Abstract
The mammalian Per1 gene is one of the most important components of circadian clock function of the suprachiasmatic nucleus and peripheral tissues. We examined whether the β2-adrenoceptor agonists, procaterol and fenoterol, induce human Per1 mRNA expression in human bronchial epithelium. The in vitro stimulation of β2-adrenoceptor agonists in BEAS-2B cells led to a remarkable increase in the level of hPer1 mRNA. Moreover, fenoterol or procaterol induced the phosphorylation of CREB in BEAS-2B cells as verified by immunoblot analysis. β2-adrenoceptor agonists induced human Per1 mRNA expression by the signaling pathways of cAMP-CREB in BEAS-2B cells.
| Original language | English |
|---|---|
| Pages (from-to) | 777-783 |
| Number of pages | 7 |
| Journal | Chronobiology International |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 4 2005 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Physiology (medical)
Cite this
β2-adrenoceptor agonists induce the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro. / Takata, Miyako; Burioka, Naoto; Ohdo, Shigehiro; Fukuoka, Yasushi; Miyata, Masanori; Endo, Masahiro; Suyama, Hisashi; Shimizu, Eiji.
In: Chronobiology International, Vol. 22, No. 4, 04.10.2005, p. 777-783.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - β2-adrenoceptor agonists induce the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro
AU - Takata, Miyako
AU - Burioka, Naoto
AU - Ohdo, Shigehiro
AU - Fukuoka, Yasushi
AU - Miyata, Masanori
AU - Endo, Masahiro
AU - Suyama, Hisashi
AU - Shimizu, Eiji
PY - 2005/10/4
Y1 - 2005/10/4
N2 - The mammalian Per1 gene is one of the most important components of circadian clock function of the suprachiasmatic nucleus and peripheral tissues. We examined whether the β2-adrenoceptor agonists, procaterol and fenoterol, induce human Per1 mRNA expression in human bronchial epithelium. The in vitro stimulation of β2-adrenoceptor agonists in BEAS-2B cells led to a remarkable increase in the level of hPer1 mRNA. Moreover, fenoterol or procaterol induced the phosphorylation of CREB in BEAS-2B cells as verified by immunoblot analysis. β2-adrenoceptor agonists induced human Per1 mRNA expression by the signaling pathways of cAMP-CREB in BEAS-2B cells.
AB - The mammalian Per1 gene is one of the most important components of circadian clock function of the suprachiasmatic nucleus and peripheral tissues. We examined whether the β2-adrenoceptor agonists, procaterol and fenoterol, induce human Per1 mRNA expression in human bronchial epithelium. The in vitro stimulation of β2-adrenoceptor agonists in BEAS-2B cells led to a remarkable increase in the level of hPer1 mRNA. Moreover, fenoterol or procaterol induced the phosphorylation of CREB in BEAS-2B cells as verified by immunoblot analysis. β2-adrenoceptor agonists induced human Per1 mRNA expression by the signaling pathways of cAMP-CREB in BEAS-2B cells.
UR - http://www.scopus.com/inward/record.url?scp=25444439285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444439285&partnerID=8YFLogxK
U2 - 10.1080/07420520500179167
DO - 10.1080/07420520500179167
M3 - Article
C2 - 16147906
AN - SCOPUS:25444439285
VL - 22
SP - 777
EP - 783
JO - Chronobiology International
JF - Chronobiology International
SN - 0742-0528
IS - 4
ER -