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Research Output 1987 2019

2006
20 Citations (Scopus)

Diverse DNA methylation statuses at alternative promoters of human genes in various tissues

Cheong, J., Yamada, Y., Yamashita, R., Irie, T., Kanai, A., Wakaguri, H., Nakai, K., Ito, T., Saito, I., Sugano, S. & Suzuki, Y., Nov 16 2006, In : DNA Research. 13, 4, p. 155-167 13 p.

Research output: Contribution to journalArticle

DNA Methylation
CpG Islands
Genes
Methylation
Alleles
17 Citations (Scopus)

Lessons from comparative analysis of species-specific imprinted genes

Okamura, K. & Ito, T., Mar 1 2006, In : Cytogenetic and Genome Research. 113, 1-4, p. 159-164 6 p.

Research output: Contribution to journalArticle

Genomic Imprinting
Mammals
Genes
Species Specificity
Marsupialia
69 Citations (Scopus)

Transcriptional activators in yeast

Titz, B., Thomas, S., Rajagopala, S. V., Chiba, T., Ito, T. & Uetz, P., Mar 20 2006, In : Nucleic acids research. 34, 3, p. 955-967 13 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Helix-Loop-Helix Motifs
Yeasts
Fungal Proteins
Asparagine
2005
20 Citations (Scopus)

A novel strategy to design highly specific PCR primers based on the stability and uniqueness of 3′-end subsequences

Miura, F., Uematsu, C., Sakaki, Y. & Ito, T., Dec 1 2005, In : Bioinformatics. 21, 24, p. 4363-4370 8 p.

Research output: Contribution to journalArticle

Subsequence
Specificity
Uniqueness
Polymerase Chain Reaction
CDNA
15 Citations (Scopus)

Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact

Okamura, K., Sakaki, Y. & Ito, T., Apr 15 2005, In : Biochemical and Biophysical Research Communications. 329, 3, p. 824-830 7 p.

Research output: Contribution to journalArticle

Tandem Repeat Sequences
Genomics
Mammals
Rodentia
Genes
17 Citations (Scopus)

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation

Matsuo, R., Kubota, H., Obata, T., Kito, K., Ota, K., Kitazono, T., Ibayashi, S., Sasaki, T., Iida, M. & Ito, T., Apr 25 2005, In : FEBS Letters. 579, 11, p. 2433-2438 6 p.

Research output: Contribution to journalArticle

Sirolimus
Yeast
Yeasts
Proteins
Amino Acids
2004
134 Citations (Scopus)

A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q

Yamada, Y., Watanabe, H., Miura, F., Soejima, H., Uchiyama, M., Iwasaka, T., Mukai, T., Sakaki, Y. & Ito, T., Feb 1 2004, In : Genome Research. 14, 2, p. 247-266 20 p.

Research output: Contribution to journalArticle

CpG Islands
Human Chromosomes
Methylation
Alleles
X Chromosome
21 Citations (Scopus)

Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors: Involvement of Pdr3 in salt tolerance

Onda, M., Ota, K., Chiba, T., Sakaki, Y. & Ito, T., May 12 2004, In : Gene. 332, 1-2, p. 51-59 9 p.

Research output: Contribution to journalArticle

Salt-Tolerance
Gene Regulatory Networks
Multiple Drug Resistance
Transcription Factors
Yeasts
9 Citations (Scopus)

An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors

Okamura, K., Yamada, Y., Sakaki, Y. & Ito, T., Dec 1 2004, In : DNA Research. 11, 6, p. 381-390 10 p.

Research output: Contribution to journalArticle

Genomic Imprinting
Genes
Genomic Segmental Duplications
Chromosomes, Human, Pair 18
Intergenic DNA

An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors.

Okamura, K., Sakaki, Y. & Ito, T., Dec 2004, In : DNA Research. 11, 6, p. 381-390

Research output: Contribution to journalArticle

7 Citations (Scopus)

A yeast one-hybrid system to detect methylation-dependent DNA-protein interactions

Feng, S. Y., Ota, K., Yamada, Y., Sawabu, N. & Ito, T., Jan 23 2004, In : Biochemical and Biophysical Research Communications. 313, 4, p. 922-925 4 p.

Research output: Contribution to journalArticle

Methylation
DNA Methylation
Hybrid systems
Yeast
Yeasts
81 Citations (Scopus)

Barrier proteins remodel and modify chromatin to restrict silenced domains.

Oki, M., Valenzuela, L., Chiba, T., Ito, T. & Kamakaka, R. T., Mar 2004, In : Molecular and Cellular Biology. 24, 5, p. 1956-1967

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mass spectrometry-based proteomics for quantitative description of cellular events

Kito, K. & Ito, T., Dec 1 2004, In : Current Genomics. 5, 8, p. 629-635 7 p.

Research output: Contribution to journalReview article

Proteomics
Mass Spectrometry
Proteins
Isotope Labeling
Saccharomycetales
24 Citations (Scopus)

Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells

Sato, S., Ito, M., Ito, T. & Yoshioka, K., Mar 31 2004, In : Gene. 329, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Growth Cones
JNK Mitogen-Activated Protein Kinases
Neurites
Kinesin
Proteins
12 Citations (Scopus)

SKIP modifies gene expression by affecting both transcription and splicing

Nagai, K., Yamaguchi, T., Takami, T., Kawasumi, A., Aizawa, M., Masuda, N., Shimizu, M., Tominaga, S., Ito, T., Tsukamoto, T. & Osumi, T., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 512-517 6 p.

Research output: Contribution to journalArticle

RNA Splice Sites
Transcription
Reporter Genes
Gene expression
Introns
32 Citations (Scopus)

Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast

Ichimura, T., Kubota, H., Goma, T., Mizushima, N., Ohsumi, Y., Iwago, M., Kakiuchi, K., Shekhar, H. U., Shinkawa, T., Taoka, M., Ito, T. & Isobe, T., May 25 2004, In : Biochemistry. 43, 20, p. 6149-6158 10 p.

Research output: Contribution to journalArticle

Proteomics
Yeast
Genes
Yeasts
Saccharomyces cerevisiae
2003
100 Citations (Scopus)

A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity

Yue, L., Saikawa, Y., Ota, K., Tanaka, M., Nishimura, R., Uehara, T., Maeba, H., Ito, T., Sasaki, T. & Koizumi, S., Jan 1 2003, In : Pharmacogenetics. 13, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

Cytidine Deaminase
Cytarabine
Single Nucleotide Polymorphism
Genes
Yeasts
22 Citations (Scopus)

Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER

Shakoori, A., Fujii, G., Yoshimura, S. I., Kitamura, M., Nakayama, K., Ito, T., Ohno, H. & Nakamura, N., Dec 19 2003, In : Biochemical and Biophysical Research Communications. 312, 3, p. 850-857 8 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Yeast
Proteins
Yeasts
Tissue
66 Citations (Scopus)

Molecular Recognition in Dimerization between PB1 Domains

Noda, Y., Kohjima, M., Izaki, T., Ota, K., Yoshinaga, S., Inagaki, F., Ito, T. & Sumimoto, H., Oct 31 2003, In : Journal of Biological Chemistry. 278, 44, p. 43516-43524 9 p.

Research output: Contribution to journalArticle

Molecular recognition
Dimerization
Lysine
Proteins
Coulomb interactions
166 Citations (Scopus)
src Homology Domains
NADPH Oxidase
Phagocytes
Phosphatidylinositols
Oxidoreductases
80 Citations (Scopus)

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2

Kubota, H., Obata, T., Ota, K., Sasaki, T. & Ito, T., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20457-20460 4 p.

Research output: Contribution to journalArticle

Sirolimus
Transfer RNA
Phosphotransferases
Chemical activation
Messenger RNA
30 Citations (Scopus)

The PB1 domain and the PC motif-containing region are structurally similar protein binding modules

Yoshinaga, S., Kohjima, M., Ogura, K., Yokochi, M., Takeya, R., Ito, T., Sumimoto, H. & Inagaki, F., Oct 1 2003, In : EMBO Journal. 22, 19, p. 4888-4897 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Protein Binding
Amino Acid Motifs
Saccharomycetales
Static Electricity
2002

Erratum: Extraction of knowledge on protein-protein interaction by association rule discovery (Bioinformatics (2002) vol. 18 (705-714))

Oyama, T., Kitano, K., Satou, K. & Ito, T., Aug 1 2002, In : Bioinformatics. 18, 8, 1 p.

Research output: Contribution to journalComment/debate

Protein-protein Interaction
Association Rules
Bioinformatics
Knowledge
68 Citations (Scopus)

Extraction of knowledge on protein-protein interaction by association rule discovery

Oyama, T., Kitano, K., Satou, K. & Ito, T., Jan 1 2002, In : Bioinformatics. 18, 5, p. 705-714 10 p.

Research output: Contribution to journalArticle

Association rules
Protein-protein Interaction
Association Rules
Proteins
Data Mining
52 Citations (Scopus)

OPR, PC and AID: All in the PB1 family

Ponting, C. P., Ito, T., Moscat, J., Diaz-Meco, M. T., Inagaki, F. & Sumimoto, H., Jan 1 2002, In : Trends in Biochemical Sciences. 27, 1, 1 p.

Research output: Contribution to journalLetter

Proto-Oncogene Proteins
Saccharomyces cerevisiae Proteins
Guanine Nucleotide Exchange Factors
Cell Cycle Proteins
Viral Proteins
96 Citations (Scopus)

Roles for the two-hybrid system in exploration of the yeast protein interactome.

Ito, T., Ota, K., Kubota, H., Yamaguchi, Y., Chiba, T., Sakuraba, K. & Yoshida, M., Aug 2002, In : Molecular & cellular proteomics : MCP. 1, 8, p. 561-566 6 p.

Research output: Contribution to journalReview article

Fungal Proteins
Hybrid systems
Two-Hybrid System Techniques
Proteins
Yeast
118 Citations (Scopus)

The adaptor protein p40 phox as a positive regulator of the superoxide-producing phagocyte oxidase

Kuribayashi, F., Nunoi, H., Wakamatsu, K., Tsunawaki, S., Sato, K., Ito, T. & Sumimoto, H., Dec 2 2002, In : EMBO Journal. 21, 23, p. 6312-6320 9 p.

Research output: Contribution to journalArticle

Phagocytes
Superoxides
Oxidoreductases
Proteins
Membranes
2001
2756 Citations (Scopus)

A comprehensive two-hybrid analysis to explore the yeast protein interactome

Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M. & Sakaki, Y., Apr 10 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 8, p. 4569-4574 6 p.

Research output: Contribution to journalArticle

Fungal Proteins
Proteins
Spindle Pole Bodies
Genome
Protein Interaction Maps
37 Citations (Scopus)

Budding Yeast GCN1 Binds the GI Domain to Activate the eIF2α Kinase GCN2

Kubota, H., Ota, K., Sakaki, Y. & Ito, T., May 18 2001, In : Journal of Biological Chemistry. 276, 20, p. 17591-17596 6 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Saccharomycetales
Yeast
Phosphotransferases
Bearings (structural)

Comparative analysis for expressed genes by polymerase chain reaction using module-shuffling primers.

Uematsu, C., Nishida, J., Okano, K., Kambara, H., Miura, F., Ito, T. & Sakaki, Y., Jan 1 2001, In : Nucleic acids research. Supplement (2001). 1, p. 91-92 2 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Genes
Electrophoresis
Complementary DNA
Yeasts
8 Citations (Scopus)

Differential display analysis of mutants for the transcription factor Pdr1p regulating multidrug resistance in the budding yeast

Miura, F., Yada, T., Nakai, K., Sakaki, Y. & Ito, T., Sep 7 2001, In : FEBS Letters. 505, 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

Saccharomycetales
Multiple Drug Resistance
Bearings (structural)
Yeast
Transcription Factors
21 Citations (Scopus)

Discovery of a novel compound: Insight into mechanisms for acrylamide-induced axonopathy and colchicine-induced apoptotic neuronal cell death

Nakagawa-Yagi, Y., Choi, D. K., Ogane, N., Shimada, S. I., Seya, M., Momoi, T., Ito, T. & Sakaki, Y., Aug 3 2001, In : Brain Research. 909, 1-2, p. 8-19 12 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Focal Adhesion Protein-Tyrosine Kinases
Acrylamide
Colchicine
Cell Death
62 Citations (Scopus)

Exploring the protein interactome using comprehensive two-hybrid projects.

Ito, T., Chiba, T. & Yoshida, M., Jan 1 2001, In : Trends in biotechnology. 19, 10 Suppl

Research output: Contribution to journalReview article

Proteins
103 Citations (Scopus)

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

Noda, Y., Takeya, R., Ohno, S., Naito, S., Ito, T. & Sumimoto, H., Apr 17 2001, In : Genes to Cells. 6, 2, p. 107-119 13 p.

Research output: Contribution to journalArticle

Cell Polarity
Monomeric GTP-Binding Proteins
Caenorhabditis elegans
GTP Phosphohydrolases
Proteins
5 Citations (Scopus)

Multiplex polymerase chain reaction (PCR) with color-tagged module-shuffling primers for comparing gene expression levels in various cells

Uematsu, C., Nishida, J., Okano, K., Miura, F., Ito, T., Sakaki, Y. & Kambara, H., Aug 15 2001, In : Nucleic acids research. 29, 16, 1 p.

Research output: Contribution to journalArticle

Multiplex Polymerase Chain Reaction
Color
Gene Expression
Electrophoresis
Gels
124 Citations (Scopus)

Novel modular domain PB1 recognizes pc motif to mediate functional protein-protein interactions

Ito, T., Matsui, Y., Ago, T., Ota, K. & Sumimoto, H., Aug 1 2001, In : EMBO Journal. 20, 15, p. 3938-3946 9 p.

Research output: Contribution to journalArticle

Proteins
Saccharomycetales
Fungal Proteins
NADPH Oxidase
Phagocytes
139 Citations (Scopus)

Solution structure of the PX domain, a target of the SH3 domain

Hiroaki, H., Ago, T., Ito, T., Sumimoto, H. & Kohda, D., 2001, In : Nature Structural Biology. 8, 6, p. 526-530 5 p.

Research output: Contribution to journalArticle

src Homology Domains
Proline
Proteins
NADPH Oxidase
Phagocytes
57 Citations (Scopus)

Structure and ligand recognition of the PB1 domain: A novel protein module binding to the PC motif

Terasawa, H., Noda, Y., Ito, T., Hatanaka, H., Ichikawa, S., Ogura, K., Sumimoto, H. & Inagaki, F., Aug 1 2001, In : EMBO Journal. 20, 15, p. 3947-3956 10 p.

Research output: Contribution to journalArticle

Protein Binding
Cell Polarity
Ligands
Proteins
Nuclear magnetic resonance
85 Citations (Scopus)

The PX domain as a novel phosphoinositide-binding module

Ago, T., Takeya, R., Hiroaki, H., Kuribayashi, F., Ito, T., Kohda, D. & Sumimoto, H., Sep 28 2001, In : Biochemical and Biophysical Research Communications. 287, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Endosomes
Phagocytes
Oxidoreductases
Proteins
2000
85 Citations (Scopus)

A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation

Iijima, Y., Ito, T., Oikawa, T., Eguchi, M., Eguchi-Ishimae, M., Kamada, N., Kishi, K., Asano, S., Sakaki, Y. & Sato, Y., Mar 15 2000, In : Blood. 95, 6, p. 2126-2131 6 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Protein-Tyrosine Kinases
Genes
Cells
Cell Line
53 Citations (Scopus)

A novel G-protein-coupled receptor gene expressed in striatum

Mizushima, K., Miyamoto, Y., Tsukahara, F., Hirai, M., Sakaki, Y. & Ito, T., Nov 1 2000, In : Genomics. 69, 3, p. 314-321 8 p.

Research output: Contribution to journalArticle

Biogenic Amines Receptors
G-Protein-Coupled Receptors
Rodentia
Genes
Behavior Control
55 Citations (Scopus)

Comparative genome analysis of the mouse imprinted gene Impact and its nonimprinted human homolog IMPACT: Toward the structural basis for species-specific imprinting

Okamura, K., Hagiwara-Takeuchi, Y., Li, T., Vu, T. H., Hirai, M., Hattori, M., Sakaki, Y., Hoffman, A. R. & Ito, T., Dec 1 2000, In : Genome Research. 10, 12, p. 1878-1889 12 p.

Research output: Contribution to journalArticle

Islands
Genome
CpG Islands
Introns
Genes
41 Citations (Scopus)
Eukaryotic Initiation Factor-2
Saccharomycetales
Yeast
Phosphotransferases
Association reactions
639 Citations (Scopus)
Protein Interaction Maps
Saccharomycetales
Fungal Proteins
Clone Cells
Saccharomyces cerevisiae Proteins
1999
39 Citations (Scopus)

Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein

Choi, D. K., Ito, T., Tsukahara, F., Hirai, M. & Sakaki, Y., Sep 3 1999, In : Gene. 237, 1, p. 135-142 8 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Neuroblastoma
Apoptosis
Chromosomes, Human, Pair 2
3' Untranslated Regions
12 Citations (Scopus)

Fluorescent differential display: A fast and reliable method for message display polymerase chain reaction

Ito, T. & Sakaki, Y., Jan 1 1999, In : Methods in enzymology. 303, p. 298-309 12 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
Display devices
13 Citations (Scopus)

Spatiotemporal, allelic, and enforced expression of Ximpact, the Xenopus homolog of mouse imprinted gene Impact

Yamada, Y., Hagiwara, Y., Shiokawa, K., Sakaki, Y. & Ito, T., Mar 5 1999, In : Biochemical and Biophysical Research Communications. 256, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

Xenopus
Yeast
Genes
Gene encoding
Polymorphism
1998
66 Citations (Scopus)
Amphiphiles
src Homology Domains
Cell-Free System
NADPH Oxidase
Phagocytes
39 Citations (Scopus)

Fluorescent differential display analysis of gene expression in apoptotic neuroblastoma cells

Choi, D. K., Ito, T., Mitsui, Y. & Sakaki, Y., Nov 26 1998, In : Gene. 223, 1-2, p. 21-31 11 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Neuroblastoma
Apoptosis
Gene Expression
Cell Death