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Research Output

2019

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

Nakano, M., Kikushige, Y., Miyawaki, K., Kunisaki, Y., Mizuno, S., Takenaka, K., Tamura, S., Okumura, Y., Ito, M., Ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Baba, E. & Akashi, K., Feb 7 2019, In : Oncogene. 38, 6, p. 780-793 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Pericytes in bone marrow

Kunisaki, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 101-114 14 p. (Advances in Experimental Medicine and Biology; vol. 1122).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., Dec 1 2019, In : Nature communications. 10, 1, 1072.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018
2 Citations (Scopus)
2017

Differential cytokine contributions of perivascular haematopoietic stem cell niches

Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N. F., Birbrair, A., Ma'ayan, A. & Frenette, P. S., Mar 1 2017, In : Nature Cell Biology. 19, 3, p. 214-223 10 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Miyawaki, K., Iwasaki, H., Jiromaru, T., Kusumoto, H., Yurino, A., Sugio, T., Uehara, Y., Odawara, J., Daitoku, S., Kunisaki, Y., Mori, Y., Arinobu, Y., Tsuzuki, H., Kikushige, Y., Iino, T., Kato, K., Takenaka, K., Miyamoto, T., Maeda, T. & Akashi, K., Jun 22 2017, In : Blood. 129, 25, p. 3332-3343 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2016

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations

Yurino, A., Takenaka, K., Yamauchi, T., Nunomura, T., Uehara, Y., Jinnouchi, F., Miyawaki, K., Kikushige, Y., Kato, K., Miyamoto, T., Iwasaki, H., Kunisaki, Y. & Akashi, K., Sep 13 2016, In : Stem Cell Reports. 7, 3, p. 425-438 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Fetal liver hematopoietic stem cell niches associate with portal vessels

Khan, J. A., Mendelson, A., Kunisaki, Y., Birbrair, A., Kou, Y., Arnal-Estapé, A., Pinho, S., Ciero, P., Nakahara, F., Ma'ayan, A., Bergman, A., Merad, M. & Frenette, P. S., Jan 1 2016, In : Science. 351, 6269, p. 176-180 5 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)
2015

Cancer stem cells and the niches

Kunisaki, Y., May 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, 5, p. 739-744 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Distinct vascular niches determine hematopoietic stem cell fate

Kunisaki, Y., Jun 1 2015, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 6, p. 606-613 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J. E., Scheiermann, C., Merad, M. & Frenette, P. S., Sep 24 2015, In : Nature. 525, 7570, p. 528-532 5 p.

Research output: Contribution to journalArticle

226 Citations (Scopus)

The hematopoietic stem cell niche

Kunisaki, Y., Oct 1 2015, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 10, p. 1888-1893 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2014

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell Niche

Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U. & Frenette, P. S., Jan 1 2014, In : Cell stem cell. 15, 3, p. 365-375 11 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Influences of vascular niches on hematopoietic stem cell fate

Kunisaki, Y. & Frenette, P. S., Jun 2014, In : International journal of hematology. 99, 6, p. 699-705 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

Bruns, I., Lucas, D., Pinho, S., Ahmed, J., Lambert, M. P., Kunisaki, Y., Scheiermann, C., Schiff, L., Poncz, M., Bergman, A. & Frenette, P. S., Nov 1 2014, In : Nature medicine. 20, 11, p. 1315-1320 6 p.

Research output: Contribution to journalArticle

238 Citations (Scopus)

Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development

Mizoguchi, T., Pinho, S., Ahmed, J., Kunisaki, Y., Hanoun, M., Mendelson, A., Ono, N., Kronenberg, H. M. & Frenette, P. S., May 12 2014, In : Developmental Cell. 29, 3, p. 340-349 10 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)
2013

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., Mar, J. C., Bergman, A. & Frenette, P. S., Oct 10 2013, In : Nature. 502, 7473, p. 637-643 7 p.

Research output: Contribution to journalArticle

542 Citations (Scopus)

CD169 + macrophages provide a niche promoting erythropoiesis under homeostasis and stress

Chow, A., Huggins, M., Ahmed, J., Hashimoto, D., Lucas, D., Kunisaki, Y., Pinho, S., Leboeuf, M., Noizat, C., Van Rooijen, N., Tanaka, M., Zhao, Z. J., Bergman, A., Merad, M. & Frenette, P. S., Apr 1 2013, In : Nature medicine. 19, 4, p. 429-436 8 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

Lucas, D., Scheiermann, C., Chow, A., Kunisaki, Y., Bruns, I., Barrick, C., Tessarollo, L. & Frenette, P. S., Jun 1 2013, In : Nature medicine. 19, 6, p. 695-703 9 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Circadian control of the immune system

Scheiermann, C., Kunisaki, Y. & Frenette, P. S., Mar 1 2013, In : Nature Reviews Immunology. 13, 3, p. 190-198 9 p.

Research output: Contribution to journalReview article

354 Citations (Scopus)

PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

Pinho, S., Lacombe, J., Hanoun, M., Mizoguchi, T., Bruns, I., Kunisaki, Y. & Frenette, P. S., Jul 1 2013, In : Journal of Experimental Medicine. 210, 7, p. 1351-1367 17 p.

Research output: Contribution to journalArticle

226 Citations (Scopus)

XRhythmic modulation of the hematopoietic niche through neutrophil clearance

Casanova-Acebes, M., Pitaval, C., Weiss, L. A., Nombela-Arrieta, C., Chèvre, R., A-González, N., Kunisaki, Y., Zhang, D., Van Rooijen, N., Silberstein, L. E., Weber, C., Nagasawa, T., Frenette, P. S., Castrillo, A. & Hidalgo, A., May 23 2013, In : Cell. 153, 5, 1 p.

Research output: Contribution to journalArticle

242 Citations (Scopus)
2012

Adrenergic nerves govern circadian leukocyte recruitment to tissues

Scheiermann, C., Kunisaki, Y., Lucas, D., Chow, A., Jang, J. E., Zhang, D., Hashimoto, D., Merad, M. & Frenette, P. S., Aug 24 2012, In : Immunity. 37, 2, p. 290-301 12 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

Norepinephrine reuptake inhibition promotes mobilization in mice: Potential impact to rescue low stem cell yields

Lucas, D., Bruns, I., Battista, M., Mendez-Ferrer, S., Magnon, C., Kunisaki, Y. & Frenette, P. S., Apr 19 2012, In : Blood. 119, 17, p. 3962-3965 4 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion

Kunisaki, Y. & Frenette, P. S., Jun 1 2012, In : Nature medicine. 18, 6, p. 864-865 2 p.

Research output: Contribution to journalComment/debate

24 Citations (Scopus)
2011

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

Hashimoto, D., Chow, A., Greter, M., Saenger, Y., Kwan, W. H., Leboeuf, M., Ginhoux, F., Ochando, J. C., Kunisaki, Y., van Rooijen, N., Liu, C., Teshima, T., Heeger, P. S., Stanley, E. R., Frenette, P. S. & Merad, M., May 1 2011, In : Journal of Experimental Medicine. 208, 5, p. 1069-1082 14 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2010

Neutrophil microdomains: Linking heterocellular interactions with vascular injury

Scheiermann, C., Kunisaki, Y., Jang, J. E. & Frenette, P. S., Jan 1 2010, In : Current Opinion in Hematology. 17, 1, p. 25-30 6 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)
2007

Marked improvement of cardiac function early after non-myeloablative BMT in a heavily transfused patient with severe aplastic anemia and heart failure [1]

Kunisaki, Y., Takase, K., Miyamoto, T., Fukata, M., Nonami, A., Kamezaki, K., Kaji, Y., Gondo, H., Harada, M. & Nagafuji, K., Sep 1 2007, In : Bone Marrow Transplantation. 40, 6, p. 593-595 3 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Successful treatment of primary plasma cell leukaemia by allogeneic stem cell transplantation from haploidentical sibling

Nonami, A., Miyamoto, T., Kuroiwa, M., Kunisaki, Y., Kamezaki, K., Takenaka, K., Harada, N., Teshima, T., Harada, M. & Nagafuji, K., Dec 1 2007, In : Japanese journal of clinical oncology. 37, 12, p. 969-972 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2

Tanaka, Y., Hamano, S., Gotoh, K., Murata, Y., Kunisaki, Y., Nishikimi, A., Takii, R., Kawaguchi, M., Inayoshi, A., Masuko, S., Himeno, K., Sasazuki, T. & Fukui, Y., Oct 1 2007, In : Nature Immunology. 8, 10, p. 1067-1075 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Toxoplasmosis encephalitis following severe graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation: 17 Yr experience in Fukuoka BMT group

Matsuo, Y., Takeishi, S., Miyamoto, T., Nonami, A., Kikushige, Y., Kunisaki, Y., Kamezaki, K., Tu, L., Hisaeda, H., Takenaka, K., Harada, N., Kamimura, T., Ohno, Y., Eto, T., Teshima, T., Gondo, H., Harada, M. & Nagafuji, K., Oct 1 2007, In : European Journal of Haematology. 79, 4, p. 317-321 5 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2006

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Kunisaki, Y., Nishikimi, A., Tanaka, Y., Takii, R., Noda, M., Inayoshi, A., Watanabe, K. I., Sanematsu, F., Sasazuki, T., Sasaki, T. & Fukui, Y., Aug 28 2006, In : Journal of Cell Biology. 174, 5, p. 647-652 6 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

DOCK2 is required in T cell precursors for development of Vα14 NK T cells

Kunisaki, Y., Tanaka, Y., Sanui, T., Inayoshi, A., Noda, M., Nakayama, T., Harada, M., Taniguchi, M., Sasazuki, T. & Fukui, Y., Apr 15 2006, In : Journal of Immunology. 176, 8, p. 4640-4645 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2005

Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

Jiang, H., Pan, F., Erickson, L. M., Jang, M. S., Sanui, T., Kunisaki, Y., Sasazuki, T., Kobayashi, M. & Fukui, Y., Oct 17 2005, In : Journal of Experimental Medicine. 202, 8, p. 1121-1130 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2004

Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor

Kunisaki, Y., Masuko, S., Noda, M., Inayoshi, A., Sanui, T., Harada, M., Sasazuki, T. & Fukui, Y., May 1 2004, In : Blood. 103, 9, p. 3362-3364 3 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Differential requirements for DOCK2 and phosphoinositide-3-kinase γ during T and B lymphocyte homing

Nombela-Arrieta, C., Lacalle, R. A., Montoya, M. C., Kunisaki, Y., Megías, D., Marqués, M., Carrera, A. C., Mañes, S., Fukui, Y., Martínez-A, C. & Stein, J. V., Sep 1 2004, In : Immunity. 21, 3, p. 429-441 13 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation

Koyama, M., Matsuoka, K. I., Kunisaki, Y., Takeuchi, M. & Matsue, K., Jan 1 2004, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 45, 10, p. 1115-1118 4 p.

Research output: Contribution to journalArticle

2003
4 Citations (Scopus)

Salazosulfapyridine induced hypersensitivity syndrome associated with reactivation of humanherpes virus 6

Kunisaki, Y., Goto, H., Kitagawa, K. & Nagano, M., Feb 1 2003, In : Internal Medicine. 42, 2, p. 203-207 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)