γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis

L. Monin, D. S. Ushakov, H. Arnesen, N. Bah, A. Jandke, M. Muñoz-Ruiz, J. Carvalho, S. Joseph, B. C. Almeida, M. J. Green, E. Nye, S. Hatano, Y. Yoshikai, M. Curtis, H. Carlsen, U. Steinhoff, P. Boysen, A. Hayday

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3 Citations (Scopus)

Abstract

This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier reports, most cells expressed a canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting with earlier reports, uterine γδ T cells were not obviously intraepithelial, being more akin to sub-epithelial Vγ6Vδ1+ T cells at several other anatomical sites. By contrast to other tissues however, the uterine compartment also included non-Vγ6+, IFN-γ-producing cells; was strikingly enriched in young mice; expressed genes hitherto associated with the uterus, including the progesterone receptor; and did not require microbes for development and/or maintenance. This notwithstanding, γδ T-cell deficiency severely impaired resistance to reproductive tract infection by Candida albicans, associated with decreased responses of IL-17-dependent neutrophils. These findings emphasise tissue-specific complexities of different mucosal γδ cell compartments, and their evident importance in lymphoid stress-surveillance against barrier infection.

Original languageEnglish
JournalMucosal Immunology
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Monin, L., Ushakov, D. S., Arnesen, H., Bah, N., Jandke, A., Muñoz-Ruiz, M., Carvalho, J., Joseph, S., Almeida, B. C., Green, M. J., Nye, E., Hatano, S., Yoshikai, Y., Curtis, M., Carlsen, H., Steinhoff, U., Boysen, P., & Hayday, A. (Accepted/In press). γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis. Mucosal Immunology. https://doi.org/10.1038/s41385-020-0305-7