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Research Output 1993 2019

  • 1520 Citations
  • 23 h-Index
  • 95 Article
2009
11 Citations (Scopus)

In situ expression of ribosomal protein L21 in developing tooth germ of the mouse lower first molar

Xie, M., Kobayashi, I., Kiyoshima, T., Nagata, K., Ookuma, Y., Fujiwara, H. & Sakai, H., Oct 1 2009, In : Journal of Molecular Histology. 40, 5-6, p. 361-367 7 p.

Research output: Contribution to journalArticle

Tooth Germ
Odontogenesis
Tooth
Epithelium
Dental Enamel
2008
14 Citations (Scopus)

Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar

Honda, J. Y., Kobayashi, I., Kiyoshima, T., Yamaza, H., Xie, M., Takahashi, K., Enoki, N., Nagata, K., Nakashima, A. & Sakai, H., Apr 2008, In : Histology and Histopathology. 23, 4, p. 423-432 10 p.

Research output: Contribution to journalArticle

Tooth Germ
Phosphoglycerate Kinase
Glyceraldehyde-3-Phosphate Dehydrogenases
Enzymes
Fluorescent Antibody Technique
2007
13 Citations (Scopus)

Age-dependent changes in cell proliferation and cell death in the periodontal tissue and the submandibular gland in mice: A comparison with other tissues and organs

Enoki, N., Kiyoshima, T., Sakai, T., Kobayashi, I., Takahashi, K., Terada, Y. & Sakai, H., Aug 1 2007, In : Journal of Molecular Histology. 38, 4, p. 321-332 12 p.

Research output: Contribution to journalArticle

Submandibular Gland
Cell Death
In Situ Nick-End Labeling
Cell Proliferation
Bromodeoxyuridine
16 Citations (Scopus)

Functional implication of nucleolin in the mouse first molar development

Xie, M., Kobayashi, I., Kiyoshima, T., Yamaza, H., Honda, J. Y., Takahashi, K., Enoki, N., Akamine, A. & Sakai, H., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23275-23283 9 p.

Research output: Contribution to journalArticle

Enamels
Tooth Germ
Dental Enamel
Mandible
Messenger RNA
2006
7 Citations (Scopus)

Transcription promoter activity of the human S100A7 gene in oral squamous cell carcinoma cell lines

Fukuzawa, H., Kiyoshima, T., Kobayashi, I., Ozeki, S. & Sakai, H., Mar 1 2006, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1759, 3-4, p. 171-176 6 p.

Research output: Contribution to journalArticle

Transcription
Human Activities
Squamous Cell Carcinoma
Genes
Cells
38 Citations (Scopus)

Type II/III Runx2/Cbfa1 is required for tooth germ development

Kobayashi, I., Kiyoshima, T., Wada, H., Matsuo, K., Nonaka, K., Honda, J. Y., Koyano, K. & Sakai, H., Jun 1 2006, In : Bone. 38, 6, p. 836-844 9 p.

Research output: Contribution to journalArticle

Tooth Germ
Mandible
Osteogenesis
Cell Differentiation
Protein Isoforms
2005
20 Citations (Scopus)

Effect of SCCA1 and SCCA2 on the suppression of TNF-α-induced cell death by impeding the release of mitochondrial cytochrome c in an oral squamous cell carcinoma cell line

Hashimoto, K. I., Kiyoshima, T., Matsuo, K., Ozeki, S. & Sakai, H., Jul 1 2005, In : Tumor Biology. 26, 4, p. 165-172 8 p.

Research output: Contribution to journalArticle

Cytochromes c
Squamous Cell Carcinoma
Cell Death
Cell Line
Staining and Labeling
30 Citations (Scopus)

Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar

Akhter, M., Kobayashi, I., Kiyoshima, T., Matsuo, K., Yamaza, H., Wada, H., Honda, J. Y., Ming, X. & Sakai, H., Sep 1 2005, In : Histochemistry and Cell Biology. 124, 3-4, p. 207-213 7 p.

Research output: Contribution to journalArticle

Tooth Germ
Dental Enamel
Enamel Organ
Tooth
Epithelium
18 Citations (Scopus)

Tissue- and bone cell-specific expression of bone sialoprotein is directed by a 9.0 kb promoter in transgenic mice

Paz, J., Wade, K., Kiyoshima, T., Sodek, J., Tang, J., Tu, Q., Yamauchi, M. & Chen, J., Aug 1 2005, In : Matrix Biology. 24, 5, p. 341-352 12 p.

Research output: Contribution to journalArticle

Integrin-Binding Sialoprotein
Transgenic Mice
Luciferases
Bone and Bones
Messenger RNA
2004
78 Citations (Scopus)

In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue

ogasawara, T., Yoshito, Y., Kiyoshima, T., Kobayashi, I., Matsuo, K., Akamine, A. & Sakai, H., Feb 1 2004, In : Journal of Periodontal Research. 39, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Osteoclasts
Cytokines
Interleukin-1
Periodontal Ligament
2002
25 Citations (Scopus)

An L1 element disrupts human bone sialoprotein promoter: Lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements

Kiyoshima, T., Yamauchi, M., Wong, C., Jheon, A., Ganss, B. & Sodek, J., Oct 16 2002, In : Gene. 299, 1-2, p. 205-217 13 p.

Research output: Contribution to journalArticle

Long Interspersed Nucleotide Elements
Core Binding Factors
Integrin-Binding Sialoprotein
Retroelements
Genes
12 Citations (Scopus)

Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland

Okamura, K., Kiyoshima, T., Shima, K., Kobayashi, I., Matsuo, K., Ishibashi, H., Komatsu, S., Rasul, A. M. E. & Sakai, H., May 7 2002, In : Oral Oncology. 38, 3, p. 244-250 7 p.

Research output: Contribution to journalArticle

Mucoepidermoid Carcinoma
Adenoid Cystic Carcinoma
Salivary Glands
Carcinoma
Epitopes
18 Citations (Scopus)

In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar

Wada, H., Kobayashi, I., Yamaza, H., Matsuo, K., Kiyoshima, T., Akhtar, M., Sakai, T., Koyano, K. & Sakai, H., Mar 1 2002, In : Histochemical Journal. 34, 3-4, p. 105-109 5 p.

Research output: Contribution to journalArticle

Tooth Germ
Heat-Shock Proteins
Dental Papilla
Dental Enamel
Enamel Organ
2001
25 Citations (Scopus)

Detection of differentially expressed genes in the early developmental stage of the mouse mandible

Yamaza, H., Matsuo, K., Kiyoshima, T., Shigemura, N., Kobayashi, I., Wada, H., Akamime, A. & Sakai, H., Aug 2 2001, In : International Journal of Developmental Biology. 45, 4, p. 675-680 6 p.

Research output: Contribution to journalArticle

Mandible
Odontogenesis
Tooth Germ
Genes
Tongue
63 Citations (Scopus)

Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands

Kiyoshima, T., Shima, K., Kobayashi, I., Matsuo, K., Okamura, K., Komatsu, S., Rasul, A. M. E. & Sakai, H., Apr 10 2001, In : Oral Oncology. 37, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

Mucoepidermoid Carcinoma
Adenoid Cystic Carcinoma
Salivary Glands
Tumor Suppressor Genes
p53 Genes
12 Citations (Scopus)

Expression of Set-α during morphogenesis of mouse lower first molar

Yamaza, H., Matsuo, K., Kobayashi, I., Wada, H., Kiyoshima, T., Akhtar, M., Ishibashi, Y., Sakai, T., Akamine, A. & Sakai, H., Dec 1 2001, In : Histochemical Journal. 33, 8, p. 437-441 5 p.

Research output: Contribution to journalArticle

Tooth Germ
Morphogenesis
Dental Papilla
Ameloblasts
Odontoblasts
26 Citations (Scopus)

Localization of activated caspase-3-positive and apoptotic cells in the developing tooth germ of the mouse lower first molar

Shigemura, N., Kiyoshima, T., Sakai, T., Matsuo, K., Momoi, T., Yamaza, H., Kobayashi, I., Wada, H., Akamine, A. & Sakai, H., Jan 1 2001, In : Histochemical Journal. 33, 5, p. 253-258 6 p.

Research output: Contribution to journalArticle

Tooth Germ
Caspase 3
Morphogenesis
Tooth
Embryonic Structures
2000
10 Citations (Scopus)

Epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the palate

Li, C. Y., Shirasuna, K., Ishibashi, H., Nakayama, H. & Kiyoshima, T., Jan 1 2000, In : Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 90, 4, p. 460-465 6 p., 49168.

Research output: Contribution to journalArticle

Pleomorphic Adenoma
Palate
Carcinoma
Neoplasms
Hyalin
33 Citations (Scopus)

Incidence of human papillomavirus 16 and 18 infection and p53 mutation in patients with oral squamous cell carcinoma in Japan

Shima, K., Kobayashi, I., Saito, I., Kiyoshima, T., Matsuo, K., Ozeki, S., Ohishi, M. & Sakai, H., Jan 1 2000, In : British Journal of Oral and Maxillofacial Surgery. 38, 5, p. 445-450 6 p.

Research output: Contribution to journalArticle

Human papillomavirus 18
Human papillomavirus 16
Squamous Cell Carcinoma
Japan
Mutation
1999
21 Citations (Scopus)

Age-dependent changes in the distribution of BrdU- and TUNEL-positive cells in the murine gingival tissue

Sakai, T., Kiyoshima, T., Kobayashi, I., Moroi, R., Ibuki, T., Nagadome, M., Terada, Y. & Sakai, H., Sep 1 1999, In : Journal of periodontology. 70, 9, p. 973-981 9 p.

Research output: Contribution to journalArticle

In Situ Nick-End Labeling
Bromodeoxyuridine
Epithelial Attachment
Connective Tissue
Epithelium
17 Citations (Scopus)

Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland

Kobayashi, I., Kiyoshima, T., Ozeki, S., Shima, K., Shigemura, N., Matsuo, K. & Sakai, H., Jul 1 1999, In : Journal of Oral Pathology and Medicine. 28, 6, p. 282-286 5 p.

Research output: Contribution to journalArticle

Papillary Cystadenocarcinoma
Sublingual Gland
Glandular and Epithelial Neoplasms
Papillary Adenocarcinoma
Lymphoid Tissue
42 Citations (Scopus)

Prevalence of Epstein-Barr virus in oral squamous cell carcinoma

Kobayashi, I., Shima, K., Saito, I., Kiyoshima, T., Matsuo, K., Ozeki, S., Ohishi, M. & Sakai, H., Sep 6 1999, In : Journal of Pathology. 189, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Squamous Cell Carcinoma
Virus Diseases
Viruses
In Situ Hybridization
47 Citations (Scopus)

The distribution of BrdU- and TUNEL-positive cells during odontogenesis in mouse lower first molars

Shigemura, N., Kiyoshima, T., Kobayashi, I., Matsuo, K., Yamaza, H., Akamine, A. & Sakai, H., Aug 11 1999, In : Histochemical Journal. 31, 6, p. 367-377 11 p.

Research output: Contribution to journalArticle

Odontogenesis
Deoxyuridine
In Situ Nick-End Labeling
Tooth Germ
Tooth
1998
10 Citations (Scopus)

Immunohistochemical localization of laminin, collagen type IV and heparan sulfate proteoglycan in human colorectal adenocarcinoma: Correlation with local invasive pattern and lymph node metastasis

Kiyoshima, T., Kobayashi, I., Matsuo, K., Ishibashi, Y., Miyoshi, A., Akashi, Y. & Sakai, H., Jan 1 1998, In : Acta Histochemica et Cytochemica. 31, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
Collagen Type IV
Laminin
Adenocarcinoma
Lymph Nodes

The role of macrophages in the absorption process of suture materials: A histological and immunohistochemical study

Manato, J. A., Kiyoshima, T., Kobayashi, I., Shima, K., Ohishi, M. & Sakai, H., Jan 1 1998, In : Acta Histochemica et Cytochemica. 31, 2, p. 113-120 8 p.

Research output: Contribution to journalArticle

dexon (fungicide)
Macrophages
Sutures
Tissue
Cicatrix
1997
21 Citations (Scopus)
Cathepsin H
Epithelial Attachment
Cathepsin B
Cysteine Proteases
Horseradish Peroxidase
8 Citations (Scopus)
Cathepsin D
Proliferating Cell Nuclear Antigen
Epidermal Growth Factor Receptor
Breast Neoplasms
Lymph Nodes
1996
18 Citations (Scopus)

An immunohistochemical study of HLA-DR and α1-antichymotrypsin- positive cells in the pulp of human non-carious and carious teeth

Izumi, T., Kobayashi, J., Okamura, K., Matsuo, K., Kiyoshima, T., Ishibashi, Y., Inoue, H. & Sakai, H., Jul 1 1996, In : Archives of Oral Biology. 41, 7, p. 627-630 4 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Tooth
S 6
Dental Pulp
Antibodies
29 Citations (Scopus)
Odontoblasts
Wheat Germ Agglutinins
Trigeminal Nerve
Dentin
Horseradish Peroxidase
52 Citations (Scopus)

Immunohistochemical localization of cathepsins D and E in human gastric cancer: A possible correlation with local invasive and metastatic activities of carcinoma cells

Matsuo, K., Kobayashi, I., Tsukuba, T., Kiyoshima, T., Ishibashi, Y., Miyoshi, A., Yamamoto, K. & Sakai, H., Jan 1 1996, In : Human Pathology. 27, 2, p. 184-190 7 p.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin D
Stomach Neoplasms
Carcinoma
Cathepsins
62 Citations (Scopus)

Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats

Murai, K., Takeshita, F., Ayukawa, Y., Kiyoshima, T., Suetsugu, T. & Tanaka, T., Apr 1 1996, In : Journal of Biomedical Materials Research. 30, 4, p. 523-533 11 p.

Research output: Contribution to journalArticle

Titanium
Rats
Bone
Electrons
Cells
12 Citations (Scopus)

Postnatal development of protein gene product 9.5- and calcitonin gene- related peptide-like immunoreactive nerve fibers in the rat temporomandibular joint

Shimizu, S., Kido, M. A., Kiyoshima, T. & Tanaka, T., Jul 19 1996, In : Anatomical Record. 245, 3, p. 568-576 9 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Temporomandibular Joint
Nerve Fibers
Proteins
Avidin
8 Citations (Scopus)
Synovial Membrane
Calcitonin Gene-Related Peptide
Neuropeptide Y
Temporomandibular Joint
Substance P
1995
27 Citations (Scopus)
Epithelial Attachment
Capsaicin
Gingiva
Substance P
Blood Vessels
38 Citations (Scopus)
Wheat Germ Agglutinins
Trigeminal Nerve
Temporomandibular Joint
Sensory Receptor Cells
Horseradish Peroxidase

Relationship between proliferative activity, and tissue differentiation and invasive mode in human oral squamous cell and colorectal carcinomas analysed by PCNA immunostaining

Asaoka, Y., Kajitani, T., Kitahara, J., Yamaza, H., Kobayashi, I., Kiyoshima, T., Matsuo, K. & Sakai, H., Jan 1 1995, In : Fukuoka igaku zasshi = Hukuoka acta medica. 86, 7, p. 317-324 8 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
Squamous Cell Carcinoma
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
7 Citations (Scopus)

The Changes in the Immunocytochemical Localization of Cathepsin L and Type I Collagen in Rat Osteoclasts Treated with E-64

Moroi, R., Yamaza, T., Ayukawa, Y., Kiyoshima, T., Ohsaki, Y., Nishimura, Y., Terada, Y., Himeno, M. & Tanaka, T., Jan 1 1995, In : Acta Histochemica et Cytochemica. 28, 6, p. 523-531 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Osteoclasts
Collagen Type I
Rats
Vacuoles
1994
14 Citations (Scopus)

Immunocytochemical localization of cathepsin L in the synovial lining cells of the rat temporomandibular joint

Kiyoshima, T., Kido, M. A., Nishimura, Y., Himeno, M., Tsukuba, T., Tashiro, H., Yamamoto, K. & Tanaka, T., Jan 1 1994, In : Archives of Oral Biology. 39, 12, p. 1049-1056 8 p.

Research output: Contribution to journalArticle

Cathepsin L
Temporomandibular Joint
Vacuoles
Lysosomes
Fibroblasts
11 Citations (Scopus)
Calcitonin Gene-Related Peptide
Substance P
Nerve Fibers
Tooth
Epithelium
77 Citations (Scopus)

Localization of cathepsins B, D, and L in the rat osteoclast by immuno-light and -electron microscopy

Goto, T., Tanaka, T., Kiyoshima, T., Moroi, R., Tsukuba, T., Yamamoto, K., Nishimura, Y. & Himeno, M., Jan 1 1994, In : Histochemistry. 101, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Cathepsin L
cathepsin B
Cathepsin B
Cathepsin D
osteoclasts
4 Citations (Scopus)

Localization of Cathepsins B And D in the Synovial Lining Cells of the Normal Rat Temporomandibular Joint by Immuno-Light and -Electron Microscopy

Kiyoshima, T., Sakai, H., Tsukuba, T., Yamamoto, K., Kido, M. A. & Tanaka, T., Jan 1 1994, In : Acta Histochemica et Cytochemica. 27, 5, p. 441-450 10 p.

Research output: Contribution to journalArticle

Cathepsin B
Cathepsin D
Immunoelectron Microscopy
Temporomandibular Joint
Cathepsins
18 Citations (Scopus)

New Human Oral Squamous Carcinoma Cell Line and Its Tumorigenic Subline Producing Granulocyte Colony‐stimulating Factor

Matsuo, K., Ishibashi, Y., Kobayashi, I., Ozeki, S., Ohishi, M., Tange, T., Hirata, J., Kiyoshima, T. & Sakai, H., Jan 1 1994, In : Japanese Journal of Cancer Research. 85, 12, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

Granulocytes
Squamous Cell Carcinoma
Cell Line
Conditioned Culture Medium
Colony-Forming Units Assay
1993
69 Citations (Scopus)

Distribution of Substance P and Calcitonin Gene-related Peptide-like lmmunoreactive Nerve Fibers in the Rat Temporomandibular Joint

Kido, M. A., Moroi, R., Terada, Y., Kiyoshima, T., Kondo, T., Tanaka, T. & Ayasaka, N., Jan 1 1993, In : Journal of Dental Research. 72, 3, p. 592-598 7 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Temporomandibular Joint
Substance P
Nerve Fibers
Joints
68 Citations (Scopus)

Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast

Goto, T., Tsukuba, T., Kiyoshima, T., Nishimura, Y., Kato, K., Yamamoto, K. & Tanaka, T., May 1 1993, In : Histochemistry. 99, 5, p. 411-414 4 p.

Research output: Contribution to journalArticle

cathepsin L
Cathepsin L
cathepsin B
Cathepsin B
Cathepsin D
10 Citations (Scopus)

Immunohistochemical localization of cathepsins B and D in the synovial lining cells of the normal rat temporomandibular joint

Kiyoshima, T., Tsukuba, T., Kido, M. A., Tashiro, H., Yamamoto, K. & Tanaka, T., Jan 1 1993, In : Archives of Oral Biology. 38, 4, p. 357-359 3 p.

Research output: Contribution to journalArticle

Cathepsin B
Cathepsin D
Temporomandibular Joint
Digestion
Cytoplasm