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Research Output 1994 2019

  • 714 Citations
  • 18 h-Index
  • 28 Article
  • 1 Letter
  • 1 Review article
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Article
2019

Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α

Higuchi, Y., Niidome, T., Miyamoto, Y., Komohara, Y., Tokunou, T., Kubota, T. & Horiuchi, T., Mar 15 2019, In : Heart and Vessels. 34, 3, p. 538-544 7 p.

Research output: Contribution to journalArticle

Gold
Transgenic Mice
Nanoparticles
Hypertrophy
Weights and Measures
2018

Cardiac sarcoidosis concomitant with large-vessel aortitis detected by 18F-fluorodeoxyglucose positron emission tomography

Higuchi, Y., kimoto, Y., Tanoue, R., Tokunou, T., Tomonari, K., Maeda, T. & Horiuchi, T., Jan 1 2018, In : Internal Medicine. 57, 11, p. 1601-1604 4 p.

Research output: Contribution to journalArticle

Aortitis
Fluorodeoxyglucose F18
Sarcoidosis
Positron-Emission Tomography
Immunosuppressive Agents
2016
10 Citations (Scopus)

FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction

Makino, N., Oyama, J., Maeda, T., Koyanagi, M., Higuchi, Y., Shimokawa, I., Mori, N. & Furuyama, T., Jan 1 2016, In : Molecular and cellular biochemistry. 412, 1-2, p. 119-130 12 p.

Research output: Contribution to journalArticle

Telomere
Telomerase
Genes
Forkhead Transcription Factors
Echocardiography
2015
10 Citations (Scopus)

Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts

Makino, N., Oyama, J. I., Maeda, T., Koyanagi, M., Higuchi, Y. & Tsuchida, K., May 1 2015, In : Molecular and cellular biochemistry. 403, 1-2

Research output: Contribution to journalArticle

Caloric Restriction
Telomerase
Autophagy
Rats
Inbred OLETF Rats
2012
22 Citations (Scopus)

Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease

Maeda, T., Guan, J. Z., Koyanagi, M., Higuchi, Y. & Makino, N., Jun 1 2012, In : Journal of Neurogenetics. 26, 2, p. 245-251 7 p.

Research output: Contribution to journalArticle

Telomere
Parkinson Disease
Methylation
Leukocytes
Chromosome Structures
9 Citations (Scopus)
Telomerase
Left Ventricular Hypertrophy
Fever
Salts
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
9 Citations (Scopus)
Protein S
Anticoagulants
Myocardium
Up-Regulation
Plasminogen Activator Inhibitor 1
2011
25 Citations (Scopus)

Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice

Makino, N., Maeda, T., Oyama, J. I., Sasaki, M., Higuchi, Y., Mimori, K. & Shimizu, T., Apr 1 2011, In : Journal of Molecular and Cellular Cardiology. 50, 4, p. 670-677 8 p.

Research output: Contribution to journalArticle

Telomerase
Superoxide Dismutase
Antioxidants
Telomere
Therapeutics
2 Citations (Scopus)

The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events

Maeda, T., Oyama, J. I., Higuchi, Y., Koyanagi, M., Sasaki, M., Arima, T., Mimori, K. & Makino, N., Mar 1 2011, In : Aging Male. 14, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Telomere
Leukocytes
Bilirubin
Outpatients
5 Citations (Scopus)

The physical ability of Japanese female elderly with cerebrovascular disease correlates with the telomere length and subtelomeric methylation status in their peripheral blood leukocytes

Maeda, T., Oyama, J. I., Higuchi, Y., Nishiyama, Y., Kudo, Y., Yamori, T., Nakazono, T., Arima, T., Mimori, K. & Makino, N., Feb 1 2011, In : Gerontology. 57, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Disorders
Telomere
Methylation
Leukocytes
Patient Admission
2010
42 Citations (Scopus)

Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers

Oyama, J. I., Maeda, T., Kouzuma, K., Ochiai, R., Tokimitsu, I., Higuchi, Y., Sugano, M. & Makino, N., Mar 1 2010, In : Circulation Journal. 74, 3, p. 578-588 11 p.

Research output: Contribution to journalArticle

Catechin
Tea
Forearm
Nitroprusside
Acetylcholine
22 Citations (Scopus)

Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers

Oyama, J. I., Maeda, T., Sasaki, M., Kozuma, K., Ochiai, R., Tokimitsu, I., Taguchi, S., Higuchi, Y. & Makino, N., Dec 10 2010, In : Internal Medicine. 49, 23, p. 2553-2559 7 p.

Research output: Contribution to journalArticle

Catechin
Tea
Forearm
Blood Vessels
Anti-Inflammatory Agents
3 Citations (Scopus)
Metabolic Brain Diseases
Telomere
Brain Infarction
Inpatients
Leukocytes
2009
22 Citations (Scopus)

Age-related changes in subtelomeric methylation in the normal Japanese population

Maeda, T., Jing, Z. G., Oyama, J. I., Higuchi, Y. & Makino, N., Apr 1 2009, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 64, 4, p. 426-434 9 p.

Research output: Contribution to journalArticle

Telomere
Methylation
Population
Blood Cells
Cell Aging
43 Citations (Scopus)

Aging-associated alteration of subtelomeric methylation in Parkinson's disease

Maeda, T., Guan, J. Z., Oyama, J. I., Higuchi, Y. & Makino, N., Sep 1 2009, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 64, 9, p. 949-955 7 p.

Research output: Contribution to journalArticle

Telomere
Methylation
Parkinson Disease
Telomere Shortening
Leukocytes
24 Citations (Scopus)

Aging-related alterations of subtelomeric methylation in sarcoidosis patients

Maeda, T., Jing, Z. G., Higuchi, Y., Oyama, J. I. & Makino, N., Jul 1 2009, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 64, 7, p. 752-760 9 p.

Research output: Contribution to journalArticle

Telomere
Sarcoidosis
Methylation
Telomere Shortening
DNA Methylation
20 Citations (Scopus)

Diagonal earlobe crease are associated with shorter telomere in male japanese patients with metabolic syndrome -A pilot study-

Higuchi, Y., Maeda, T., Guan, J. Z., Oyama, J., Sugano, M. & Makino, N., Feb 10 2009, In : Circulation Journal. 73, 2, p. 274-279 6 p.

Research output: Contribution to journalArticle

Telomere
Cardiovascular Diseases
Atherosclerosis
Premature Aging
Telomere Shortening
35 Citations (Scopus)
Inbred OLETF Rats
Peroxisome Proliferator-Activated Receptors
Telomerase
Insulin Resistance
pioglitazone
2008
58 Citations (Scopus)

A percentage analysis of the telomere length in Parkinson's disease patients

Jing, Z. G., Maeda, T., Sugano, M., Oyama, J. I., Higuchi, Y., Suzuki, T. & Makino, N., May 1 2008, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 63, 5, p. 467-473 7 p.

Research output: Contribution to journalArticle

Telomere
Parkinson Disease
Telomere Shortening
Oxidative Stress
Leukocytes
2007
33 Citations (Scopus)

A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction

Funakoshi, H., Zacharia, L. C., Tang, Z., Zhang, J., Lee, L. L., Good, J. C., Herrmann, D. E., Higuchi, Y., Koch, W. J., Jackson, E. K., Chan, T. O. & Feldman, A. M., May 1 2007, In : Circulation. 115, 17, p. 2307-2315 9 p.

Research output: Contribution to journalArticle

Adenosine A1 Receptors
Left Ventricular Dysfunction
Adenosine
Up-Regulation
Purinergic P1 Receptors
25 Citations (Scopus)

An analysis of telomere length in sarcoidosis

Jing, Z. G., Maeda, T., Sugano, M., Oyama, J. I., Higuchi, Y., Suzuki, T. & Makino, N., Nov 1 2007, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 62, 11, p. 1199-1203 5 p.

Research output: Contribution to journalArticle

Telomere
Sarcoidosis
Age of Onset
42 Citations (Scopus)

Change in the telomere length distribution with age in the Japanese population

Guan, J. Z., Maeda, T., Sugano, M., Oyama, J. I., Higuchi, Y. & Makino, N., Oct 1 2007, In : Molecular and Cellular Biochemistry. 304, 1-2, p. 353-360 8 p.

Research output: Contribution to journalArticle

Age Distribution
Telomere
Aging of materials
Population
Tissue
2006
44 Citations (Scopus)

Cardioprotection afforded by NF-κB ablation is associated with activation of Akt in mice overexpressing TNF-α

Higuchi, Y., Chan, T. O., Brown, M. A., Zhang, J., DeGeorge, B. R., Funakoshi, H., Gibson, G., McTiernan, C. F., Kubota, T., Jones, W. K. & Feldman, A. M., Feb 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 2

Research output: Contribution to journalArticle

Phosphorylation
Proto-Oncogene Proteins c-akt
Tumor Necrosis Factor Receptors
Transgenes
Cardiomyopathies
2004
41 Citations (Scopus)

Gene expression profiling during the transition to failure in TNF-α over-expressing mice demonstrates the development of autoimmune myocarditis

Tang, Z., McGowan, B. S., Huber, S. A., McTiernan, C. F., Addya, S., Surrey, S., Kubota, T., Fortina, P., Higuchi, Y., Diamond, M. A., Wyre, D. S. & Feldman, A. M., Apr 1 2004, In : Journal of Molecular and Cellular Cardiology. 36, 4, p. 515-530 16 p.

Research output: Contribution to journalArticle

Myocarditis
Gene Expression Profiling
Myocardium
B-Lymphocytes
Phenotype
33 Citations (Scopus)

Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model

Janczewski, A. M., Zahid, M., Lemster, B. H., Frye, C. S., Gibson, G., Higuchi, Y., Kranias, E. G., Feldman, A. M. & McTiernan, C. F., Jun 1 2004, In : Cardiovascular research. 62, 3, p. 468-480 13 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Heart Failure
Calcium
Genes
Sarcoplasmic Reticulum
105 Citations (Scopus)

Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice with Tumor Necrosis Factor-α-Induced Cardiomyopathy

Higuchi, Y., McTiernan, C. F., Frye, C. B., McGowan, B. S., Chan, T. O. & Feldman, A. M., Apr 20 2004, In : Circulation. 109, 15, p. 1892-1897 6 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type II
Cardiomyopathies
Transgenic Mice
Tumor Necrosis Factor-alpha
Receptors, Tumor Necrosis Factor, Type I
1996
22 Citations (Scopus)

CPA induces a sustained increase in [Ca2+](i) of endothelial cells in situ and relaxes porcine coronary artery

Higuchi, Y., Nishimura, J., Kobayashi, S. & Kanaide, H., Jun 1 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 270, 6 39-6

Research output: Contribution to journalArticle

Coronary Vessels
Swine
Endothelial Cells
Endothelium
Arginine
1994
5 Citations (Scopus)
Motilin
Endothelial cells
Endothelium
Smooth Muscle
Muscle