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Research Output 1996 2019

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Article
2015

An update on novel oral anticoagulants

Ago, T., Wakisaka, Y. & Kuroda, J., Jan 1 2015, In : Japanese Journal of Neurosurgery. 24, 4, p. 220-225 6 p.

Research output: Contribution to journalArticle

Anticoagulants
Stroke
Atrial Fibrillation
Therapeutics
4 Citations (Scopus)

Cerebral Small-Vessel Disease in Neuro-Behçet Disease

Yoshimura, S., Ago, T., Koga, M., Kamouchi, M. & Kitazono, T., Aug 1 2015, In : Journal of Stroke and Cerebrovascular Diseases. 24, 8, p. e237-e239

Research output: Contribution to journalArticle

Cerebral Small Vessel Diseases
Dysarthria
Pons
Mesencephalon
Stroke
27 Citations (Scopus)

Day-by-Day Blood Pressure Variability and Functional Outcome after Acute Ischemic Stroke: Fukuoka Stroke Registry

Fukuda, K., Kai, H., Kamouchi, M., Hata, J., Ago, T., Nakane, H., Imaizumi, T. & Kitazono, T., Jul 4 2015, In : Stroke. 46, 7, p. 1832-1839 8 p.

Research output: Contribution to journalArticle

Registries
Stroke
Blood Pressure
Antihypertensive Agents
Sex Factors
2 Citations (Scopus)

Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: The EMINENT study

EMINENT Study Investigators, Jan 1 2015, In : Internal Medicine. 54, 6, p. 573-577 5 p.

Research output: Contribution to journalArticle

Hydrochlorothiazide
Oxidative Stress
Stroke
Blood Pressure
Antihypertensive Agents
19 Citations (Scopus)

Hematocrit and the risk of cardiovascular disease in a Japanese community: The Hisayama Study

Gotoh, S., Hata, J., Ninomiya, T., Hirakawa, Y., Nagata, M., Mukai, N., Fukuhara, M., Ikeda, F., Ago, T., Kitazono, T. & Kiyohara, Y., Sep 1 2015, In : Atherosclerosis. 242, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

Hematocrit
Cardiovascular Diseases
Stroke
Coronary Disease
Independent Living
35 Citations (Scopus)
Platelet-Derived Growth Factor Receptors
Extracellular Matrix Proteins
Fibrosis
Collagen Type I
Stroke
4 Citations (Scopus)

Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation

Liu, T., Wu, C., Jain, M. R., Nagarajan, N., Yan, L., Dai, H., Cui, C., Baykal, A., Pan, S., Ago, T., Sadoshima, J. & Li, H., Dec 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 12, p. 1816-1822 7 p.

Research output: Contribution to journalArticle

Thioredoxins
Methylation
Lysine
Oxidation-Reduction
Up-Regulation
20 Citations (Scopus)

Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia

Tong, X., Khandelwal, A. R., Qin, Z., Wu, X., Chen, L., Ago, T., Sadoshima, J. & Cohen, R. A., Dec 1 2015, In : Journal of Molecular and Cellular Cardiology. 89, p. 185-194 10 p.

Research output: Contribution to journalArticle

Thrombospondin 1
NADPH Oxidase
Hyperplasia
Smooth Muscle
Down-Regulation
24 Citations (Scopus)

Sex differences in short-term outcomes after acute ischemic stroke: The fukuoka stroke registry

Irie, F., Kamouchi, M., Hata, J., Matsuo, R., Wakisaka, Y., Kuroda, J., Ago, T., Kitazono, T., Ishitsuka, T., Fujimoto, S., Ibayashi, S., Kusuda, K., Arakawa, S., Tamaki, K., Sadoshima, S., Irie, K., Fujii, K., Okada, Y., Yasaka, M., Nagao, T. & 7 others, Ooboshi, H., Omae, T., Toyoda, K., Nakane, H., Sugimori, H., Fukuda, K. & Fukushima, Y., Feb 6 2015, In : Stroke. 46, 2, p. 471-476 6 p.

Research output: Contribution to journalArticle

Sex Characteristics
Registries
Stroke
National Institutes of Health (U.S.)
Japan
2014
48 Citations (Scopus)

ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack

Kiyohara, T., Kamouchi, M., Kumai, Y., Ninomiya, T., Hata, J., Yoshimura, S., Ago, T., Okada, Y. & Kitazono, T., Feb 1 2014, In : Stroke. 45, 2, p. 418-425 8 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Stroke
Proportional Hazards Models
Carotid Stenosis
Neuroimaging
1 Citation (Scopus)

A case of CNS-limited ANCA-associated vasculitis presenting as recurrent ischemic stroke

Wakisaka, K., Hagiwara, N., Kanazawa, Y., Arakawa, S., Ago, T. & Kitazono, T., Jan 1 2014, In : Clinical Neurology. 54, 5, p. 429-433 5 p.

Research output: Contribution to journalArticle

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Infarction
Stroke
Fever of Unknown Origin
Antineutrophil Cytoplasmic Antibodies
3 Citations (Scopus)

A case of intravascular large B-cell lymphoma (IVLBCL) with central nervous system symptoms diagnosed by renal biopsy

Kanazawa, Y., Hagiwara, N., Matsuo, R., Arakawa, S., Ago, T. & Kitazono, T., 2014, In : Clinical Neurology. 54, 6, p. 484-488 5 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Parietal Lobe
Central Nervous System
Kidney
Biopsy
85 Citations (Scopus)

A redox-dependent mechanism for regulation of AMPK activation by thioredoxin1 during energy starvation

Shao, D., Oka, S. I., Liu, T., Zhai, P., Ago, T., Sciarretta, S., Li, H. & Sadoshima, J., Feb 4 2014, In : Cell metabolism. 19, 2, p. 232-245 14 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Starvation
Oxidation-Reduction
Oxidative Stress
High Fat Diet
28 Citations (Scopus)

Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines

Chen, L., Hou, X., Xiao, J., Kuroda, J., Ago, T., Sadoshima, J., Cohen, R. A. & Tong, X. Y., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2489-2499 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Transforming Growth Factor beta
Hydrogen Peroxide
Transgenic Mice
Endothelial Cells
6 Citations (Scopus)

Gastrointestinal bleeding in acute ischemic stroke: recent trends from the fukuoka stroke registry

Fukuoka Stroke Registry, May 2014, In : Cerebrovascular diseases extra. 4, 2, p. 156-64 9 p.

Research output: Contribution to journalArticle

Registries
Stroke
Hemorrhage
Peptic Ulcer
Nervous System
45 Citations (Scopus)

High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka stroke registry

Ishitsuka, K., Kamouchi, M., Hata, J., Fukuda, K., Matsuo, R., Kuroda, J., Ago, T., Kuwashiro, T., Sugimori, H., Nakane, H. & Kitazono, T., Jan 1 2014, In : Hypertension. 63, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Registries
Stroke
Blood Pressure
Hypertension
Odds Ratio
1 Citation (Scopus)
Registries
Stroke
Recurrence
Genotype
Single Nucleotide Polymorphism
39 Citations (Scopus)

Intracranial hemorrhage during dabigatran treatment - Case series of eight patients -

Komori, M., Yasaka, M., Kokuba, K., Matsuoka, H., Fujimoto, S., Yoshida, M., Kameda, K., Shono, T., Nagata, S., Ago, T., Kitazono, T. & Okada, Y., 2014, In : Circulation Journal. 78, 6, p. 1335-1341 7 p.

Research output: Contribution to journalArticle

Intracranial Hemorrhages
Subdural Hematoma
Cerebral Hemorrhage
Hematoma
Traumatic Subarachnoid Hemorrhage
13 Citations (Scopus)

Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: The Fukuoka Stroke Registry

FSR Investigators, Oct 16 2014, In : PloS one. 9, 10, e110444.

Research output: Contribution to journalArticle

t-plasminogen activator
Tissue Plasminogen Activator
stroke
Registries
Stroke
34 Citations (Scopus)

Nox4 is a major source of superoxide production in human brain pericytes

Kuroda, J., Ago, T., Nishimura, A., Nakamura, K., Matsuo, R., Wakisaka, Y., Kamouchi, M. & Kitazono, T., Mar 6 2014, In : Journal of Vascular Research. 51, 6, p. 429-438 10 p.

Research output: Contribution to journalArticle

Pericytes
Superoxides
Brain
Reactive Oxygen Species
Angiotensin II
13 Citations (Scopus)

Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke

Wakisaka, Y., Ago, T., Kamouchi, M., Kuroda, J., Matsuo, R., Hata, J., Gotoh, S., Isomura, T., Awano, H., Suzuki, K., Fukuda, K., Okada, Y., Kiyohara, Y., Ooboshi, H. & Kitazono, T., May 15 2014, In : Journal of the Neurological Sciences. 340, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

Biomarkers
Stroke
Research
Granulocytes
Brain Injuries
30 Citations (Scopus)

Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS)

Kuwashiro, T., Ago, T., Kamouchi, M., Matsuo, R., Hata, J., Kuroda, J., Fukuda, K., Sugimori, H., Fukuhara, M., Awano, H., Isomura, T., Suzuki, K., Yasaka, M., Okada, Y., Kiyohara, Y. & Kitazono, T., Sep 2014, In : Metabolism: Clinical and Experimental. 63, 9, p. 1093-1103 11 p.

Research output: Contribution to journalArticle

Adiponectin
Biomarkers
Stroke
Research
Brain
10 Citations (Scopus)

Thrombolytic therapy for stroke in patients with preexisting cognitive impairment

Murao, K., Leys, D., Jacquin, A., Kitazono, T., Bordet, R., Béjot, Y., Kimura, K., Godefroy, O., Wakisaka, Y., Moulin, S., Ago, T., Sibon, I., Bombois, S., Mas, J. L., Hénon, H., Pasquier, F., Giroud, M., Cordonnier, C. & Okada, Y., Jun 10 2014, In : Neurology. 82, 23, p. 2048-2054 7 p.

Research output: Contribution to journalArticle

Thrombolytic Therapy
Stroke
Tissue Plasminogen Activator
Cerebral Hemorrhage
Odds Ratio
6 Citations (Scopus)
Thrombolytic Therapy
Tissue Plasminogen Activator
stroke
Registries
confidence
2013
60 Citations (Scopus)

Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α

Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Ikeda, Y., Oka, S., Fong, G. H., Tian, R. & Sadoshima, J., Apr 12 2013, In : Circulation research. 112, 8, p. 1135-1149 15 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Peroxisome Proliferator-Activated Receptors
NADPH Oxidase
Reperfusion Injury
Up-Regulation
44 Citations (Scopus)

Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study

Matsuo, R., Ago, T., Kamouchi, M., Kuroda, J., Kuwashiro, T., Hata, J., Sugimori, H., Fukuda, K., Gotoh, S., Makihara, N., Fukuhara, M., Awano, H., Isomura, T., Suzuki, K., Yasaka, M., Okada, Y., Kiyohara, Y. & Kitazono, T., Apr 8 2013, In : BMC neurology. 13, 32.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Biomarkers
Stroke
Research
Infarction
96 Citations (Scopus)

Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy

Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Park, J. Y., Xie, L. H., Tian, B. & Sadoshima, J., Feb 15 2013, In : Circulation research. 112, 4, p. 651-663 13 p.

Research output: Contribution to journalArticle

Cardiomegaly
Phenylephrine
Oxidative Stress
Cysteine
NADP
21 Citations (Scopus)

Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke the Fukuoka stroke Registry

Nakamura, A., Ago, T., Kamouchi, M., Hata, J., Matsuo, R., Kuroda, J., Kuwashiro, T., Sugimori, H. & Kitazono, T., Nov 1 2013, In : Stroke. 44, 11, p. 3239-3242 4 p.

Research output: Contribution to journalArticle

International Normalized Ratio
Prothrombin Time
Registries
Stroke
Odds Ratio
8 Citations (Scopus)

Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: The Fukuoka Stroke Registry

Kuwashiro, T., Sugimori, H., Ago, T., Kuroda, J., Kamouchi, M. & Kitazono, T., Nov 27 2013, In : BMJ open. 3, 11, 4.

Research output: Contribution to journalArticle

C-Reactive Protein
Registries
Stroke
Recurrence
Blood Pressure
22 Citations (Scopus)

RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke

Tokami, H., Ago, T., Sugimori, H., Kuroda, J., Awano, H., Suzuki, K., Kiyohara, Y., Kamouchi, M. & Kitazono, T., Jun 23 2013, In : Brain Research. 1517, p. 122-132 11 p.

Research output: Contribution to journalArticle

Stroke
T-Lymphocytes
Nerve Growth Factors
Neurons
Middle Cerebral Artery Infarction
8 Citations (Scopus)

Statins and the risks of stroke recurrence and death after ischemic stroke: The Fukuoka Stroke Registry

Makihara, N., Kamouchi, M., Hata, J., Matsuo, R., Ago, T., Kuroda, J., Kuwashiro, T., Sugimori, H., Kitazono, T., Ishitsuka, T., Fujimoto, S., Ibayashi, S., Kusuda, K., Arakawa, S., Irie, K., Fujii, K., Wakugawa, Y., Okada, Y., Yasaka, M., Nagao, T. & 8 others, Ooboshi, H., Omae, T., Toyoda, K., Nakane, H., Fukuda, K., Fukushima, Y., Tamaki, K. & Sadoshima, S., Dec 1 2013, In : Atherosclerosis. 231, 2, p. 211-215 5 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registries
Stroke
Recurrence
Mortality
16 Citations (Scopus)

The impact of predisposing factors on long-term outcome after stroke in diabetic patients: The Fukuoka Stroke Registry

Kuwashiro, T., Sugimori, H., Ago, T., Kuroda, J., Kamouchi, M. & Kitazono, T., Jun 1 2013, In : European Journal of Neurology. 20, 6, p. 921-927 7 p.

Research output: Contribution to journalArticle

Causality
Registries
Stroke
Diabetes Mellitus
Odds Ratio
2012
8 Citations (Scopus)
Pericytes
Sodium-Hydrogen Antiporter
Carrier Proteins
Protein Isoforms
Central Nervous System
6 Citations (Scopus)
compound A 12
HDL Cholesterol
Registries
Stroke
Recurrence
43 Citations (Scopus)

Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection

Ishitsuka, K., Ago, T., Arimura, K., Nakamura, K., Tokami, H., Makihara, N., Kuroda, J., Kamouchi, M. & Kitazono, T., May 1 2012, In : Microvascular Research. 83, 3, p. 352-359 8 p.

Research output: Contribution to journalArticle

Pericytes
Nerve Growth Factors
Astrocytes
Brain
Nerve Growth Factor
95 Citations (Scopus)

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

Shichita, T., Ago, T., Kamouchi, M., Kitazono, T., Yoshimura, A. & Ooboshi, H., Nov 1 2012, In : Journal of Neurochemistry. 123, SUPPL. 2, p. 29-38 10 p.

Research output: Contribution to journalArticle

T-cells
Innate Immunity
Brain
Stroke
Inflammation
60 Citations (Scopus)

PDGF receptor β signaling in pericytes following ischemic brain injury

Arimura, K., Ago, T., Kamouchi, M., Nakamura, K., Ishitsuka, K., Kuroda, J., Sugimori, H., Ooboshi, H., Sasaki, T. & Kitazono, T., Feb 2012, In : Current Neurovascular Research. 9, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Pericytes
Proto-Oncogene Proteins c-sis
Brain Injuries
Brain
84 Citations (Scopus)

Proteinuria and clinical outcomes after ischemic stroke

Kumai, Y., Kamouchi, M., Hata, J., Ago, T., Kitayama, J., Nakane, H., Sugimori, H. & Kitazono, T., Jun 12 2012, In : Neurology. 78, 24, p. 1909-1915 7 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Proteinuria
Stroke
Glomerular Filtration Rate
Nervous System
18 Citations (Scopus)

Relationship between Asian dust and ischemic stroke: A time-stratified case-crossover study

Kamouchi, M., Ueda, K., Ago, T., Nitta, H. & Kitazono, T., Nov 1 2012, In : Stroke. 43, 11, p. 3085-3087 3 p.

Research output: Contribution to journalArticle

Dust
Cross-Over Studies
Stroke
Incidence
Brain Infarction
41 Citations (Scopus)

Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset: The Fukuoka Stroke Registry

Kuwashiro, T., Sugimori, H., Ago, T., Kamouchi, M. & Kitazono, T., Feb 1 2012, In : Cerebrovascular Diseases. 33, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

Registries
Stroke
Recurrence
Chronic Renal Insufficiency
HDL Cholesterol
11 Citations (Scopus)

The factors associated with a functional outcome after ischemic stroke in diabetic patients: The Fukuoka Stroke Registry

Kuwashiro, T., Kamouchi, M., Ago, T., Hata, J., Sugimori, H. & Kitazono, T., Feb 15 2012, In : Journal of the Neurological Sciences. 313, 1-2, p. 110-114 5 p.

Research output: Contribution to journalArticle

Registries
Stroke
Angiotensin Receptor Antagonists
Odds Ratio
Proteinuria
2011
2 Citations (Scopus)

A case of sle presenting stroke-like symptoms

Ishitsuka, K., Ago, T., Fukuda, K., Fukushima, Y., Gotoh, S., Yubi, T., Kamouchi, M. & Kitazono, T., Feb 21 2011, In : Internal Medicine. 50, 4, p. 359-362 4 p.

Research output: Contribution to journalArticle

Stroke
Systemic Lupus Erythematosus
Cerebrovascular Circulation
Parietal Lobe
Cerebral Arteries
79 Citations (Scopus)

Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: The fukuoka stroke registry

Kamouchi, M., Matsuki, T., Hata, J., Kuwashiro, T., Ago, T., Sambongi, Y., Fukushima, Y., Sugimori, H. & Kitazono, T., Oct 1 2011, In : Stroke. 42, 10, p. 2788-2794 7 p.

Research output: Contribution to journalArticle

Registries
Stroke
National Institutes of Health (U.S.)
Infarction
Diabetes Mellitus
105 Citations (Scopus)

Thioredoxin 1 negatively regulates angiotensin II-Induced cardiac hypertrophy through upregulation of miR-98/let-7

Yang, Y., Ago, T., Zhai, P., Abdellatif, M. & Sadoshima, J., Feb 4 2011, In : Circulation research. 108, 3, p. 305-313 9 p.

Research output: Contribution to journalArticle

Cyclin D2
Thioredoxins
Cardiomegaly
Angiotensin II
Up-Regulation
2010
429 Citations (Scopus)

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D. & Sadoshima, J., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15565-15570 6 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Cardiac Myocytes
Pressure
Mitochondria
17 Citations (Scopus)

Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload

Ago, T., Yang, Y., Zhai, P. & Sadoshima, J., Aug 1 2010, In : Journal of Cardiovascular Translational Research. 3, 4, p. 304-313 10 p.

Research output: Contribution to journalArticle

Cardiomegaly
Left Ventricular Dysfunction
Nifedipine
NFATC Transcription Factors
Pressure
48 Citations (Scopus)

The NADPH oxidase Nox4 and aging in the heart

Ago, T., Matsushima, S., Kuroda, J., Zablocki, D., Kitazono, T. & Sadoshima, J., Dec 2010, In : Aging. 2, 12, p. 1012-1016 5 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Mitochondria
Cardiac Myocytes
Intracellular Membranes
306 Citations (Scopus)

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes

Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H. & Sadoshima, J., Apr 1 2010, In : Circulation research. 106, 7, p. 1253-1264 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Up-Regulation
Apoptosis
Oxidative Stress
NADPH Oxidase
2009
13 Citations (Scopus)

Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes

Nakamura, K., Kamouchi, M., Kitazono, T., Kuroda, J., Shono, Y., Hagiwara, N., Ago, T., Ooboshi, H., Ibayashi, S. & Iida, M., May 1 2009, In : Microvascular Research. 77, 3, p. 327-334 8 p.

Research output: Contribution to journalArticle

Pericytes
Amiloride
Hydrogen Peroxide
Sodium-Hydrogen Antiporter
Acid Sensing Ion Channels
56 Citations (Scopus)

Elucidation of thioredoxin target protein networks in mouse

Fu, C., Wu, C., Liu, T., Ago, T., Zhai, P., Sadoshima, J. & Li, H., Dec 8 2009, In : Molecular and Cellular Proteomics. 8, 7, p. 1674-1687 14 p.

Research output: Contribution to journalArticle

Thioredoxins
Proteins
Cysteine
S-Nitrosothiols
Signal transduction