If you made any changes in Pure these will be visible here soon.

Research Output 1985 2018

Filter
Article
2018
5 Citations (Scopus)

Insecticidal activity of the metalloprotease AprA occurs through suppression of host cellular and humoral immunity

Lee, S. A., Jang, S. H., Kim, B. H., Shibata, T., Yoo, J., Jung, Y., Kawabata, S-I. & Lee, B. L., Apr 1 2018, In : Developmental and Comparative Immunology. 81, p. 116-126 11 p.

Research output: Contribution to journalArticle

Metalloproteases
Humoral Immunity
Cellular Immunity
Insects
Innate Immunity
1 Citation (Scopus)
Enzyme Precursors
Serine Proteases
Lipopolysaccharides
Chemical activation
Molecules
2017
7 Citations (Scopus)

Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations

Shibata, T., Hadano, J., Kawasaki, D., Dong, X., Kawabata, S-I. & Sllner, T., Jan 1 2017, In : Journal of Biological Chemistry. 292, 25, p. 10723-10734 12 p.

Research output: Contribution to journalArticle

Exosomes
Acylation
Transglutaminases
Drosophila
Lipoylation
2 Citations (Scopus)

Genetic engineering approach to develop next-generation reagents for endotoxin quantification

Mizumura, H., Ogura, N., Aketagawa, J., Aizawa, M., Kobayashi, Y., Kawabata, S. I. & Oda, T., Jan 1 2017, In : Innate Immunity. 23, 2, p. 136-146 11 p.

Research output: Contribution to journalArticle

Genetic Engineering
Endotoxins
Horseshoe Crabs
Insects
Peptide Hydrolases
2 Citations (Scopus)
Takifugu
Saxitoxin
Tetraodontiformes
Tetrodotoxin
Denaturation
3 Citations (Scopus)
Transglutaminases
Polyamines
Masks
Transcription Factors
DNA
2016
4 Citations (Scopus)

RNA interference directed against the Transglutaminase gene triggers dysbiosis of gut microbiota in Drosophila

Sekihara, S., Shibata, T., Hyakkendani, M. & Kawabata, S-I., Nov 25 2016, In : Journal of Biological Chemistry. 291, 48, p. 25077-25087 11 p.

Research output: Contribution to journalArticle

Dysbiosis
Transglutaminases
Acetobacter
RNA Interference
Diptera
2015
14 Citations (Scopus)

Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

Shibata, T., Maki, K., Hadano, J., Fujikawa, T., Kitazaki, K., Koshiba, T. & Kawabata, S. I., Jan 1 2015, In : PLoS pathogens. 11, 10, e1005244.

Research output: Contribution to journalArticle

Exotoxins
Transglutaminases
Epithelium
Diptera
Proteins
3 Citations (Scopus)

Factor B is the second lipopolysaccharide-binding protease zymogen in the horseshoe crab coagulation cascade

Kobayashi, Y., Takahashi, T., Shibata, T., Ikeda, S., Koshiba, T., Mizumura, H., Oda, T. & Kawabata, S-I., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 19379-19386 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Enzyme Precursors
Complement Factor B
Coagulation
Lipopolysaccharides
2014
67 Citations (Scopus)

Influenza a virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S-I., Mihara, K. & Koshiba, T., Aug 20 2014, In : Nature communications. 5, 4713.

Research output: Contribution to journalArticle

influenza
Mitochondria
mitochondria
immunity
viruses
39 Citations (Scopus)

Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide

Kushibiki, T., Kamiya, M., Aizawa, T., Kumaki, Y., Kikukawa, T., Mizuguchi, M., Demura, M., Kawabata, S-I. & Kawano, K., Mar 1 2014, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 3, p. 527-534 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Lipopolysaccharides
Peptides
Tryptophan
Fluorescence
8 Citations (Scopus)

The N-terminal Arg residue is essential for autocatalytic activation of a lipopolysaccharide-responsive protease zymogen

Kobayashi, Y., Shiga, T., Shibata, T., Sako, M., Maenaka, K., Koshiba, T., Mizumura, H., Oda, T. & Kawabata, S-I., Sep 12 2014, In : Journal of Biological Chemistry. 289, 37, p. 25987-25995 9 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Lipopolysaccharides
Peptide Hydrolases
Chemical activation
Molecules
2013
13 Citations (Scopus)

A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer

Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S-I. & Koshiba, T., May 1 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Energy Transfer
Mitochondrial Membranes
Antiviral Agents
RNA Virus Infections
Mitochondria
25 Citations (Scopus)

Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-κB-like transcription factor relish

Shibata, T., Sekihara, S., Fujikawa, T., Miyaji, R., Maki, K., Ishihara, T., Koshiba, T. & Kawabata, S-I., Jul 23 2013, In : Science Signaling. 6, 285, ra61.

Research output: Contribution to journalArticle

Transglutaminases
Transcription Factors
Diptera
RNA Interference
Proteins
2012
13 Citations (Scopus)

Microbe-specific C3b deposition in the horseshoe crab complement system in a C2/factor B-dependent or -independent manner

Tagawa, K., Yoshihara, T., Shibata, T., Kitazaki, K., Endo, Y., Fujita, T., Koshiba, T. & Kawabata, S-I., May 7 2012, In : PloS one. 7, 5, e36783.

Research output: Contribution to journalArticle

Merostomata
Horseshoe Crabs
Complement Factor B
Lectins
lectins
2011
112 Citations (Scopus)

Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

Koshiba, T., Yasukawa, K., Yanagi, Y. & Kawabata, S-I., Feb 1 2011, In : Science Signaling. 4, 158, ra7.

Research output: Contribution to journalArticle

Mitochondrial Membrane Potential
Antiviral Agents
Membranes
Mitochondria
Innate Immunity
30 Citations (Scopus)

Peptidoglycan activation of the proPO-system without a peptidoglycan receptor protein (PGRP)?

Liu, H., Wu, C., Matsuda, Y., Kawabata, S-I., Lee, B. L., Söderhäll, K. & Söderhäll, I., Jan 1 2011, In : Developmental and Comparative Immunology. 35, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Peptidoglycan
Lysine
Lipopolysaccharides
Astacoidea
Proteins
8 Citations (Scopus)

Purification and characterization of tributyltin-binding protein of tiger puffer, Takifugu rubripes

Oba, Y., Yamauchi, A., Hashiguchi, Y., Satone, H., Miki, S., Nassef, M., Shimasaki, Y., Kitano, T., Nakao, M., Kawabata, S. I., Honjo, T. & Oshima, Y., Jan 1 2011, In : Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 153, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Takifugu
Tetraodontiformes
Purification
Carrier Proteins
Electrophoresis
22 Citations (Scopus)

Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: Implications for mitochondrial inheritance

Koshiba, T., Holman, H. A., Kubara, K., Yasukawa, K., Kawabata, S-I., Okamoto, K., Macfarlane, J. & Shaw, J. M., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 354-362 9 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Mitochondrial Genes
GTP Phosphohydrolases
EF Hand Motifs
Yeast
8 Citations (Scopus)

Tributyltin-binding protein type 1, a lipocalin, prevents inhibition of osteoblastic activity by tributyltin in fish scales

Satone, H., Lee, M., Oba, Y., Kusakabe, T., Akahoshi, E., Miki, S., Suzuki, N., Sasayama, Y., Nassef, M., Shimasaki, Y., Kawabata, S-I., Honjo, T. & Oshima, Y., May 1 2011, In : Aquatic Toxicology. 103, 1-2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Lipocalin 1
tributyltin
binding proteins
Carrier Proteins
Fishes
2010
30 Citations (Scopus)

Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila

Shibata, T., Ariki, S., Shinzawa, N., Miyaji, R., Suyama, H., Sako, M., Inomata, N., Koshiba, T., Kanuka, H. & Kawabata, S-I., Nov 17 2010, In : PloS one. 5, 10, e13477.

Research output: Contribution to journalArticle

Transglutaminases
protein-glutamine gamma-glutamyltransferase
crosslinking
Morphogenesis
Crosslinking
2009
10 Citations (Scopus)

A novel β-defensin structure: Big defensin changes its N-terminal structure to associate with the target membrane

Kouno, T., Mizuguchi, M., Aizawa, T., Shinoda, H., Demura, M., Kawabata, S. I. & Kawano, K., Aug 18 2009, In : Biochemistry. 48, 32, p. 7629-7635 7 p.

Research output: Contribution to journalArticle

Defensins
Membranes
Micelles
Nuclear magnetic resonance
Horseshoe Crabs
45 Citations (Scopus)

Factor C acts as a lipopolysaccharide-responsive C3 convertase in horseshoe crab complement activation

Ariki, S., Takahara, S., Shibata, T., Fukuoka, T., Ozaki, A., Endo, Y., Fujita, T., Koshiba, T. & Kawabata, S-I., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7994-8001 8 p.

Research output: Contribution to journalArticle

Complement C3-C5 Convertases
Horseshoe Crabs
Complement Activation
Lipopolysaccharides
Gram-Negative Bacteria
6 Citations (Scopus)

Factor G utilizes a carbohydrate-binding cleft that is conserved between horseshoe crab and bacteria for the recognition of β-1,3-D-glucans

Ueda, Y., Ohwada, S., Abe, Y., Shibata, T., Iijima, M., Yoshimitsu, Y., Koshiba, T., Nakata, M., Ueda, T. & Kawabata, S-I., Sep 15 2009, In : Journal of Immunology. 183, 6, p. 3810-3818 9 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Carbohydrates
Bacteria
Endo-1,4-beta Xylanases
Cellvibrio
140 Citations (Scopus)

Mitofusin 2 inhibits mitochondrial antiviral signaling

Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S-I. & Koshiba, T., Aug 18 2009, In : Science Signaling. 2, 84

Research output: Contribution to journalArticle

Antiviral Agents
Mitochondrial Dynamics
Genes
Chemical activation
Interferon Regulatory Factor-3
2008
24 Citations (Scopus)

A novel β-defensin structure: A potential strategy of big defensin for overcoming resistance by gram-positive bacteria

Kouno, T., Fujitani, N., Mizuguchi, M., Osaki, T., Nishimura, S. I., Kawabata, S-I., Aizawa, T., Demura, M., Nitta, K. & Kawano, K., Oct 7 2008, In : Biochemistry. 47, 40, p. 10611-10619 9 p.

Research output: Contribution to journalArticle

Defensins
Gram-Positive Bacteria
Bacteria
Micelles
Gram-Negative Bacteria
17 Citations (Scopus)

Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus

Satone, H., Oshima, Y., Shimasaki, Y., Tawaratsumida, T., Oba, Y., Takahashi, E., Kitano, T., Kawabata, S-I., Kakuta, Y. & Honjo, T., Dec 11 2008, In : Aquatic Toxicology. 90, 4, p. 292-299 8 p.

Research output: Contribution to journalArticle

Lipocalins
Flounder
Paralichthys olivaceus
tributyltin
excretion
2007
20 Citations (Scopus)

A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites

Matsuda, Y., Osaki, T., Hashii, T., Koshiba, T. & Kawabata, S-I., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33545-33552 8 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Hemocytes
Transglutaminases
Cysteine
Bacteria
17 Citations (Scopus)

An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh

Matsuda, Y., Koshiba, T., Osaki, T., Suyama, H., Arisaka, F., Toh, Y. & Kawabata, S-I., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37316-37324 9 p.

Research output: Contribution to journalArticle

Transglutaminases
Chitin
Arthropods
Carrier Proteins
Horseshoe Crabs
39 Citations (Scopus)
Gram-Negative Bacteria
Lipopolysaccharides
Bacteria
Innate Immunity
Horseshoe Crabs
30 Citations (Scopus)

Purification and characterization of tributyltin-binding protein type 2 from plasma of Japanese flounder, Paralichthys olivaceus

Oba, Y., Shimasaki, Y., Oshima, Y., Satone, H., Kitano, T., Nakao, M., Kawabata, S-I. & Honjo, T., Aug 1 2007, In : Journal of biochemistry. 142, 2, p. 229-238 10 p.

Research output: Contribution to journalArticle

Flounder
Purification
Carrier Proteins
Plasmas
Electrophoresis
143 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S-I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
13 Citations (Scopus)

The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif

Fujitani, N., Kouno, T., Nakahara, T., Takaya, K., Osaki, T., Kawabata, S-I., Mizuguchi, M., Aizawa, T., Demura, M., Nishimura, S. I. & Kawano, K., Apr 1 2007, In : Journal of Peptide Science. 13, 4, p. 269-279 11 p.

Research output: Contribution to journalArticle

Cystine Knot Motifs
Horseshoe Crabs
Cystine
Chitin
Peptides
2006
15 Citations (Scopus)

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation

Friedrich, R., Panizzi, P., Kawabata, S-I., Bode, W., Bock, P. E. & Fuentes-Prior, P., Jan 13 2006, In : Journal of Biological Chemistry. 281, 2, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

Coagulase
Prothrombin
Chemical activation
Thrombin
Enzyme Precursors
2005
17 Citations (Scopus)

An antimicrobial peptide tachyplesin acts as a secondary secretagogue and amplifies lipopolysaccharide-induced hemocyte exocytosis

Ozaki, A., Ariki, S. & Kawabata, S. I., Aug 1 2005, In : FEBS Journal. 272, 15, p. 3863-3871 9 p.

Research output: Contribution to journalArticle

Hemocytes
Exocytosis
Lipopolysaccharides
GTP-Binding Proteins
Peptides
31 Citations (Scopus)

Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking

Iijima, M., Hashimoto, T., Matsuda, Y., Nagai, T., Yamano, Y., Ichi, T., Osaki, T. & Kawabata, S-I., Sep 1 2005, In : FEBS Journal. 272, 18, p. 4774-4786 13 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Transglutaminases
Chitin
Sequence Analysis
Molecular mass
2004
59 Citations (Scopus)

A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides

Ariki, S., Koori, K., Osaki, T., Motoyama, K., Inamori, K. I. & Kawabata, S-I., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 953-958 6 p.

Research output: Contribution to journalArticle

Pattern Recognition Receptors
Hemocytes
Enzyme Precursors
Serine Proteases
Lipopolysaccharides
77 Citations (Scopus)

Peptidoglycan Recognition Proteins Involved in 1,3-β -D-Glucan-dependent Prophenoloxidase Activation System of Insect

Lee, M. H., Osaki, T., Lee, J. Y., Baek, M. J., Zhang, R., Park, J. W., Kawabata, S. I., Söderhäll, K. & Lee, B. L., Jan 30 2004, In : Journal of Biological Chemistry. 279, 5, p. 3218-3227 10 p.

Research output: Contribution to journalArticle

Insects
Chemical activation
Peptidoglycan
Monophenol Monooxygenase
Pattern recognition
2003
68 Citations (Scopus)

Characterization and Properties of a 1,3-β-D-Glucan Pattern Recognition Protein of Tenebrio molitor Larvae That Is Specifically Degraded by Serine Protease during Prophenoloxidase Activation

Zhang, R., Cho, H. Y., Kim, H. S., Ma, Y. G., Osaki, T., Kawabata, S-I., Söderhäll, K. & Lee, B. L., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 42072-42079 8 p.

Research output: Contribution to journalArticle

Tenebrio
Serine Proteases
Pattern recognition
Larva
Chemical activation
156 Citations (Scopus)

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

Friedrich, R., Panizzi, P., Fuentes-Prior, P., Richter, K., Verhamme, I., Anderson, P. J., Kawabata, S-I., Huber, R., Bode, W. & Bock, P. E., Oct 2 2003, In : Nature. 425, 6957, p. 535-539 5 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Coagulase
Blood Coagulation
Trypsinogen
Streptokinase
86 Citations (Scopus)

The iron-binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni

Ishikawa, T., Mizunoe, Y., Kawabata, S-I., Takade, A., Harada, M., Wai, S. N. & Yoshida, S. I., Feb 1 2003, In : Journal of bacteriology. 185, 3, p. 1010-1017 8 p.

Research output: Contribution to journalArticle

Iron-Binding Proteins
Campylobacter jejuni
Hydrogen Peroxide
Iron
Proteins
2002
239 Citations (Scopus)

An immune-responsive Serpin regulates the melanization cascade in Drosophila

De Gregorio, E., Han, S. J., Lee, W. J., Baek, M. J., Osaki, T., Kawabata, S-I., Lee, B. L., Iwanaga, S., Lemaitre, B. & Brey, P. T., Oct 1 2002, In : Developmental Cell. 3, 4, p. 581-592 12 p.

Research output: Contribution to journalArticle

Serpins
Arthropods
Drosophila
Serine Proteinase Inhibitors
Monophenol Monooxygenase
77 Citations (Scopus)

A zymogen form of masquerade-like serine proteinase homologue is cleaved during pro-phenoloxidase activation by Ca2+ in coleopteran and Tenebrio molitor larvae

Lee, K. Y., Zhang, R., Kim, M. S., Park, J. W., Park, H. Y., Kawabata, S-I. & Lee, B. L., Sep 25 2002, In : European Journal of Biochemistry. 269, 17, p. 4375-4383 9 p.

Research output: Contribution to journalArticle

Tenebrio
Enzyme Precursors
Serine Proteases
Monophenol Monooxygenase
Larva
43 Citations (Scopus)

Duplicated binding sites for (1→3)-β-D-glucan in the horseshoe crab coagulation factor G. Implications for a molecular basis of the pattern recognition in innate immunity

Takaki, Y., Seki, N., Kawabata, S-I., Iwanaga, S. & Muta, T., Apr 19 2002, In : Journal of Biological Chemistry. 277, 16, p. 14281-14287 7 p.

Research output: Contribution to journalArticle

Glucans
Innate Immunity
Pattern recognition
Binding Sites
Enzyme Precursors
9 Citations (Scopus)

Production and characterization of recombinant tachycitin, the Cys-rich chitin-binding protein

Suetake, T., Aizawa, T., Koganesawa, N., Osaki, T., Kobashigawa, Y., Demura, M., Kawabata, S-I., Kawano, K., Tsuda, S. & Nitta, K., Sep 1 2002, In : Protein Engineering. 15, 9, p. 763-769 7 p.

Research output: Contribution to journalArticle

Chitin
Fungi
Bacteria
Carrier Proteins
Nuclear magnetic resonance
44 Citations (Scopus)

Proline-rich cell surface antigens of horseshoe crab hemocytes are substrates for protein cross-linking with a clotting protein coagulin

Osaki, T., Okino, N., Tokunaga, F., Iwanaga, S. & Kawabata, S-I., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 40084-40090 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Hemocytes
Thromboplastin
Surface Antigens
Proline
23 Citations (Scopus)

Purification, characterization, and cDNA cloning of α-N-acetylgalactosamine-specific lectin from starfish, Asterina pectinifera

Kakiuchi, M., Okino, N., Sueyoshi, N., Ichinose, S., Omori, A., Kawabata, S-I., Yamaguchi, K. & Ito, M., Jan 1 2002, In : Glycobiology. 12, 2, p. 85-94 10 p.

Research output: Contribution to journalArticle

Asterina
Starfish
Acetylgalactosamine
Cloning
Lectins
30 Citations (Scopus)

Purification and identification of a tributyltin-binding protein from serum of Japanese flounder, Paralichthys olivaceus

Shimasaki, Y., Oshima, Y., Yokota, Y., Kitano, T., Nakao, M., Kawabata, S-I., Imada, N. & Honjo, T., Jan 1 2002, In : Environmental Toxicology and Chemistry. 21, 6, p. 1229-1235 7 p.

Research output: Contribution to journalArticle

Flounder
tributyltin
Purification
purification
serum
33 Citations (Scopus)

Structure of the antimicrobial peptide tachystatin A

Fujitani, N., Kawabata, S-I., Osaki, T., Kumaki, Y., Demura, M., Nitta, K. & Kawano, K., Jun 28 2002, In : Journal of Biological Chemistry. 277, 26, p. 23651-23657 7 p.

Research output: Contribution to journalArticle

Agatoxins
Chitin
Peptides
Defensins
Horseshoe Crabs