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Research Output 2001 2019

  • 1128 Citations
  • 16 h-Index
  • 26 Article
  • 1 Comment/debate
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Article
2019

S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches

Kunimura, K., Sakata, D., Tun, X., Uruno, T., Ushijima, M., Katakai, T., Shiraishi, A., Aihara, R., Kamikaseda, Y., Matsubara, K., Kanegane, H., Sawa, S., Eberl, G., Ohga, S., Yoshikai, Y. & Fukui, Y., Nov 26 2019, In : Cell Reports. 29, 9, p. 2823-2834.e7

Research output: Contribution to journalArticle

Open Access
Peyer's Patches
Cytokine Receptors
Domes
Muramidase
Cells

Selective role of neurokinin B in IL-31–induced itch response in mice

Sakata, D., Uruno, T., Matsubara, K., Andoh, T., Yamamura, K., Magoshi, Y., Kunimura, K., Kamikaseda, Y., Furue, M. & Fukui, Y., Oct 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1130-1133.e8

Research output: Contribution to journalArticle

Open Access
Neurokinin B
2018

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fukui, Y., Jul 31 2018, In : Science Signaling. 11, 541

Research output: Contribution to journalArticle

Immune Evasion
Cytokinesis
Tissue
Guanine Nucleotide Exchange Factors
Proteins
3 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., Jul 31 2018, In : Science Signaling. 11, 541, eaao4874.

Research output: Contribution to journalArticle

Immune Evasion
Cytokinesis
Tissue
Guanine Nucleotide Exchange Factors
Proteins
5 Citations (Scopus)

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation

Tomino, T., Tajiri, H., Tatsuguchi, T., Shirai, T., Oisaki, K., Matsunaga, S., Sanematsu, F., Sakata, D., Yoshizumi, T., Maehara, Y., Kanai, M., Cote, J. F., Fukui, Y. & Uruno, T., Feb 26 2018, In : Biochemical and Biophysical Research Communications. 497, 1, p. 298-304 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Guanine Nucleotide Exchange Factors
Cells
Guanosine Triphosphate
Mutation
4 Citations (Scopus)

The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production

Ushijima, M., Uruno, T., Nishikimi, A., Sanematsu, F., Kamikaseda, Y., Kunimura, K., Sakata, D., Okada, T. & Fukui, Y., Feb 16 2018, In : Frontiers in Immunology. 9, FEB, 243.

Research output: Contribution to journalArticle

Plasma Cells
Antibody Formation
Cell Differentiation
B-Lymphocytes
Immunoglobulin G
2017
5 Citations (Scopus)

DOCK8 protein regulates macrophage migration through Cdc42 protein activation and LRAP35a protein interaction

Shiraishi, A., Uruno, T., Sanematsu, F., Ushijima, M., Sakata, D., Hara, T. & Fukui, Y., Feb 10 2017, In : Journal of Biological Chemistry. 292, 6, p. 2191-2202 12 p.

Research output: Contribution to journalArticle

cdc42 GTP-Binding Protein
Macrophages
Chemical activation
Guanine Nucleotide Exchange Factors
Proteins
18 Citations (Scopus)

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1

Tajiri, H., Uruno, T., Shirai, T., Takaya, D., Matsunaga, S., Setoyama, D., Watanabe, M., Kukimoto-Niino, M., Oisaki, K., Ushijima, M., Sanematsu, F., Honma, T., Terada, T., Oki, E., Shirasawa, S., Maehara, Y., Kang, D., Côté, J. F., Yokoyama, S., Kanai, M. & 1 others, Fukui, Y., May 2 2017, In : Cell Reports. 19, 5, p. 969-980 12 p.

Research output: Contribution to journalArticle

Nutrients
Cell Survival
Cells
Pyridones
Guanine Nucleotide Exchange Factors
19 Citations (Scopus)

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Yamamura, K., Uruno, T., Shiraishi, A., Tanaka, Y., Ushijima, M., Nakahara, T., Watanabe, M., Kido-Nakahara, M., Tsuge, I., Furue, M. & Fukui, Y., Jan 9 2017, In : Nature communications. 8, 13946.

Research output: Contribution to journalArticle

T-cells
Aryl Hydrocarbon Receptor Nuclear Translocator
dermatitis
Skin
induction
1 Citation (Scopus)
Medical problems
Type 1 Diabetes Mellitus
Epithelial Cells
Ovalbumin
Nude Mice
2015
16 Citations (Scopus)

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus

Yanagihara, T., Sanematsu, F., Sato, T., Uruno, T., Duan, X., Tomino, T., Harada, Y., Watanabe, M., Wang, Y., Tanaka, Y., Nakanishi, Y., Suyama, M. & Yoshinori, F., Nov 4 2015, In : Nature communications. 6, 8820.

Research output: Contribution to journalArticle

Self Tolerance
Thymus
Autoantigens
Thymus Gland
induction
2014
26 Citations (Scopus)

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation

Watanabe, M., Terasawa, M., Miyano, K., Yanagihara, T., Uruno, T., Sanematsu, F., Nishikimi, A., Côté, J. F., Sumimoto, H. & Fukui, Y., Dec 1 2014, In : Journal of Immunology. 193, 11, p. 5660-5667 8 p.

Research output: Contribution to journalArticle

Chemotaxis
Superoxides
Neutrophils
Reactive Oxygen Species
Guanine Nucleotide Exchange Factors
19 Citations (Scopus)

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

Ogawa, K., Tanaka, Y., Uruno, T., Duan, X., Harada, Y., Sanematsu, F., Yamamura, K., Terasawa, M., Nishikimi, A., Côté, J. F. & Fukui, Y., Jun 2014, In : Journal of Experimental Medicine. 211, 7, p. 1407-1419 13 p.

Research output: Contribution to journalArticle

Cell Degranulation
Mast Cells
Microtubules
Guanine Nucleotide Exchange Factors
Anaphylaxis
2012
38 Citations (Scopus)

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2

Nishikimi, A., Uruno, T., Duan, X., Cao, Q., Okamura, Y., Saitoh, T., Saito, N., Sakaoka, S., Du, Y., Suenaga, A., Kukimoto-Niino, M., Miyano, K., Gotoh, K., Okabe, T., Sanematsu, F., Tanaka, Y., Sumimoto, H., Honma, T., Yokoyama, S., Nagano, T. & 3 others, Kohda, D., Kanai, M. & Fukui, Y., Apr 20 2012, In : Chemistry and Biology. 19, 4, p. 488-497 10 p.

Research output: Contribution to journalArticle

PDZ Domains
Lymphocytes
Chemical activation
Guanine Nucleotide Exchange Factors
Antigen Receptors
12 Citations (Scopus)

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

Terasawa, M., Uruno, T., Mori, S., Kukimoto-Niino, M., Nishikimi, A., Sanematsu, F., Tanaka, Y., Yokoyama, S. & Fukui, Y., Sep 26 2012, In : PloS one. 7, 9, e46277.

Research output: Contribution to journalArticle

dimerization
Lymphocytes
Dimerization
Lymphocyte Activation
Guanine Nucleotide Exchange Factors
121 Citations (Scopus)

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Kyoko, H. S., Mutsuko, K. N., Nishizaki, T., Shirouzu, M., Duan, X., Uruno, T., Nishikimi, A., Sanematsu, F., Yokoyama, S., Stein, J. V., Kinashi, T. & Fukui, Y., May 10 2012, In : Blood. 119, 19, p. 4451-4461 11 p.

Research output: Contribution to journalArticle

Dendritic Cells
Cell Movement
Guanine Nucleotide Exchange Factors
Chemical activation
PDZ Domains
38 Citations (Scopus)

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Hanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S. I., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., Terada, T., Shirouzu, M., Nishikimi, A., Uruno, T., Katakai, T., Kinashi, T., Kohda, D., Fukui, Y. & Yokoyama, S., Feb 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3305-3310 6 p.

Research output: Contribution to journalArticle

Molecular Motor Proteins
Guanine Nucleotide Exchange Factors
Cytokinesis
Cell Movement
src Homology Domains
2010
17 Citations (Scopus)

Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1

Zwolak, A., Uruno, T., Piszczek, G., Hammer, J. A. & Tjandra, N., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 29014-29026 13 p.

Research output: Contribution to journalArticle

Proteins
Actins
Protozoa
Mutagenesis
Mammals
73 Citations (Scopus)

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

Gotoh, K., Tanaka, Y., Nishikimi, A., Nakamura, R., Yamada, H., Maeda, N., Ishikawa, T., Hoshino, K., Uruno, T., Cao, Q., Higashi, S., Kawaguchi, Y., Enjoji, M., Takayanagi, R., Kaisho, T., Yoshikai, Y. & Fukui, Y., Apr 12 2010, In : Journal of Experimental Medicine. 207, 4, p. 721-730 10 p.

Research output: Contribution to journalArticle

Dendritic Cells
Autoimmune Diseases
Nucleic Acids
Antiviral Agents
Immunity
2009
3 Citations (Scopus)

Purification of capping protein using the capping protein binding site of CARMIL as an affinity matrix

Remmert, K., Uruno, T. & Hammer, J. A., Oct 1 2009, In : Protein Expression and Purification. 67, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Protein Binding
Binding Sites
Proteins
Acanthamoeba
Microfilament Proteins
2006
41 Citations (Scopus)
Actin Cytoskeleton
Actins
Proteins
Glutathione Transferase
Gelsolin
2004
25 Citations (Scopus)

Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling

Li, Y., Uruno, T., Haudenschild, C., Dudek, S. M., Garcia, J. G. N. & Zhan, X., Aug 1 2004, In : Experimental Cell Research. 298, 1, p. 107-121 15 p.

Research output: Contribution to journalArticle

Cortactin
Actin-Related Protein 2-3 Complex
Endothelial Cells
Actins
sphingosine 1-phosphate
2003
54 Citations (Scopus)

Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization

Uruno, T., Zhang, P., Liu, J., Hao, J. J. & Zhan, X., Apr 15 2003, In : Biochemical Journal. 371, 2, p. 485-493 9 p.

Research output: Contribution to journalArticle

Actin-Related Protein 2-3 Complex
Polymerization
Cortactin
Actins
Proteins
67 Citations (Scopus)
Cortactin
Actin-Related Protein 2-3 Complex
Wiskott-Aldrich Syndrome
Actin Cytoskeleton
Actins
2002
113 Citations (Scopus)

Osmotic stress-induced remodeling of the cortical cytoskeleton

Ciano, C. D., Nie, Z., Szászi, K., Lewis, A., Uruno, T., Zhan, X., Rotstein, O. D., Mak, A. & Kapus, A., Sep 1 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3

Research output: Contribution to journalArticle

Cortactin
Osmotic Pressure
Cytoskeleton
Actin-Related Protein 2
Actin-Related Protein 3
2001
410 Citations (Scopus)

Activation of Arp2/3 complex-mediated actin polymerization by cortactin

Uruno, T., Liu, J., Zhang, P., Fan, Y. X., Egile, C., Li, R., Mueller, S. C. & Zhan, X., Mar 20 2001, In : Nature Cell Biology. 3, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

Cortactin
Actin-Related Protein 2-3 Complex
Polymerization
Actins
Actin Cytoskeleton