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Research Output 2000 2019

  • 291 Citations
  • 11 h-Index
  • 23 Article
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Article
2019
1 Citation (Scopus)

Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., May 1 2019, In : Journal of Endodontics. 45, 5, p. 591-598.e6

Research output: Contribution to journalArticle

Aspirin
Stem Cells
Tooth Root
NFI Transcription Factors
Small Interfering RNA

Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling

Badawy, T., Kyumoto, Y., Uehara, N., Zhang, J., Sonoda, S., Hiura, H., Yamaza, T., Kukita, A. & Kukita, T., Jun 1 2019, In : Laboratory Investigation. 99, 6, p. 866-884 19 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoclasts
Surface Antigens
Osteoblasts
Antigens
2018
4 Citations (Scopus)

Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells

Sonoda, S., Mei, Y. F., Ikiru, A., Danjo, A., Yamaza, H., Hama, S., Nishida, K., Tang, R., Kyumoto, Y., Uehara, N., Kukita, T., Nishimura, F. & Yamaza, T., Dec 1 2018, In : Scientific reports. 8, 1, 3419.

Research output: Contribution to journalArticle

Dental Pulp
Nitric Oxide
Stem Cells
Odontoblasts
Dentin
5 Citations (Scopus)

IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity: A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1

Shiratori, T., Kyumoto, Y., Kukita, A., Uehara, N., Zhang, J., Koda, K., Kamiya, M., Badawy, T., Tomoda, E., Xu, X., Yamaza, T., Urano, Y., Koyano, K. & Kukita, T., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 218-228 11 p.

Research output: Contribution to journalArticle

Talin
Osteoclasts
Interleukin-1
Bone and Bones
Confocal Microscopy
4 Citations (Scopus)

Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Hama, S., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., Nov 29 2018, In : Stem Cell Research and Therapy. 9, 1, 334.

Research output: Contribution to journalArticle

Sirolimus
Stem cells
Signal Transduction
Stem Cells
1-Phosphatidylinositol 4-Kinase
2017

Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments

Uehara, N., Kukita, A., Kyumoto, Y., Yamaza, T., Yasuda, H. & Kukita, T., Oct 1 2017, In : Laboratory Investigation. 97, 10, p. 1235-1244 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteogenesis
Bone and Bones
Laminin
Osteoclasts
1 Citation (Scopus)

The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes

Park, G., Horie, T., Kanayama, T., Fukasawa, K., Iezaki, T., Onishi, Y., Ozaki, K., Kyumoto, Y., Yoneda, Y., Takarada, T. & Hinoi, E., Mar 1 2017, In : FEBS Journal. 284, 5, p. 784-795 12 p.

Research output: Contribution to journalArticle

Brown Adipocytes
Adrenergic Agents
Interferons
Modulators
Gene expression
2016
1 Citation (Scopus)
Antisense RNA
Wilms Tumor
Osteoclasts
Osteogenesis
Proteins
12 Citations (Scopus)

The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption

Iezaki, T., Onishi, Y., Ozaki, K., Fukasawa, K., Takahata, Y., Kyumoto, Y., Fujikawa, K., Takarada, T., Yoneda, Y., Yamashita, Y., Shioi, G. & Hinoi, E., Mar 1 2016, In : Journal of Bone and Mineral Research. 31, 3, p. 573-584 12 p.

Research output: Contribution to journalArticle

Bone Resorption
Osteoblasts
Osteogenesis
Interferons
Catenins
9 Citations (Scopus)

Transcriptional modulator Ifrd1 regulates osteoclast differentiation through enhancing the NF-κB/NFATc1 pathway

Iezaki, T., Fukasawa, K., Park, G., Horie, T., Kanayama, T., Ozaki, K., Onishi, Y., Takahata, Y., Kyumoto, Y., Takarada, T., Yoneda, Y., Nakamura, T., Vacher, J. & Hinoi, E., Jan 1 2016, In : Molecular and cellular biology. 36, 19, p. 2451-2463 13 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Osteoclasts
Interferons
Bone and Bones
Osteogenesis
2014
28 Citations (Scopus)

Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure

Hinoi, E., Kyumoto, Y., Takada, S., Fujita, H., Iezaki, T., Hashizume, S., Takahashi, S., Odaka, Y., Watanabe, T. & Yoneda, Y., Jan 1 2014, In : Diabetes. 63, 1, p. 162-175 14 p.

Research output: Contribution to journalArticle

Growth Differentiation Factor 5
Adipogenesis
Energy Metabolism
Bone Morphogenetic Protein Receptors
Obesity
2013
20 Citations (Scopus)

Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia

Kyumoto, Y., Hinoi, E., Iezaki, T., Takada, S., Hashizume, S., Takahata, Y., Tsuruta, E., Takahashi, S. & Yoneda, Y., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1117-1128 12 p.

Research output: Contribution to journalArticle

Catenins
Adipogenesis
Adipocytes
Acetates
3T3-L1 Cells
2012
8 Citations (Scopus)

Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts

Takarada, T., Takarada-Iemata, M., Takahata, Y., Yamada, D., Yamamoto, T., Kyumoto, Y., Hinoi, E. & Yoneda, Y., Oct 1 2012, In : Journal of cellular physiology. 227, 10, p. 3477-3487 11 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteogenesis
Serine
Osteoclasts
Amino Acid Transport Systems
12 Citations (Scopus)

Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4

Takahata, Y., Hinoi, E., Takarada, T., Kyumoto, Y., Ogawa, S. & Yoneda, Y., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33293-33303 11 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
Aminobutyrates
Chondrogenesis
Chondrocytes
Hedgehogs
2011
16 Citations (Scopus)

A negative correlation between expression profiles of runt-related transcription factor-2 and cystine/glutamate antiporter xCT subunit in ovariectomized mouse bone

Uno, K., Takarada, T., Kyumoto, Y., Fujita, H., Hinoi, E. & Yoneda, Y., Mar 24 2011, In : Journal of Pharmacological Sciences. 115, 3, p. 309-319 11 p.

Research output: Contribution to journalArticle

Antiporters
Cystine
Core Binding Factor Alpha 1 Subunit
Glutamic Acid
Transcription Factors
19 Citations (Scopus)

Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells.

Takarada-Iemata, M., Takarada, T., Kyumoto, Y., Nakatani, E., Hori, O. & Yoneda, Y., Jan 1 2011, In : Journal of cellular physiology. 226, 3, p. 652-665 14 p.

Research output: Contribution to journalArticle

Antiporters
Adipogenesis
Cystine
Stem cells
Mesenchymal Stromal Cells
6 Citations (Scopus)

Negative regulation of osteoblastogenesis through downregulation of runt-related transcription factor-2 in osteoblastic MC3T3-E1 cells with stable overexpression of the cystine/glutamate antiporter xCT subunit

Uno, K., Takarada, T., Takarada-Iemata, M., Nakamura, Y., Fujita, H., Hinoi, E. & Yoneda, Y., Nov 1 2011, In : Journal of cellular physiology. 226, 11, p. 2953-2964 12 p.

Research output: Contribution to journalArticle

Antiporters
Cystine
Glutamic Acid
Transcription Factors
Down-Regulation
19 Citations (Scopus)

Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone

Takahata, Y., Takarada, T., Hinoi, E., Kyumoto, Y., Fujita, H. & Yoneda, Y., Sep 23 2011, In : Journal of Biological Chemistry. 286, 38, p. 32906-32917 12 p.

Research output: Contribution to journalArticle

Aminobutyrates
Osteoblasts
Cytoplasmic and Nuclear Receptors
Osteogenesis
Bone Morphogenetic Protein 2
13 Citations (Scopus)

Positive regulation by GABAbR1 subunit of leptin expression through gene transactivation in adipocytes

Nakamura, Y., Hinoi, E., Takarada, T., Takahata, Y., Yamamoto, T., Fujita, H., Takada, S., Hashizume, S. & Yoneda, Y., Jun 6 2011, In : PloS one. 6, 5, e20167.

Research output: Contribution to journalArticle

transcriptional activation
Leptin
leptin
adipocytes
Adipocytes
2009
25 Citations (Scopus)

Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes

Kyumoto, Y., Takarada, T., Kodama, A., Hinoi, E. & Yoneda, Y., Jun 22 2009, In : Journal of Pharmacological Sciences. 109, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

Tacrolimus
Chondrocytes
Alcian Blue
Alkaline Phosphatase
Transcription Factors
2008
13 Citations (Scopus)

Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine

Takahata, Y., Takarada, T., Osawa, M., Hinoi, E., Kyumoto, Y. & Yoneda, Y., Jul 1 2008, In : Cell and tissue research. 333, 1, p. 91-103 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Chondrocytes
Glycine
N-Methyl-D-Aspartate Receptors
Glycine Plasma Membrane Transport Proteins
2001
74 Citations (Scopus)

Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts

Hinoi, E., Fujimori, S., Kyumoto, Y. & Yoneda, Y., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 281, 2, p. 341-346 6 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Osteoblasts
Rats
Glutamic Acid
Messenger RNA
2000
1 Citation (Scopus)

Regulating factors for microglial activation

Nakamura, Y., 2000, In : Seikagaku. The Journal of Japanese Biochemical Society. 72, 6, p. 465-468 4 p.

Research output: Contribution to journalArticle

Chemical activation