• 7183 Citations
  • 54 h-Index
1993 …2020

Research output per year

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Research Output

2020

Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural α-Amino Acid Synthesis

Matsumoto, Y., Sawamura, J., Murata, Y., Nishikata, T., Yazaki, R. & Ohshima, T., May 6 2020, In : Journal of the American Chemical Society. 142, 18, p. 8498-8505 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route to α,α-Disubstituted α-Amino Acids

Tsuji, T., Tanaka, T., Tanaka, T., Yazaki, R. & Ohshima, T., Jun 5 2020, In : Organic letters. 22, 11, p. 4164-4170 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mechanistic studies of nickel(II)-catalyzed direct alcoholysis of 8-aminoquinoline amides

Morimoto, H., Akkad, W., Deguchi, T. & Ohshima, T., Jan 1 2020, In : Heterocycles. 101, 2, p. 471-485 15 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Recent Progress on Catalytic Addition Reactions to N-Unsubstituted Imines

Morisaki, K., Morimoto, H. & Ohshima, T., Jun 19 2020, In : ACS Catalysis. 10, 12, p. 6924-6951 28 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Recent progress towards the use of benzophenone imines as an ammonia equivalent

Kondo, Y., Morimoto, H. & Ohshima, T., May 2020, In : Chemistry Letters. 49, 5, p. 497-504 8 p.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Rhodium(I)/Chiral Diene-Catalyzed Enantioselective Addition of Boronic Acids to N-Unsubstituted Isatin-Derived Ketimines

Yonesaki, R., Kusagawa, I., Morimoto, H., Hayashi, T. & Ohshima, T., Jan 1 2020, (Accepted/In press) In : Chemistry - An Asian Journal. 15, 4, p. 499-502 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines

Kondo, Y., Kadota, T., Hirazawa, Y., Morisaki, K., Morimoto, H. & Ohshima, T., Jan 3 2020, In : Organic Letters. 22, 1, p. 120-125 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2019

A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride

Kondo, Y., Morisaki, K., Hirazawa, Y., Morimoto, H. & Ohshima, T., Aug 16 2019, In : Organic Process Research and Development. 23, 8, p. 1718-1724 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Noshita, M., Shimizu, Y., Morimoto, H., Akai, S., Hamashima, Y., Ohneda, N., Odajima, H. & Ohshima, T., Apr 19 2019, In : Organic Process Research and Development. 23, 4, p. 588-594 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

Yokoyama, T., Yukuhiro, M., Iwasaki, Y., Tanaka, C., Sankoda, K., Fujiwara, R., Shibuta, A., Higashi, T., Motoyama, K., Arima, H., Yoshida, K., Sugimoto, N., Morimoto, H., Kosako, H., Ohshima, T. & Fujita, M., Dec 1 2019, In : Scientific reports. 9, 1, 16825.

Research output: Contribution to journalArticle

Open Access

Mechanistic insight into catalytic aerobic chemoselective α-oxidation of acylpyrazoles

Taninokuchi, S., Yazaki, R. & Ohshima, T., Jan 1 2019, In : Heterocycles. 99, 2, p. 906-918 13 p.

Research output: Contribution to journalArticle

Open Access

Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds

Yazaki, R. & Ohshima, T., Nov 7 2019, In : Tetrahedron Letters. 60, 45, 151225.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Thionoesters as 1,2-Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones

Matsumoto, Y., Tsuji, T., Nakatake, D., Yazaki, R. & Ohshima, T., Jul 1 2019, In : Asian Journal of Organic Chemistry. 8, 7, p. 1071-1074 4 p.

Research output: Contribution to journalArticle

2018

3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester

Yonesaki, R., Kondo, Y., Akkad, W., Sawa, M., Morisaki, K., Morimoto, H. & Ohshima, T., Oct 12 2018, In : Chemistry - A European Journal. 24, 57, p. 15211-15214 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
34 Citations (Scopus)

Bioconjugation with Thiols by Benzylic Substitution

Watanabe, K. & Ohshima, T., Mar 15 2018, In : Chemistry - A European Journal. 24, 16, p. 3959-3964 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines

Sawa, M., Miyazaki, S., Yonesaki, R., Morimoto, H. & Ohshima, T., Sep 7 2018, In : Organic letters. 20, 17, p. 5393-5397 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope

Tanaka, T., Hashiguchi, K., Tanaka, T., Yazaki, R. & Ohshima, T., Sep 7 2018, In : ACS Catalysis. 8, 9, p. 8430-8440 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1 Citation (Scopus)

Growth suppression of human colorectal cancer cells with mutated KRAS by 3-deaza-cytarabine in 3d floating culture

Luo, H., Nishi, K., Ishikura, S., Swain, A., Morishige, N., Yazaki, R., Ohshima, T., Shirasawa, S. & Tsunoda, T., Jul 2018, In : Anticancer research. 38, 7, p. 4247-4256 10 p.

Research output: Contribution to journalArticle

Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer

Tanaka, T., Tanaka, T., Tsuji, T., Yazaki, R. & Ohshima, T., Jun 15 2018, In : Organic letters. 20, 12, p. 3541-3544 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

フェニルビスオキサゾリンロジウム(III)錯体を用いたα-ケトエステルおよびα-ケチミノエステルに対する直接的触媒的不斉アルキニル化反応の開発

Translated title of the contribution: Development of Direct Enantioselective Alkynylation of α-Ketoester and α-Ketiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes森崎一宏, 森本浩之, 真島和志 & 大嶋孝志, 2018, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 76, 3, p. 226-240 15 p.

Research output: Contribution to journalArticle

2017

Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids

Das, A., Watanabe, K., Morimoto, H. & Ohshima, T., Nov 3 2017, In : Organic Letters. 19, 21, p. 5794-5797 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Catalytic Aerobic Chemoselective α-Oxidation of Acylpyrazoles en Route to α-Hydroxy Acid Derivatives

Taninokuchi, S., Yazaki, R. & Ohshima, T., Jun 16 2017, In : Organic letters. 19, 12, p. 3187-3190 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
5 Citations (Scopus)

Chemical and Pharmaceutical Bulletin: Foreword

Fujioka, H. & Ohshima, T., 2017, In : Chemical and Pharmaceutical Bulletin. 65, 1, p. 1 1 p.

Research output: Contribution to journalEditorial

18 Citations (Scopus)
18 Citations (Scopus)

Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides

Deguchi, T., Xin, H. L., Morimoto, H. & Ohshima, T., May 5 2017, In : ACS Catalysis. 7, 5, p. 3157-3161 5 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Direct enantioselective alkynylation of α-ketoesters and α-ketiminoesters catalyzed by [bis(oxazoline)phenyl]rhodium(III) complexes

Morisaki, K., Morimoto, H., Mashima, K. & Ohshima, T., 2017, In : Heterocycles. 95, 2, p. 637-661 25 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Metabolomic profiling of brain tissues of mice chronically exposed to heroin

Li, R. S., Takeda, T., Ohshima, T., Yamada, H. & Ishii, Y., Feb 2017, In : Drug metabolism and pharmacokinetics. 32, 1, p. 108-111 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Preface to heterocycles issue honoring the 70th birthday of professor Masakatsu Shibasaki

Ohshima, T., Jan 1 2017, In : Heterocycles. 95, 1, p. 3-6 4 p.

Research output: Contribution to journalEditorial

Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp3 C–H bonds

Morisaki, K., Kondo, Y., Sawa, M., Morimoto, H. & Ohshima, T., Jan 1 2017, In : Chemical and Pharmaceutical Bulletin. 65, 11, p. 1089-1092 4 p.

Research output: Contribution to journalArticle

Tetranuclear zinc cluster-catalyzed transesterification

Ohshima, T., Jan 1 2017, New Horizons of Process Chemistry: Scalable Reactions and Technologies. Springer Singapore, p. 65-87 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

A highly stable but highly reactive zinc catalyst for transesterification supported by a bis(imidazole) ligand

Nakatake, D., Yokote, Y., Matsushima, Y., Yazaki, R. & Ohshima, T., Mar 21 2016, In : Green Chemistry. 18, 6, p. 1524-1530 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
14 Citations (Scopus)
4 Citations (Scopus)
15 Citations (Scopus)

Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas

Noshita, M., Shimizu, Y., Morimoto, H. & Ohshima, T., Dec 2 2016, In : Organic Letters. 18, 23, p. 6062-6065 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
43 Citations (Scopus)

Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells

Yamamoto, Y., Arai, J., Hisa, T., Saito, Y., Mukai, T., Ohshima, T., Maeda, M. & Yamamoto, F., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3727-3733 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
41 Citations (Scopus)

Studies of the Electronic Effects of Zinc Cluster Catalysts and Their Application to the Transesterification of β-Keto Esters

Agura, K., Hayashi, Y., Wada, M., Nakatake, D., Mashima, K. & Ohshima, T., May 20 2016, In : Chemistry - An Asian Journal. 11, 10, p. 1548-1554 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor

Hagimori, M., Murakami, T., Shimizu, K., Nishida, M., Ohshima, T. & Mukai, T., 2016, In : MedChemComm. 7, 5, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Transesterification Reactions Catalyzed by a Recyclable Heterogeneous Zinc/Imidazole Catalyst

Nakatake, D., Yazaki, R., Matsushima, Y. & Ohshima, T., 2016, In : Advanced Synthesis and Catalysis. 358, 15, p. 2569-2574 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
14 Citations (Scopus)
2015

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

Ohira, M., Iwasaki, Y., Tanaka, C., Kuroki, M., Matsuo, N., Kitamura, T., Yukuhiro, M., Morimoto, H., Pang, N., Liu, B., Kiyono, T., Amemiya, M., Tanaka, K., Yoshida, K., Sugimoto, N., Ohshima, T. & Fujita, M., May 19 2015, In : Biochimica et Biophysica Acta - General Subjects. 1850, 9, p. 1676-1684 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties

Yamamoto, Y., Hisa, T., Arai, J., Saito, Y., Yamamoto, F., Mukai, T., Ohshima, T., Maeda, M. & Ohkubo, Y., Nov 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 21, p. 6807-6814 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

A short scalable route to (-)-α-kainic acid using Pt-catalyzed direct allylic amination

Zhang, M., Watanabe, K., Tsukamoto, M., Shibuya, R., Morimoto, H. & Ohshima, T., Oct 7 2014, In : Chemistry - A European Journal. 21, 10, p. 3937-3941 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)