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Research Output 1983 2017

  • 2066 Citations
  • 27 h-Index
  • 49 Article
  • 2 Review article
2017
21 Citations (Scopus)

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism

Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, Y., Omura, M., Nishikawa, T. & Mukai, K., Feb 5 2017, In : Molecular and Cellular Endocrinology. 441, p. 124-133 10 p.

Research output: Contribution to journalReview article

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Steroid 11-beta-Hydroxylase
Zona Glomerulosa
Aldosterone
2014
69 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jul 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
2013
4 Citations (Scopus)

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Vecchiola, A., Lagos, C. F., Fuentes, C. A., Allende, F., Campino, C., Valdivia, C., Tapia-Castillo, A., Ogishima, T., Mukai, K., Owen, G., Solari, S., Carvajal, C. A. & Fardella, C. E., Aug 13 2013, In : Reproductive Biology and Endocrinology. 11, 1, 76.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Progesterone
Estradiol
Aldosterone
Steroid 11-beta-Hydroxylase
19 Citations (Scopus)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., Apr 1 2013, In : Journal of Clinical Pathology. 66, 4, p. 351-354 4 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Immunohistochemistry
Adenoma
Hyperplasia
2012
28 Citations (Scopus)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., Sep 25 2012, In : PloS one. 7, 9, e45612.

Research output: Contribution to journalArticle

Selenium Compounds
Corneal Epithelium
Lactoferrin
Oxidative stress
selenium
2010
151 Citations (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
Aldosterone
Adenoma
Enzymes
2008
10 Citations (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., Jul 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

Research output: Contribution to journalArticle

Cytochromes
Lyases
Androstenedione
Rats
Pancreas
2007
21 Citations (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., Feb 1 2007, In : Journal of bacteriology. 189, 3, p. 844-850 7 p.

Research output: Contribution to journalArticle

Rickettsia prowazekii
Protein Transport
Protein Sorting Signals
Mitochondria
Peptide Hydrolases
15 Citations (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

Mitochondria
Liver Mitochondrion
Heme
Liver
Rats
90 Citations (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 2
Gluconeogenesis
Adrenal Glands
Knockout Mice
Adrenocorticotropic Hormone
4 Citations (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 889-895 7 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Yeast
Yeasts
Glycine
mitochondrial processing peptidase
26 Citations (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., Mar 13 2007, In : Life Sciences. 80, 14, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
2005
5 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex
7 Citations (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., Feb 1 2005, In : Biochemical Journal. 385, 3, p. 755-761 7 p.

Research output: Contribution to journalArticle

Polyproteins
Processing
Mitochondria
Succinate Dehydrogenase
mitochondrial processing peptidase
2004
3 Citations (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., Dec 1 2004, In : Endocrine Research. 30, 4, p. 639-644 6 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Adrenal Cortex
Mitochondrial Membranes
Cytochromes
monodehydroascorbate reductase (NADH)
2003
35 Citations (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

Research output: Contribution to journalArticle

Cytochromes b5
Leydig Cells
Mitochondrial Membranes
Modulators
Androgens
2001
23 Citations (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

Research output: Contribution to journalArticle

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine
5 Citations (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., Jan 1 2001, In : Journal of biochemistry. 130, 4, p. 497-502 6 p.

Research output: Contribution to journalArticle

Protein Precursors
Mitochondrial Proteins
Cytochrome P-450 Enzyme System
Arginine
Processing
2000
36 Citations (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

Research output: Contribution to journalArticle

Protein Precursors
Glycine
Mutation
Enzymes
Peptides
1999
8 Citations (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
1998
21 Citations (Scopus)

Cooperative formation of a substrate binding pocket by α- and β- subunits of mitochondrial processing peptidase

Kojima, K., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32542-32546 5 p.

Research output: Contribution to journalArticle

Substrates
Peptides
Arginine
Protein Precursors
mitochondrial processing peptidase
31 Citations (Scopus)

Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase

Kitada, S., Kojima, K., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32547-32553 7 p.

Research output: Contribution to journalArticle

Glutamic Acid
Substrates
Peptides
Glutamates
Mutation
16 Citations (Scopus)
Serine
Peptide Hydrolases
Peptides
Arginine
Substrates
37 Citations (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

Research output: Contribution to journalArticle

Substrates
Processing
Adrenodoxin
Acidic Amino Acids
Peptides
1997

Processing of mitochondrial protein precursors

Ito, A., Ogishima, T. & Kitada, S., Jan 1 1997, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 14 Suppl, p. 2362-2367 6 p.

Research output: Contribution to journalReview article

Metalloendopeptidases
Protein Precursors
Mitochondrial Proteins
Mitochondria
22 Citations (Scopus)

Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor

Shimokata, K., Nishio, T., Song, M. C., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1997, In : Journal of biochemistry. 122, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

Malate Dehydrogenase
Arginine
Peptides
Substrates
Protein Precursors
1996
11 Citations (Scopus)

Evidence for 54-kD protein in chicken kidney as a cytochrome P450 with a high molecular activity of 25-hydroxyvitamin D3 1β-hydroxylase

Wakino, S., Meguro, M., Suzuki, H., Saruta, T., Ogishima, T., Shimada, H., Ishimura, Y., Shinki, T. & Suda, T., Jan 1 1996, In : Gerontology. 42, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

Calcifediol
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Chickens
Kidney
31 Citations (Scopus)

Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase

Song, M. C., Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1996, In : Journal of biochemistry. 120, 6, p. 1163-1166 4 p.

Research output: Contribution to journalArticle

Basic Amino Acids
Ornithine-Oxo-Acid Transaminase
Peptides
Substrates
Processing
1995
46 Citations (Scopus)

Analysis of elements in the substrate required for processing by mitochondrial processing peptidase

Ogishima, T., Niidome, T., Shimokata, K., Kitada, S. & Ito, A., Dec 22 1995, In : Journal of Biological Chemistry. 270, 51, p. 30322-30326 5 p.

Research output: Contribution to journalArticle

Arginine
Peptide Hydrolases
Proline
Glycine
Substrates
56 Citations (Scopus)

A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity

Kitada, S., Shimokata, K., Niidome, T., Ogishima, T. & Ito, A., Jan 1 1995, In : Journal of biochemistry. 117, 6, p. 1148-1150 3 p.

Research output: Contribution to journalArticle

Rats
Catalyst activity
Metals
Binding Sites
Catalytic Domain
30 Citations (Scopus)

Localization of p450aldo and p45011β in normal and regenerating rat adrenal cortex

Mitani, F., Ogishima, T., Miyamoto, H. & Ishimura, Y., Jan 1 1995, In : Endocrine Research. 21, 1-2, p. 413-423 11 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Zona Glomerulosa
Zona Fasciculata
Corticosterone
Aldosterone
1994
128 Citations (Scopus)

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiological role

Mitani, F., Suzuki, H., Hata, J. I., Ogishima, T., Shimada, H. & Ishimura, Y., Jan 1 1994, In : Endocrinology. 135, 1, p. 431-438 8 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Adrenal Cortex Hormones
Enzymes
Cytochrome P-450 CYP11B2
Zona Fasciculata
60 Citations (Scopus)

Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate

Niidome, T., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Jan 1 1994, In : Journal of Biological Chemistry. 269, 40, p. 24719-24722 4 p.

Research output: Contribution to journalArticle

Arginine
Demonstrations
Peptides
Substrates
Amino Acids
1993
14 Citations (Scopus)

Molecular Cloning of the Smaller Subunit (P52) of Rat Liver Mitochondrial Processing Protease

Kitada, S., Niidome, T., Nagano, T., Ogishima, T. & Ito, A., Jan 1 1993, In : Biochemical and Biophysical Research Communications. 190, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Liver
Yeast
Rats
35 Citations (Scopus)

Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour

Shibata, H., Suzuki, H., Ogishima, T., Ishimura, Y. & Saruta, T., Jan 1 1993, In : Acta Endocrinologica. 128, 3, p. 235-242 8 p.

Research output: Contribution to journalArticle

Glandular and Epithelial Neoplasms
Adenoma
Aldosterone
Enzymes
Cushing Syndrome
1992
28 Citations (Scopus)

Effect of dietary sodium restriction on mrna for aldosterone synthase cytochrome P-450 in rat adrenals

Imai, M., Ogishima, T., Shimada, H. & Ishimura, Y., Apr 1992, In : Journal of biochemistry. 111, 4, p. 440-443 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Dietary Sodium
Cytochromes
Rats
Sodium
154 Citations (Scopus)

Zone-specific expression of aldosterone synthase cytochrome p-450 and cytochrome p-45011β in rat adrenal cortex: Histochemical basis for the functional zonation

Ogishima, T., Suzuki, H., Hata, J. I., Mitani, F. & Ishimura, Y., Jan 1 1992, In : Endocrinology. 130, 5, p. 2971-2977 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Adrenal Cortex
Cytochromes
Zona Glomerulosa
Aldosterone
1991
124 Citations (Scopus)

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T. & Ishimura, Y., Sep 6 1991, In : Journal of Biological Chemistry. 266, 17, p. 10731-10734 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Cytochrome P-450 Enzyme System
Genes
Aldosterone
56 Citations (Scopus)

Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium

Shibata, H., Ogishima, T., Mitani, F., Suzuki, H., Murakami, M., Saruta, T. & Ishimura, Y., May 1 1991, In : Endocrinology. 128, 5, p. 2534-2539 6 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Angiotensin II
Potassium
Diet
Aldosterone
26 Citations (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Cytochromes
Rats
Genes
Nuclease Protection Assays
1990
87 Citations (Scopus)

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T. & Ishimura, Y., Apr 24 1990, In : FEBS Letters. 263, 2, p. 299-302 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Cloning
Adrenal Cortex
Molecular Cloning
Rats
1989
117 Citations (Scopus)

Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex

Ogishima, T., Mitani, F. & Ishimura, Y., 1989, In : Journal of Biological Chemistry. 264, 19, p. 10935-10938 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Zona Glomerulosa
Mitochondria
Adrenal Cortex
Rats
63 Citations (Scopus)

Isolation of two distinct cytochromes P-45011β with aldosterone synthase activity from bovine adrenocortical mitochondria

Ogishima, T., Mitani, F. & Ishimura, Y., Jan 1 1989, In : Journal of biochemistry. 105, 4, p. 497-499 3 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Mitochondria
Cytochromes
Desoxycorticosterone
Hydroxylation
1987
52 Citations (Scopus)

Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes.

Ogishima, T., Deguchi, S. & Okuda, K., Jun 5 1987, In : Journal of Biological Chemistry. 262, 16, p. 7646-7650 5 p.

Research output: Contribution to journalArticle

Cholesterol 7-alpha-Hydroxylase
Liver Microsomes
Liver
Purification
Hydroxylation
1986
89 Citations (Scopus)

An improved method for assay of cholesterol 7α-hydroxylase activity

Ogishima, T. & Okuda, K., Jan 1 1986, In : Analytical Biochemistry. 158, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

Cholesterol 7-alpha-Hydroxylase
Assays
Cholesterol Oxidase
Cholesterol
Hydroxycholesterols
1985
48 Citations (Scopus)

Effects of synthetic model peptides resembling the extension peptides of mitochondrial enzyme precursors on import of the precursors into mitochondria

Ito, A., Ogishima, T., Ou, W., Omura, T., Aoyagi, H., Lee, S., Mihara, H. & Izumiya, N., Jan 1 1985, In : Journal of Biochemistry. 98, 6, p. 1571-1582 12 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Mitochondria
Peptides
Basic Amino Acids
Membranes
35 Citations (Scopus)

Import and processing of the precursor of cytochrome P-450(SCC) by bovine adrenal cortex mitochondria

Ogishima, T., Okada, Y. & Omura, T., Jan 1 1985, In : Journal of biochemistry. 98, 3, p. 781-791 11 p.

Research output: Contribution to journalArticle

Mitochondria
Adrenal Cortex
Cytochrome P-450 Enzyme System
Membranes
Processing
1984
6 Citations (Scopus)

Fractionation of mammalian tissue mRNAs by high-performance gel filtration chromatography

Ogishima, T., Okada, Y. & Omura, T., May 1 1984, In : Analytical Biochemistry. 138, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

Fractionation
Chromatography
Gel Chromatography
Gels
Tissue
41 Citations (Scopus)

Interaction between cytochrome P-450 (P-450(C21)) and NADPH-cytochrome P-450 reductase from adrenocortical microsomes in a reconstituted system

Kominami, S., Hara, H., Ogishima, T. & Takemori, S., Jan 1 1984, In : Journal of Biological Chemistry. 259, 5, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
Microsomes
Cytochrome P-450 Enzyme System
Hydroxylation
Oxidoreductases
4 Citations (Scopus)

Presence of a prepiece at the NH2-terminai end of pre-cytochrome P-450(SCC) peptide

Ogishima, T., Okada, Y. & Omura, T., Jan 1 1984, In : Journal of biochemistry. 95, 5, p. 1525-1528 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Peptides
Radio
Amino Acids
Acids