β-Adrenergic receptor and insulin resistance in the heart

Supachoke Mangmool, Tananat Denkaew, Warisara Parichatikanond, Hitoshi Kurose

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Overstimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR overstimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs overstimulation leads to induction of insulin resistance in the heart.

Original languageEnglish
Pages (from-to)44-56
Number of pages13
JournalBiomolecules and Therapeutics
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2017

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Adrenergic Receptors
Insulin Resistance
Insulin
Heart Failure
Sympathetic Nervous System
Neurology
Myocardium
Cardiovascular Diseases
Up-Regulation
Muscle
Morbidity
Glucose
Tissue
Mortality

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

β-Adrenergic receptor and insulin resistance in the heart. / Mangmool, Supachoke; Denkaew, Tananat; Parichatikanond, Warisara; Kurose, Hitoshi.

In: Biomolecules and Therapeutics, Vol. 25, No. 1, 01.2017, p. 44-56.

Research output: Contribution to journalArticle

Mangmool, Supachoke ; Denkaew, Tananat ; Parichatikanond, Warisara ; Kurose, Hitoshi. / β-Adrenergic receptor and insulin resistance in the heart. In: Biomolecules and Therapeutics. 2017 ; Vol. 25, No. 1. pp. 44-56.
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