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Research Output 1985 2018

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Article
2002
34 Citations (Scopus)

Structure of the antimicrobial peptide tachystatin A

Fujitani, N., Kawabata, S-I., Osaki, T., Kumaki, Y., Demura, M., Nitta, K. & Kawano, K., Jun 28 2002, In : Journal of Biological Chemistry. 277, 26, p. 23651-23657 7 p.

Research output: Contribution to journalArticle

Agatoxins
Chitin
Peptides
Defensins
Horseshoe Crabs
2001
149 Citations (Scopus)

Functional Conversion of Hemocyanin to Phenoloxidase by Horseshoe Crab Antimicrobial Peptides

Nagai, T., Osaki, T. & Kawabata, S. I., Jul 20 2001, In : Journal of Biological Chemistry. 276, 29, p. 27166-27170 5 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Hemocyanin
Monophenol Monooxygenase
Peptides
Chitin
5 Citations (Scopus)

Horseshoe crab hemocyte-derived lectin recognizing specific O-antigens of lipopolysaccharides

Inamori, K., Saito, T., Iwaki, D., Nagira, T., Iwanaga, S., Arisaka, F. & Kawabata, S-I., Jan 1 2001, In : Advances in Experimental Medicine and Biology. 484, p. 185-190 6 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Carbohydrate Sequence
Horseshoe Crabs
Hemocytes
O Antigens
9 Citations (Scopus)

Role of tachylectins in host defense of the Japanese horseshoe crab Tachypleus tridentatus

Kawabata, S., Beisel, H. G., Huber, R., Bode, W., Gokudan, S., Muta, T., Tsuda, R., Koori, K., Kawahara, T., Seki, N., Mizunoe, Y., Wai, S. N. & Iwanaga, S., Jan 1 2001, In : Advances in experimental medicine and biology. 484, p. 195-202 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Protein Conformation
Molecular Models
Hemolymph
Lectins
108 Citations (Scopus)

The 2.0-Å crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems

Kairies, N., Beisel, H. G., Fuentes-Prior, P., Tsuda, R., Muta, T., Iwanaga, S., Bode, W., Huber, R. & Kawabata, S. I., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 13519-13524 6 p.

Research output: Contribution to journalArticle

Hemolymph
Blood Coagulation
Innate Immunity
Fibrinogen
Horseshoe Crabs
2000
30 Citations (Scopus)

Activated phenoloxidase from Tenebrio molitor larvae enhances the synthesis of melanin by using a vitellogenin-like protein in the presence of dopamine

Lee, K. M., Lee, K. Y., Choi, H. W., Cho, M. Y., Kwon, T. H., Kawabata, S-I. & Lee, B. L., Jul 12 2000, In : European Journal of Biochemistry. 267, 12, p. 3695-3703 9 p.

Research output: Contribution to journalArticle

Tenebrio
Vitellogenins
Monophenol Monooxygenase
Melanins
Larva
12 Citations (Scopus)

A horseshoe crab receptor structurally related to Drosophila Toll

Inamori, K. I., Koori, K., Mishima, C., Muta, T. & Kawabata, S-I., Dec 1 2000, In : Journal of Endotoxin Research. 6, 5, p. 397-399 3 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Toll-Like Receptors
Drosophila
Lipopolysaccharides
Interleukin-1 Receptors
128 Citations (Scopus)

A link between blood coagulation and prophenol oxidase activation in arthropod host defense

Nagai, T. & Kawabata, S. I., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29264-29267 4 p.

Research output: Contribution to journalArticle

Arthropods
Blood Coagulation
Coagulation
Blood
Horseshoe Crabs
117 Citations (Scopus)

Chitin-binding proteins in invertebrates and plants comprise a common chitin-binding structural motif

Suetake, T., Tsuda, S., Kawabata, S. I., Miura, K., Iwanaga, S., Hikichi, K., Nitta, K. & Kawano, K., Jun 16 2000, In : Journal of Biological Chemistry. 275, 24, p. 17929-17932 4 p.

Research output: Contribution to journalArticle

Chitin
Invertebrates
Carrier Proteins
Horseshoe Crabs
Hemocytes
29 Citations (Scopus)

Head-to-tail polymerization of coagulin, a clottable protein of the horseshoe crab

Kawasaki, H., Nose, T., Muta, T., Iwanaga, S., Shimohigashi, Y. & Kawabata, S. I., Nov 10 2000, In : Journal of Biological Chemistry. 275, 45, p. 35297-35301 5 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Thromboplastin
Polymerization
Head
Tail
1999
56 Citations (Scopus)

A newly identified horseshoe crab lectin with specificity for blood group A antigen recognizes specific O-antigens of bacterial lipopolysaccharides

Inamori, K. I., Saito, T., Iwaki, D., Nagira, T., Iwanaga, S., Arisaka, F. & Kawabata, S. I., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3272-3278 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
O Antigens
Blood Group Antigens
Lectins
Lipopolysaccharides
4 Citations (Scopus)

Cloning, sequencing, and functional expression in Escherichia coli of chaperonin (groESL) genes from Vibrio cholerae

Mizunoe, Y., Wai, S. N., Umene, K., Kokubo, T., Kawabata, S. I. & Yoshida, S. I., Jan 1 1999, In : MICROBIOLOGY and IMMUNOLOGY. 43, 6, p. 513-520 8 p.

Research output: Contribution to journalArticle

Chaperonins
Vibrio cholerae
Organism Cloning
Chaperonin 10
Escherichia coli
44 Citations (Scopus)

Functional and structural diversities of C-reactive proteins present in horseshoe crab hemolymph plasma

Iwaki, D., Osaki, T., Mizunoe, Y., Wai, S. N., Iwanaga, S. & Kawabata, S. I., Sep 1 1999, In : European Journal of Biochemistry. 264, 2, p. 314-326 13 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Hemolymph
C-Reactive Protein
Sepharose
Plasmas
155 Citations (Scopus)

Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen

Gokudan, S., Muta, T., Tsuda, R., Koori, K., Kawahara, T., Seki, N., Mizunoe, Y., Wai, S. N., Iwanaga, S. & Kawabata, S. I., Aug 31 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 18, p. 10086-10091 6 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Lectins
Innate Immunity
Fibrinogen
Hemolymph
78 Citations (Scopus)

Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins

Osaki, T., Omotezako, M., Nagayama, R., Hirata, M., Iwanaga, S., Kasahara, J., Hattori, J., Ito, I., Sugiyama, H. & Kawabata, S. I., Sep 10 1999, In : Journal of Biological Chemistry. 274, 37, p. 26172-26178 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Hemocytes
Spiders
Neurotoxins
Chitin
17 Citations (Scopus)

Purification, characterization, and amino acid sequence of an embryonic lectin in perivitelline fluid of the horseshoe crab

Nagai, T., Kawabata, S-I., Shishikura, F. & Sugita, H., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 37673-37678 6 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Lectins
Purification
Amino Acid Sequence
Amino Acids
78 Citations (Scopus)

Role of lectins in the innate immunity of horseshoe crab

Kawabata, S-I. & Iwanaga, S., Jun 1 1999, In : Developmental and Comparative Immunology. 23, 4-5, p. 391-400 10 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Lectins
Innate Immunity
Lipopolysaccharides
Hemolymph
133 Citations (Scopus)

Tachylectin-2: Crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus

Beisel, H. G., Kawabata, S. I., Iwanaga, S., Huber, R. & Bode, W., May 4 1999, In : EMBO Journal. 18, 9, p. 2313-2322 10 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Lectins
Innate Immunity
Acetylglucosamine
Crystal structure
1998
104 Citations (Scopus)

In vitro activation of pro-phenol-oxidase by two kinds of pro-phenol- oxidase-activating factors isolated from hemolymph of coleopteran, Holotrichia diomphalia larvae

Lee, S. Y., Kwon, T. H., Hyun, J. H., Choi, J. S., Kawabata, S-I., Iwanaga, S. & Lee, B. L., May 15 1998, In : European Journal of Biochemistry. 254, 1, p. 50-57 8 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Hemolymph
Larva
Chemical activation
amidase
103 Citations (Scopus)

Molecular cloning of cDNA for pro-phenol-oxidase-activating factor i, a serine protease is induced by lipopolysaccharide or 1,3-β-glucan in coleopteran insect, Holotrichia diomphalia larvae

Lee, S. Y., Cho, M. Y., Hyun, J. H., Lee, K. M., Homma, K. I., Natori, S., Kawabata, S-I., Iwanaga, S. & Lee, B. L., Nov 1 1998, In : European Journal of Biochemistry. 257, 3, p. 615-621 7 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Glucans
Monophenol Monooxygenase
Cloning
Molecular Cloning
6 Citations (Scopus)

Purification of a novel muscle cell growth factor S-myotrophin from porcine skeletal muscle

Hayashi, T., Takeshita, K., Tsuchida, N., Kitano, K., Kawabata, S-I., Iwanaga, S. & Ito, T., Aug 1 1998, In : International Journal of Biochemistry and Cell Biology. 30, 8, p. 897-908 12 p.

Research output: Contribution to journalArticle

Cell growth
Muscle Cells
Purification
Muscle
Intercellular Signaling Peptides and Proteins
106 Citations (Scopus)

Two hevein homologs isolated from the seed of Pharbitis nil L. exhibit potent antifungal activity

Koo, J. C., Lee, S. Y., Chun, H. J., Cheong, Y. H., Choi, J. S., Kawabata, S-I., Miyagi, M., Tsunasawa, S., Ha, K. S., Bae, D. W., Han, C. D., Lee, B. L. & Cho, M. J., Jan 15 1998, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1382, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Ipomoea nil
Adenosine Monophosphate
Seed
Seeds
Chitin
187 Citations (Scopus)

Vibrio cholerae O1 strain TSI-4 produces the exopolysaccharide materials that determine colony morphology, stress resistance, and biofilm formation

Wai, S. N., Mizunoe, Y., Takade, A., Kawabata, S. I. & Yoshida, S. I., Oct 1 1998, In : Applied and environmental microbiology. 64, 10, p. 3648-3655 8 p.

Research output: Contribution to journalArticle

Vibrio cholerae O1
stress resistance
cholera
exopolysaccharides
Biofilms
1997
84 Citations (Scopus)

A newly identified horseshoe crab lectin with binding specificity to O- antigen of bacterial lipopolysaccharides

Saito, T., Hatada, M., Iwanaga, S. & Kawabata, S-I., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30703-30708 6 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
O Antigens
Lectins
Lipopolysaccharides
Hemocytes
4 Citations (Scopus)

Big defensin and tachylectins-1 and -2.

Kawabata, S-I. & Iwanaga, S., Jan 1 1997, In : Methods in molecular biology (Clifton, N.J.). 78, p. 51-61 11 p.

Research output: Contribution to journalArticle

Cytoplasmic Granules
Defensins
Hemagglutination Tests
Horseshoe Crabs
Hemocytes
43 Citations (Scopus)

Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity

Yakushiji, H., Maraboeuf, F., Takahashi, M., Deng, Z. S., Kawabata, S-I., Nakabeppu, Y. & Sekiguchi, M., Sep 1 1997, In : Mutation Research - DNA Repair. 384, 3, p. 181-194 14 p.

Research output: Contribution to journalArticle

Proteins
Substitution reactions
Valine
Circular Dichroism
Methionine
19 Citations (Scopus)

CDNA cloning, tissue distribution, and subcellular localization of horseshoe crab big defensin

Kawabata, S-I., Saito, T., Saeki, K., Okino, N., Mizutani, A., Toh, Y. & Iwanaga, S., Jan 1 1997, In : Biological Chemistry. 378, 3-4, p. 289-292 4 p.

Research output: Contribution to journalArticle

Defensins
Horseshoe Crabs
Cloning
Tissue Distribution
Organism Cloning
50 Citations (Scopus)

Purification and Characterization of Prophenoloxidase from the Hemolymph of Coleopteran Insect, Holotrichia diomphalia Larvae

Kwon, T. H., Lee, S. Y., Lee, J. H., Choi, J. S., Kawabata, S. I., Iwanaga, S. & Lee, B. L., Feb 28 1997, In : Molecules and cells. 7, 1, p. 90-97 8 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Hemolymph
Larva
Insects
Dextran Sulfate
7 Citations (Scopus)

Tissue distribution and subcellular localization of rabbit liver metalloendopeptidase

Nakagawa, K., Kawabata, S. I., Nakashima, Y., Iwanaga, S. & Sueishi, K., Jan 1997, In : Journal of Histochemistry and Cytochemistry. 45, 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

Metalloendopeptidases
Tissue Distribution
Rabbits
Liver
thimet oligopeptidase
1996
35 Citations (Scopus)

A cysteine protease inhibitor stored in the large granules of horseshoe crab hemocytes: Purification, characterization, cDNA cloning and tissue localization

Agarwala, K. L., Kawabata, S-I., Hirata, M., Miyagi, M., Tsunasawa, S. & Iwanaga, S., Jan 1996, In : Journal of Biochemistry. 119, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

Cystatins
Cysteine Proteinase Inhibitors
Horseshoe Crabs
Hemocytes
Cloning
59 Citations (Scopus)

Limulus factor D, a 43-kDa protein isolated from horseshoe crab hemocytes, is a serine protease homologue with antimicrobial activity

Kawabata, S-I., Tokunaga, F., Kugi, Y., Motoyama, S., Miura, Y., Hirata, M. & Iwanaga, S., Dec 2 1996, In : FEBS Letters. 398, 2-3, p. 146-150 5 p.

Research output: Contribution to journalArticle

Arthropod Proteins
Complement Factor D
Horseshoe Crabs
Hemocytes
Serine Proteases
36 Citations (Scopus)

Limulus intracellular coagulation inhibitor type 3. Purification, characterization, cDNA cloning, and tissue localization

Agarwala, K. L., Kawabata, S. I., Miura, Y., Kuroki, Y. & Iwanaga, S., Oct 10 1996, In : Journal of Biological Chemistry. 271, 39, p. 23768-23774 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Cloning
Coagulation
Serpins
Purification
8 Citations (Scopus)

Limulus kexin: A new type of Kex2-like endoprotease specifically expressed in hemocytes of the horseshoe crab

Kawabata, S. I., Saeki, K. & Iwanaga, S., May 20 1996, In : FEBS Letters. 386, 2-3, p. 201-204 4 p.

Research output: Contribution to journalArticle

Furin
Horseshoe Crabs
Hemocytes
Protein Sorting Signals
Gene Library
73 Citations (Scopus)

Molecular cloning of Limulus α2-macroglobulin

Iwaki, D., Kawabata, S-I., Miura, Y., Kato, A., Armstrong, P. B., Quigley, J. P., Nielsen, K. L., Dolmer, K., Sottrup-Jensen, L. & Iwanaga, S., Jan 1 1996, In : European Journal of Biochemistry. 242, 3, p. 822-831 10 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Macroglobulins
Cloning
Molecular Cloning
Hemocytes

Structural analysis of defense molecules found in large and small granules in hemocytes of horseshoe crab

Kawabata, S., Dec 1 1996, In : Seikagaku. 68, 9, p. 1523-1536 14 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
alpha-Macroglobulins
Horseshoe Crabs
Hemocytes
Protease Inhibitors
109 Citations (Scopus)

Tachycitin, a small granular component in horseshoe crab hemocytes, is an antimicrobial protein with chitin-binding activity

Kawabata, S-I., Nagayama, R., Hirata, M., Shigenaga, T., Lal Agarwala, K., Saito, T., Cho, J., Nakajima, H., Takagi, T. & Iwanaga, S., Jan 1 1996, In : Journal of biochemistry. 120, 6, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Hemocytes
Chitin
Defensins
Proteins
1995
59 Citations (Scopus)

A limulus intracellular coagulation inhibitor type 2: Purification, characterization, cDNA cloning, and tissue localization

Miura, Y., Kawabata, S-I., Wakamiya, Y., Nakamura, T. & Iwanaga, S., Jan 13 1995, In : Journal of Biological Chemistry. 270, 2, p. 558-565 8 p.

Research output: Contribution to journalArticle

Serpins
Horseshoe Crabs
Cloning
Coagulation
Purification
17 Citations (Scopus)

An abnormal fibrinogen Fukuoka II (Gly-Bβ15 → Cys) characterized by defective fibrin lateral association and mixed disulfide formation

Kamura, T., Tsuda, H., Yae, Y., Hattori, S., Ohga, S., Shibata, Y., Kawabata -, S. I. & Hamasaki, N., Jan 1 1995, In : Journal of Biological Chemistry. 270, 49, p. 29392-29399 8 p.

Research output: Contribution to journalArticle

Abnormal Fibrinogens
Fibrin
Disulfides
Fibrinogen
Association reactions
12 Citations (Scopus)

Annexin V is localized in association with Z-line of rat cardiac myocytes

Wang, L., Rahman, M. M., Iida, H., Inai, T., Kawabata, S. I., Iwanaga, S. & Shibata, Y., Sep 1995, In : Cardiovascular research. 30, 3, p. 363-371 9 p.

Research output: Contribution to journalArticle

Annexin A5
Cardiac Myocytes
Actins
Annexins
Fluorescence Microscopy
143 Citations (Scopus)

A novel big defensin identified in horseshoe crab hemocytes: Isolation, amino acid sequence, and antibacterial activity

Saito, T., Kawabata, S-I., Shigenaga, T., Takayenoki, Y., Cho, J., Nakajima, H., Hirata, M. & Iwanaga, S., Jan 1 1995, In : Journal of Biochemistry. 117, 5, p. 1131-1137 7 p.

Research output: Contribution to journalArticle

Defensins
Horseshoe Crabs
Hemocytes
Amino Acid Sequence
Amino Acids
71 Citations (Scopus)

A novel type of limulus lectin-L6: Purification, primary structure, and antibacterial activity

Saito, T., Kawabata, S-I., Hirata, M. & Iwanaga, S., Jun 16 1995, In : Journal of Biological Chemistry. 270, 24, p. 14493-14499 7 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Purification
Lipopolysaccharides
Bacteria
lysyl endopeptidase
20 Citations (Scopus)

A Sapecin Homologue of Holotrichia Diomphalia: Purification, Sequencing and Determination of Disulfide Pairs

Lee, S., Moon, H., Lee, B., Kawabata, S-I., Natori, S. & Kurata, S., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 3, p. 457-459 3 p.

Research output: Contribution to journalArticle

Hemolymph
Gram-Positive Bacteria
Gram-Negative Bacteria
Disulfides
Larva
79 Citations (Scopus)

cDNA Cloning and Deduced Amino Acid Sequence of Prothrombin Activator (Ecarin) from Kenyan Echis carinatus Venom

Nishida, S., Fujita, T., Kohno, N., Atoda, H., Morita, T., Takeya, H., Kido, I., Paine, M. J. I., Kawabata, S-I. & Iwanaga, S., Jan 1 1995, In : Biochemistry. 34, 5, p. 1771-1778 8 p.

Research output: Contribution to journalArticle

Cloning
Venoms
Prothrombin
Organism Cloning
Amino Acid Sequence
128 Citations (Scopus)

Nucleotide sequence of the cDNA encoding the proenzyme of phenol oxidase of A1 Drosophila melanogaster

Fujimoto, K., Okino, N., Kawabata, S. I., Iwanaga, S. & Ohnishi, E., Aug 31 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 17, p. 7769-7773 5 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Monophenol Monooxygenase
Drosophila melanogaster
Hemocyanin
Complementary DNA
61 Citations (Scopus)

Purification, characterization, and cDNA cloning of a 27-kDa lectin (L10) from horseshoe crab hemocytes

Okino, N., Kawabata, S. I., Saito, T., Hirata, M., Takagi, T. & Iwanaga, S., Dec 29 1995, In : Journal of Biological Chemistry. 270, 52, p. 31008-31015 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Hemocytes
Cloning
Lectins
Purification
3 Citations (Scopus)

Substrate specificity of rabbit liver metalloendopeptidase and its new fluorogenic peptide substrates

Kojima, N., Kawabata, S-I., Makinose, Y., Nishino, N. & Iwanaga, S., Jan 1 1995, In : Journal of biochemistry. 118, 4, p. 855-861 7 p.

Research output: Contribution to journalArticle

Metalloendopeptidases
Substrate Specificity
Fluorescent Dyes
Liver
thimet oligopeptidase
1994
40 Citations (Scopus)

Activation Peptide of Human Factor IX Has Oligosaccharides O-Glycosidically Linked to Threonine Residues at 159 and 169

Agarwala, K. L., Kawabata, S. I., Nishimura, H., Iwanaga, S., Takao, T., Murata, H. & Shimonishi, Y., May 1 1994, In : Biochemistry. 33, 17, p. 5167-5171 5 p.

Research output: Contribution to journalArticle

Factor IX
Threonine
Human engineering
Oligosaccharides
Chemical activation
67 Citations (Scopus)
Serpins
Horseshoe Crabs
Cloning
Serine Proteases
Coagulation
82 Citations (Scopus)

CDN a cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol

Alam, R., Hachiya, N., Sakaguchi, M., Kawabata, S-I., Iwanaga, S., Kitajima, M., Mihara, K. & Omura, T., Jan 1 1994, In : Journal of biochemistry. 116, 2, p. 416-425 10 p.

Research output: Contribution to journalArticle

Cloning
Liver
Cytosol
14-3-3 Proteins
Protein Precursors
7 Citations (Scopus)

Chlorophyll deficiency caused by a specific blockage of the C5-pathway in seedlings of virescent mutant rice

Kusumi, K., Inada, H., Kawabata, S. I., Iba, K. & Nishimura, M., Dec 1 1994, In : Plant and Cell Physiology. 35, 3, p. 445-449 5 p.

Research output: Contribution to journalArticle

Chlorophyll
Seedlings
chlorophyll
rice
mutants