• 2082 Citations
  • 27 h-Index
1983 …2017

Research output per year

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Research Output

  • 2082 Citations
  • 27 h-Index
  • 49 Article
  • 2 Review article
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Article

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jul 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

Research output: Contribution to journalArticle

71 Citations (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T. & Ishimura, Y., Sep 6 1991, In : Journal of Biological Chemistry. 266, 17, p. 10731-10734 4 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Analysis of elements in the substrate required for processing by mitochondrial processing peptidase

Ogishima, T., Niidome, T., Shimokata, K., Kitada, S. & Ito, A., Dec 22 1995, In : Journal of Biological Chemistry. 270, 51, p. 30322-30326 5 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
8 Citations (Scopus)

An improved method for assay of cholesterol 7α-hydroxylase activity

Ogishima, T. & Okuda, K., Oct 1986, In : Analytical Biochemistry. 158, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiological role

Mitani, F., Suzuki, H., Hata, J. I., Ogishima, T., Shimada, H. & Ishimura, Y., Jul 1994, In : Endocrinology. 135, 1, p. 431-438 8 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., Feb 1 2007, In : Journal of bacteriology. 189, 3, p. 844-850 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity

Kitada, S., Shimokata, K., Niidome, T., Ogishima, T. & Ito, A., Jan 1 1995, In : Journal of biochemistry. 117, 6, p. 1148-1150 3 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate

Niidome, T., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Jan 1 1994, In : Journal of Biological Chemistry. 269, 40, p. 24719-24722 4 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cooperative formation of a substrate binding pocket by α- and β- subunits of mitochondrial processing peptidase

Kojima, K., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32542-32546 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., Jul 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Vecchiola, A., Lagos, C. F., Fuentes, C. A., Allende, F., Campino, C., Valdivia, C., Tapia-Castillo, A., Ogishima, T., Mukai, K., Owen, G., Solari, S., Carvajal, C. A. & Fardella, C. E., Aug 13 2013, In : Reproductive Biology and Endocrinology. 11, 1, 76.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect of dietary sodium restriction on mrna for aldosterone synthase cytochrome P-450 in rat adrenals

Imai, M., Ogishima, T., Shimada, H. & Ishimura, Y., Apr 1992, In : Journal of biochemistry. 111, 4, p. 440-443 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Effects of synthetic model peptides resembling the extension peptides of mitochondrial enzyme precursors on import of the precursors into mitochondria

Ito, A., Ogishima, T., Ou, W., Omura, T., Aoyagi, H., Lee, S., Mihara, H. & Izumiya, N., Jan 1 1985, In : Journal of Biochemistry. 98, 6, p. 1571-1582 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Evidence for 54-kD protein in chicken kidney as a cytochrome P450 with a high molecular activity of 25-hydroxyvitamin D3 1β-hydroxylase

Wakino, S., Meguro, M., Suzuki, H., Saruta, T., Ogishima, T., Shimada, H., Ishimura, Y., Shinki, T. & Suda, T., Jan 1996, In : Gerontology. 42, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Fractionation of mammalian tissue mRNAs by high-performance gel filtration chromatography

Ogishima, T., Okada, Y. & Omura, T., May 1 1984, In : Analytical Biochemistry. 138, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase

Kitada, S., Kojima, K., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32547-32553 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., Apr 1 2013, In : Journal of Clinical Pathology. 66, 4, p. 351-354 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
16 Citations (Scopus)

Import and processing of the precursor of cytochrome P-450(SCC) by bovine adrenal cortex mitochondria

Ogishima, T., Okada, Y. & Omura, T., Jan 1 1985, In : Journal of biochemistry. 98, 3, p. 781-791 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Interaction between cytochrome P-450 (P-450(C21)) and NADPH-cytochrome P-450 reductase from adrenocortical microsomes in a reconstituted system

Kominami, S., Hara, H., Ogishima, T. & Takemori, S., Jan 1 1984, In : Journal of Biological Chemistry. 259, 5, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex

Ogishima, T., Mitani, F. & Ishimura, Y., 1989, In : Journal of Biological Chemistry. 264, 19, p. 10935-10938 4 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Isolation of two distinct cytochromes P-45011β with aldosterone synthase activity from bovine adrenocortical mitochondria

Ogishima, T., Mitani, F. & Ishimura, Y., Jan 1 1989, In : Journal of biochemistry. 105, 4, p. 497-499 3 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Localization of p450aldo and p45011β in normal and regenerating rat adrenal cortex

Mitani, F., Ogishima, T., Miyamoto, H. & Ishimura, Y., Jan 1 1995, In : Endocrine Research. 21, 1-2, p. 413-423 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T. & Ishimura, Y., Apr 24 1990, In : FEBS Letters. 263, 2, p. 299-302 4 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Molecular Cloning of the Smaller Subunit (P52) of Rat Liver Mitochondrial Processing Protease

Kitada, S., Niidome, T., Nagano, T., Ogishima, T. & Ito, A., Jan 1 1993, In : Biochemical and Biophysical Research Communications. 190, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Partial amino acid sequences of two mitochondrial and two microsomal cytochrome p-450's from adrenal cortex

Ogishima, T., Okada, Y., Kominami, S., Takemori, S. & Omura, T., Nov 1983, In : Journal of Biochemistry. 94, 5, p. 1711-1714 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., Dec 1 2004, In : Endocrine Research. 30, 4, p. 639-644 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Presence of a prepiece at the NH2-terminai end of pre-cytochrome P-450(SCC) peptide

Ogishima, T., Okada, Y. & Omura, T., Jan 1 1984, In : Journal of biochemistry. 95, 5, p. 1525-1528 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes.

Ogishima, T., Deguchi, S. & Okuda, K., Jun 5 1987, In : Journal of Biological Chemistry. 262, 16, p. 7646-7650 5 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., Feb 1 2005, In : Biochemical Journal. 385, 3, p. 755-761 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., Jan 1 2001, In : Journal of biochemistry. 130, 4, p. 497-502 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium

Shibata, H., Ogishima, T., Mitani, F., Suzuki, H., Murakami, M., Saruta, T. & Ishimura, Y., May 1 1991, In : Endocrinology. 128, 5, p. 2534-2539 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase

Song, M. C., Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1996, In : Journal of biochemistry. 120, 6, p. 1163-1166 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., Sep 25 2012, In : PloS one. 7, 9, e45612.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour

Shibata, H., Suzuki, H., Ogishima, T., Ishimura, Y. & Saruta, T., Jan 1 1993, In : Acta Endocrinologica. 128, 3, p. 235-242 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 889-895 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor

Shimokata, K., Nishio, T., Song, M. C., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1997, In : Journal of biochemistry. 122, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., Mar 13 2007, In : Life Sciences. 80, 14, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Zone-specific expression of aldosterone synthase cytochrome p-450 and cytochrome p-45011β in rat adrenal cortex: Histochemical basis for the functional zonation

Ogishima, T., Suzuki, H., Hata, J. I., Mitani, F. & Ishimura, Y., May 1992, In : Endocrinology. 130, 5, p. 2971-2977 7 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)