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Research Output 2001 2019

  • 947 Citations
  • 16 h-Index
  • 27 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K-I. & Fukami, M., Mar 1 2019, In : Bone. 120, p. 219-231 13 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone and Bones
Cell Lineage
Genes
Polycomb-Group Proteins

Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody

Yokoyama, C., Chigi, Y., Baba, T., Ohshitanai, A., Harada, Y., Takahashi, F. & Morohashi, K-I., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 916-920 5 p.

Research output: Contribution to journalArticle

Leydig Cells
Testis
Rats
3-Hydroxysteroid Dehydrogenases
Steroids
2018

Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids

Baba, T., Otake, H., Inoue, M., Sato, T., Ishihara, Y., Moon, J. Y., Tsuchiya, M., Miyabayashi, K., Ogawa, H., Shima, Y., Wang, L., Sato, R., Yamazaki, T., Suyama, M., Nomura, M., Choi, M. H., Ohkawa, Y. & Morohashi, K-I., Dec 1 2018, In : Communications Biology. 1, 1, 18.

Research output: Contribution to journalArticle

Open Access
steroids
Steroids
Cholesterol
cholesterol
Metabolic Networks and Pathways

The role of Ad4BP/SF-1 in the development of adrenal gland and the synthesis of adrenal steroid

Baba, T., Jan 1 2018, In : Japanese Journal of Clinical Urology. 72, 6, p. 424-429 6 p.

Research output: Contribution to journalArticle

Adrenal Glands
Steroids
2017
10 Citations (Scopus)

Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

Miyabayashi, K., Shima, Y., Inoue, M., Sato, T., Baba, T., Ohkawa, Y., Suyama, M. & Morohashi, K-I., May 1 2017, In : Sexual Development. 11, 2, p. 53-63 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Fetal Development
Gene Expression
Testis
Mitochondrial Genes
1 Citation (Scopus)

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

Shishido, Y., Baba, T., Sato, T., Shima, Y., Miyabayashi, K., Inoue, M., Akiyama, H., Kimura, H., Kanai, Y., Ishihara, Y., Haraguchi, S., Miyazaki, A., Rozman, D., Yamazaki, T., Choi, M. H., Ohkawa, Y., Suyama, M. & Morohashi, K-I., Jan 1 2017, In : Scientific reports. 7, 41912.

Research output: Contribution to journalArticle

Sertoli Cells
Lactic Acid
Cholesterol
Germ Cells
Nursing
18 Citations (Scopus)

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues

Igarashi, M., Takasawa, K., Hakoda, A., Kanno, J., Takada, S., Miyado, M., Baba, T., Morohashi, K-I., Tajima, T., Hata, K., Nakabayashi, K., Matsubara, Y., Sekido, R., Ogata, T., Kashimada, K. & Fukami, M., Jan 1 2017, In : Human mutation. 38, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
46, XX Testicular Disorders of Sex Development
46,XY Gonadal Dysgenesis
Ovotesticular Disorders of Sex Development
3 Citations (Scopus)

Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth

Syu, J. S., Baba, T., Huang, J. Y., Ogawa, H., Hsieh, C. H., Hu, J. X., Chen, T. Y., Lin, T. C., Tsuchiya, M., Morohashi, K-I., Huang, B. M., Lu, F. I. & Wang, C. Y., Jan 1 2017, In : Scientific reports. 7, 1, 240.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Cyclins
Glycolysis
Growth
Protein Stability
3 Citations (Scopus)

Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells

Li, B., Baba, T., Miyabayashi, K., Sato, T., Shima, Y., Ichinose, T., Miura, D., Ohkawa, Y., Suyama, M. & Morohashi, K-I., Jan 1 2017, In : Endocrine Journal. 64, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
NADP
Genes
Pentose Phosphate Pathway
Chromatin Immunoprecipitation
2016
20 Citations (Scopus)

Isolation and characterization of Fetal Leydig progenitor cells of male mice

Inoue, M., Shima, Y., Miyabayashi, K., Tokunaga, K., Sato, T., Baba, T., Ohkawa, Y., Akiyama, H., Suyama, M. & Morohashi, K-I., Mar 1 2016, In : Endocrinology. 157, 3, p. 1222-1233 12 p.

Research output: Contribution to journalArticle

Leydig Cells
Stem Cells
Testis
Growth Factor Receptors
Transcriptome
2015
25 Citations (Scopus)

Fetal leydig cells persist as an androgen-independent subpopulation in the postnatal testis

Shima, Y., Matsuzaki, S., Miyabayashi, K., Otake, H., Baba, T., Kato, S., Huhtaniemi, I. & Morohashi, K-I., Nov 1 2015, In : Molecular Endocrinology. 29, 11, p. 1581-1593 13 p.

Research output: Contribution to journalArticle

Leydig Cells
Androgens
Testis
Androgen Receptors
Knockout Mice
5 Citations (Scopus)

Heterogeneity of ovarian theca and interstitial gland cells in Mice

Miyabayashi, K., Tokunaga, K., Otake, H., Baba, T., Shima, Y. & Morohashi, K-I., Jun 3 2015, In : PloS one. 10, 6, e0128352.

Research output: Contribution to journalArticle

Genes
Gene expression
Reporter Genes
reporter genes
mice
7 Citations (Scopus)

Testicular dysgenesis/regression without campomelic dysplasia in patients carrying missense mutations and upstream deletion of sox9

Katoh-Fukui, Y., Igarashi, M., Nagasaki, K., Horikawa, R., Nagai, T., Tsuchiya, T., Suzuki, E., Miyado, M., Hata, K., Nakabayashi, K., Hayashi, K., Matsubara, Y., Baba, T., Morohashi, K-I., Igarashi, A., Ogata, T., Takada, S. & Fukami, M., Jan 1 2015, In : Molecular Genetics and Genomic Medicine. 3, 6, p. 550-557 8 p.

Research output: Contribution to journalArticle

Open Access
Campomelic Dysplasia
Missense Mutation
XY Disorders of Sex Development 46
Mutation
Exome
2014
34 Citations (Scopus)

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1

Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, C. Y., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, B. C. & Morohashi, K-I., Apr 14 2014, In : Nature communications. 5, 3634.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
genes
Genes
Tissue
adrenal gland
18 Citations (Scopus)

Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex

Yokoyama, A., Igarashi, K., Sato, T., Takagi, K., Otsuka, M. I., Shishido, Y., Baba, T., Ito, R., Kanno, J., Ohkawa, Y., Morohashi, K-I. & Sugawara, A., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18152-18162 11 p.

Research output: Contribution to journalArticle

Myelin Sheath
Lysine
Transcription Factors
Genes
Histone Demethylases
2013
29 Citations (Scopus)

Aristaless Related Homeobox Gene, Arx, Is Implicated in Mouse Fetal Leydig Cell Differentiation Possibly through Expressing in the Progenitor Cells

Miyabayashi, K., Katoh-Fukui, Y., Ogawa, H., Baba, T., Shima, Y., Sugiyama, N., Kitamura, K. & Morohashi, K-I., Jun 28 2013, In : PloS one. 8, 6, e68050.

Research output: Contribution to journalArticle

homeotic genes
Leydig cells
Leydig Cells
Homeobox Genes
cell differentiation
82 Citations (Scopus)

Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes

Shima, Y., Miyabayashi, K., Haraguchi, S., Arakawa, T., Otake, H., Baba, T., Matsuzaki, S., Shishido, Y., Akiyama, H., Tachibana, T., Tsutsui, K. & Morohashi, K-I., Jan 7 2013, In : Molecular Endocrinology. 27, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Sertoli Cells
Testosterone
Testis
Androstenedione
2012
78 Citations (Scopus)

Cbx2, a polycomb group gene, is required for Sry gene expression in mice

Katoh-Fukui, Y., Miyabayashi, K., Komatsu, T., Owaki, A., Baba, T., Shima, Y., Kidokoro, T., Kanai, Y., Schedl, A., Wilhelm, D., Koopman, P., Okuno, Y. & Morohashi, K-I., Feb 1 2012, In : Endocrinology. 153, 2, p. 913-924 12 p.

Research output: Contribution to journalArticle

sry Genes
Gonads
Testis
Gene Expression
Knockout Mice
30 Citations (Scopus)

Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal leydig cells

Shima, Y., Miyabayashi, K., Baba, T., Otake, H., Oka, S., Zubair, M. & Morohashi, K-I., Jan 1 2012, In : Endocrinology. 153, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Leydig Cells
Genes
Gonads
Adrenal Glands
2010
37 Citations (Scopus)

Abnormal epithelial cell polarity and ectopic Epidermal Growth Factor Receptor (EGFR) expression induced in Emx2 KO Embryonic Gonads

Kusaka, M., Katoh-Fukui, Y., Ogawa, H., Miyabayashi, K., Baba, T., Shima, Y., Sugiyama, N., Sugimoto, Y., Okuno, Y., Kodama, R., Iizuka-Kogo, A., Senda, T., Sasaoka, T., Kitamura, K., Aizawa, S. & Morohashi, K-I., Dec 1 2010, In : Endocrinology. 151, 12, p. 5893-5904 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Tight Junctions
Gonads
Epidermal Growth Factor Receptor
Tyrosine
2008
32 Citations (Scopus)

Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice

Baba, T., Shima, Y., Owaki, A., Mimura, J., Oshima, M., Fujii-Kuriyama, Y. & Morohashi, K-I., Apr 1 2008, In : Sexual Development. 2, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Seminal Vesicles
Reproduction
Fertility
Testosterone
12 Citations (Scopus)

Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature

Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K-I. & Katoh-Fukui, Y., Sep 1 2008, In : Molecular Reproduction and Development. 75, 9, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Apoptosis
Testis
Endothelial Cells
Fas Ligand Protein
44 Citations (Scopus)

Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence

Fukami, M., Wada, Y., Okada, M., Kato, F., Katsumata, N., Baba, T., Morohashi, K-I., Laporte, J., Kitagawa, M. & Ogata, T., Feb 29 2008, In : Journal of Biological Chemistry. 283, 9, p. 5525-5532 8 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Chromosomes, Human, Pair 1
X Chromosome
Chromosomes
Open Reading Frames
2007
141 Citations (Scopus)

Germ cells are essential for sexual dimorphism in the medaka gonad

Kurokawa, H., Saito, D., Nakamura, S., Katoh-Fukui, Y., Ohta, K., Baba, T., Morohashi, K-I. & Tanaka, M., Oct 23 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 43, p. 16958-16963 6 p.

Research output: Contribution to journalArticle

Oryzias
Gonads
Germ Cells
Sex Characteristics
Sex Differentiation
2005
168 Citations (Scopus)

Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction

Baba, T., Mimura, J., Nakamura, N., Harada, N., Yamamoto, M., Morohashi, K-I. & Fujii-Kuriyama, Y., Nov 1 2005, In : Molecular and Cellular Biology. 25, 22, p. 10040-10051 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Reproduction
Poisons
Orphan Nuclear Receptors
Teratogenesis
2002

Action mechanism of dioxin receptor

Fujii-Kuriyama, Y., Mimura, J., Baba, T., Numayama-Tsuruta, K. & Sogawa, K., Jan 1 2002, In : Nippon Nogeikagaku Kaishi. 76, 11, p. 1073-1075 3 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Dioxins
dioxins
mechanism of action
2001
122 Citations (Scopus)

Structure and Expression of the Ah Receptor Repressor Gene

Baba, T., Mimura, J., Gradin, K., Kuroiwa, A., Watanabe, T., Matsuda, Y., Inazawa, J., Sogawa, K. & Fujii-Kuriyama, Y., Aug 31 2001, In : Journal of Biological Chemistry. 276, 35, p. 33101-33110 10 p.

Research output: Contribution to journalArticle

Genes
Chromosomes
Aryl Hydrocarbon Receptors
Methylcholanthrene
Electrophoretic Mobility Shift Assay