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Research Output 1982 2019

  • 1455 Citations
  • 20 h-Index
  • 49 Article
  • 2 Comment/debate
  • 2 Review article
2019

RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121

Sekiguchi, T., Furuno, N., Ishii, T., Hirose, E., Sekiguchi, F., Wang, Y. & Kobayashi, H., Feb 1 2019, In : Genes to Cells. 24, 2, p. 151-161 11 p.

Research output: Contribution to journalArticle

Hedgehog Proteins
ras Proteins
Monomeric GTP-Binding Proteins
S 6
Inborn Genetic Diseases
2018
5 Citations (Scopus)

Specific binding of PCBP1 to heavily oxidized RNA to induce cell death

Ishii, T., Hayakawa, H., Igawa, T., Sekiguchi, T. & Sekiguchi, M., Jun 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. 6715-6720 6 p.

Research output: Contribution to journalArticle

Oligoribonucleotides
Cell Death
RNA
Clustered Regularly Interspaced Short Palindromic Repeats
Poly C
2015
1 Citation (Scopus)

Phylogenetic relationships of the malay peninsula otters (Lutra sumatrana, lutrogale perspicillata, and aonyx cinereus) based on dna sequences of mitochondrial d-loop region

Rosli, M. K., Abdul-Patah, P., Syed-Shabthar, S. M. F., Burhanuddin, M. N., Sekiguchi, T., Sasaki, H., Shukor, M. N., Yaakop, S. & Md-Zain, B. M., Jun 1 2015, In : Journal of Animal and Plant Sciences. 25, 3, p. 836-843 8 p.

Research output: Contribution to journalArticle

Lutra
topology
Malaysia
genetic distance
nucleotide sequences
7 Citations (Scopus)

Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells

Ishii, T., Hayakawa, H., Sekiguchi, T., Adachi, N. & Sekiguchi, M., Jan 1 2015, In : Free Radical Biology and Medicine. 79, p. 109-116 8 p.

Research output: Contribution to journalArticle

Cells
RNA
Messenger RNA
Gene expression
Oxidative stress
2014
8 Citations (Scopus)

Amino acid residues required for Gtr1p-Gtr2p complex formation and its interactions with the Ego1p-Ego3p complex and TORC1 components in yeast

Sekiguchi, T., Kamada, Y., Furuno, N., Funakoshi, M. & Kobayashi, H., Jan 1 2014, In : Genes to Cells. 19, 6, p. 449-463 15 p.

Research output: Contribution to journalArticle

Yeasts
Amino Acids
Guanosine Triphosphate
ras Proteins
Two-Hybrid System Techniques
15 Citations (Scopus)

A new subspecies identification and population study of the Asian small-clawed otter (Aonyx cinereus) in Malay Peninsula and southern Thailand based on fecal DNA method

Rosli, M. K. A., Syed-Shabthar, S. M. F., Abdul-Patah, P., Abdul-Samad, Z., Abdul, S. N., Burhanuddin, M. N., Zulkifli, N. A., Shukor, M. N., Budsabong, K., Changtragoon, S., Sekiguchi, T., Sasaki, H. & Md-Zain, B. M., Jan 1 2014, In : The Scientific World Journal. 2014, 457350.

Research output: Contribution to journalArticle

Otters
Malaysia
Thailand
subspecies
Coastal zones
1 Citation (Scopus)

Food habits of the urban Japanese weasels mustela itatsi revealed by faecal DNA analysis

Okawara, Y., Sekiguchi, T., Ikeda, A., Miura, S., Sasaki, H., Fujii, T. & Kaneko, Y., Sep 1 2014, In : Mammal Study. 39, 3, p. 155-161 7 p.

Research output: Contribution to journalArticle

2013
10 Citations (Scopus)

Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors

Sekiguchi, T., Ito, R., Hayakawa, H. & Sekiguchi, M., Mar 22 2013, In : Journal of Biological Chemistry. 288, 12, p. 8128-8135 8 p.

Research output: Contribution to journalArticle

Guanine Nucleotides
RNA Precursors
Guanosine Triphosphate
Nucleoside-Diphosphate Kinase
Oxidation
7 Citations (Scopus)

Search for proteins required for accurate gene expression under oxidative stress: Roles of Guanylate Kinase and RNA Polymerase

Inokuchi, H., Ito, R., Sekiguchi, T. & Sekiguchi, M., Nov 15 2013, In : Journal of Biological Chemistry. 288, 46, p. 32952-32962 11 p.

Research output: Contribution to journalArticle

Guanylate Kinases
Oxidative stress
DNA-Directed RNA Polymerases
Gene expression
Oxidative Stress
2011
3 Citations (Scopus)

Ubiquitin chains in the Dsk2 UBL domain mediate Dsk2 stability and protein degradation in yeast

Sekiguchi, T., Sasaki, T., Funakoshi, M., Ishii, T., Saitoh, Y. H., Kaneko, S. I. & Kobayashi, H., Aug 5 2011, In : Biochemical and Biophysical Research Communications. 411, 3, p. 555-561 7 p.

Research output: Contribution to journalArticle

Ubiquitin
Yeast
Proteolysis
Yeasts
Degradation
2010
2 Citations (Scopus)

New methods for species and sex determination in three sympatric Mustelids, Mustela itatsi, Mustela sibirica and Martes melampus

Sekiguchi, T., Sasaki, H., Kurihara, Y., Watanabe, S., Moriyama, D., Kurose, N., Matsuki, R., Yamazaki, K. & Saeki, M., Nov 1 2010, In : Molecular Ecology Resources. 10, 6, p. 1089-1091 3 p.

Research output: Contribution to journalArticle

mustelid
Mustelidae
Mustela
sex determination
Martes
2009
7 Citations (Scopus)

Gtr1p differentially associates with Gtr2p and Ego1p

Wang, Y., Kurihara, Y., Sato, T., Toh, H., Kobayashi, H. & Sekiguchi, T., May 15 2009, In : Gene. 437, 1-2, p. 32-38 7 p.

Research output: Contribution to journalArticle

Caffeine
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
Cell Nucleus Active Transport
GTP Phosphohydrolases
2 Citations (Scopus)

Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro

Horiike, Y., Kobayashi, H. & Sekiguchi, T., Apr 1 2009, In : Molecular Biology Reports. 36, 4, p. 717-723 7 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
Serine
Phosphotransferases
Phosphorylation
2008
10 Citations (Scopus)
ras Proteins
GTP Phosphohydrolases
Epigenomics
Gene expression
Yeast
2007
21 Citations (Scopus)

Phosphorylation of threonine 204 of DEAD-box RNA helicase DDX3 by cyclin B/cdc2 in vitro

Sekiguchi, T., Kurihara, Y. & Fukumura, J., May 11 2007, In : Biochemical and Biophysical Research Communications. 356, 3, p. 668-673 6 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Cyclin B
Phosphorylation
Threonine
Cyclin A
2006
23 Citations (Scopus)

NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47

Sekiguchi, T., Hayano, T., Yanagida, M., Takahashi, N. & Nishimoto, T., Sep 1 2006, In : Nucleic acids research. 34, 16, p. 4593-4608 16 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
RNA Precursors
Proteins
Ribosomes
Nuclear Proteins
2005
9 Citations (Scopus)

Association of the GTP-binding protein Gtr1p with Rpc19p, a shared subunit of RNA polymerase I and III in yeast Saccharomyces cerevisiae

Todaka, Y., Wang, Y., Tashiro, K., Nakashima, N., Nishimoto, T. & Sekiguchi, T., Aug 1 2005, In : Genetics. 170, 4, p. 1515-1524 10 p.

Research output: Contribution to journalArticle

RNA Polymerase I
RNA Polymerase III
Guanosine Triphosphate
GTP-Binding Proteins
Saccharomyces cerevisiae
11 Citations (Scopus)
ran GTP-Binding Protein
Saccharomyces cerevisiae Proteins
GTP Phosphohydrolases
Cell proliferation
Yeast
2004
6 Citations (Scopus)

A Hamster Temperature-Sensitive Alanyl-tRNA Synthetase Mutant Causes Degradation of Cell-Cycle Related Proteins and Apoptosis

Wang, Y., Sekiguchi, T., Noguchi, E. & Nishimoto, T., Jan 1 2004, In : Journal of Biochemistry. 135, 1, p. 7-16 10 p.

Research output: Contribution to journalArticle

Alanine-tRNA Ligase
Cell Cycle Proteins
Cricetinae
Cells
Apoptosis
23 Citations (Scopus)

A Novel Human Nucleolar Protein, Nop132, Binds to the G Proteins, RRAG A/C/D

Sekiguchi, T., Todaka, Y., Wang, Y., Hirose, E., Nakashima, N. & Nishimoto, T., Feb 27 2004, In : Journal of Biological Chemistry. 279, 9, p. 8343-8350 8 p.

Research output: Contribution to journalArticle

Nuclear Proteins
GTP-Binding Proteins
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
Cell growth
49 Citations (Scopus)

Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation

Sekiguchi, T., Iida, H., Fukumura, J. & Nishimoto, T., Oct 15 2004, In : Experimental Cell Research. 300, 1, p. 213-222 10 p.

Research output: Contribution to journalArticle

RNA Helicases
DEAD-box RNA Helicases
Cricetinae
Protein Isoforms
Spermatogenesis
2003
35 Citations (Scopus)

A temperature-sensitive mutant of the mammalian RNA helicase, DEAD-BOX X isoform, DBX, defective in the transition from G1 to S phase

Fukumura, J., Noguchi, E., Sekiguchi, T. & Nishimoto, T., Jul 1 2003, In : Journal of Biochemistry. 134, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

RNA Helicases
S Phase
Protein Isoforms
Temperature
Cricetinae
2001
138 Citations (Scopus)

Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B

Sekiguchi, T., Hirose, E., Nakashima, N., Ii, M. & Nishimoto, T., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 7246-7257 12 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Protein C
GTP-Binding Proteins
Yeast
Saccharomyces cerevisiae
2000
21 Citations (Scopus)

Inhibition of N-linked glycosylation causes apoptosis in hamster BHK21 cells

Yoshimi, M., Sekiguchi, T., Hara, N. & Nishimoto, T., Oct 5 2000, In : Biochemical and Biophysical Research Communications. 276, 3, p. 965-969 5 p.

Research output: Contribution to journalArticle

Glycosylation
Cricetinae
Tunicamycin
Apoptosis
Cells
1999
19 Citations (Scopus)

Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation

Sekiguchi, T., Nishimoto, T. & Hunter, T., Mar 11 1999, In : Oncogene. 18, 10, p. 1797-1806 10 p.

Research output: Contribution to journalArticle

Cyclin D
Polyomavirus Transforming Antigens
Viral Tumor Antigens
Cyclin D1
Cell Cycle Checkpoints

The function of Ran GTPase cycle

Sekiguchi, T., Nishitani, H. & Nishimoto, T., Jan 1 1999, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 44, 12 Suppl, p. 1869-1876 8 p.

Research output: Contribution to journalReview article

ran GTP-Binding Protein
Biological Transport
Microtubule Proteins
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
1998
48 Citations (Scopus)

Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells

Sekiguchi, T. & Hunter, T., Jan 22 1998, In : Oncogene. 16, 3, p. 369-380 12 p.

Research output: Contribution to journalArticle

Cyclins
Tetracycline
Cricetinae
Cell Death
Growth
69 Citations (Scopus)

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway

Hirose, E., Nakashima, N., Sekiguchi, T. & Nishimoto, T., 1998, In : Journal of Cell Science. 111, 1, p. 11-21 11 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Saccharomyces cerevisiae
Complementary DNA
Cytoplasm
Mutation
1996
25 Citations (Scopus)

D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAF11250 mutant cells arrest in G1 at the restrictive temperature

Sekiguchi, T., Noguchi, E., Hayashida, T., Nakashima, T., Toyoshima, H., Nishimoto, T. & Hunter, T., Jan 1 1996, In : Genes to Cells. 1, 7, p. 687-705 19 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin D
Temperature
Cyclin A
1995
35 Citations (Scopus)

Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor

Sekiguchi, T., Nakashima, T., Hayashida, T., Kuraoka, A., Hashimoto, S., Tsuchida, N., Shibata, Y., Hunter, T. & Nishimoto, T., Jan 1 1995, In : Experimental Cell Research. 218, 2, p. 490-498 9 p.

Research output: Contribution to journalArticle

Transcription Factor TFIID
Apoptosis
Mutation
Viral Tumor Antigens
Polyomavirus Transforming Antigens
1994

Erratum: Structure of the human CCG1 gene: Relationship between the exons/introns and functional domain/modules of the protein (Gene, 141 (1994) 193-200))

Nakashima, T., Sekiguchi, T., Sunamoto, H., Yura, K., Tomoda, S., Go, M., Kere, J., Schlessinger, D. & Nishimoto, T., Jan 1 1994, In : Gene. 148, 2, 1 p.

Research output: Contribution to journalComment/debate

Gene Regulatory Networks
Introns
Exons
Genes
Proteins
4 Citations (Scopus)

Mammalian cells have two functional RCC1 proteins produced by alternative splicing

Miyabashira, J., Sekiguchi, T. & Nishimoto, T., Aug 1 1994, In : Journal of Cell Science. 107, 8, p. 2203-2208 6 p.

Research output: Contribution to journalArticle

Alternative Splicing
Complementary DNA
Cricetinae
Exons
Proteins
10 Citations (Scopus)

Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells

Noguchi, E., Sekiguchi, T., Nohiro, Y., Hayashida, T., Hirose, E., Hayashi, N. & Nishimoto, T., Nov 1 1994, In : Somatic Cell and Molecular Genetics. 20, 6, p. 505-513 9 p.

Research output: Contribution to journalArticle

Cricetinae
Cell Cycle
Yeasts
Transcription Factor TFIID
HMGB1 Protein
1 Citation (Scopus)

Preliminary findings of chromosomal alterations and expression of cell cycle genes in head an neck tumors

Nakashima, T., Masuda, A., Sekiguchi, T., Nishimoto, T. & Uemura, T., Aug 1 1994, In : European Archives of Oto-Rhino-Laryngology. 251, 1 Supplement

Research output: Contribution to journalArticle

cdc Genes
Thyroid Gland
Neck
Head
CDC2 Protein Kinase
12 Citations (Scopus)

Structure of the human CCG1 gene: relationship between the exons/introns and functional domain/modules of the protein

Nakashima, T., Sekiguchi, T., Hidetoshi, S., Kei, Y., Shirou, T., Mitiko, G., Juha, K., David, S. & Takeharu, N., Apr 20 1994, In : Gene. 141, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Introns
Exons
Genes
Cell Cycle Checkpoints
Proteins

Structure of the human CCG1 gene: Relationship between the exons/introns and functional domain/modules of the protein

Nakashima, T., Sekiguchi, T., Hidetoshi, S., Kei, Y., Shirou, T., Mitiko, G., Juha, K., Schlessinger, D. & Takeharu, N., Oct 21 1994, In : Gene. 148, 2, 1 p.

Research output: Contribution to journalComment/debate

Introns
Exons
Cell Cycle
Genes
Protein Domains
55 Citations (Scopus)

The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster

Toshiro, H., Sekiguchi, T., Eishi, N., Hidetoshi, S., Tomoyuki, O. & Takeharu, N., Apr 20 1994, In : Gene. 141, 2, p. 267-270 4 p.

Research output: Contribution to journalArticle

Mesocricetus
Complementary DNA
Cell Line
General Transcription Factors
Genes

The CCG1 gene

Sekiguchi, T., Nakashima, T., Hayashida, T., Sunamoto, H. & Nishimoto, T., Jan 1 1994, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 39, 6, p. 967-971 5 p.

Research output: Contribution to journalReview article

Trans-Activators
Molecular Cloning
Cricetinae
Cell Cycle
Transcription Factors
1993
17 Citations (Scopus)

Molecular cloning and identification of two types of hamster cyclin-dependent kinases: CDK2 and CDK2L

Noguchi, E., Sekiguchi, T., Yamashita, K. & Nishimoto, T., Dec 30 1993, In : Biochemical and Biophysical Research Communications. 197, 3, p. 1524-1529 6 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases
Cloning
Molecular Cloning
Cricetinae
197 Citations (Scopus)

Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells

Nakashima, T., Sekiguchi, T., Kuraoka, A., Fukushima, K., Shibata, Y., Komiyama, S. & Nishimoto, T., Jan 1 1993, In : Molecular and Cellular Biology. 13, 10, p. 6367-6374 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Cricetinae
Cell Death
Complementary DNA
Apoptosis
1992
48 Citations (Scopus)

DNA-binding domain of RCC1 protein is not essential for coupling mitosis with DNA replication

Seino, H., Hisamoto, N., Uzawa, S., Sekiguchi, T. & Nishimoto, T., Jul 1992, In : Journal of Cell Science. 102, 3, p. 393-400 8 p.

Research output: Contribution to journalArticle

DNA Replication
Mitosis
DNA
Proteins
S Phase
1991
18 Citations (Scopus)

Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: Identity of CCG2 with the human X chromosomal SCAR/RPS4X gene

Watanabe, M., Furuno, N., Goebl, M., Go, M., Miyauchi, K., Sekiguchi, T. & Basilico Nishimito, C. T., 1991, In : Journal of Cell Science. 100, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Molecular Cloning
Cell Cycle
Temperature
G1 Phase
Genes
11 Citations (Scopus)

RCC1 is a nuclear protein required for coupling activation of cdc2 kinase with DNA synthesis and for start of the cell cycle

Seino, H., Nishitani, H., Seki, T., Hisamoto, N., Tazunoki, T., Shiraki, N., Ohtsubo, M., Yamashita, K., Sekiguchi, T. & Nishimoto, T., Jan 1 1991, In : Cold Spring Harbor Symposia on Quantitative Biology. 56, p. 367-375 9 p.

Research output: Contribution to journalArticle

enzyme activation
DNA-binding proteins
cyclin-dependent kinase
nuclear proteins
DNA replication
109 Citations (Scopus)

The Human CCG1 Gene, Essential for Progression of the G1 Phase, Encodes a 210-Kilodalton Nuclear DNA-Binding Protein

Sekiguchi, T., Nohiro, Y., Nakamura, Y., Hisamoto, N. & Nishimoto, T., Jan 1 1991, In : Molecular and Cellular Biology. 11, 6, p. 3317-3325 9 p.

Research output: Contribution to journalArticle

Essential Genes
DNA-Binding Proteins
G1 Phase
Nuclear Proteins
Complementary DNA
1990

Molecular cloning of the unknown genes from mutant cells

Sekiguchi, T., Jan 1 1990, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 35, 14, p. 2423-2431 9 p.

Research output: Contribution to journalArticle

Molecular Cloning
Mutation
Temperature
DNA
Genes
68 Citations (Scopus)

Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene

Uchida, S., Sekiguchi, T., Nishitani, H., Miyauchi, K., Ohtsubo, M. & Nishimoto, T., Jan 1 1990, In : Molecular and Cellular Biology. 10, 2, p. 577-584 8 p.

Research output: Contribution to journalArticle

Point Mutation
Cricetinae
Complementary DNA
Chromosomes
Genes
1989
18 Citations (Scopus)

Regional localization of CCG1 gene which complements hamster cell cycle mutation BN462 to Xq11-Xq13

Brown, C. J., Sekiguchi, T., Nishimoto, T. & Willard, H. F., Jan 1 1989, In : Somatic Cell and Molecular Genetics. 15, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

Cricetinae
Cell Cycle
Chromosomes, Human, X
Mutation
Hybrid Cells
1988
66 Citations (Scopus)
Cloning
Molecular Cloning
Tandem Repeat Sequences
Complementary DNA
Genes
1987
146 Citations (Scopus)

Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.

Ohtsubo, M., Kai, R., Furuno, N., Sekiguchi, T., Sekiguchi, M., Hayashida, H., Kuma, K., Miyata, T., Fukushige, S. & Murotsu, T., Jan 1 1987, In : Genes & development. 1, 6, p. 585-593 9 p.

Research output: Contribution to journalArticle

cdc Genes
Complementary DNA
Chromosomes
Clone Cells
Genes
26 Citations (Scopus)

Isolation of a human X chromosome-linked gene essential for progression from G1 to S phase of the cell cycle

Sekiguchi, T., Yoshida, M. C., Sekiguchi, M. & Nishimoto, T., Jan 1 1987, In : Experimental Cell Research. 169, 2, p. 395-407 13 p.

Research output: Contribution to journalArticle

Chromosomes, Human, X
X-Linked Genes
S Phase
Cell Cycle
DNA