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Research Output

  • 3233 Citations
  • 31 h-Index
  • 100 Article
  • 3 Review article
  • 2 Chapter
2019
1 Citation (Scopus)

Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts

Shiraki, M., Xu, X., Iovanna, J. L., Kukita, T., Hirata, H., Kamohara, A., Kubota, Y., Miyamoto, H., Mawatari, M. & Kukita, A., Aug 1 2019, In : FASEB Journal. 33, 8, p. 8836-8852 17 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling

Badawy, T., Kyumoto-Nakamura, Y., Uehara, N., Zhang, J., Sonoda, S., Hiura, H., Yamaza, T., Kukita, A. & Kukita, T., Jun 1 2019, In : Laboratory Investigation. 99, 6, p. 866-884 19 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth

Yamaza, H., Tomoda, E., Sonoda, S., Nonaka, K., Kukita, T. & Yamaza, T., Jul 2018, In : Oral Diseases. 24, 5, p. 809-819 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells

Sonoda, S., Mei, Y. F., Atsuta, I., Danjo, A., Yamaza, H., Hama, S., Nishida, K., Tang, R., Kyumoto-Nakamura, Y., Uehara, N., Kukita, T., Nishimura, F. & Yamaza, T., Dec 1 2018, In : Scientific reports. 8, 1, 3419.

Research output: Contribution to journalArticle

4 Citations (Scopus)

IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity: A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1

Shiratori, T., Kyumoto, Y., Kukita, A., Uehara, N., Zhang, J., Koda, K., Kamiya, M., Badawy, T., Tomoda, E., Xu, X., Yamaza, T., Urano, Y., Koyano, K. & Kukita, T., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 218-228 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1 Citation (Scopus)

Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis

Funakubo, N., Xu, X., Kukita, T., Nakamura, S., Miyamoto, H. & Kukita, A., Apr 2018, In : Journal of cellular physiology. 233, 4, p. 3105-3118 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Hama, S., Kyumoto-Nakamura, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., Nov 29 2018, In : Stem Cell Research and Therapy. 9, 1, 334.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017

Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments

Uehara, N., Kukita, A., Kyumoto-Nakamura, Y., Yamaza, T., Yasuda, H. & Kukita, T., Oct 1 2017, In : Laboratory Investigation. 97, 10, p. 1235-1244 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016
1 Citation (Scopus)

Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells

Sonoda, S., Yamaza, H., Ma, L., Tanaka, Y., Tomoda, E., Aijima, R., Nonaka, K., Kukita, T., Shi, S., Nishimura, F. & Yamaza, T., Jan 18 2016, In : Scientific reports. 6, 19286.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2015

Inhibition of RANKL-dependent cellular fusion in pre-osteoclasts by amiloride and a NHE10-specific monoclonal antibody

Mine, Y., Shuto, T., Nikawa, H., Kawai, T., Ohara, M., Kawahara, K., Ohta, K., Kukita, T., Terada, Y. & Makihira, S., Jun 1 2015, In : Cell Biology International. 39, 6, p. 696-709 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Membrane nanotube formation in osteoclastogenesis

Kukita, T., Takahashi, A., Zhang, J. Q. & Kukita, A., Jan 1 2015, In : Methods in Molecular Biology. 1313, p. 193-202 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Membrane nanotube formation in osteoclastogenesis

Kukita, T., takahashi, A., Zhang, J. Q. & Kukita, A., May 6 2015, Cell Fusion: Overviews and Methods: Second Edition. Springer New York, p. 193-202 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Involvement of CXCL14 in osteolytic bone metastasis from lung cancer

Takiguchi, S., Korenaga, N., Inoue, K., Sugi, E., Kataoka, Y., Matsusue, K., Futagami, K., Li, Y. J., Kukita, T., Teramoto, N. & Iguchi, H., Apr 1 2014, In : International journal of oncology. 44, 4, p. 1316-1324 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Involvement of deoxyadenosine and adenosine deaminase in the methotrexate-induced suppression of inflammatory bone destruction

Qu, P. F., Kukita, A., Li, Y. J., Moriyama, K., Lei, L. & Kukita, T., Jan 1 2014, Adenosine Receptors: Pharmacology, Functions and Therapeutic Aspects. Nova Science Publishers, Inc., p. 143-164 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis

Takano, T., Li, Y. J., Kukita, A., Yamaza, T., Ayukawa, Y., Moriyama, K., Uehara, N., Nomiyama, H., Koyano, K. & Kukita, T., Mar 1 2014, In : Laboratory Investigation. 94, 3, p. 286-296 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Regulation of osteoclastogenesis through Tim-3: Possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction

Moriyama, K., Kukita, A., Li, Y. J., Uehara, N., Zhang, J. Q., Takahashi, I. & Kukita, T., Nov 5 2014, In : Laboratory Investigation. 94, 11, p. 1200-1211 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

Adenosine blocks aminopterin-induced suppression of osteoclast differentiation

Teramachi, J., Kukita, A., Qu, P., Wada, N., Li, Y. J., Nakamura, S. & Kukita, T., Jan 1 2013, In : Journal of Bone and Mineral Metabolism. 31, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Immune therapeutic potential of stem cells from human supernumerary teeth

Makino, Y., Yamaza, H., Akiyama, K., Ma, L., Hoshino, Y., Nonaka, K., Terada, Y., Kukita, T., Shi, S. & Yamaza, T., Jul 1 2013, In : Journal of Dental Research. 92, 7, p. 609-615 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis

Kukita, A. & Kukita, T., Nov 1 2013, In : Future Oncology. 9, 11, p. 1609-1622 14 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

Tunneling nanotube formation is essential for the regulation of osteoclastogenesis

takahashi, A., Kukita, A., Li, Y. J., Zhang, J. Q., Nomiyama, H., Yamaza, T., Ayukawa, Y., Koyano, K. & Kukita, T., Jun 1 2013, In : Journal of Cellular Biochemistry. 114, 6, p. 1238-1247 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2012

Characterization and Identification of Subpopulations of Mononuclear Preosteoclasts Induced by TNF-α in Combination with TGF-β in Rats

Matsubara, R., Kukita, T., Ichigi, Y., Takigawa, I., Qu, P. F., Funakubo, N., Miyamoto, H., Nonaka, K. & Kukita, A., Oct 24 2012, In : PloS one. 7, 10, e47930.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine

Ma, L., Makino, Y., Yamaza, H., Akiyama, K., Hoshino, Y., Song, G., Kukita, T., Nonaka, K., Shi, S. & Yamaza, T., Dec 14 2012, In : PloS one. 7, 12, e51777.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Infection of RANKL-primed RAW-D macrophages with porphyromonas gingivalis promotes osteoclastogenesis in a TNF-α-independent manner

Kukita, A., Ichigi, Y., Takigawa, I., Watanabe, T., Kukita, T. & Miyamoto, H., Jun 18 2012, In : PloS one. 7, 6, e38500.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats

Li, Y. J., Kukita, A., Watanabe, T., Takano, T., Qu, P., Sanematsu, K., Ninomiya, Y. & Kukita, T., Dec 1 2012, In : Laboratory Investigation. 92, 12, p. 1777-1787 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2011

Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis

Teramachi, J., Kukita, A., Li, Y. J., Ushijima, Y., Ohkuma, H., Wada, N., Watanabe, T., Nakamura, S. & Kukita, T., May 1 2011, In : Laboratory Investigation. 91, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo

Kukita, A., Kukita, T., Nagata, K., Teramachi, J., Li, Y. J., Yoshida, H., Miyamoto, H., Gay, S., Pessler, F. & Shobuike, T., Sep 1 2011, In : Arthritis and rheumatism. 63, 9, p. 2744-2754 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2010

Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss

Wu, Z., Ma, H. M., Kukita, T., Nakanishi, Y. & Nakanishi, H., Mar 15 2010, In : Journal of Immunology. 184, 6, p. 3191-3201 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2009

A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats

Li, Y. J., Kukita, A., Teramachi, J., Nagata, K., Wu, Z., Akamine, A. & Kukita, T., Jan 1 2009, In : Laboratory Investigation. 89, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Liu, J., Shiono, J., Shimizu, K., Kukita, A., Kukita, T. & Kondo, R., Apr 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 8, p. 2154-2157 4 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
25 Citations (Scopus)

Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

Miyamoto, I., Liu, J., Shimizu, K., Sato, M., Kukita, A., Kukita, T. & Kondo, R., Jan 5 2009, In : European Journal of Pharmacology. 602, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2008

Adiponectin inhibits induction of TNF-α/RANKL-stimulated NFATc1 via the AMPK signaling

Yamaguchi, N., Kukita, T., Li, Y. J., Kamio, N., Fukumoto, S., Nonaka, K., Ninomiya, Y., Hanazawa, S. & Yamashita, Y., Feb 6 2008, In : FEBS Letters. 582, 3, p. 451-456 6 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2007

Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans

Yamaguchi, N., Kukita, T., Li, Y. J., Martinez Argueta, J. G., Saito, T., Hanazawa, S. & Yamashita, Y., Feb 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2006

Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: Successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats

Quan, Y. T., Kukita, T., Ushijima, Y., Kukita, A., Nagata, K., Sandra, F., Watanabe, T., Toh, K., Okuma, Y., Kawasaki, S., Rasubala, L., Teramachi, J., Miyamoto, I., Wu, Z. & Iijima, T., Mar 1 2006, In : Histochemistry and Cell Biology. 125, 3, p. 215-225 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
75 Citations (Scopus)
2005

Ameloblastoma induces osteoclastogenesis: A possible role of ameloblastoma in expanding in the bone

Sandra, F., Hendarmin, L., Kukita, T., Nakao, Y., Nakamura, N. & Nakamura, S., Jul 1 2005, In : Oral Oncology. 41, 6, p. 637-644 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of genes differentially expressed in osteoclast-like cells

Nomiyama, H., Egami, K., Wada, N., Tou, K., Horiuchi, M., Matsusaki, H., Miura, R., Yoshie, O. & Kukita, T., Apr 1 2005, In : Journal of Interferon and Cytokine Research. 25, 4, p. 227-231 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-β production

Nakamura, T., Kukita, T., Shobuike, T., Nagata, K., Take, H., Ogawa, K., Hotokebuchi, T., Kohashi, O. & Kukita, A., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5809-5816 8 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines

Ohishi, M., Matsumura, Y., Aki, D., Mashima, R., Taniguchi, K., Kobayashi, T., Kukita, T., Iwamoto, Y. & Yoshimura, A., Mar 1 2005, In : Journal of Immunology. 174, 5, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2004

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-requlated osteoclast differentiation

Ikeda, F., Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J. I., Reddy, S. V., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., Kukita, T., Yoshioka, K., Rao, A. & Yoneda, T., Aug 1 2004, In : Journal of Clinical Investigation. 114, 4, p. 475-484 10 p.

Research output: Contribution to journalArticle

342 Citations (Scopus)

Direct stimulation of osteoclastogenesis by MIP-1α: Evidence obtained from studies using RAW264 cell clone highly responsive to RANKL

Watanabe, T., Kukita, T., Kukita, A., Wada, N., Toh, K., Nagata, K., Nomiyama, H. & Iijima, T., Jan 1 2004, In : Journal of Endocrinology. 180, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
6 Citations (Scopus)

Possible involvement of MIP-1α in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis

Toh, K., Kukita, T., Wu, Z., Kukita, A., Sandra, F., Tang, Q. Y., Nomiyama, H. & Iijima, T., Sep 1 2004, In : Laboratory Investigation. 84, 9, p. 1092-1102 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

RANKL-induced DC-STAMP is essential for osteoclastogenesis

Kukita, T., Wada, N., Kukita, A., Kakimoto, T., Sandra, F., Toh, K., Nagata, K., Iijima, T., Horiuchi, M., Matsusaki, H., Hieshima, K., Yoshie, O. & Nomiyama, H., Oct 4 2004, In : Journal of Experimental Medicine. 200, 7, p. 941-946 6 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)
2003

Extremely high expression of β-actin mRNA in osteoclasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newborn rats

Kukita, T., Kukita, A., Xu, L., Toh, K., Tang, Q., Nomiyama, H. & Iijima, T., Dec 1 2003, In : Journal of Electron Microscopy. 52, 6, p. 545-550 6 p.

Research output: Contribution to journalArticle

Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages

Rahman, M., Kukita, A., Kukita, T., Shobuike, T., Nakamura, T. & Kohashi, O., May 1 2003, In : Blood. 101, 9, p. 3451-3459 9 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)
2002

Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells

Sakai, H., Jingushi, S., Shuto, T., Urabe, K., Ikenoue, T., Okazaki, K., Kukita, T., Kukita, A. & Iwamoto, Y., Jan 1 2002, In : Annals of the Rheumatic Diseases. 61, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)