α-helical polypeptide microcapsules formed by emulsion-templated self-assembly

Masa Aki Morikawa, Masakuni Yoshihara, Takeshi Endo, Nobuo Kimizuka

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    α-Helical peptide microcapsules were prepared by the emulsion-templated self-assembly of amphiphilic poly(γ-benzyl L-glutamate)s (PBLG) 1. By mixing solutions of 1 in dichloromethane (in the form of a sodium salt) with water, oil-in-water emulsions were obtained. Spontaneous stripping of the dichloromethane phase caused a decrease in the diameter of the microdroplets and finally stable microcapsules formed. The microcapsules contain an inner aqueous phase as observed by confocal laser scanning microscopy (CLSM). Binding of hydrophobic pyrene molecules to the polypeptide shell was also demonstrated. The present polypeptide microcapsules are stable even after drying in air and they would serve as supramolecular vehicles for both hydrophobic and water-soluble molecules.

    Original languageEnglish
    Pages (from-to)1574-1578
    Number of pages5
    JournalChemistry - A European Journal
    Volume11
    Issue number5
    DOIs
    Publication statusPublished - Feb 18 2005

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'α-helical polypeptide microcapsules formed by emulsion-templated self-assembly'. Together they form a unique fingerprint.

    Cite this