• 12912 Citations
  • 47 h-Index
1989 …2020

Research output per year

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Research Output

  • 12912 Citations
  • 47 h-Index
  • 223 Article
  • 12 Review article
  • 10 Comment/debate
  • 1 Letter
1989

Cytotoxin of Pseudomonas aeruginosa

Hayashi, T., Nov 1 1989, In : Seikagaku. The Journal of Japanese Biochemical Society. 61, 11, p. 1380-1384 5 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa cytotoxin: the nucleotide sequence of the gene and the mechanism of activation of the protoxin

Hayashi, T., Kamio, Y., Hishinuma, F., Usami, Y., Titani, K. & Terawaki, Y., Jan 1 1989, In : Molecular Microbiology. 3, 7, p. 861-868 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Purification and characterization of cytotoxin from the crude extract of Pseudomonas aeruginosa

Hayashi, T., Kamio, Y. & Terawaki, Y., Feb 1989, In : Microbial Pathogenesis. 6, 2, p. 103-112 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1990

Effects of mutations in the repA gene of plasmid Rts1 on plasmid replication and autorepressor function

Terawaki, Y., Nozue, H., Zeng, H., Hayashi, T., Kamio, Y. & Itoh, Y., Jan 1 1990, In : Journal of bacteriology. 172, 2, p. 786-792 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phage‐conversion of cytotoxin production in Pseudomonas aeruginosa

Hayashi, T., Baba, T., Matsumoto, H. & Terawaki, Y., Jan 1 1990, In : Molecular Microbiology. 4, 10, p. 1703-1709 7 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Site-directed mutations in the repA C-terminal region of plasmid Rts1: Pleiotropic effects on the replication and autorepressor functions

Zeng, H., Hayashi, T. & Terawaki, Y., Jan 1 1990, In : Journal of bacteriology. 172, 5, p. 2535-2540 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1991

Molecular approach to Pseudomonas aeruginosa cytotoxin: structure, activation mechanism and phage conversion.

Hayashi, T. & Terawaki, Y., Dec 1 1991, In : Antibiotics and chemotherapy. 44, p. 48-53 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
1992

Function of the N-terminal half of RepA in activation of Rts1 ori

Terawaki, Y., Itoh, Y., Zeng, H., Hayashi, T. & Tabuchi, A., Jan 1 1992, In : Journal of bacteriology. 174, 21, p. 6904-6910 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Isolation and characterization of Shewanella alga from human clinical specimens and emendation of the description of S. alga Simidu et al., 1990, 335

Nozue, H., Hayashi, T., Hashimoto, Y., Ezaki, T., Hamasaki, K., Ohwada, K. & Terawaki, Y., Jan 1 1992, In : International Journal of Systematic Bacteriology. 42, 4, p. 628-634 7 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
1993

Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans

Higuchi, M., Shimada, M., Yamamoto, Y., Hayashi, T., Koga, T. & Kamio, Y., Jan 1 1993, In : Journal of General Microbiology. 139, 10, p. 2343-2351 9 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Molecular analysis of a cytotoxin‐converting phage, φCTX, of Pseudomonas aeruginosa: structure of the attP–cos–ctx region and integration into the serine tRNA gene

Hayashi, T., Matsumoto, H., Ohnishi, M. & Terawaki, Y., Jan 1 1993, In : Molecular Microbiology. 7, 5, p. 657-667 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
1994

Botulinum neurotoxin type g proteolyses the ala81-Ala82 bond of rat synaptobrevin 2

Yamasaki, S., Binz, T., Hayashi, T., Szabo, E., Yamasaki, N., Eklund, M., Jahn, R. & Niemann, H., Apr 30 1994, In : Biochemical and Biophysical Research Communications. 200, 2, p. 829-835 7 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Cytotoxin-converting phages, φCTX and PS21, are R pyocin-related phages

Hayashi, T., Matsumoto, H., Ohnishi, M., Yokota, S. I., Shinomiya, T., Kageyama, M. & Terawaki, Y., Oct 1 1994, In : FEMS microbiology letters. 122, 3, p. 239-244 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Identification of the lipopolysaccharide core region as the receptor site for a cytotoxin-converting phage, φCTX, of Pseudomonas aeruginosa

Yokota, S. I., Hayashi, T. & Matsumoto, H., Jan 1 1994, In : Journal of Bacteriology. 176, 17, p. 5262-5269 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Mechanism of the cytolytic action of Pseudomonas aeruginosa cytotoxin: Oligomerization of the cytotoxin on target membranes

Ohnishi, M., Hayashi, T., Tomita, T. & Terawaki, Y., Dec 19 1994, In : FEBS Letters. 356, 2-3, p. 357-360 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pseudomonas aeruginosa Cytotoxin and Its Phage Conversion

Hayashi, T., Jan 1 1994, In : Nippon Nogeikagaku Kaishi. 68, 2, p. 259-262 4 p.

Research output: Contribution to journalArticle

Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly

Hayashi, T., McMahon, H., Yamasaki, S., Binz, T., Hata, Y., Südhof, T. C. & Niemann, H., Jan 1 1994, In : EMBO Journal. 13, 21, p. 5051-5061 11 p.

Research output: Contribution to journalArticle

632 Citations (Scopus)
1995

Analysis of functional domains of Rts1 RepA by means of a series of hybrid proteins with P1 RepA

Tabuchi, A., Ohnishi, M., Hayashi, T. & Terawaki, Y., Jan 1 1995, In : Journal of bacteriology. 177, 14, p. 4028-4035 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro

Hayashi, T., Yamasaki, S., Nauenburg, S., Binz, T. & Niemann, H., Jan 1 1995, In : EMBO Journal. 14, 10, p. 2317-2325 9 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

IgA protease from Neisseria gonorrhoeae inhibits exocytosis in bovine chromaffin cells like tetanus toxin

Binscheck, T., Bartels, F., Bergel, H., Bigalke, H., Yamasaki, S., Hayashi, T., Niemann, H. & Pohlner, J., Jan 1 1995, In : Journal of Biological Chemistry. 270, 4, p. 1770-1774 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Multiple mitochondrial DNA deletions in a patient with mitochondrial myopathy and cardiomyopathy but no ophthalmoplegia

Takei, YI. I., Ikeda, SI. I., Yanagisawa, N., Takahashi, W., Sekiguchi, M. & Hayashi, T., 1995, In : Muscle and Nerve. 18, 11, p. 1321-1325 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Study on Pseudomonas aeruginosa cytotoxin and cytotoxin-converting phages

Hayashi, T., Jan 1 1995, In : Nippon saikingaku zasshi. Japanese journal of bacteriology. 50, 2, p. 391-401 11 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
1996

Gene product identification and promoter analysis of hig locus of plasmid Rts1

Tian, Q. B., Hayashi, T., Murata, T. & Terawaki, Y., Aug 14 1996, In : Biochemical and Biophysical Research Communications. 225, 2, p. 679-684 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1997
1 Citation (Scopus)
1998

Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak

Makino, K., Ishii, K., Yasunaga, T., Hattori, M., Yokoyama, K., Yutsudo, C. H., Kubota, Y., Yamaichi, Y., Iida, T., Yamamoto, K., Honda, T., Han, C. G., Ohtsubo, E., Kasamatsu, M., Hayashi, T., Kuhara, S. & Shinagawa, H., Jan 1 1998, In : DNA Research. 5, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Functional domains of Rts1 and P1 RepA proteins for initiation of replication

Li, Y. F., Hayashi, T. & Terawaki, Y., Sep 1998, In : Plasmid. 40, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
6 Citations (Scopus)
1999

Chromosome of the enterohemorrhagic Escherichia coli O157:H7; Comparative analysis with K-12 MG1655 revealed the acquisition of a large amount of foreign DNAs

Ohnishi, M., Tanaka, C., Kuhara, S., Ishii, K., Hattori, M., Kurokawa, K., Yasunaga, T., Makino, K., Shinagawa, H., Murata, T., Nakayama, K., Terawaki, Y. & Hayashi, T., Jan 1 1999, In : DNA Research. 6, 6, p. 361-368 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid

Tobe, T., Hayashi, T., Han, C. G., Schoolnik, G. K., Ohtsubo, E. & Sasakawa, C., Oct 7 1999, In : Infection and Immunity. 67, 10, p. 5455-5462 8 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak

Makino, K., Yokoyama, K., Kubota, Y., Yutsudo, C. H., Kimura, S., Kurokawa, K., Ishii, K., Hattori, M., Tatsuno, I., Abe, H., Iida, T., Yamamoto, K., Onishi, M., Hayashi, T., Yasunaga, T., Honda, T., Sasakawa, C. & Shinagawa, H., Oct 1 1999, In : Genes and Genetic Systems. 74, 5, p. 227-239 13 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Molecular cloning, sequencing, purification, and characterization of Pseudomonas aeruginosa ribosome recycling factor

Ohnishi, M., Janosi, L., Shuda, M., Matsumoto, H., Hayashi, T., Terawaki, Y. & Kaji, A., Feb 1 1999, In : Journal of bacteriology. 181, 4, p. 1281-1291 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The complete nucleotide sequence of ΦCTX, a cytotoxin-converting phage of Pseudomonas aeruginosa: Implications for phage evolution and horizontal gene transfer via bacteriophages

Nakayama, K., Kanaya, S., Ohnishi, M., Terawaki, Y. & Hayashi, T., Jan 30 1999, In : Molecular Microbiology. 31, 2, p. 399-419 21 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)
2000

Comparative analysis of the whole set of rRNA operons between an enterohemorrhagic Escherichia coli O157:H7 Sakai strain and an Escherichia coli K-12 strain MG1655

Ohnishi, M., Murata, T., Nakayama, K., Kuhara, S., Hattori, M., Kurokawa, K., Yasunaga, T., Yokoyamas, K., Makinos, K., Shinagawa, H. & Hayashi, T., Jan 1 2000, In : Systematic and Applied Microbiology. 23, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Complete nucleotide sequence of the prophage VT1-Sakai carrying the Shiga toxin 1 genes of the enterohemorrhagic Escherichia coli O157:H7 strain derived from the Sakai outbreak

Yokoyama, K., Makino, K., Kubota, Y., Watanabe, M., Kimura, S., Yutsudo, C. H., Kurokawa, K., Ishii, K., Hattori, M., Tatsuno, I., Abe, H., Yoh, M., Iida, T., Ohnishi, M., Hayashi, T., Yasunaga, T., Honda, T., Sasakawa, C. & Shinagawa, H., Nov 27 2000, In : Gene. 258, 1-2, p. 127-139 13 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Development of disinfectant mats and evaluation of their effectiveness

Ohta, S., Nagai, K., Zenda, H., Ogata, H., Hayashi, T., Oguchi, M., Okimura, Y., Akahane, T., Saitou, H. & Kawakami, Y., Mar 20 2000, In : Biocontrol Science. 5, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Molecular analysis of the folC gene of Pseudomonas aeruginosa

Murata, T., Bognar, A. L., Hayashi, T., Ohnishi, M., Nakayama, K. & Terawaki, Y., Jan 1 2000, In : MICROBIOLOGY and IMMUNOLOGY. 44, 11, p. 879-886 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Phage conversion of exfoliative toxin A production in Staphylococcus aureus

Yamaguchi, T., Hayashi, T., Takami, H., Nakasone, K., Ohnishi, M., Nakayama, K., Yamada, S., Komatsuzawa, H. & Sugai, M., Dec 30 2000, In : Molecular Microbiology. 38, 4, p. 694-705 12 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

The R-type pyocin of Pseudomonas aeruginosa is related to P2 phage, and the F-type is related to lambda phage

Nakayama, K., Takashima, K., Ishihara, H., Shinomiya, T., Kageyama, M., Kanaya, S., Ohnishi, M., Murata, T., Mori, H. & Hayashi, T., Nov 16 2000, In : Molecular Microbiology. 38, 2, p. 213-231 19 p.

Research output: Contribution to journalArticle

204 Citations (Scopus)
2001

Association of the urease gene with enterohemorrhagic Escherichia coli strains irrespective of their serogroups

Nakano, M., Iida, T., Ohnishi, M., Kurokawa, K., Takahashi, A., Tsukamoto, T., Yasunaga, T., Hayashi, T. & Honda, T., Dec 17 2001, In : Journal of Clinical Microbiology. 39, 12, p. 4541-4543 3 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Complete genome sequence of enterohemorrhagic Eschelichia coli O157:H7 and genomic comparison with a laboratory strain K-12

Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T. & 2 others, Hattori, M. & Shinagawa, H., Jan 1 2001, In : DNA Research. 8, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

940 Citations (Scopus)

Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C

Yamaguchi, T., Hayashi, T., Takami, H., Ohnishi, M., Murata, T., Nakayama, K., Asakawa, K., Ohara, M., Komatsuzawa, H. & Sugai, M., Dec 5 2001, In : Infection and Immunity. 69, 12, p. 7760-7771 12 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Determination of the whole genome sequence of enterohemorrhagic Escherichia coli O157:H7

Ohnishi, M., Hayashi, T. & Kurokawa, K., Jan 1 2001, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 46, 12, p. 1862-1867 6 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Diversification of Escherichia coli genomes: Are bacteriophages the major contributors?

Ohnishi, M., Kurokawa, K. & Hayashi, T., Oct 1 2001, In : Trends in Microbiology. 9, 10, p. 481-485 5 p.

Research output: Contribution to journalReview article

163 Citations (Scopus)

Diversity and uniqueness of pyocins produced by Pseudomonas aeruginosa

Hayashi, T. & Nakayama, K., Jan 1 2001, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 46, 4 Suppl, p. 341-347 7 p.

Research output: Contribution to journalReview article

DNA inversion in the tail fiber gene alters the host range specificity of carotovoricin Er, a phage-tail-like bacteriocin of phytopathogenic Erwinia carotovora subsp. carotovora Er

Nguyen, H. A., Tomita, T., Hirota, M., Kaneko, J., Hayashi, T. & Kamio, Y., Dec 1 2001, In : Journal of bacteriology. 183, 21, p. 6274-6281 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Molecular and epidemiological study of the first outbreak of vanB type vancomycin-resistant Enterococcus faecalis in Japan

Oana, K., Kawakami, Y., Ohnishi, M., Ishikawa, M., Hirota, M., Tozuka, M., Atarashi, K., Baba, K., Fujiki, K., Okazaki, M., Honda, T. & Hayashi, T., Jun 13 2001, In : Japanese Journal of Infectious Diseases. 54, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Specific protein-DNA and protein-protein interaction in the hig gene system, a plasmid-borne proteic killer gene system of plasmid Rts1

Tian, Q. B., Ohnishi, M., Murata, T., Nakayama, K., Terawaki, Y. & Hayashi, T., Jan 1 2001, In : Plasmid. 45, 2, p. 63-74 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

toxB gene on pO157 of enterohemorrhagic Escherichia coli O157:H7 is required for full epithelial cell adherence phenotype

Tatsuno, I., Horie, M., Abe, H., Miki, T., Makino, K., Shinagawa, H., Taguchi, H., Kamiya, S., Hayashi, T. & Sasakawa, C., Nov 6 2001, In : Infection and Immunity. 69, 11, p. 6660-6669 10 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)
2002

Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan

Yamaguchi, T., Yokota, Y., Terajima, J., Hayashi, T., Aepfelbacher, M., Ohara, M., Komatsuzawa, H., Watanabe, H. & Sugai, M., May 15 2002, In : Journal of Infectious Diseases. 185, 10, p. 1511-1516 6 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)