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Research Output 1996 2019

1996
7 Citations (Scopus)

Systemic vascular change associated with moyamoya-like cerebrovascular disease and microvascular coronary artery disease

Tokunaga, Y., Toyoda, K., Ago, T., Ibayashi, S., Usui, M. & Fujishima, M., Jul 10 1996, In : Clinical Neurology. 36, 2, p. 318-322 5 p.

Research output: Contribution to journalArticle

Moyamoya Disease
Blood Vessels
Coronary Artery Disease
Angiography
Pathologic Constriction
1997
Lymph Node Tuberculosis
Tuberculosis
Drug Therapy
Lung
Lymphadenitis
1998
69 Citations (Scopus)

The PC motif: A novel and evolutionarily conserved sequence involved in interaction between p40(phox) and p67(phox), SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase

Nakamura, R., Sumimoto, H., Mizuki, K., Hata, K., Ago, T., Kitajima, S., Takeshige, K., Sakaki, Y. & Ito, T., Feb 1 1998, In : European Journal of Biochemistry. 251, 3, p. 583-589 7 p.

Research output: Contribution to journalArticle

Conserved Sequence
NADPH Oxidase
Phagocytes
Mutagenesis
Amphiphiles
1999
16 Citations (Scopus)

Dermatomyositis associated with invasive thymoma

Ago, T., Nakamura, M., Iwata, I., Murai, H., Okuma, K., Tsuru, T., Kaji, Y., Hayashida, K. & Niho, Y., Feb 1999, In : Internal Medicine. 38, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

Dermatomyositis
Thymoma
X Ray Computed Tomography
Methylprednisolone
Internal Medicine
2001
33 Citations (Scopus)

Inhibition of Na+/H+ exchanger reduces infarct volume of focal cerebral ischemia in rats

Kitayama, J., Kitazono, T., Yao, H., Ooboshi, H., Takaba, H., Ago, T., Fujishima, M. & Ibayashi, S., Dec 20 2001, In : Brain Research. 922, 2, p. 223-228 6 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Brain Ischemia
Cerebrovascular Circulation
Brain Edema
Regional Blood Flow
124 Citations (Scopus)

Novel modular domain PB1 recognizes pc motif to mediate functional protein-protein interactions

Ito, T., Matsui, Y., Ago, T., Ota, K. & Sumimoto, H., Aug 1 2001, In : EMBO Journal. 20, 15, p. 3938-3946 9 p.

Research output: Contribution to journalArticle

Proteins
Saccharomycetales
Fungal Proteins
NADPH Oxidase
Phagocytes
7 Citations (Scopus)

Role of Na+/H+ exchanger in dilator responses of rat basilar artery in vivo

Kitazono, T., Kamouchi, M., Ago, T., Ooboshi, H., Nakamura, H., Fujishima, M. & Ibayashi, S., Jul 6 2001, In : Brain Research. 906, 1-2, p. 101-106 6 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Basilar Artery
Acetylcholine
Bradykinin
Vasodilation
139 Citations (Scopus)

Solution structure of the PX domain, a target of the SH3 domain

Hiroaki, H., Ago, T., Ito, T., Sumimoto, H. & Kohda, D., 2001, In : Nature Structural Biology. 8, 6, p. 526-530 5 p.

Research output: Contribution to journalArticle

src Homology Domains
Proline
Proteins
NADPH Oxidase
Phagocytes
85 Citations (Scopus)

The PX domain as a novel phosphoinositide-binding module

Ago, T., Takeya, R., Hiroaki, H., Kuribayashi, F., Ito, T., Kohda, D. & Sumimoto, H., Sep 28 2001, In : Biochemical and Biophysical Research Communications. 287, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Endosomes
Phagocytes
Oxidoreductases
Proteins
2002
13 Citations (Scopus)

Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension

Kitayama, J., Kitazono, T., Ooboshi, H., Ago, T., Ohgami, T., Fujishima, M. & Ibayashi, S., Nov 1 2002, In : Journal of hypertension. 20, 11, p. 2205-2211 7 p.

Research output: Contribution to journalArticle

Basilar Artery
Genistein
Protein-Tyrosine Kinases
Inbred WKY Rats
Hypertension
22 Citations (Scopus)

Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo

Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M. & Ibayashi, S., May 1 2002, In : Journal of hypertension. 20, 5, p. 879-884 6 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Basilar Artery
Calcium Channels
Inbred WKY Rats
Inbred SHR Rats

Paradoxical embolism in a case with Graves' ophthalmopathy during steroid therapy

Yonekura, T., Ago, T., Sato, K., Okamura, K., Fukuda, K., Abe, I. & Iida, M., Aug 10 2002, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 91, 8, p. 2479-2480 2 p.

Research output: Contribution to journalArticle

Paradoxical Embolism
Graves Ophthalmopathy
Betamethasone
Graves Disease
Plasminogen Activator Inhibitor 1
2003
25 Citations (Scopus)

ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo

Santa, N., Kitazono, T., Ago, T., Ooboshi, H., Kamouchi, M., Wakisaka, M., Ibayashi, S. & Iida, M., May 1 2003, In : Stroke. 34, 5, p. 1276-1280 5 p.

Research output: Contribution to journalArticle

KATP Channels
Basilar Artery
Dilatation
Acidosis
Cerebral Arteries
44 Citations (Scopus)

Deterioration of pre-existing hemiparesis brought about by subsequent ipsilateral lacunar infarction

Ago, T., Kitazono, T., Ooboshi, H., Takada, J., Yoshiura, T., Mihara, F., Ibayashi, S. & Iida, M., Aug 1 2003, In : Journal of Neurology Neurosurgery and Psychiatry. 74, 8, p. 1152-1153 2 p.

Research output: Contribution to journalArticle

Lacunar Stroke
Paresis
Motor Cortex
Putaminal Hemorrhage
Pyramidal Tracts
166 Citations (Scopus)
src Homology Domains
NADPH Oxidase
Phagocytes
Phosphatidylinositols
Oxidoreductases
2004
7 Citations (Scopus)

Brain infarction associated with antiphospholipid antibody syndrome caused by paradoxical embolism through patent foramen ovale [4]

Ago, T., Ooboshi, H., Kitazono, T., Imamura, T., Takada, J., Ibayashi, S. & Iida, M., Jun 1 2004, In : Journal of Neurology. 251, 6, p. 757-759 3 p.

Research output: Contribution to journalLetter

Paradoxical Embolism
Brain Infarction
Patent Foramen Ovale
Occipital Lobe
Antiphospholipid Syndrome
30 Citations (Scopus)

Calcium influx pathways in rat CNS pericytes

Kamouchi, M., Kitazono, T., Ago, T., Wakisaka, M., Ooboshi, H., Ibayashi, S. & Iida, M., Jul 26 2004, In : Molecular Brain Research. 126, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

Pericytes
Central Nervous System
Calcium
Smooth Muscle
Actins
404 Citations (Scopus)

Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase

Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y. H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H. & Iida, M., Jan 20 2004, In : Circulation. 109, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Superoxides
Endothelial Cells
Membranes
Reactive Oxygen Species
12 Citations (Scopus)

PPARγ ligands attenuate mesangial contractile dysfunction in high glucose

Ueta, M., Wakisaka, M., Ago, T., Kitazono, T., Nakamura, U., Yoshinari, M., Iwase, M. & Iida, M., Mar 2004, In : Kidney International. 65, 3, p. 961-971 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Mesangial Cells
Contractile Proteins
Ligands
Glucose
2005
14 Citations (Scopus)

Cerebral sinus thrombosis in a patient with Cushing's syndrome [2]

Yoshimura, S., Ago, T., Kitazono, T., Yonekura, T., Kumai, Y., Kuroda, J., Kamouchi, M., Ooboshi, H., Ibayashi, S. & Iida, M., Aug 1 2005, In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 8, p. 1182-1183 2 p.

Research output: Contribution to journalLetter

Intracranial Sinus Thrombosis
Intracranial Thrombosis
X Ray Computed Tomography
Cushing Syndrome
Magnetic Resonance Imaging
98 Citations (Scopus)

NAD(P)H oxidases in rat basilar arterial endothelial cells

Ago, T., Kitazono, T., Kuroda, J., Kumai, Y., Kamouchi, M., Ooboshi, H., Wakisaka, M., Kawahara, T., Rokutan, K., Ibayashi, S. & Iida, M., May 1 2005, In : Stroke. 36, 5, p. 1040-1046 7 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Endothelial Cells
Basilar Artery
Cerebral Arteries
Superoxides
137 Citations (Scopus)

Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia

Ooboshi, H., Ibayashi, S., Shichita, T., Kumai, Y., Takada, J., Ago, T., Arakawa, S., Sugimori, H., Kamouchi, M., Kitazono, T. & Iida, M., Feb 22 2005, In : Circulation. 111, 7, p. 913-919 7 p.

Research output: Contribution to journalArticle

Brain Ischemia
Interleukin-10
Ischemia
Genes
Brain Infarction
33 Citations (Scopus)

Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia

Takada, J., Ooboshi, H., Ago, T., Kitazono, T., Yao, H., Kadomatsu, K., Muramatsu, T., Ibayashi, S. & Iida, M., Mar 1 2005, In : Gene Therapy. 12, 6, p. 487-493 7 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Brain Ischemia
Ischemia
Genes
Cerebrovascular Circulation
2006
82 Citations (Scopus)

GDF15, a cardioprotective TGF-β superfamily protein

Ago, T. & Sadoshima, J., Feb 1 2006, In : Circulation research. 98, 3, p. 294-297 4 p.

Research output: Contribution to journalEditorial

TGF-beta Superfamily Proteins
Cardiotonic Agents
Bone Morphogenetic Proteins
Gene Expression Regulation
Transforming Growth Factor beta
34 Citations (Scopus)

Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart

Ago, T., Yeh, I., Yamamoto, M., Schinke-Braun, M., Brown, J. A., Tian, B. & Sadoshima, J., Sep 1 2006, In : Antioxidants and Redox Signaling. 8, 9-10, p. 1635-1649 15 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Oxidative Phosphorylation
Nuclear Respiratory Factor 1
Up-Regulation
Genes
61 Citations (Scopus)

Thioredoxin and ventricular remodeling

Ago, T. & Sadoshima, J., Nov 1 2006, In : Journal of Molecular and Cellular Cardiology. 41, 5, p. 762-773 12 p.

Research output: Contribution to journalReview article

Thioredoxins
Ventricular Remodeling
Reactive Oxygen Species
Antioxidants
Post Translational Protein Processing
21 Citations (Scopus)

Valsartan improves the lower limit of cerebral autoregulation in rats

Takada, J., Ibayashi, S., Ooboshi, H., Ago, T., Ishikawa, E., Kamouchi, M., Kitazono, T. & Iida, M., Aug 1 2006, In : Hypertension Research. 29, 8, p. 621-626 6 p.

Research output: Contribution to journalArticle

Valsartan
Cerebrovascular Circulation
Homeostasis
Angiotensin II Type 1 Receptor Blockers
Angiotensin Type 1 Receptor
2007
21 Citations (Scopus)

Hydrogen peroxide-induced Ca2+ responses in CNS pericytes

Kamouchi, M., Kitazono, T., Ago, T., Wakisaka, M., Kuroda, J., Nakamura, K., Hagiwara, N., Ooboshi, H., Ibayashi, S. & Iida, M., Apr 6 2007, In : Neuroscience Letters. 416, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

Pericytes
Hydrogen Peroxide
Central Nervous System
Protein-Tyrosine Kinases
Nicardipine
21 Citations (Scopus)

NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: The Fukuoka Stroke Registry and the Hisayama study

Kuroda, J., Kitazono, T., Ago, T., Ninomiya, T., Ooboshi, H., Kamouchi, M., Kumai, Y., Hagiwara, N., Yoshimura, S., Tamaki, K., Kusuda, K., Fujii, K., Nagao, T., Okada, Y., Toyoda, K., Nakane, H., Sugimori, H., Yamashita, Y., Wakugawa, Y., Asano, K. & 4 others, Tanizaki, Y., Kiyohara, Y., Ibayashi, S. & Iida, M., Oct 1 2007, In : European Journal of Neurology. 14, 10, p. 1091-1097 7 p.

Research output: Contribution to journalArticle

Brain Infarction
Lacunar Stroke
NADPH Oxidase
Registries
Japan
46 Citations (Scopus)

Thioredoxin1 as a negative regulator of cardiac hypertrophy

Ago, T. & Sadoshima, J., Jun 1 2007, In : Antioxidants and Redox Signaling. 9, 6, p. 679-687 9 p.

Research output: Contribution to journalArticle

Cardiomegaly
Reactive Oxygen Species
Antioxidants
Transcription Factors
Molecules
2008
218 Citations (Scopus)

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

Ago, T., Liu, T., Zhai, P., Chen, W., Li, H., Molkentin, J. D., Vatner, S. F. & Sadoshima, J., Jun 13 2008, In : Cell. 133, 6, p. 978-993 16 p.

Research output: Contribution to journalArticle

Thioredoxins
Histone Deacetylases
Cardiomegaly
Oxidation-Reduction
Disulfides
136 Citations (Scopus)

Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion

Matsui, Y., Kyoi, S., Takagi, H., Hsu, C. P., Hariharan, N., Ago, T., Vatner, S. F. & Sadoshima, J., May 16 2008, In : Autophagy. 4, 4, p. 409-415 7 p.

Research output: Contribution to journalReview article

Myocardial Reperfusion
Autophagy
Myocardial Ischemia
Reperfusion
Lysosomes
6 Citations (Scopus)

Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: The Fukuoka Stroke Registry and the Hisayama study

Hagiwara, N., Kitazono, T., Kamouchi, M., Kuroda, J., Ago, T., Hata, J., Ninomiya, T., Ooboshi, H., Kumai, Y., Yoshimura, S., Tamaki, K., Fujii, K., Nagao, T., Okada, Y., Toyoda, K., Nakane, H., Sugimori, H., Yamashita, Y., Wakugawa, Y., Kubo, M. & 4 others, Tanizaki, Y., Kiyohara, Y., Ibayashi, S. & Iida, M., May 1 2008, In : European Journal of Neurology. 15, 5, p. 481-486 6 p.

Research output: Contribution to journalArticle

Brain Infarction
src Homology Domains
Registries
Stroke
Genotype
11 Citations (Scopus)

Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population: The Fukuoka Stroke Registry and the Hisayama Study

Hagiwara, N., Kitazono, T., Kamouchi, M., Kuroda, J., Ago, T., Hata, J., Ninomiya, T., Ooboshi, H., Kumai, Y., Yoshimura, S., Tamaki, K., Fujii, K., Nagao, T., Okada, Y., Toyoda, K., Nakane, H., Sugimori, H., Yamashita, Y., Wakugawa, Y., Kubo, M. & 4 others, Tanizaki, Y., Kiyohara, Y., Ibayashi, S. & Iida, M., May 1 2008, In : Cerebrovascular Diseases. 25, 5, p. 417-422 6 p.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Registries
Stroke
Population
Genes
35 Citations (Scopus)

Protective effects of angiotensin II Type 1 receptor blocker on cerebral circulation independent of blood pressure

Kumai, Y., Ooboshi, H., Ago, T., Ishikawa, E., Takada, J., Kamouchi, M., Kitazono, T., Ibayashi, S. & Iida, M., Apr 1 2008, In : Experimental Neurology. 210, 2, p. 441-448 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Angiotensin II Type 1 Receptor Blockers
Inbred SHR Rats
Blood Pressure
Inbred WKY Rats
80 Citations (Scopus)

Quantitative analysis of redox-sensitive proteome with DIGE and ICAT

Fu, C., Hu, J., Liu, T., Ago, T., Sadoshima, J. & Li, H., Sep 1 2008, In : Journal of Proteome Research. 7, 9, p. 3789-3802 14 p.

Research output: Contribution to journalArticle

Proteome
Electrophoresis
Isotopes
Oxidation-Reduction
Gels
2009
13 Citations (Scopus)

Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes

Nakamura, K., Kamouchi, M., Kitazono, T., Kuroda, J., Shono, Y., Hagiwara, N., Ago, T., Ooboshi, H., Ibayashi, S. & Iida, M., May 1 2009, In : Microvascular Research. 77, 3, p. 327-334 8 p.

Research output: Contribution to journalArticle

Pericytes
Amiloride
Hydrogen Peroxide
Sodium-Hydrogen Antiporter
Acid Sensing Ion Channels
56 Citations (Scopus)

Elucidation of thioredoxin target protein networks in mouse

Fu, C., Wu, C., Liu, T., Ago, T., Zhai, P., Sadoshima, J. & Li, H., Dec 8 2009, In : Molecular and Cellular Proteomics. 8, 7, p. 1674-1687 14 p.

Research output: Contribution to journalArticle

Thioredoxins
Proteins
Cysteine
S-Nitrosothiols
Signal transduction
21 Citations (Scopus)

Midkine gene transfer protects against focal brain ischemia and augments neurogenesis

Ishikawa, E., Ooboshi, H., Kumai, Y., Takada, J., Nakamura, K., Ago, T., Sugimori, H., Kamouchi, M., Kitazono, T., Ibayashi, S. & Iida, M., Oct 15 2009, In : Journal of the Neurological Sciences. 285, 1-2, p. 78-84 7 p.

Research output: Contribution to journalArticle

Neurogenesis
Brain Ischemia
Brain Infarction
Cerebrovascular Circulation
Fluorescence
44 Citations (Scopus)

The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy

Oka, S. I., Ago, T., Kitazono, T., Zablocki, D. & Sadoshima, J., Aug 1 2009, In : Journal of Molecular Medicine. 87, 8, p. 785-791 7 p.

Research output: Contribution to journalReview article

Histone Deacetylases
Cardiomegaly
Oxidation-Reduction
Thioredoxins
Cell Nucleus Active Transport
2010
429 Citations (Scopus)

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D. & Sadoshima, J., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15565-15570 6 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Cardiac Myocytes
Pressure
Mitochondria
17 Citations (Scopus)

Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload

Ago, T., Yang, Y., Zhai, P. & Sadoshima, J., Aug 1 2010, In : Journal of Cardiovascular Translational Research. 3, 4, p. 304-313 10 p.

Research output: Contribution to journalArticle

Cardiomegaly
Left Ventricular Dysfunction
Nifedipine
NFATC Transcription Factors
Pressure
48 Citations (Scopus)

The NADPH oxidase Nox4 and aging in the heart

Ago, T., Matsushima, S., Kuroda, J., Zablocki, D., Kitazono, T. & Sadoshima, J., Dec 2010, In : Aging. 2, 12, p. 1012-1016 5 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Mitochondria
Cardiac Myocytes
Intracellular Membranes
306 Citations (Scopus)

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes

Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H. & Sadoshima, J., Apr 1 2010, In : Circulation research. 106, 7, p. 1253-1264 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Up-Regulation
Apoptosis
Oxidative Stress
NADPH Oxidase
2011
2 Citations (Scopus)

A case of sle presenting stroke-like symptoms

Ishitsuka, K., Ago, T., Fukuda, K., Fukushima, Y., Gotoh, S., Yubi, T., Kamouchi, M. & Kitazono, T., Feb 21 2011, In : Internal Medicine. 50, 4, p. 359-362 4 p.

Research output: Contribution to journalArticle

Stroke
Systemic Lupus Erythematosus
Cerebrovascular Circulation
Parietal Lobe
Cerebral Arteries
54 Citations (Scopus)

Brain pericytes: Emerging concepts and functional roles in brain homeostasis

Kamouchi, M., Ago, T. & Kitazono, T., Mar 1 2011, In : Cellular and molecular neurobiology. 31, 2, p. 175-193 19 p.

Research output: Contribution to journalReview article

Pericytes
Homeostasis
Brain
Hemostasis
Blood-Brain Barrier
67 Citations (Scopus)

Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Ago, T., Kuroda, J., Kamouchi, M., Sadoshima, J. & Kitazono, T., Aug 1 2011, In : Circulation Journal. 75, 8, p. 1791-1800 10 p.

Research output: Contribution to journalReview article

NADPH Oxidase
Vascular Diseases
Blood Vessels
Reperfusion Injury
Reactive Oxygen Species
79 Citations (Scopus)

Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: The fukuoka stroke registry

Kamouchi, M., Matsuki, T., Hata, J., Kuwashiro, T., Ago, T., Sambongi, Y., Fukushima, Y., Sugimori, H. & Kitazono, T., Oct 1 2011, In : Stroke. 42, 10, p. 2788-2794 7 p.

Research output: Contribution to journalArticle

Registries
Stroke
National Institutes of Health (U.S.)
Infarction
Diabetes Mellitus
109 Citations (Scopus)

Regulation of myocardial growth and death by NADPH oxidase

Maejima, Y., Kuroda, J., Matsushima, S., Ago, T. & Sadoshima, J., Mar 1 2011, In : Journal of Molecular and Cellular Cardiology. 50, 3, p. 408-416 9 p.

Research output: Contribution to journalReview article

NADPH Oxidase
Cardiomegaly
Oxidative Stress
Mitochondria
Heart Failure