α-helical polypeptide microcapsules formed by emulsion-templated self-assembly

Masa-Aki Morikawa, Masakuni Yoshihara, Takeshi Endo, Nobuo Kimizuka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

α-Helical peptide microcapsules were prepared by the emulsion-templated self-assembly of amphiphilic poly(γ-benzyl L-glutamate)s (PBLG) 1. By mixing solutions of 1 in dichloromethane (in the form of a sodium salt) with water, oil-in-water emulsions were obtained. Spontaneous stripping of the dichloromethane phase caused a decrease in the diameter of the microdroplets and finally stable microcapsules formed. The microcapsules contain an inner aqueous phase as observed by confocal laser scanning microscopy (CLSM). Binding of hydrophobic pyrene molecules to the polypeptide shell was also demonstrated. The present polypeptide microcapsules are stable even after drying in air and they would serve as supramolecular vehicles for both hydrophobic and water-soluble molecules.

Original languageEnglish
Pages (from-to)1574-1578
Number of pages5
JournalChemistry - A European Journal
Volume11
Issue number5
DOIs
Publication statusPublished - Feb 18 2005

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Polypeptides
Emulsions
Self assembly
Capsules
Dichloromethane
Peptides
Methylene Chloride
Water
Molecules
Pyrene
Drying
Microscopic examination
Sodium
Salts
Scanning
Oils
Lasers
Air

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

α-helical polypeptide microcapsules formed by emulsion-templated self-assembly. / Morikawa, Masa-Aki; Yoshihara, Masakuni; Endo, Takeshi; Kimizuka, Nobuo.

In: Chemistry - A European Journal, Vol. 11, No. 5, 18.02.2005, p. 1574-1578.

Research output: Contribution to journalArticle

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