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Research Output 1990 2019

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Article
2019
3 Citations (Scopus)

Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone

shiota, M., Narita, S., Akamatsu, S., Fujimoto, N., Sumiyoshi, T., Fujiwara, M., Uchiumi, T., Habuchi, T., Ogawa, O. & Eto, M., Feb 1 2019, In : JAMA network open. 2, 2, p. e190115

Research output: Contribution to journalArticle

Open Access
Androgens
Prostatic Neoplasms
Odds Ratio
Therapeutics
Castration
1 Citation (Scopus)

Diagnostic challenge of the newborn patients with heritable protein C deficiency

Ichiyama, M., Inoue, H., Ochiai, M., Ishimura, M., Shiraishi, A., Fujiyoshi, J., Yamashita, H., Sato, K., Matsumoto, S., Hotta, T., Uchiumi, T., Kang, D. & Ohga, S., Feb 1 2019, In : Journal of Perinatology. 39, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

Protein C Deficiency
Protein C
Protein S
Newborn Infant
Mutation
Sex Hormone-Binding Globulin
Genetic Polymorphisms
Androgens
Prostatic Neoplasms
Testosterone
1 Citation (Scopus)
Genetic Polymorphisms
Polymorphism
Androgens
Testosterone
Prostatic Neoplasms
2 Citations (Scopus)

Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study

Fujii, T., Takase, K. I., Honda, H., Kawamura, N., Yamasaki, R., Urata, M., Uchiumi, T., Iwaki, T. & Kira, J-I., Apr 1 2019, In : Neuropathology. 39, 2, p. 162-167 6 p.

Research output: Contribution to journalArticle

Poisons
Muscular Diseases
Hepatitis B
Mitochondrial DNA
Nucleosides
2018
3 Citations (Scopus)
Taxoids
Androgen Receptors
Prostatic Neoplasms
docetaxel
MDV 3100
3 Citations (Scopus)

Mineralocorticoid receptor signaling affects therapeutic effect of enzalutamide

shiota, M., Fujimoto, N., Higashijima, K., Imada, K., Kashiwagi, E., takeuchi, A., Inokuchi, J., Tatsugami, K., Kajioka, S., Uchiumi, T. & Eto, M., Oct 1 2018, In : Prostate. 78, 14, p. 1045-1052 8 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Therapeutic Uses
Prostatic Neoplasms
Androgen Receptors
Adrenal Cortex Hormones
2 Citations (Scopus)

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

Gotou, K., Morisaki, T., Setoyama, D., Sasaki, K., Yagi, M., Igami, K., Mizuguchi, S., Uchiumi, T., Fukui, Y. & Kang, D., Nov 13 2018, In : Cell Reports. 25, 7, p. 1800-1815.e4

Research output: Contribution to journalArticle

Metabolism
Dendritic Cells
Pyruvic Acid
Citric Acid
Oxidoreductases
1 Citation (Scopus)
Open Access
Mineralocorticoid Receptors
Genetic Polymorphisms
Androgens
Comorbidity
Hypertension
6 Citations (Scopus)
Gonadotropin-Releasing Hormone
Androgens
Testosterone
Prostatic Neoplasms
Serum
2017
2 Citations (Scopus)

Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway

Yamamichi, K., Fukuda, T., Sanui, T., Toyoda, K., Tanaka, U., Nakao, Y., Yotsumoto, K., Yamato, H., Taketomi, T., Uchiumi, T. & Nishimura, F., Nov 1 2017, In : Archives of Oral Biology. 83, p. 241-251 11 p.

Research output: Contribution to journalArticle

Amelogenin
Dinoprostone
Macrophages
Anti-Inflammatory Agents
Microarray Analysis
8 Citations (Scopus)

Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies

Feichtinger, R. G., Oláhová, M., Kishita, Y., Garone, C., Kremer, L. S., Yagi, M., Uchiumi, T., Jourdain, A. A., Thompson, K., D'Souza, A. R., Kopajtich, R., Alston, C. L., Koch, J., Sperl, W., Mastantuono, E., Strom, T. M., Wortmann, S. B., Meitinger, T., Pierre, G., Chinnery, P. F. & 19 others, Chrzanowska-Lightowlers, Z. M., Lightowlers, R. N., DiMauro, S., Calvo, S. E., Mootha, V. K., Moggio, M., Sciacco, M., Comi, G. P., Ronchi, D., Murayama, K., Ohtake, A., Rebelo-Guiomar, P., Kohda, M., Kang, D., Mayr, J. A., Taylor, R. W., Okazaki, Y., Minczuk, M. & Prokisch, H., Oct 5 2017, In : American journal of human genetics. 101, 4, p. 525-538 14 p.

Research output: Contribution to journalArticle

Chronic Progressive External Ophthalmoplegia
Oxidative Phosphorylation
Muscular Diseases
Electron Transport
Cardiomyopathies
6 Citations (Scopus)

Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses

Saito, T., Uchiumi, T., Yagi, M., Amamoto, R., Setoyama, D., Matsushima, Y. & Kang, D., Aug 1 2017, In : Cardiovascular research. 113, 10, p. 1173-1185 13 p.

Research output: Contribution to journalArticle

Takotsubo Cardiomyopathy
Cardiac Myocytes
Mitochondria
Mitochondrial Proteins
Sirolimus
6 Citations (Scopus)

Comparison of the Abbott RealTime HCV and Roche COBAS Ampliprep/COBAS TaqMan HCV assays for the monitoring of sofosbuvir-based therapy

Ogawa, E., Furusyo, N., Masayuki, M., Shimizu, M., Toyoda, K., Hotta, T., Uchiumi, T. & Hayashi, J., Jan 1 2017, In : Antiviral Therapy. 22, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

RNA
Genotype
Therapeutics
Fibrosis
Sofosbuvir
9 Citations (Scopus)
Endoplasmic Reticulum Stress
Neoplastic Stem Cells
Doxycycline
Stem Cells
Apoptosis
3 Citations (Scopus)
Protein Biosynthesis
Drosophila
Peptide Hydrolases
Unfolded Protein Response
Mitochondrial Genes
12 Citations (Scopus)
Androgens
Prostatic Neoplasms
Oxidative Stress
Antioxidants
Alleles
3 Citations (Scopus)

Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: A case report

Mezuki, S., Fukuda, K., Matsushita, T., Fukushima, Y., Matsuo, R., Goto, Y. I., Yasukawa, T., Uchiumi, T., Kang, D., Kitazono, T. & Ago, T., Dec 13 2017, In : BMC neurology. 17, 1, 217.

Research output: Contribution to journalArticle

NADH Dehydrogenase
Mitochondrial Diseases
Stroke
Mitochondrial DNA
Mutation
2 Citations (Scopus)
Leukoencephalopathies
Oligodendroglia
Axons
Electron Transport
Central Nervous System
4 Citations (Scopus)

p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock

Sasaki, K., Gotou, K., Miake, S., Setoyama, D., Yagi, M., Igami, K., Uchiumi, T. & Kang, D., Jun 1 2017, In : EBioMedicine. 20, p. 161-172 12 p.

Research output: Contribution to journalArticle

Endotoxins
Lipopolysaccharides
Shock
Interleukin-6
Fibroblasts
4 Citations (Scopus)

Protein kinase C regulates Twist1 expression via NF-κB in prostate cancer

Shiota, M., Yokomizo, A., Takeuchi, A., Kashiwagi, E., Dejima, T., Inokuchi, J., Tatsugami, K., Uchiumi, T. & Eto, M., Apr 2017, In : Endocrine-Related Cancer. 24, 4, p. 171-180 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Protein Kinase C
Prostatic Neoplasms
Castration
Androgen Antagonists
5 Citations (Scopus)

The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene

Inoue, H., Terachi, S. I., Uchiumi, T., Sato, T., Urata, M., Ishimura, M., Koga, Y., Hotta, T., Hara, T., Kang, D. & Ohga, S., Jul 2017, In : Pediatric Blood and Cancer. 64, 7, e26404.

Research output: Contribution to journalArticle

Protein C Deficiency
Protein C
Genotype
Thrombophilia
Mutation
2016
3 Citations (Scopus)
MELAS Syndrome
Rhabdomyolysis
Status Epilepticus
Stroke
Occipital Lobe
9 Citations (Scopus)

Dihydroorotate dehydrogenase depletion hampers mitochondrial function and osteogenic differentiation in osteoblasts

Fang, J., Yamaza, H., Uchiumi, T., Hoshino, Y., Masuda, K., Hirofuji, Y., Wagener, F. A. D. T. G., Kang, D. & Nonaka, K., Jun 1 2016, In : European Journal of Oral Sciences. 124, 3, p. 241-245 5 p.

Research output: Contribution to journalArticle

Osteoblasts
Small Interfering RNA
Adenosine Triphosphate
Cell Proliferation
dihydroorotate dehydrogenase
12 Citations (Scopus)

Equol inhibits prostate cancer growth through degradation of androgen receptor by S-phase kinase-associated protein 2

Itsumi, M., Shiota, M., Takeuchi, A., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Kajioka, S., Uchiumi, T., Naito, S., Eto, M. & Yokomizo, A., Jul 1 2016, In : Cancer Science. 107, 7, p. 1022-1028 7 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Equol
Androgen Receptors
Isoflavones
Prostatic Neoplasms
2 Citations (Scopus)

Grp78 Is Critical for Amelogenin-Induced Cell Migration in a Multipotent Clonal Human Periodontal Ligament Cell Line

Toyoda, K., Fukuda, T., Sanui, T., Tanaka, U., Yamamichi, K., Atomura, R., Maeda, H., Tomokiyo, A., Taketomi, T., Uchiumi, T. & Nishimura, F., Feb 1 2016, In : Journal of cellular physiology. 231, 2, p. 414-427 14 p.

Research output: Contribution to journalArticle

Amelogenin
Periodontal Ligament
Ligaments
Cell Movement
Cells
5 Citations (Scopus)

Impact of HCV kinetics on treatment outcome differs by the type of real-time HCV assay in NS3/4A protease inhibitor-based triple therapy

Ogawa, E., Furusyo, N., Masayuki, M., Hayashi, T., shimizu, M., Mukae, H., Toyoda, K., Hotta, T., Uchiumi, T. & Hayashi, J., Feb 1 2016, In : Antiviral Research. 126, p. 35-42 8 p.

Research output: Contribution to journalArticle

Protease Inhibitors
Hepacivirus
RNA
Therapeutics
Recurrence
1 Citation (Scopus)

Neuraminidase Amino Acid Sequences of Influenza A/H3N2 and B Viruses Isolated from Influenza Patients in the 2014/15 Japanese Influenza Season

Ikematsu, H., Jeong, Y., Shirane, K., Toh, H., Sasaki, H., Matsumoto, S., Noda, N., Hotta, T., Uchiumi, T. & Kang, D., May 1 2016, In : Fukuoka igaku zasshi = Hukuoka acta medica. 107, 5, p. 98-104 7 p.

Research output: Contribution to journalArticle

H3N2 Subtype Influenza A Virus
Influenza B virus
Influenza A virus
Neuraminidase
Human Influenza
24 Citations (Scopus)

Potential role for YB-1 in castration-resistant prostate cancer and resistance to enzalutamide through the androgen receptor V7

shiota, M., Fujimoto, N., Imada, K., Yokomizo, A., Itsumi, M., takeuchi, A., Kuruma, H., Inokuchi, J., Tatsugami, K., Uchiumi, T., Oda, Y. & Naito, S., Jan 1 2016, In : Journal of the National Cancer Institute. 108, 7, djw005.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Androgens
Phosphotransferases
2 Citations (Scopus)

Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells

Monji, K., Uchiumi, T., Hoshizawa, S., Yagi, M., Matsumoto, T., Setoyama, D., Matsushima, Y., Gotoh, K., Amamoto, R. & Kang, D., Jan 1 2016, In : Oncotarget. 7, 46, p. 75221-75234 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Oxygen Consumption
Nitric Oxide
Phenotype
Serum
6 Citations (Scopus)

The expression of ubiquitous mitochondrial creatine kinase is downregulated as prostate cancer progressionz

Amamoto, R., Uchiumi, T., Yagi, M., Monji, K., Song, Y. H., Oda, Y., shiota, M., Yokomizo, A., Naito, S. & Kang, D., Jan 1 2016, In : Journal of Cancer. 7, 1, p. 50-59 10 p.

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Prostatic Neoplasms
Down-Regulation
Adenine Nucleotides
Prostate
2015

Analysis of influenza A/H3N2 neuraminidase genes obtained from influenza patients in the 2011/12 and 2012/13 seasons in Japan

Ikematsu, H., Jeong, Y., Shirane, K., Toh, H., Sasaki, H., Koga, Y., Urata, M., Hotta, T., Uchiumi, T. & Kang, D., Jan 1 2015, In : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

Neuraminidase
Human Influenza
Japan
Inhibitory Concentration 50
Mutation
1 Citation (Scopus)

Analysis of the Neuraminidase Amino Acid Sequences of Influenza A/H1N1pdm09, A/H3N2, and B Viruses Isolated from Influenza Patients in the 2013/14 Japanese Influenza Season

Ikematsu, H., Jeong, Y., Shirane, K., Toh, H., Sasaki, H., Koga, Y., Matsumoto, S., Hotta, T., Uchiumi, T. & Kang, D., Aug 1 2015, In : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 8, p. 231-239 9 p.

Research output: Contribution to journalArticle

H3N2 Subtype Influenza A Virus
Cercopithecine Herpesvirus 1
Protein Sequence Analysis
Neuraminidase
Human Influenza
26 Citations (Scopus)

Crosstalk between epithelialmesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer

Shiota, M., Itsumi, M., Takeuchi, A., Imada, K., Yokomizo, A., Kuruma, H., Inokuchi, J., Tatsugami, K., Uchiumi, T., Oda, Y. & Naito, S., Dec 2015, In : Endocrine-Related Cancer. 22, 6, p. 889-900 12 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Transforming Growth Factors
Epithelial-Mesenchymal Transition
12 Citations (Scopus)

SRD5A gene polymorphism in Japanese men predicts prognosis of metastatic prostate cancer with androgen-deprivation therapy

shiota, M., Fujimoto, N., Yokomizo, A., takeuchi, A., Itsumi, M., Inokuchi, J., Tatsugami, K., Uchiumi, T. & Naito, S., Jun 17 2015, In : European Journal of Cancer. 51, 14, p. 1962-1969 8 p., 9525.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Castration
Genes
Therapeutics
2014
25 Citations (Scopus)
Castration
Protein Kinase C
Androgens
Prostatic Neoplasms
Protein C Inhibitor
10 Citations (Scopus)

Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer

shiota, M., Yokomizo, A., takeuchi, A., Itsumi, M., Imada, K., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Uchiumi, T. & Naito, S., Jan 1 2014, In : Prostate. 74, 9, p. 959-969 11 p.

Research output: Contribution to journalArticle

Castration
Ribosomal Protein S6 Kinases
Prostatic Neoplasms
Androgen Receptors
Neoplasms
7 Citations (Scopus)

PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells

Itsumi, M., Shiota, M., Yokomizo, A., Takeuchi, A., Kashiwagi, E., Dejima, T., Inokuchi, J., Tatsugami, K., Uchiumi, T. & Naito, S., Apr 29 2014, In : Journal of Molecular Endocrinology. 53, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Acetates
Down-Regulation
Apoptosis
15 Citations (Scopus)

Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer

shiota, M., Itsumi, M., Yokomizo, A., takeuchi, A., Imada, K., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Uchiumi, T. & Naito, S., Jan 1 2014, In : Prostate. 74, 8, p. 829-838 10 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Ribosomal Protein S6 Kinases
Prostatic Neoplasms
Taxoids
Mitogen-Activated Protein Kinase 3
18 Citations (Scopus)

Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast

Aihara, M., Jin, X., Kurihara, Y., Yoshida, Y., Matsushima, Y., Oku, M., Hirota, Y., Saigusa, T., Aoki, Y., Uchiumi, T., Yamamoto, T., Sakai, Y., Kang, D. & Kanki, T., 2014, In : Journal of Cell Science. 127, 14, p. 3184-3196 13 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Yeasts
Proteins
Pichia
Sirolimus
11 Citations (Scopus)

Twist1 and Y-box-binding protein-1 are potential prognostic factors in bladder cancer

Song, Y. H., shiota, M., Yokomizo, A., Uchiumi, T., Kiyoshima, K., Kuroiwa, K., Oda, Y. & Naito, S., Jan 1 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1, p. 31.e1-31.e7

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Urinary Bladder Neoplasms
Immunohistochemistry
Basic Helix-Loop-Helix Transcription Factors
Paraffin
2013
65 Citations (Scopus)

Casein kinase 2 is essential for mitophagy

Kanki, T., Kurihara, Y., Jin, X., Goda, T., Ono, Y., Aihara, M., Hirota, Y., Saigusa, T., Aoki, Y., Uchiumi, T. & Kang, D., Sep 1 2013, In : EMBO Reports. 14, 9, p. 788-794 7 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Casein Kinase II
Mitochondria
Yeast
Serine
30 Citations (Scopus)

Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction

Fang, J. X., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K. & Kang, D., May 20 2013, In : Bioscience reports. 33, 2, p. 217-227 11 p., e00021.

Research output: Contribution to journalArticle

Electron Transport
Biosynthesis
G2 Phase Cell Cycle Checkpoints
Native Polyacrylamide Gel Electrophoresis
dihydroorotate dehydrogenase

Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction.

Fang, J. X., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K. & Kang, D., 2013, In : Bioscience Reports. 33, 2

Research output: Contribution to journalArticle

Electron Transport
Biosynthesis
G2 Phase Cell Cycle Checkpoints
Native Polyacrylamide Gel Electrophoresis
dihydroorotate dehydrogenase
8 Citations (Scopus)

Human heterochromatin protein 1 Isoforms regulate androgen receptor signaling in prostate cancer

Itsumi, M., shiota, M., Yokomizo, A., Kashiwagi, E., takeuchi, A., Tatsugami, K., Inokuchi, J., Song, Y., Uchiumi, T. & Naito, S., Mar 27 2013, In : Journal of Molecular Endocrinology. 50, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Protein Isoforms
Castration
Cell Proliferation
12 Citations (Scopus)

Identification of Novel Amelogenin-Binding Proteins by Proteomics Analysis

Fukuda, T., Sanui, T., Toyoda, K., Tanaka, U., Taketomi, T., Uchiumi, T. & Nishimura, F., Oct 22 2013, In : PloS one. 8, 10, e78129.

Research output: Contribution to journalArticle

Amelogenin
Proteomics
proteomics
binding proteins
Carrier Proteins
35 Citations (Scopus)

Interaction between docetaxel resistance and castration resistance in prostate cancer: Implications of Twist1, YB-1, and androgen receptor

shiota, M., Kashiwagi, E., Yokomizo, A., takeuchi, A., Dejima, T., Song, Y., Tatsugami, K., Inokuchi, J., Uchiumi, T. & Naito, S., Sep 1 2013, In : Prostate. 73, 12, p. 1336-1344 9 p.

Research output: Contribution to journalArticle

docetaxel
Castration
Androgen Receptors
Prostatic Neoplasms
Cytotoxins
9 Citations (Scopus)

Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome

Uchiumi, T., Tanamachi, H., Kuchiwaki, K., Kajita, M., Matsumoto, S., Yagi, M., Kanki, T. & Kang, D., May 1 2013, In : Hepatology Research. 43, 5, p. 569-575 7 p.

Research output: Contribution to journalArticle

Chronic Idiopathic Jaundice
Mutation
Hyperbilirubinemia
HEK293 Cells
Protein Transport
25 Citations (Scopus)
Prostaglandin Receptors
Castration
Androgen Receptors
Aspirin
Prostatic Neoplasms

The clinical evaluation of high risk human papillomavirus (HPV) genotyping in cervical cancer tissue using a novel electric DNA chip-based diagnostic system

Koga, Y., Urata, M., Uchiumi, T., Sato, O., Kobayashi, H. & Kang, D., Apr 1 2013, In : Japanese Journal of Clinical Chemistry. 42, 2, p. 140-145 6 p.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Uterine Cervical Neoplasms
Vaccines
Tissue
DNA