensin identified in horseshoe crab hemocytes: Isolation, amino acid sequence, and antibacterial activity

Saito, T., Kawabata, S-I., Shigenaga, T., Takayenoki, Y., Cho, J., Nakajima, H., Hirata, M. & Iwanaga, S., Jan 1 1995, In : Journal of Biochemistry. 117, 5, p. 1131-1137 7 p.

Research output: Contribution to journalArticle

Defensins
Horseshoe Crabs
Hemocytes
Amino Acid Sequence
Amino Acids
71 Citations (Scopus)

A novel type of limulus lectin-L6: Purification, primary structure, and antibacterial activity

Saito, T., Kawabata, S-I., Hirata, M. & Iwanaga, S., Jun 16 1995, In : Journal of Biological Chemistry. 270, 24, p. 14493-14499 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Purification
Lipopolysaccharides
Bacteria
lysyl endopeptidase
25 Citations (Scopus)

A novel β-defensin structure: A potential strategy of big defensin for overcoming resistance by gram-positive bacteria

Kouno, T., Fujitani, N., Mizuguchi, M., Osaki, T., Nishimura, S. I., Kawabata, S-I., Aizawa, T., Demura, M., Nitta, K. & Kawano, K., Oct 7 2008, In : Biochemistry. 47, 40, p. 10611-10619 9 p.

Research output: Contribution to journalArticle

Defensins
Gram-Positive Bacteria
Bacteria
Micelles
Gram-Negative Bacteria
10 Citations (Scopus)

A novel β-defensin structure: Big defensin changes its N-terminal structure to associate with the target membrane

Kouno, T., Mizuguchi, M., Aizawa, T., Shinoda, H., Demura, M., Kawabata, S. I. & Kawano, K., Aug 18 2009, In : Biochemistry. 48, 32, p. 7629-7635 7 p.

Research output: Contribution to journalArticle

Defensins
Membranes
Micelles
Nuclear magnetic resonance
Horseshoe Crabs
1 Citation (Scopus)

Antigenic Determinants on Fimbriae of Serratia marcescens US5 Analyzed Using Monoclonal Antibodies

Jingushi, S., Mitsuyama, M., Moriya, T., Amako, K., Kawabata, S-I. & Iwanaga, S., Jan 1 1987, In : MICROBIOLOGY and IMMUNOLOGY. 31, 9, p. 879-889 11 p.

Research output: Contribution to journalArticle

Serratia marcescens
Epitopes
Monoclonal Antibodies
Peptides
Cysteine
20 Citations (Scopus)

A Sapecin Homologue of Holotrichia Diomphalia: Purification, Sequencing and Determination of Disulfide Pairs

Lee, S., Moon, H., Lee, B., Kawabata, S-I., Natori, S. & Kurata, S., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 3, p. 457-459 3 p.

Research output: Contribution to journalArticle

Hemolymph
Gram-Positive Bacteria
Gram-Negative Bacteria
Disulfides
Larva
59 Citations (Scopus)

A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides

Ariki, S., Koori, K., Osaki, T., Motoyama, K., Inamori, K. I. & Kawabata, S. I., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 953-958 6 p.

Research output: Contribution to journalArticle

Pattern Recognition Receptors
Hemocytes
Enzyme Precursors
Serine Proteases
Lipopolysaccharides
13 Citations (Scopus)

A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer

Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S-I. & Koshiba, T., May 1 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Energy Transfer
Mitochondrial Membranes
Antiviral Agents
RNA Virus Infections
Mitochondria
40 Citations (Scopus)
Gram-Negative Bacteria
Lipopolysaccharides
Bacteria
Innate Immunity
Horseshoe Crabs
77 Citations (Scopus)

A zymogen form of masquerade-like serine proteinase homologue is cleaved during pro-phenoloxidase activation by Ca2+ in coleopteran and Tenebrio molitor larvae

Lee, K. Y., Zhang, R., Kim, M. S., Park, J. W., Park, H. Y., Kawabata, S. I. & Lee, B. L., Sep 25 2002, In : European Journal of Biochemistry. 269, 17, p. 4375-4383 9 p.

Research output: Contribution to journalArticle

Tenebrio
Enzyme Precursors
Serine Proteases
Monophenol Monooxygenase
Larva
4 Citations (Scopus)

Big defensin and tachylectins-1 and -2.

Kawabata, S-I. & Iwanaga, S., Jan 1 1997, In : Methods in molecular biology (Clifton, N.J.). 78, p. 51-61 11 p.

Research output: Contribution to journalArticle

Cytoplasmic Granules
Defensins
Hemagglutination Tests
Horseshoe Crabs
Hemocytes
43 Citations (Scopus)

Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity

Yakushiji, H., Maraboeuf, F., Takahashi, M., Deng, Z. S., Kawabata, S-I., Nakabeppu, Y. & Sekiguchi, M., Sep 1 1997, In : Mutation Research - DNA Repair. 384, 3, p. 181-194 14 p.

Research output: Contribution to journalArticle

Proteins
Substitution reactions
Valine
Circular Dichroism
Methionine
17 Citations (Scopus)

Blood clotting factor IX B(M) Nagoya. Substitution of arginine 180 by tryptophan and its activation by α-chymotrypsin and rat mast cell chymase

Suehiro, K., Kawabata, S-I., Miyata, T., Takeya, H., Takamatsu, J., Ogata, K., Kamiya, T., Saito, H., Niho, Y. & Iwanaga, S., Dec 1 1989, In : Journal of Biological Chemistry. 264, 35, p. 21257-21265 9 p.

Research output: Contribution to journalArticle

Chymases
Factor IX
Blood Coagulation Factors
Chymotrypsin
Blood Coagulation
13 Citations (Scopus)

Blood clotting factor IX niigata: Substitution of alanine-390 by valine in the catalytic domain

Sugimoto, M., Miyata, T., Kawabata, S-I., Yoshioka, A., Fukui, H., Takahashi, H. & Iwanaga, S., Jan 1 1988, In : Journal of biochemistry. 104, 6, p. 878-880 3 p.

Research output: Contribution to journalArticle

Factor IX
Blood Coagulation Factors
Valine
Blood Coagulation
Factor IXa
37 Citations (Scopus)

Bovine factor VII. Its purification and complete amino acid sequence

Takeya, H., Kawabata, S-I., Nakagawa, K., Yamamichi, Y., Miyata, T., Iwanaga, S., Takao, T. & Shimonishi, Y., Jan 1 1988, In : Journal of Biological Chemistry. 263, 29, p. 14868-14877 10 p.

Research output: Contribution to journalArticle

Factor VII
Purification
Amino Acid Sequence
Light
Amino Acids
19 Citations (Scopus)

CDNA cloning, tissue distribution, and subcellular localization of horseshoe crab big defensin

Kawabata, S-I., Saito, T., Saeki, K., Okino, N., Mizutani, A., Toh, Y. & Iwanaga, S., Jan 1 1997, In : Biological Chemistry. 378, 3-4, p. 289-292 4 p.

Research output: Contribution to journalArticle

Defensins
Horseshoe Crabs
Cloning
Tissue Distribution
Organism Cloning
82 Citations (Scopus)

CDN a cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol

Alam, R., Hachiya, N., Sakaguchi, M., Kawabata, S-I., Iwanaga, S., Kitajima, M., Mihara, K. & Omura, T., Jan 1 1994, In : Journal of biochemistry. 116, 2, p. 416-425 10 p.

Research output: Contribution to journalArticle

Cloning
Liver
Cytosol
14-3-3 Proteins
Protein Precursors
79 Citations (Scopus)

cDNA Cloning and Deduced Amino Acid Sequence of Prothrombin Activator (Ecarin) from Kenyan Echis carinatus Venom

Nishida, S., Fujita, T., Kohno, N., Atoda, H., Morita, T., Takeya, H., Kido, I., Paine, M. J. I., Kawabata, S-I. & Iwanaga, S., Jan 1 1995, In : Biochemistry. 34, 5, p. 1771-1778 8 p.

Research output: Contribution to journalArticle

Cloning
Venoms
Prothrombin
Organism Cloning
Amino Acid Sequence
68 Citations (Scopus)

Characterization and Properties of a 1,3-β-D-Glucan Pattern Recognition Protein of Tenebrio molitor Larvae That Is Specifically Degraded by Serine Protease during Prophenoloxidase Activation

Zhang, R., Cho, H. Y., Kim, H. S., Ma, Y. G., Osaki, T., Kawabata, S. I., Söderhäll, K. & Lee, B. L., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 42072-42079 8 p.

Research output: Contribution to journalArticle

Tenebrio
Serine Proteases
Pattern recognition
Larva
Chemical activation
116 Citations (Scopus)

Chitin-binding proteins in invertebrates and plants comprise a common chitin-binding structural motif

Suetake, T., Tsuda, S., Kawabata, S-I., Miura, K., Iwanaga, S., Hikichi, K., Nitta, K. & Kawano, K., Jun 16 2000, In : Journal of Biological Chemistry. 275, 24, p. 17929-17932 4 p.

Research output: Contribution to journalArticle

Chitin
Invertebrates
Carrier Proteins
Horseshoe Crabs
Hemocytes
7 Citations (Scopus)

Chlorophyll deficiency caused by a specific blockage of the C5-pathway in seedlings of virescent mutant rice

Kusumi, K., Inada, H., Kawabata, S-I., Iba, K. & Nishimura, M., Dec 1 1994, In : Plant and Cell Physiology. 35, 3, p. 445-449 5 p.

Research output: Contribution to journalArticle

Chlorophyll
Seedlings
chlorophyll
rice
mutants
4 Citations (Scopus)

Cloning, sequencing, and functional expression in Escherichia coli of chaperonin (groESL) genes from Vibrio cholerae

Mizunoe, Y., Wai, S. N., Umene, K., Kokubo, T., Kawabata, S-I. & Yoshida, S. I., Jan 1 1999, In : Microbiology and Immunology. 43, 6, p. 513-520 8 p.

Research output: Contribution to journalArticle

Chaperonins
Vibrio cholerae
Organism Cloning
Chaperonin 10
Escherichia coli
354 Citations (Scopus)

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo- dGTP, a mutagenic substrate for DNA synthesis

Kunihiko, S., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S-I., Maki, H. & Sekiguchi, M., 1993, In : Journal of Biological Chemistry. 268, 31, p. 23524-23530 7 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Complementary DNA
Nucleotides
DNA
20 Citations (Scopus)

Cloning and sequence of the gene encoding the major structural component of mannose-resistant fimbriae of Serratia marcescens

Mizunoe, Y., Nakabeppu, Y., Sekiguchi, M., Kawabata, S. I., Moriya, T. & Amako, K., Jan 1 1988, In : Journal of bacteriology. 170, 8, p. 3567-3574 8 p.

Research output: Contribution to journalArticle

Serratia marcescens
Mannose
Organism Cloning
Genes
Escherichia coli
23 Citations (Scopus)

Cloning and sequencing of the cDNA encoding human glutaredoxin

Fernando, M. R., Sumimoto, H., Nanri, H., Kawabata, S. I., Iwanaga, S., Minakami, S., Fukumaki, Y. & Takeshige, K., Jun 21 1994, In : BBA - Gene Structure and Expression. 1218, 2, p. 229-231 3 p.

Research output: Contribution to journalArticle

Glutaredoxins
Cloning
Organism Cloning
Complementary DNA
Amino Acids
35 Citations (Scopus)

Coagulation factor XII (Hageman factor) Washington D.C. Inactive factor XIIa results from Cys-571 → Ser substitution

Miyata, T., Kawabata, S. I., Iwanaga, S., Takahashi, I., Alving, B. & Saito, H., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 21, p. 8319-8322 4 p.

Research output: Contribution to journalArticle

Factor XIIa
Factor XII
Serine
Catalytic Domain
Protein Sequence Analysis
32 Citations (Scopus)
Trimeresurus
Snake Venoms
Phospholipases
Phospholipases A2
Isoenzymes
31 Citations (Scopus)

Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking

Iijima, M., Hashimoto, T., Matsuda, Y., Nagai, T., Yamano, Y., Ichi, T., Osaki, T. & Kawabata, S. I., Sep 1 2005, In : FEBS Journal. 272, 18, p. 4774-4786 13 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Transglutaminases
Chitin
Sequence Analysis
Molecular mass